Works matching IS 17501326 AND DT 2025 AND VI 20 AND IP 1

Results: 94

Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00879-0

By:

Liang, Jingfeng;
Li, Rongzhen;
Wong, Garry;
Huang, Xiaobing

Publication type:

Article

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00880-7

By:

Maloney, Michael T.;
Wang, Xiang;
Ghosh, Rajarshi;
Andrews, Shan V.;
Maciuca, Romeo;
Masoud, Shababa T.;
Agam, Maayan;
Caprioli, Richard M.;
Astarita, Giuseppe;
Bondar, Vitaliy V.;
Chen, John;
Chiu, Chi-Lu;
Davis, Sonnet S.;
Ho, Audrey Cheuk-Nga;
Nguyen, Hoang N.;
Propson, Nicholas E.;
Reyzer, Michelle L.;
Davis, Oliver B.;
Deen, Matthew C.;
Zhu, Sha

Publication type:

Article

A manifesto for Alzheimer's disease drug discovery in the era of disease-modifying therapies.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00872-7

By:

Hering, Heike;
Bussiere, Thierry;
Liu, Chia-Chen;
Glajch, Kelly E.;
Weihofen, Andreas;
Grogan, Jane;
Walsh, Dominic M.

Publication type:

Article

Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies.

Published in:

2025

By:

Overk, Cassia R;
Cartier, Anna;
Shaked, Gideon;
Rockenstein, Edward;
Ubhi, Kiren;
Spencer, Brian;
Price, Diana L;
Patrick, Christina;
Desplats, Paula;
Masliah, Eliezer

Publication type:

Correction Notice

Glycerophospholipids in ALS: insights into disease mechanisms and clinical implication.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00876-3

By:

Burg, Thibaut;
Van Den Bosch, Ludo

Publication type:

Article

The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00873-6

By:

Takahashi, Hideyuki;
Strittmatter, Stephen M.

Publication type:

Article

Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00875-4

By:

Zhang, Pingao;
Song, Chenghuan;
Shi, Jiyun;
Wei, Zijie;
Wang, Jing;
Huang, Wanying;
Zhang, Rui;
Wang, Jintao;
Yang, Xiaoli;
Wang, Gang;
Gao, Xiaoling;
Zhang, Yongfang;
Chen, Hongzhuan;
Wang, Hao

Publication type:

Article

Proteomic landscape of Alzheimer's disease: emerging technologies, advances and insights (2021 – 2025).

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00874-5

By:

Yarbro, Jay M.;
Shrestha, Him K.;
Wang, Zhen;
Zhang, Xue;
Zaman, Masihuz;
Chu, Mengqi;
Wang, Xusheng;
Yu, Gang;
Peng, Junmin

Publication type:

Article

Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00867-4

By:

Noh, Min-Young;
Kwon, Hyuk Sung;
Kwon, Min-Soo;
Nahm, Minyeop;
Jin, Hee Kyung;
Bae, Jae-sung;
Kim, Seung Hyun

Publication type:

Article

Mechanisms of interventions targeting modifiable factors for dementia risk reduction.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00845-w

By:

Matton, Anna;
Stephen, Ruth;
Daniilidou, Makrina;
Barbera, Mariagnese;
Alanko, Vilma;
Ballin, Marcel;
Ford, Jamie;
Hemiö, Katri;
Lehtisalo, Jenni;
Rocha, Sabsil López;
Mangialasche, Francesca;
Ngandu, Tiia;
Rosenberg, Anna;
Saadmaan, Gazi;
Udeh-Momoh, Chinedu;
Uusimäki, Kerttu;
Solomon, Alina;
Kivipelto, Miia

Publication type:

Article

Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00870-9

By:

Choi, Yeseong;
Chung, Won-Suk

Publication type:

Article

Skin biopsy: an emerging tool for the diagnosis of protein misfolding diseases of the central nervous system.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00871-8

By:

Zhu, Wei;
Sun, Hao-Lun;
Wang, Yan-Jiang;
Lei, Xia;
Bu, Xian-Le

Publication type:

Article

Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00868-3

By:

Bregendahl, Maria;
Kaya, Zeynep Bengisu;
Singer, Wolfgang;
McLean, Pamela J.

