Works in Frontiers in Aging Neuroscience, 2025

Results: 479

Editorial: Lifestyle and environmental influences on Alzheimer's disease: exploring the roles of diet, exercise, cognitive reserve, sleep, and air quality.

Published in:

2025

By:

Cheng, Ruogu;
Qiao, Song;
Wang, Hongquan;
Liu, Yan;
Wang, Zhengjun;
Wang, Guohao;
Shang, Pei

Publication type:

Editorial

The interplay between physical exercise and autophagy signaling in brain health, neurodegenerative diseases and aging.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1579208

By:

Gao, Bo;
Wang, Li;
Gong, Jian;
Zhu, Zehua;
Liu, Qi;
Yuan, Han;
Wang, Haitao

Publication type:

Article

Neuromotor functions across the lifespan: percentiles from 6 to 80 years.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1543408

By:

Kakebeeke, Tanja H.;
Caflisch, Jon;
Chaouch, Aziz;
Rousson, Valentin;
Wehrle, Flavia M.;
Jenni, Oskar G.

Publication type:

Article

AI-driven precision diagnosis and treatment in Parkinson's disease: a comprehensive review and experimental analysis.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1638340

By:

Twala, Bhekisipho

Publication type:

Article

Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer's disease progression.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1609793

By:

Yu, Peng;
Shen, Lu;
Tang, Lijun

Publication type:

Article

Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1592678

By:

Liu, Yilin;
Sundman, Mark H.;
Hinderaker, Dalen;
Yu-Chin Chen, Allison;
Green, Jacob M.;
Haaheim, Lisbeth G.;
Siu, Hannah M.;
Jezerc, Catherine;
Lai, Kaitlyn;
Chen, Carol;
Guss, Parker;
Chou, Ying-hui

Publication type:

Article

A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1587575

By:

Zou, Beibei;
Xiang, Jinxi;
Zhang, Muhua;
Huang, Jing;
Feng, Chao

Publication type:

Article

Modeling and validation of wearable sensor-based gait parameters in Parkinson's disease patients with cognitive impairment.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1590224

By:

Hong, Guo;
Mao, Fengju;
Zhang, Mingming;
Zhang, Fei;
Wang, Xiangcheng;
Ren, Kang;
Chen, Zhonglue;
Luo, Xiaoguang

Publication type:

Article

Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1561282

By:

Yang, Haoyue;
Li, Zekun;
Zhang, Lu;
Zhang, Haifeng;
Liu, Yang;
Chen, Wei;
Zhang, Feng

Publication type:

Article

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1626021

By:

Almassri, Laila S.;
Crane, Kristen M.;
Hergenrother, Sean R.;
Singh, Gurveer;
Barach, Gillian L.;
Iafrate, Melina C.;
Harris, Joshua C.;
Tokar, Nick;
Ohl, Andrew P.;
Young, Jesse W.;
Mellott, Jeffrey G.

Publication type:

Article

Estimating progression of Alzheimer's disease with extracellular vesicle-related multi-omics risk models.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1617611

By:

Zhang, Xiao;
Wijenayake, Sanoji;
Hossain, Shakhawat;
Liu, Qian

Publication type:

Article

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1604378

By:

Zhang, Keyi;
Wen, Ming;
Nan, Xinyue;
Zhao, Shuaizhu;
Li, Hao;
Ai, Yanping;
Zhu, Houze

Publication type:

Article

GLP-1R as a potential link between diabetes and Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1601602

By:

Li, Shujun;
Huang, Nanqu;
Wang, Mei;
Huang, Wendi;
Shi, Jingshan;
Luo, Yong;
Huang, Juan

Publication type:

Article

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1626021

By:

Almassri, Laila S.;
Crane, Kristen M.;
Hergenrother, Sean R.;
Singh, Gurveer;
Barach, Gillian L.;
Iafrate, Melina C.;
Harris, Joshua C.;
Tokar, Nick;
Ohl, Andrew P.;
Young, Jesse W.;
Mellott, Jeffrey G.

Publication type:

Article

Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1617191

By:

Pang, Xuerui;
Ji, Yi;
Hu, Chenyang;
Dai, Yulong;
Hu, Panpan;
Wu, Xingqi;
Wang, Kai

Publication type:

Article

Region-informed machine learning model for choroid plexus segmentation in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1613320

By:

Zhou, Liangdong;
Butler, Tracy A.;
Wang, Xiuyuan H.;
Keil, Samantha A.;
Hojjati, Seyed Hani;
Hu, Tsung-Wei;
Savard, Mélissa;
Lussier, Firoza Z.;
Rosa-Neto, Pedro;
Glodzik, Lidia;
de Leon, Mony J.;
Chiang, Gloria C.;
Li, Yi

Publication type:

Article

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer's-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1607289

By:

Ahmad, Waqas;
Choe, Kyonghwan;
Ahmad, Riaz;
Park, Tae Ju;
Kim, Myeong Ok

Publication type:

Article

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1598245

By:

Colwell, Julia C.;
Emborg, Marina E.

