Works matching IS 17501326 AND DT 2012 AND VI 7 AND IP 1

Results: 61

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 1, doi. 10.1186/1750-1326-7-61

By:

Rogers, Kathryn;
Felsenstein, Kevin M;
Hrdlicka, Lori;
Tu, Zhiming;
Albayya, Faris;
Lee, Winnie;
Hopp, Sarah;
Miller, Mary-Jo;
Spaulding, Darcie;
Yang, Zhiyong;
Hodgdon, Hilliary;
Nolan, Scott;
Wen, Melody;
Costa, Don;
Blain, Jean-Francois;
Freeman, Emily;
De Strooper, Bart;
Vulsteke, Veerle;
Scrocchi, Louise;
Zetterberg, Henrik

Publication type:

Article

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 1, doi. 10.1186/1750-1326-7-59

By:

Torres, Manuel;
Jimenez, Sebastian;
Sanchez-Varo, Raquel;
Navarro, Victoria;
Trujillo-Estrada, Laura;
Sanchez-Mejias, Elisabeth;
Carmona, Irene;
Carlos Davila, Jose;
Vizuete, Marisa;
Gutierrez, Antonia;
Vitorica, Javier

Publication type:

Article

Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 55, doi. 10.1186/1750-1326-7-55

By:

Slowik, Alexander;
Merres, Julika;
Elfgen, Anne;
Jansen, Sandra;
Mohr, Fabian;
Wruck, Christoph J.;
Pufe, Thomas;
Brandenburg, Lars-Ove

Publication type:

Article

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 52, doi. 10.1186/1750-1326-7-52

By:

Chami, Linda;
Checler, Frédéric

Publication type:

Article

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 57, doi. 10.1186/1750-1326-7-57

By:

McColl, Gawain;
Roberts, Blaine R.;
Pukala, Tara L.;
Kenche, Vijaya B.;
Roberts, Christine M.;
Link, Christopher D.;
Ryan, Timothy M.;
Masters, Colin L.;
Barnham, Kevin J.;
Bush, Ashley I.;
Cherny, Robert A.

Publication type:

Article

Regulated protein aggregation: stress granules and neurodegeneration.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 56, doi. 10.1186/1750-1326-7-56

By:

Wolozin, Benjamin

Publication type:

Article

Neuromuscular effects of G93A-SOD1 expression in zebrafish.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 44, doi. 10.1186/1750-1326-7-44

By:

Sakowski, Stacey A;
Lunn, J Simon;
Busta, Angela S;
Oh, Sang Su;
Zamora-Berridi, Grettel;
Palmer, Madeline;
Rosenberg, Andrew A;
Philip, Stephen G;
Dowling, James J;
Feldman, Eva L

Publication type:

Article

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 60, doi. 10.1186/1750-1326-7-60

By:

Tamayev, Robert;
Nsikan Akpan;
Arancio, Ottavio;
Troy, Carol M.;
D¨Adamio, Luciano

Publication type:

Article

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 58, doi. 10.1186/1750-1326-7-58

By:

Brautigam, Hannah;
Steele, John W.;
Westaway, David;
Fraser, Paul E.;
St George-Hyslop, Peter H.;
Gandy, Sam;
Hof, Patrick R.;
Dickstein, Dara L.

Publication type:

Article

Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 51, doi. 10.1186/1750-1326-7-51

By:

Franco, Carolina;
Fern ndez, Silvia;
Torres-Alem n, Ignacio

Publication type:

Article

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 48, doi. 10.1186/1750-1326-7-48

By:

Keiichi Inoue;
Rispoli, Joanne;
Hanoch Kaphzan;
Klann, Eric;
Chen, Emily I.;
Jongpil Kim;
Masaaki Komatsu;
Abeliovich, Asa

Publication type:

Article

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 54, doi. 10.1186/1750-1326-7-54

By:

Aulas, Anaïs;
Stabile, Stéphanie;
Vande Velde, Christine

Publication type:

Article

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 53, doi. 10.1186/1750-1326-7-53

By:

Verbeeck, Christophe;
Qiudong Deng;
DeJesus-Hernandez, Mariely;
Taylor, Georgia;
Ceballos-Diaz, Carolina;
Kocerha, Jannet;
Golde, Todd;
Das, Pritam;
Rademakers, Rosa;
Dickson, Dennis W.;
Kukar, Thomas

Publication type:

Article

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 49, doi. 10.1186/1750-1326-7-49

By:

Desplats, Paula;
Patel, Pruthul;
Kosberg, Kori;
Mante, Michael;
Patrick, Christina;
Rockenstein, Edward;
Fujita, Masayo;
Hashimoto, Makoto;
Masliah, Eliezer

Publication type:

Article

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 50, doi. 10.1186/1750-1326-7-50

By:

Yuhki Saito;
Tsuyoshi Inoue;
Gang Zhu;
Naoki Kimura;
Motohiro Okada;
Masaki Nishimura;
Nobuyuki Kimura;
Shigeo Murayama;
Sunao Kaneko;
Ryuichi Shigemoto;
Keiji Imoto;
Toshiharu Suzuki

Publication type:

Article

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 43, doi. 10.1186/1750-1326-7-43

By:

Bauer, Peter O;
Hudec, Roman;
Goswami, Anand;
Kurosawa, Masaru;
Matsumoto, Gen;
Mokoshiba, Katsuhiko;
Nukina, Nobuyuki

Publication type:

Article

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 34, doi. 10.1186/1750-1326-7-34

By:

Ribeiro-Resende, Victor Tulio;
Carrier-Ruiz, Alvaro;
Lemes, Robertha M R;
Reis, Ricardo A M;
Mendez-Otero, Rosalia

Publication type:

Article

Progranulin regulates neuronal outgrowth independent of Sortilin.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 33, doi. 10.1186/1750-1326-7-33

By:

Gass, Jennifer;
Lee, Wing C;
Cook, Casey;
Finch, Nicole;
Stetler, Caroline;
Jansen-West, Karen;
Lewis, Jada;
Link, Christopher D;
Rademakers, Rosa;
Nykijaer, Anders;
Petrucelli, Leonard

Publication type:

Article

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 21, doi. 10.1186/1750-1326-7-21

By:

Jiankun Cui;
Shanyan Chen;
Chunyang Zhang;
Fanjun Meng;
Wei Wu;
Rong Hu;
Hadass, Or;
Lehmidi, Tareq;
Blair, Gregory J;
Mijon Lee;
Chang, Mayland;
Mobashery, Shariar;
Sun, Grace Y;
Zezong Gu

Publication type:

Article

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 42, doi. 10.1186/1750-1326-7-42

By:

Danzer, Karin M.;
Kranich, Lisa R.;
Ruf, Wolfgang P.;
Cagsal-Getkin, Ozge;
Winslow, Ashley R.;
Zhu, Liya;
Vanderburg, Charles R.;
McLean, Pamela J.

Publication type:

Article

IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 47, doi. 10.1186/1750-1326-7-47

By:

Lian, Hong;
Shim, David J.;
Gaddam, Samson S. K.;
Rodriguez-Rivera, Jennifer;
Bitner, Brittany R.;
Pautler, Robia G.;
Robertson, Claudia S.;
Zheng, Hui

Publication type:

Article

Identification of BACE2 as an avid β-amyloid-degrading protease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 46, doi. 10.1186/1750-1326-7-46

By:

Abdul-Hay, Samer O.;
Sahara, Tomoko;
McBride, Melinda;
Kang, Dongcheul;
Leissring, Malcolm A.

Publication type:

Article

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 45, doi. 10.1186/1750-1326-7-45

By:

Martinez, Terina N.;
Chen, Xi;
Bandyopadhyay, Sibali;
Merrill, Alfred H.;
Tansey, Malú G.

Publication type:

Article

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 32, doi. 10.1186/1750-1326-7-32

By:

Proctor, Carole J.;
Pienaar, Ilse Sanet;
Elson, Joanna L.;
Kirkwood, Thomas B. L.

Publication type:

Article

Mass spectrometry quantification of clusterin in the human brain.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 41, doi. 10.1186/1750-1326-7-41

By:

Chen, Junjun;
Wang, Meiyao;
Turko, Illarion V.

Publication type:

Article

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 31, doi. 10.1186/1750-1326-7-31

By:

Brodeur, Julie;
Thériault, Caroline;
Lessard-Beaudoin, Mélissa;
Marcil, Alexandre;
Dahan, Sophie;
Lavoie, Christine

Publication type:

Article

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 30, doi. 10.1186/1750-1326-7-30

By:

Yonghao Zhao;
Yunshu Wang;
Jiaye Yang;
Xin Wang;
Yingjun Zhao;
Xian Zhang;
Yun-wu Zhang

Publication type:

Article

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 40, doi. 10.1186/1750-1326-7-40

By:

Ren, Haigang;
Fu, Kai;
Mu, Chenchen;
Zhen, Xuechu;
Wang, Guanghui

Publication type:

Article

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 39, doi. 10.1186/1750-1326-7-39

By:

Das, Pritam;
Verbeeck, Christophe;
Minter, Lisa;
Chakrabarty, Paramita;
Felsenstein, Kevin;
Kukar, Thomas;
Maharvi, Ghulam;
Fauq, Abdul;
Osborne, Barbara A.;
Golde, Todd E.