Publication type:

Article

Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00856-7

By:

Erskine, Daniel;
Taylor, John-Paul

Publication type:

Article

The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00865-6

By:

Rehman, Hasibur;
Yan, Shun;
Saggu, Shalini;
Aida, Mae;
Zhang, Fang;
Shu, Yang;
Jones, Alexis;
Trang, Amy;
Dew, Emily;
Zhi, Wenbo;
Claeboe, Emily T.;
Baucum II, Anthony J.;
Wu, Guangyu;
Jiao, Kai;
Wang, Qin

Publication type:

Article

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00869-2

By:

Vicente, Cristina T.;
Niranjan, Tejasvi;
Coopman, Elise;
Faura, Júlia;
Alidadiani, Sara;
Schrauwen, Claudia;
Matchett, Billie J.;
Heeman, Bavo;
Van den Broeck, Marleen;
De Coster, Wouter;
Nguyen, Thuy;
Lau, Julie S.;
Baheti, Saurabh;
de Pooter, Tim;
De Rijk, Peter;
Strazisar, Mojca;
Baker, Matt;
DeJesus-Hernandez, Mariely;
Finch, NiCole A.;
Pottier, Cyril

Publication type:

Article

In Memoriam of Edward H. Koo, MD 1954–2025.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00862-9

By:

Zheng, Hui;
Galasko, Douglas;
Sisodia, Sangram S.

Publication type:

Article

Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00866-5

By:

Passaretti, Massimiliano;
Veréb, Daniel;
Mijalkov, Mite;
Chang, Yu-Wei;
Zhao, Hang;
Zufiria-Gerbolés, Blanca;
Sun, Jiawei;
Volpe, Giovanni;
Rivera, Natalia;
Bologna, Matteo;
Pereira, Joana B.

Publication type:

Article

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00863-8

By:

Yang, Cha;
Du, Huan;
Lee, Gwang Bin;
Uematsu, Masaaki;
He, Weiguo;
Doré, Etienne;
Yu, Weizhi;
Sanford, Ethan J.;
Smolka, Marcus B.;
Boilard, Eric;
Baskin, Jeremy M.;
Hao, Ling;
Hu, Fenghua

Publication type:

Article

The many connections of UFMylation with Alzheimer’s disease: a comprehensive review.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00855-8

By:

Yan, Tingxiang;
Clarkson, Benjamin D.;
Lou, Zhenkun;
Springer, Wolfdieter;
Fiesel, Fabienne C.

Publication type:

Article

The many connections of UFMylation with Alzheimer’s disease: a comprehensive review.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00855-8

By:

Yan, Tingxiang;
Clarkson, Benjamin D.;
Lou, Zhenkun;
Springer, Wolfdieter;
Fiesel, Fabienne C.

Publication type:

Article

RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00851-y

By:

Rummens, Jens;
Da Cruz, Sandrine

Publication type:

Article

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00864-7

By:

Ziff, Oliver J.;
Parfitt, Gustavo Morrone;
Jolly, Sarah;
Casey, Jackie M.;
Granat, Lucy;
Samra, Satinder;
Setó-Salvia, Núria;
Alatza, Argyro;
Phadke, Leela;
Galet, Benjamin;
Ravassard, Philippe;
Potier, Marie-Claude;
Hardy, John;
Salih, Dervis A.;
Whiting, Paul;
Ducotterd, Fiona;
Patani, Rickie;
Wray, Selina;
Arber, Charles

Publication type:

Article

Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00857-6

By:

Wang, Zitong;
Zhang, Ling;
Qin, Chuan

Publication type:

Article

Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00857-6

By:

Wang, Zitong;
Zhang, Ling;
Qin, Chuan

Publication type:

Article

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00859-4

By:

Dellar, Elizabeth R.;
Nikel, Lara;
Fowler, Stephanie;
Vahsen, Björn F.;
Dafinca, Ruxandra;
Feneberg, Emily;
Talbot, Kevin;
Turner, Martin R.;
Thompson, Alexander G.

