Works in ChemMedChem, 2012, Vol 7, Issue 3

Results: 29

The Science and Business of Drug Discovery: Demystifying the Jargon. By Edward D. Zanders.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 533, doi. 10.1002/cmdc.201200067
By:
- Müller, Klaus
Publication type:
Article
M. Rarey.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 355, doi. 10.1002/cmdc.201200004
Publication type:
Article
Chiral Drugs: Chemistry and Biological Action. Edited by Guo-Qiang Lin, Qi-Dong You and Jie-Fei Cheng.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 534, doi. 10.1002/cmdc.201200019
By:
- Anthonsen, Thorleif
Publication type:
Article
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 391, doi. 10.1002/cmdc.201100469
By:
- Contino, Marialessandra;
- Cantore, Mariangela;
- Capparelli, Elena;
- Perrone, Maria Grazia;
- Niso, Mauro;
- Inglese, Carmela;
- Berardi, Francesco;
- Leopoldo, Marcello;
- Perrone, Roberto;
- Colabufo, Nicola Antonio
Publication type:
Article
Chromenopyrazoles: Non-psychoactive and Selective CB1 Cannabinoid Agonists with Peripheral Antinociceptive Properties.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 452, doi. 10.1002/cmdc.201100568
By:
- Cumella, Jose;
- Hernández-Folgado, Laura;
- Girón, Rocio;
- Sánchez, Eva;
- Morales, Paula;
- Hurst, Dow P.;
- Gómez-Cañas, Maria;
- Gómez-Ruiz, Maria;
- Pinto, Diana C. G. A.;
- Goya, Pilar;
- Reggio, Patricia H.;
- Martin, María Isabel;
- Fernández-Ruiz, Javier;
- Silva, Artur M. S.;
- Jagerovic, Nadine
Publication type:
Article
Spotlights on our sister journals: ChemMedChem 3/2012.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 352, doi. 10.1002/cmdc.201290009
Publication type:
Article
Investigation of D1 Receptor-Agonist Interactions and D1/D2 Agonist Selectivity Using a Combination of Pharmacophore and Receptor Homology Modeling.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 483, doi. 10.1002/cmdc.201100546
By:
- Malo, Marcus;
- Brive, Lars;
- Luthman, Kristina;
- Svensson, Peder
Publication type:
Article
Discovery of Selective Alpha2C Adrenergic Receptor Agonists.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 385, doi. 10.1002/cmdc.201100528
By:
- Jnoff, Eric;
- Christophe, Bernard;
- Collart, Philippe;
- Coloretti, Francis;
- Debeuckelaere, Aurel;
- De Ryck, Marc;
- Fuks, Bruno;
- Genicot, Christophe;
- Gillard, Michel;
- Guyaux, Michel;
- Price, Nathalie;
- Vandergeten, Marie-Christine;
- Vermeiren, Céline
Publication type:
Article
Why as a Medicinal Chemist I Am Not Optimistic about the Possibility of Finding, in a Reasonable Timeframe, Small-Molecule Drugs Capable of Curing the Evolution of Alzheimer's Disease.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 357, doi. 10.1002/cmdc.201100431
By:
- Kraus, Jean-Louis
Publication type:
Article
8-Substituted 3-Arylcoumarins as Potent and Selective MAO-B Inhibitors: Synthesis, Pharmacological Evaluation, and Docking Studies.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 464, doi. 10.1002/cmdc.201100538
By:
- Viña, Dolores;
- Matos, Maria J.;
- Ferino, Giulio;
- Cadoni, Enzo;
- Laguna, Reyes;
- Borges, Fernanda;
- Uriarte, Eugenio;
- Santana, Lourdes
Publication type:
Article
Investigation of D2 Receptor-Agonist Interactions Using a Combination of Pharmacophore and Receptor Homology Modeling.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 471, doi. 10.1002/cmdc.201100545
By:
- Malo, Marcus;
- Brive, Lars;
- Luthman, Kristina;
- Svensson, Peder
Publication type:
Article
Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 359, doi. 10.1002/cmdc.201100585
By:
- Liu, Tingyu;
- Bitan, Gal
Publication type:
Article
Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 440, doi. 10.1002/cmdc.201100578
By:
- Kaae, Birgitte H.;
- Harpsøe, Kasper;
- Kvist, Trine;
- Mathiesen, Jesper M.;
- Mølck, Christina;
- Gloriam, David;
- Jimenez, Hermogenes N.;
- Uberti, Michelle A.;
- Nielsen, Søren M.;
- Nielsen, Birgitte;
- Bräuner-Osborne, Hans;
- Sauerberg, Per;
- Clausen, Rasmus P.;
- Madsen, Ulf
Publication type:
Article
Inside Back Cover: Chromenopyrazoles: Non-psychoactive and Selective CB1 Cannabinoid Agonists with Peripheral Antinociceptive Properties (ChemMedChem 3/2012).
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 536, doi. 10.1002/cmdc.201290011
By:
- Cumella, Jose;
- Hernández-Folgado, Laura;
- Girón, Rocio;
- Sánchez, Eva;
- Morales, Paula;
- Hurst, Dow P.;
- Gómez-Cañas, Maria;
- Gómez-Ruiz, Maria;
- Pinto, Diana C. G. A.;
- Goya, Pilar;
- Reggio, Patricia H.;
- Martin, María Isabel;
- Fernández-Ruiz, Javier;
- Silva, Artur M. S.;
- Jagerovic, Nadine
Publication type:
Article
Graphical Abstract: ChemMedChem 3/2012.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 343, doi. 10.1002/cmdc.201290008
Publication type:
Article
Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ-Secretase Inhibitors.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 396, doi. 10.1002/cmdc.201200014
