Works matching IS 17574676 AND DT 2017 AND VI 9 AND IP 10

Results: 12

Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1346, doi. 10.15252/emmm.201707601

By:

Porro, Fabiola;
Bortolussi, Giulia;
Barzel, Adi;
De Caneva, Alessia;
Iaconcig, Alessandra;
Vodret, Simone;
Zentilin, Lorena;
Kay, Mark A;
Muro, Andrés F

Publication type:

Article

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1356, doi. 10.15252/emmm.201707672

By:

Schlepckow, Kai;
Kleinberger, Gernot;
Fukumori, Akio;
Feederle, Regina;
Lichtenthaler, Stefan F;
Steiner, Harald;
Haass, Christian

Publication type:

Article

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1366, doi. 10.15252/emmm.201707673

By:

Thornton, Peter;
Sevalle, Jean;
Deery, Michael J;
Fraser, Graham;
Zhou, Ye;
Ståhl, Sara;
Franssen, Elske H;
Dodd, Roger B;
Qamar, Seema;
Gomez Perez‐Nievas, Beatriz;
Nicol, Louise SC;
Eketjäll, Susanna;
Revell, Jefferson;
Jones, Clare;
Billinton, Andrew;
St George‐Hyslop, Peter H;
Chessell, Iain;
Crowther, Damian C

Publication type:

Article

mRNA mediates passive vaccination against infectious agents, toxins, and tumors.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1434, doi. 10.15252/emmm.201707678

By:

Thran, Moritz;
Mukherjee, Jean;
Pönisch, Marion;
Fiedler, Katja;
Thess, Andreas;
Mui, Barbara L;
Hope, Michael J;
Tam, Ying K;
Horscroft, Nigel;
Heidenreich, Regina;
Fotin‐Mleczek, Mariola;
Shoemaker, Charles B;
Schlake, Thomas

Publication type:

Article

Spironolactone is an antagonist of NRG1- ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1448, doi. 10.15252/emmm.201707691

By:

Wehr, Michael C;
Hinrichs, Wilko;
Brzózka, Magdalena M;
Unterbarnscheidt, Tilmann;
Herholt, Alexander;
Wintgens, Jan P;
Papiol, Sergi;
Soto‐Bernardini, Maria Clara;
Kravchenko, Mykola;
Zhang, Mingyue;
Nave, Klaus‐Armin;
Wichert, Sven P;
Falkai, Peter;
Zhang, Weiqi;
Schwab, Markus H;
Rossner, Moritz J

Publication type:

Article

β-Klotho sustains postnatal Gn RH biology and spins the thread of puberty.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1334, doi. 10.15252/emmm.201708180

By:

Misrahi, Micheline

Publication type:

Article

One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1338, doi. 10.15252/emmm.201707950

By:

Argente, Jesús;
Chowen, Julie A;
Pérez‐Jurado, Luis A;
Frystyk, Jan;
Oxvig, Claus

Publication type:

Article

KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1379, doi. 10.15252/emmm.201607376

By:

Xu, Cheng;
Messina, Andrea;
Somm, Emmanuel;
Miraoui, Hichem;
Kinnunen, Tarja;
Acierno, James;
Niederländer, Nicolas J;
Bouilly, Justine;
Dwyer, Andrew A;
Sidis, Yisrael;
Cassatella, Daniele;
Sykiotis, Gerasimos P;
Quinton, Richard;
De Geyter, Christian;
Dirlewanger, Mirjam;
Schwitzgebel, Valérie;
Cole, Trevor R;
Toogood, Andrew A;
Kirk, Jeremy MW;
Plummer, Lacey

Publication type:

Article

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1415, doi. 10.15252/emmm.201607012

By:

Dall'Acqua, Alessandra;
Sonego, Maura;
Pellizzari, Ilenia;
Pellarin, Ilenia;
Canzonieri, Vincenzo;
D'Andrea, Sara;
Benevol, Sara;
Sorio, Roberto;
Giorda, Giorgio;
Califano, Daniela;
Bagnoli, Marina;
Militello, Loredana;
Mezzanzanica, Delia;
Chiappetta, Gennaro;
Armenia, Joshua;
Belletti, Barbara;
Schiappacassi, Monica;
Baldassarre, Gustavo

Publication type:

Article

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1398, doi. 10.15252/emmm.201607446

By:

Tacconi, Eliana MC;
Lai, Xianning;
Folio, Cecilia;
Porru, Manuela;
Zonderland, Gijs;
Badie, Sophie;
Michl, Johanna;
Sechi, Irene;
Rogier, Mélanie;
Matía García, Verónica;
Batra, Ankita Sati;
Rueda, Oscar M;
Bouwman, Peter;
Jonkers, Jos;
Ryan, Anderson;
Reina‐San‐Martin, Bernardo;
Hui, Joannie;
Tang, Nelson;
Bruna, Alejandra;
Biroccio, Annamaria

Publication type:

Article

Thwarting endogenous stress: BRCA protects against aldehyde toxicity.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1331, doi. 10.15252/emmm.201708194

By:

Ray Chaudhuri, Arnab;
Nussenzweig, André

Publication type:

Article

Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1327, doi. 10.15252/emmm.201708072

By:

Teixeira, Andre A;
Marchiò, Serena;
Dias‐Neto, Emmanuel;
Nunes, Diana N;
da Silva, Israel T;
Chackerian, Bryce;
Barry, Marc;
Lauer, Richard C;
Giordano, Ricardo J;
Sidman, Richard L;
Wheeler, Cosette M;
Cavenee, Webster K;
Pasqualini, Renata;
Arap, Wadih

Publication type:

Article