Publication type:

Article

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00822-3

By:

Franzmeier, Nicolai;
Roemer-Cassiano, Sebastian Niclas;
Bernhardt, Alexander Maximilian;
Dehsarvi, Amir;
Dewenter, Anna;
Steward, Anna;
Biel, Davina;
Frontzkowski, Lukas;
Zhu, Zeyu;
Gnörich, Johannes;
Pescoller, Julia;
Wagner, Fabian;
Hirsch, Fabian;
de Bruin, Hannah;
Ossenkoppele, Rik;
Palleis, Carla;
Strübing, Felix;
Schöll, Michael;
Levin, Johannes;
Brendel, Matthias

Publication type:

Article

RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00851-y

By:

Rummens, Jens;
Da Cruz, Sandrine

Publication type:

Article

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00850-z

By:

Karunakaran, Devi Krishna Priya;
Ley, Makenna;
Guo, Joanna;
Khatri, Ammaarah;
Sadleir, Katherine;
Popovic, Jelena;
Upadhyay, Arun Kumar;
Savas, Jeffrey;
Procissi, Daniele;
Atwal, Jasvinder;
Vassar, Robert

Publication type:

Article

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00850-z

By:

Karunakaran, Devi Krishna Priya;
Ley, Makenna;
Guo, Joanna;
Khatri, Ammaarah;
Sadleir, Katherine;
Popovic, Jelena;
Upadhyay, Arun Kumar;
Savas, Jeffrey;
Procissi, Daniele;
Atwal, Jasvinder;
Vassar, Robert

Publication type:

Article

CD2AP at the junction of nephropathy and Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00852-x

By:

Vandal, Milene;
Janmaleki, Mohsen;
Rea, Isabel;
Gunn, Colin;
Hirai, Sotaro;
Biernaskie, Jeff;
Chun, Justin;
Gordon, Grant;
Shaw, Andrey;
Sanati-Nezhad, Amir;
Pfeffer, Gerald;
Calon, Frederic;
Nguyen, Minh Dang

Publication type:

Article

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00853-w

By:

Yan, Zhong-Jiang;
Ye, Maosen;
Li, Jiexi;
Zhang, Deng-Feng;
Yao, Yong-Gang

Publication type:

Article

Bridging systemic metabolic dysfunction and Alzheimer's disease: the liver interface.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00849-6

By:

Song, Dan;
Li, Yang;
Yang, Ling-Ling;
Luo, Ya-Xi;
Yao, Xiu-Qing

Publication type:

Article

Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00854-9

By:

Xiang, Jie;
Qian, Zhengjiang;
Xi, Ye;
Wei, Yanuo;
Wang, Guangxing;
Liu, Xia;
Wang, Zhi-Hao;
Zhang, Zhentao;
Wu, Shengxi;
Ye, Keqiang

Publication type:

Article

Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00848-7

By:

Noh, Min-Young;
Oh, Seong-il;
Kim, Young-Eun;
Cha, Sun Joo;
Sung, Wonjae;
Oh, Ki-Wook;
Park, Yurim;
Mun, Ji Young;
Ki, Chang-Seok;
Nahm, Minyeop;
Kim, Seung Hyun

Publication type:

Article

Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00838-9

By:

Trautwig, Adam N.;
Fox, Edward J.;
Dammer, Eric B.;
Shantaraman, Anantharaman;
Ping, Lingyan;
Duong, Duc M.;
Watson, Caroline M.;
Wu, Fang;
Asress, Seneshaw;
Guo, Qi;
Levey, Allan I.;
Lah, James J.;
Verde, Federico;
Doretti, Alberto;
Ratti, Antonia;
Ticozzi, Nicola;
Ly, Cindy V.;
Miller, Timothy M.;
Garret, Mark A.;
Berry, James D.

Publication type:

Article

Mouse models of Anti-Aβ immunotherapies.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00836-x

By:

Pikus, Philip;
Turner, R. Scott;
Rebeck, G. William

Publication type:

Article

Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00842-z

By:

Donison, Neil;
Palik, Jacqueline;
Volkening, Kathryn;
Strong, Michael J.

Publication type:

Article

Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00847-8

By:

Hardy, John;
Lewis, Patrick

Publication type:

Article

Cautions on utilizing plasma GFAP level as a biomarker for reactive astrocytes in neurodegenerative diseases.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00846-9

By:

Youn, Wongu;
Yun, Mijin;
Lee, C. Justin;
Schöll, Michael

Publication type:

Article

Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00839-8

By:

Kellett, Elise A.;
Bademosi, Adekunle T.;
Walker, Adam K.