Publication type:

Article

Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 28, doi. 10.1186/1750-1326-7-28

By:

Rodgers, Shaefali P.;
Born, Heather A.;
Das, Pritam;
Jankowsky, Joanna L

Publication type:

Article

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 25, doi. 10.1186/1750-1326-7-25

By:

Hinkle, Kelly M.;
Mei Yue;
Behrouz, Bahareh;
Dächsel, Justus C.;
Lincoln, Sarah J.;
Bowles, Erin E.;
Beevers, Joel E.;
Dugger, Brittany;
Winner, Beate;
Prots, Iryna;
Kent, Caroline B.;
Nishioka, Kenya;
Wen-Lang Lin;
Dickson, Dennis W.;
Janus, Christopher J.;
Farrer, Matthew J.;
Melrose, Heather L.

Publication type:

Article

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 38, doi. 10.1186/1750-1326-7-38

By:

Konno, Masatoshi;
Hasegawa, Takafumi;
Baba, Toru;
Miura, Emiko;
Sugeno, Naoto;
Kikuchi, Akio;
Fiesel, Fabienne C.;
Sasaki, Tsutomu;
Aoki, Masashi;
Itoyama, Yasuto;
Takeda, Atsushi

Publication type:

Article

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 37, doi. 10.1186/1750-1326-7-37

By:

Rasool, Suhail;
Albay III, Ricardo;
Martinez-Coria, Hilda;
Breydo, Leonid;
Wu, Jessica;
Milton, Saskia;
Misra, Sunit;
Tran, Andy;
Pensalfini, Anna;
Laferla, Frank;
Kayed, Rakez;
Glabe, Charles G.

Publication type:

Article

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with á-synuclein at the single molecule level.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 35, doi. 10.1186/1750-1326-7-35

By:

Nübling, Georg;
Bader, Benedikt;
Levin, Johannes;
Hildebrandt, Jenna;
Kretzschmar, Hans;
Giese, Armin

Publication type:

Article

Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 24, doi. 10.1186/1750-1326-7-24

By:

Xu, Zhao-Hui;
Yang, Qi;
Feng, Bin;
Liu, Shui-bing;
Zhang, Nan;
Xing, Jiang-hao;
Li, Xiao-Qiang;
Wu, Yu-mei;
Gao, Guo-Dong;
Zhao, Ming-Gao

Publication type:

Article

Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 20, doi. 10.1186/1750-1326-7-20

By:

Sugaya, Keizo;
Matsubara, Shiro

Publication type:

Article

Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 17, doi. 10.1186/1750-1326-7-17

By:

Sun, Yanyan;
Zhang, Yu;
Wang, Xiaoyang;
Blomgren, Klas;
Zhu, Changlian

Publication type:

Article

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 15, doi. 10.1186/1750-1326-7-15

By:

Maekawa, Tatsunori;
Mori, Sayuri;
Sasaki, Yui;
Miyajima, Takashi;
Azuma, Sadahiro;
Ohta, Etsuro;
Obata, Fumiya

Publication type:

Article

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 36, doi. 10.1186/1750-1326-7-36

By:

Chakrabarty, Paramita;
Tianbai, Li;
Herring, Amanda;
Ceballos-Diaz, Carolina;
Das, Pritam;
Golde, Todd E.

Publication type:

Article

Does a loss of TDP-43 function cause neurodegeneration?

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 27, doi. 10.1186/1750-1326-7-27

By:

Zuo-Shang Xu

Publication type:

Article

A molecular signature in blood identifies early Parkinson's disease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 26, doi. 10.1186/1750-1326-7-26

By:

Molochnikov, Leonid;
Rabey, Jose M.;
Dobronevsky, Evgenya;
Bonucelli, Ubaldo;
Ceravolo, Roberto;
Frosini, Daniela;
Grünblatt, Edna;
Riederer, Peter;
Jacob, Christian;
Aharon-Peretz, Judith;
Bashenko, Yulia;
Youdim, Moussa B. H.;
Mandel, Silvia A.

Publication type:

Article

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 16, doi. 10.1186/1750-1326-7-16

By:

Hata, Saori;
Taniguchi, Miyako;
Yi Piao;
Ikeuchi, Takeshi;
Fagan, Anne M.;
Holtzman, David M.;
Bateman, Randall;
Sohrabi, Hamid R.;
Martins, Ralph N.;
Gandy, Sam;
Urakami, Katsuya;
Suzuki, Toshiharu

Publication type:

Article

Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 29, doi. 10.1186/1750-1326-7-29
Publication type:: Article

Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 11, doi. 10.1186/1750-1326-7-11
Publication type:: Article

Regulation of mitochondrial permeability transition pore by PINK1.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 22, doi. 10.1186/1750-1326-7-22
Publication type:: Article

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 19, doi. 10.1186/1750-1326-7-19
Publication type:: Article

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 14, doi. 10.1186/1750-1326-7-14
Publication type:: Article

Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 13, doi. 10.1186/1750-1326-7-13
Publication type:: Article

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer's disease neuropathology.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 23, doi. 10.1186/1750-1326-7-23
Publication type:: Article

FE65 as a link between VLDLR and APP to regulate their trafficking and processing.

Published in:: Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 9, doi. 10.1186/1750-1326-7-9
Publication type:: Article