Publication type:

Article

Advancements in multi-omics research to address challenges in Alzheimer's disease: a systems biology approach utilizing molecular biomarkers and innovative strategies.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1591796

By:

Cardillo, Madison;
Katam, Keyura;
Suravajhala, Prashanth

Publication type:

Article

Vulnerability of long-range inputome of basal forebrain in normal aging mice.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1573906

By:

Sun, Tingting;
Chen, Jiale;
Liu, Bimin;
Li, Anan;
Gong, Hui;
Li, Xiangning

Publication type:

Article

Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1547162

By:

Toloza-Ramirez, David;
Santibañez, Rodrigo;
Arraño-Carrasco, Leonardo;
Zunino-Pesce, Romina;
Julio-Ramos, Teresa;
Copland, David A.;
Quezada, Camilo;
Mendez-Orellana, Carolina

Publication type:

Article

Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1559067

By:

Hu, Shiang;
Xiang, Xue;
Huang, Xiaolong;
Lu, Yan;
Zhang, Xulai;
Yao, Dezhong;
Valdes-Sosa, Pedro A.

Publication type:

Article

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1642043

By:

Coleborn, Samantha G.;
Gilson, Zoë M.;
Guo, Yunyong;
Tremblay, Marie-Ève

Publication type:

Article

miR-423-5p and miR-92a-3p in Alzheimer's disease: relationship with pathology and cognition.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1637368

By:

Han, Sang-Won;
Park, Young Ho;
Pyun, Jung-Min;
Bice, Paula J.;
Kim, SangYun;
Saykin, Andrew J.;
Nho, Kwangsik

Publication type:

Article

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer's disease spectrum: a dynamic graph theory analysis for early detection.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1589018

By:

Jiang, Juanjuan;
Kang, Tao;
Ling, Ronghua;
Liu, Yingqian;
Sun, Jiuai;
Li, Yiming;
Li, Xiaoou;
Yang, Hui;
Huang, Bingcang

Publication type:

Article

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1587986

By:

Zhou, Bingyuan;
Li, Jing;
Wu, Anqi;
Wang, Xuewei;
Cheng, Le;
Yang, Gaoshang;
Gao, Dahong;
Zhu, Caifeng

Publication type:

Article

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1501011

By:

Miura, Gen;
Morita, Tomoyo;
Park, Jihoon;
Naito, Eiichi

Publication type:

Article

Motor symptoms of Parkinson's disease: critical markers for early AI-assisted diagnosis.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1602426

By:

Yang, Ni;
Liu, Jing;
Sun, Dan;
Ding, Jiajun;
Sun, Lingzhi;
Qi, Xianghua;
Yan, Wei

Publication type:

Article

Orthostatic hypotension in Parkinson's disease: effects on clinical features and disease severity-a systematic review and meta-analysis.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1612960

By:

Wang, Hui;
Zhang, Chi;
Xu, Dongxun

Publication type:

Article

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1597311

By:

Sundman, Mark H.;
Liu, Yilin;
Chen, Nan-kuei;
Chou, Ying-hui

Publication type:

Article

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1623050

By:

Yang, Yanrong;
Chen, Hua;
Liu, Qibing;
Niu, Yang;
Mao, Chunyang;
Wang, Rui

Publication type:

Article

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1621106

By:

Chen, Fenyang;
Heng, Tiantian;
Feng, Qi;
Hua, Rui;
Wu, Jiaojiao;
Shi, Feng;
Liao, Zhengluan;
Qiao, Keyin;
Zhang, Zhiliang;
Miao, Jianliang

Publication type:

Article

Evaluation of non-motor symptoms in Parkinson's disease using multiparametric MRI with the multiplex sequence.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1602245

By:

Sui, He;
Mo, Zhanhao;
Shi, Feng;
Zhou, Qing;
Yu, Dan;
Wang, Jiaqi;
Liu, Lin

Publication type:

Article

Predictive value of pan-immune-inflammation value in the prognosis of adults with status epilepticus: a retrospective study.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1601816

By:

Fu, Jie;
Chu, Yifei;
Zhao, Chenxin;
Peng, Lilei

Publication type:

Article

Brain structural MRI marker for predicting conversion to Parkinson's disease in individuals with prodromal symptoms.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1579326

By:

Park, Chang-hyun;
Yoon, Uicheul;
Lee, Phil Hyu;
Kim, Jinna;
Lee, Seung-Koo;
Shin, Na-Young

Publication type:

Article

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1542857

By:

Schultz, Vivian;
Schmitz-Koep, Benita;
Menegaux, Aurore;
Thalhammer, Melissa;
Schramm, Severin;
Kim, Su Hwan;
Zimmer, Claus;
Sorg, Christian;
Giannakopoulos, Panteleimon;
Montandon, Marie-Louise;
Herrmann, François R.;
Rodriguez, Cristelle;
Haller, Sven;
Hedderich, Dennis M.