Publication type:

Article

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00820-5

By:

Grima, Natalie;
Smith, Andrew N.;
Shepherd, Claire E.;
Henden, Lyndal;
Zaw, Thiri;
Carroll, Luke;
Rowe, Dominic B.;
Kiernan, Matthew C.;
Blair, Ian P.;
Williams, Kelly L.

Publication type:

Article

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00840-1

By:

Zhao, Xiaojie;
Li, Yan;
Zhang, Siwei;
Sudwarts, Ari;
Zhang, Hanwen;
Kozlova, Alena;
Moulton, Matthew J.;
Goodman, Lindsey D.;
Pang, Zhiping P.;
Sanders, Alan R.;
Bellen, Hugo J.;
Thinakaran, Gopal;
Duan, Jubao

Publication type:

Article

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00830-3

By:

Martiskainen, Henna;
Willman, Roosa-Maria;
Harju, Päivi;
Heikkinen, Sami;
Heiskanen, Mette;
Müller, Stephan A.;
Sinisalo, Rosa;
Takalo, Mari;
Mäkinen, Petra;
Kuulasmaa, Teemu;
Pekkala, Viivi;
Galván del Rey, Ana;
Juopperi, Sini-Pauliina;
Jeskanen, Heli;
Kervinen, Inka;
Saastamoinen, Kirsi;
FinnGen;
Palotie, Aarno;
Daly, Mark;
Riley-Gills, Bridget

Publication type:

Article

TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00833-0

By:

Vizziello, Maria;
Dellarole, Ilaria Linda;
Ciullini, Arianna;
Pascuzzo, Riccardo;
Lombardo, Annalisa;
Bellandi, Floriana;
Celauro, Luigi;
Battipaglia, Claudia;
Ciusani, Emilio;
Rizzo, Ambra;
Catania, Marcella;
Devigili, Grazia;
Della Seta, Sara Adriana;
Margiotta, Valentina;
Consonni, Monica;
Faltracco, Veronica;
Tiraboschi, Pietro;
Riva, Nilo;
Portaleone, Sara Maria Silvia;
Zanusso, Gianluigi

Publication type:

Article

Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00832-1

By:

Fernández, Sara Gutiérrez;
Oria, Cristina Gan;
Petit, Dieter;
Annaert, Wim;
Ringman, John M.;
Fox, Nick C.;
Ryan, Natalie S.;
Chávez-Gutiérrez, Lucía

Publication type:

Article

Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00841-0

By:

Weiner, Sophia;
Sauer, Mathias;
Montoliu-Gaya, Laia;
Benedet, Andrea L.;
Ashton, Nicholas J.;
Gonzalez-Ortiz, Fernando;
Simrén, Joel;
Rahmouni, Nesrine;
Tissot, Cecile;
Therriault, Joseph;
Servaes, Stijn;
Stevenson, Jenna;
Leinonen, Ville;
Rauramaa, Tuomas;
Hiltunen, Mikko;
Rosa-Neto, Pedro;
Blennow, Kaj;
Zetterberg, Henrik;
Gobom, Johan

Publication type:

Article

Apolipoprotein E in Alzheimer's disease: molecular insights and therapeutic opportunities.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00843-y

By:

Belaidi, Abdel Ali;
Bush, Ashley I.;
Ayton, Scott

Publication type:

Article

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00820-5

By:

Grima, Natalie;
Smith, Andrew N.;
Shepherd, Claire E.;
Henden, Lyndal;
Zaw, Thiri;
Carroll, Luke;
Rowe, Dominic B.;
Kiernan, Matthew C.;
Blair, Ian P.;
Williams, Kelly L.

Publication type:

Article

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00831-2

By:

Perneel, Jolien;
Lastra Osua, Miranda;
Alidadiani, Sara;
Peeters, Nele;
De Witte, Linus;
Heeman, Bavo;
Manzella, Simona;
De Rycke, Riet;
Brooks, Mieu;
Perkerson, Ralph B.;
Calus, Elke;
De Coster, Wouter;
Neumann, Manuela;
Mackenzie, Ian R. A.;
Van Dam, Debby;
Asselbergh, Bob;
Ellender, Tommas;
Zhou, Xiaolai;
Rademakers, Rosa

Publication type:

Article