By:
- Sehgelmeble, Fernando;
- Janson, Juliette;
- Ray, Colin;
- Rosqvist, Susanne;
- Gustavsson, Susanne;
- Nilsson, Linda I.;
- Minidis, Alexander;
- Holenz, Jörg;
- Rotticci, Didier;
- Lundkvist, Johan;
- Arvidsson, Per I.
Publication type:
Article
Discovery of [(2 R,5 R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 415, doi. 10.1002/cmdc.201200025
By:
- Coleman, Paul J.;
- Schreier, John D.;
- Cox, Christopher D.;
- Breslin, Michael J.;
- Whitman, David B.;
- Bogusky, Michael J.;
- McGaughey, Georgia B.;
- Bednar, Rodney A.;
- Lemaire, Wei;
- Doran, Scott M.;
- Fox, Steven V.;
- Garson, Susan L.;
- Gotter, Anthony L.;
- Harrell, C. Meacham;
- Reiss, Duane R.;
- Cabalu, Tamara D.;
- Cui, Donghui;
- Prueksaritanont, Thomayant;
- Stevens, Joanne;
- Tannenbaum, Pamela L.
Publication type:
Article
Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase 6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 425, doi. 10.1002/cmdc.201100522
By:
- Kalin, Jay H.;
- Zhang, Hankun;
- Gaudrel-Grosay, Sophie;
- Vistoli, Giulio;
- Kozikowski, Alan P.
Publication type:
Article
A Two-Step Strategy for Structure-Activity Relationship Studies of N -Methylated Aβ42 C-Terminal Fragments as Aβ42 Toxicity Inhibitors.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 515, doi. 10.1002/cmdc.201100584
By:
- Li, Huiyuan;
- Zemel, Reeve;
- Lopes, Dahabada H. J.;
- Monien, Bernhard H.;
- Bitan, Gal
Publication type:
Article
High-Affinity, Selective σ Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 523, doi. 10.1002/cmdc.201100423
By:
- Tacke, Reinhold;
- Bertermann, Rüdiger;
- Burschka, Christian;
- Dörrich, Steffen;
- Fischer, Markus;
- Müller, Barbara;
- Meyerhans, Géraldine;
- Schepmann, Dirk;
- Wünsch, Bernhard;
- Arnason, Ingvar;
- Bjornsson, Ragnar
Publication type:
Article
Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 495, doi. 10.1002/cmdc.201100537
By:
- Tovilovic, Gordana;
- Zogovic, Nevena;
- Harhaji-Trajkovic, Ljubica;
- Misirkic-Marjanovic, Maja;
- Janjetovic, Kristina;
- Vucicevic, Ljubica;
- Kostic-Rajacic, Sladjana;
- Schrattenholz, Andre;
- Isakovic, Aleksandra;
- Soskic, Vukic;
- Trajkovic, Vladimir
Publication type:
Article
Preview: ChemMedChem 4/2012.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 535, doi. 10.1002/cmdc.201290010
Publication type:
Article
Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 375, doi. 10.1002/cmdc.201100559
By:
- Joubert, Jacques;
- Geldenhuys, Werner J.;
- Van der Schyf, Cornelis J.;
- Oliver, Douglas W.;
- Kruger, Hendrik Gert;
- Govender, Thavendran;
- Malan, Sarel F.
Publication type:
Article
Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 400, doi. 10.1002/cmdc.201100438
By:
- Ronco, Cyril;
- Carletti, Eugénie;
- Colletier, Jacques-Philippe;
- Weik, Martin;
- Nachon, Florian;
- Jean, Ludovic;
- Renard, Pierre-Yves
Publication type:
Article
Inside Cover: Investigation of D2 Receptor-Agonist Interactions Using a Combination of Pharmacophore and Receptor Homology Modeling / Investigation of D1 Receptor-Agonist Interactions and D1/D2 Agonist Selectivity Using a Combination of Pharmacophore and Receptor Homology Modeling (ChemMedChem 3/2012)
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 338, doi. 10.1002/cmdc.201290007
By:
- Malo, Marcus;
- Brive, Lars;
- Luthman, Kristina;
- Svensson, Peder
Publication type:
Article
Editorial: Challenges and Opportunities in Neuroscience Research.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 339, doi. 10.1002/cmdc.201200075
Publication type:
Article
Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 406, doi. 10.1002/cmdc.201100510
By:
- Mueller, Ralf;
- Dawson, Eric S.;
- Meiler, Jens;
- Rodriguez, Alice L.;
- Chauder, Brian A.;
- Bates, Brittney S.;
- Felts, Andrew S.;
- Lamb, Jeffrey P.;
- Menon, Usha N.;
- Jadhav, Sataywan B.;
- Kane, Alexander S.;
- Jones, Carrie K.;
- Gregory, Karen J.;
- Niswender, Colleen M.;
- Conn, P. Jeffrey;
- Olsen, Christopher M.;
- Winder, Danny G.;
- Emmitte, Kyle A.;
- Lindsley, Craig W.
Publication type:
Article
Selective Agonists for Dopamine/Neurotensin Receptor Heterodimers.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 509, doi. 10.1002/cmdc.201100499
By:
- Koschatzky, Susanne;
- Gmeiner, Peter
Publication type:
Article
Cover Picture: Discovery of [(2 R,5 R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012).
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 337, doi. 10.1002/cmdc.201290006
By:
- Coleman, Paul J.;
- Schreier, John D.;
- Cox, Christopher D.;
- Breslin, Michael J.;
- Whitman, David B.;
- Bogusky, Michael J.;
- McGaughey, Georgia B.;
- Bednar, Rodney A.;
- Lemaire, Wei;
- Doran, Scott M.;
- Fox, Steven V.;
- Garson, Susan L.;
- Gotter, Anthony L.;
- Harrell, C. Meacham;
- Reiss, Duane R.;
- Cabalu, Tamara D.;
- Cui, Donghui;
- Prueksaritanont, Thomayant;
- Stevens, Joanne;
- Tannenbaum, Pamela L.
Publication type:
Article