Publication type:

Article

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1532884

By:

Huang, Yushu;
Yang, Xifan;
Wang, Qi;
Abula, Adila;
Dong, Yue;
Li, Wenyuan

Publication type:

Article

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer's disease neuropathology.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1610350

By:

Arnsten, Amy F. T.;
Perone, Isabella;
Wang, Min;
Yang, Shengtao;
Uchendu, Stacy;
Bolat, Dinara;
Datta, Dibyadeep

Publication type:

Article

Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1579560

By:

Fan, Hui-Ying;
Sun, He-Li;
Feng, Yuan;
Zhang, Qinge;
Xing, Hua-Qing;
Huang, Qian-Hua;
Su, Zhaohui;
Cheung, Teris;
Ng, Chee H.;
Xiang, Yu-Tao;
Wang, Gang

Publication type:

Article

Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1597263

By:

Disdier, Clémence;
Lhotellier, Clara;
Wagner, Stéphanie;
Andriambeloson, Emile;
Théodoro, Frédéric;
Pruvost, Alain;
Joudinaud, Thomas;
Bénech, Henri;
Mabondzo, Aloïse

Publication type:

Article

Stem cell extracellular vesicles: a new dawn for anti-inflammatory treatment of neurodegenerative diseases.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1592578

By:

Yu, Miao;
Ma, Hongxia;
Lai, Xiaoyi;
Wu, Jiannan;
Shen, Mengmeng;
Yan, Junqiang

Publication type:

Article

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1566247

By:

Lu, Jianping;
Cai, Guoen;
Xiao, Naian;
Zheng, Kunmu;
Ye, Qinyong;
Chen, Xiaochun

Publication type:

Article

Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1510773

By:

Han, Han;
Zhang, Jinhao;
Zhang, Fan;
Li, Fanghui;
Wu, Zhijian

Publication type:

Article

Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1615734

By:

Zhang, Yu;
Wang, Yulin;
Xu, Ke;
Zhang, Chengguang;
Lv, Peizhu;
Bai, Yan;
Wang, Shun

Publication type:

Article

Differential methylation of SNCA and MAPT genes associated with Parkinson's disease in Mexican Mestizos.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1612544

By:

Miranda-Morales, Ernesto G.;
Ramos-Rosales, Daniel F.;
Salas-Leal, Alma C.;
Salas-Pacheco, Sergio M.;
Castellanos-Juárez, Francisco X.;
Méndez-Hernández, Edna M.;
La Llave-León, Osmel;
Peñaherrera, María S.;
Quiñones-Canales, Gerardo;
Arias-Carrión, Oscar;
Sandoval-Carrillo, Ada A.;
Salas-Pacheco, José M.

Publication type:

Article

Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1605144

By:

McCann, Ryan P.;
Bowley, Bethany;
Pessina, Monica;
Yang, Qiong;
Xin, Hongqi;
DeVries, Sarah A.;
Wang, Mingjin;
Zhang, Yi;
Chopp, Michael;
Zhang, Zhenggang;
Rosene, Douglas L.;
Zeldich, Ella;
Medalla, Maria;
Moore, Tara L.

Publication type:

Article

Regulation of BBB function and pathological evolution of PD by microenvironment "spatiotemporal gradient": unique advantages of microfluidic chips.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1599509

By:

Yu, Sixun;
Jiang, Lingli;
Song, Min;
Yang, Tao;
Yuan, Ma;
Chen, Xin;
Shu, Haifeng

Publication type:

Article

Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1566785

By:

Zhou, Wei;
Tang, MengYue;
Cheng, Bo;
Sun, Ling;
Lin, HongYu;
Fan, Yang;
Liu, Nian;
Zhang, Shushan

Publication type:

Article

Sedentary behavior, cognition, and brain health in older adults: a systematic review.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1622049

By:

Gogniat, Marissa A.;
Won, Junyeon;
Cruz, Carlos;
Aranda, Amaya;
Verma, Aryan;
Gujral, Swathi;
Weinstein, Andrea M.;
Zaheed, Afsara B.;
Cole, Keith R.;
Full, Kelsie M.;
Snitz, Beth E.

Publication type:

Article

Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1593868

By:

Rodríguez-Nieto, Geraldine;
Seer, Caroline;
Adab, Hamed Zivari;
Jimenez-Marin, Antonio;
Chalavi, Sima;
Rasooli, Amirhossein;
Cortés, Jesús M.;
Sunaert, Stefan;
Swinnen, Stephan P.

Publication type:

Article