Works in ChemMedChem, 2012, Vol 7, Issue 3

The Science and Business of Drug Discovery: Demystifying the Jargon. By Edward D. Zanders.

M. Rarey.

Chiral Drugs: Chemistry and Biological Action. Edited by Guo-Qiang Lin, Qi-Dong You and Jie-Fei Cheng.

A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease.

Chromenopyrazoles: Non-psychoactive and Selective CB<sub>1</sub> Cannabinoid Agonists with Peripheral Antinociceptive Properties.

Spotlights on our sister journals: ChemMedChem 3/2012.

Investigation of D<sub>1</sub> Receptor-Agonist Interactions and D<sub>1</sub>/D<sub>2</sub> Agonist Selectivity Using a Combination of Pharmacophore and Receptor Homology Modeling.

Discovery of Selective Alpha<sub>2C</sub> Adrenergic Receptor Agonists.

Why as a Medicinal Chemist I Am Not Optimistic about the Possibility of Finding, in a Reasonable Timeframe, Small-Molecule Drugs Capable of Curing the Evolution of Alzheimer's Disease.

8-Substituted 3-Arylcoumarins as Potent and Selective MAO-B Inhibitors: Synthesis, Pharmacological Evaluation, and Docking Studies.

Investigation of D<sub>2</sub> Receptor-Agonist Interactions Using a Combination of Pharmacophore and Receptor Homology Modeling.

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms.

Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators.

Inside Back Cover: Chromenopyrazoles: Non-psychoactive and Selective CB<sub>1</sub> Cannabinoid Agonists with Peripheral Antinociceptive Properties (ChemMedChem 3/2012).

Graphical Abstract: ChemMedChem 3/2012.

Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ-Secretase Inhibitors.

Discovery of [(2 R,5 R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties.

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase 6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress.

A Two-Step Strategy for Structure-Activity Relationship Studies of N -Methylated Aβ42 C-Terminal Fragments as Aβ42 Toxicity Inhibitors.

High-Affinity, Selective σ Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties.

Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis.

Preview: ChemMedChem 4/2012.

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs.

Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography.

Editorial: Challenges and Opportunities in Neuroscience Research.

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.

Selective Agonists for Dopamine/Neurotensin Receptor Heterodimers.

Cover Picture: Discovery of [(2 R,5 R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012).