Works matching IS 15507416 AND DT 2021 AND VI 23 AND IP 3

Results: 24

Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00589-7

By:

Meyer, Michael E.;
Doshi, Arpit;
Yasuda, Dennis;
Zaveri, Nurulain T.

Publication type:

Article

Perspectives on Existing and Novel Alternative Intravaginal Probiotic Delivery Methods in the Context of Bacterial Vaginosis Infection.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00602-z

By:

Chandrashekhar, Priyadarshini;
Minooei, Farnaz;
Arreguin, Wenndy;
Masigol, Mohammadali;
Steinbach-Rankins, Jill M.

Publication type:

Article

There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00591-z

By:

Benet, Leslie Z.;
Sodhi, Jasleen K.;
Makrygiorgos, George;
Mesbah, Ali

Publication type:

Article

FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00585-x

By:

Bai, Jane P. F.;
Schmidt, Brian J.;
Gadkar, Kapil G.;
Damian, Valeriu;
Earp, Justin C.;
Friedrich, Christina;
van der Graaf, Piet H.;
Madabushi, Rajanikanth;
Musante, Cynthia J.;
Naik, Kunal;
Rogge, Mark;
Zhu, Hao

Publication type:

Article

Development of a Pediatric Relative Bioavailability/Bioequivalence Database and Identification of Putative Risk Factors Associated With Evaluation of Pediatric Oral Products.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00592-y

By:

Pawar, Gopal;
Wu, Fang;
Zhao, Liang;
Fang, Lanyan;
Burckart, Gilbert J.;
Feng, Kairui;
Mousa, Youssef M.;
Naumann, Franci;
Batchelor, Hannah K.

Publication type:

Article

Assessing Treatment Effects with Pharmacometric Models: A New Method that Addresses Problems with Standard Assessments.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00596-8

By:

Chasseloup, Estelle;
Tessier, Adrien;
Karlsson, Mats O.

Publication type:

Article

Bioanalysis in the Age of New Drug Modalities.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00594-w

By:

Shi, Jing;
Chen, Xuesong;
Diao, Jianbo;
Jiang, Liying;
Li, Lan;
Li, Stephen;
Liang, Wenzhong;
Jin, Xiaoying;
Wang, Yonghui;
Wong, Colton;
Zhang, Xiaolong Tom;
Tse, Francis L.S.

Publication type:

Article

A Two-Pore Physiologically Based Pharmacokinetic Model to Predict Subcutaneously Administered Different-Size Antibody/Antibody Fragments.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00588-8

By:

Li, Zhe;
Yu, Xiaoying;
Li, Yingyi;
Verma, Ashwni;
Chang, Hsuan Ping;
Shah, Dhaval K.

Publication type:

Article

Choroid Plexus and Drug Removal Mechanisms.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00587-9

By:

Sun, Austin;
Wang, Joanne

Publication type:

Article

Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00595-9

By:

Cristea, Sînziana;
Krekels, Elke H. J.;
Allegaert, Karel;
De Paepe, Peter;
de Jaeger, Annick;
De Cock, Pieter;
Knibbe, Catherijne A. J.

Publication type:

Article

Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00590-0

By:

Martinez, Marilyn N.;
Mochel, Jonathan P.;
Neuhoff, Sibylle;
Pade, Devendra

Publication type:

Article

Quantitative Evaluation of the Effect of Antigen Expression Level on Antibody–Drug Conjugate Exposure in Solid Tumor.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00584-y

By:

Bussing, David;
Sharma, Sharad;
Li, Zhe;
Meyer, Lyndsey F.;
Shah, Dhaval K.

Publication type:

Article

Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00583-z

By:

Morse, Bridget L.;
Fallon, John K.;
Kolur, Anil;
Hogan, Andrew T.;
Smith, Philip C.;
Hillgren, Kathleen M.

Publication type:

Article

Elucidating the Effect of Fine Lactose Ratio on the Rheological Properties and Aerodynamic Behavior of Dry Powder for Inhalation.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00582-0

By:

Sun, Ying;
Qin, Lu;
Li, Jiayi;
Su, Jian;
Song, Ruxiao;
Zhang, Xin;
Guan, Jian;
Mao, Shirui

Publication type:

Article

Age-Related Changes in Pediatric Physiology: Quantitative Analysis of Organ Weights and Blood Flows: Age-Related Changes in Pediatric Physiology.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00581-1

By:

Chang, Hsuan Ping;
Kim, Se Jin;
Wu, Di;
Shah, Kushal;
Shah, Dhaval K.

Publication type:

Article

A Systematic Review of the Efforts and Hindrances of Modeling and Simulation of CAR T-cell Therapy.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00579-9

By:

Nukala, Ujwani;
Rodriguez Messan, Marisabel;
Yogurtcu, Osman N.;
Wang, Xiaofei;
Yang, Hong

Publication type:

Article

Correction to: Insights on Droplet Digital PCR–Based Cellular Kinetics and Biodistribution Assay Support for CAR-T Cell Therapy.

Published in:

2021

By:

Sugimoto, Hiroshi;
Chen, Susan;
Minembe, Jean-Pierre;
Chouitar, Johara;
He, Xingyue;
Wang, Haiqing;
Fang, Xiaodong;
Qian, Mark G.

Publication type:

Correction Notice

Dosing Recommendations for Vancomycin in Children and Adolescents with Varying Levels of Obesity and Renal Dysfunction: a Population Pharmacokinetic Study in 1892 Children Aged 1–18 Years.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00577-x

By:

Smit, Cornelis;
Goulooze, Sebastiaan C.;
Brüggemann, Roger J. M.;
Sherwin, Catherine M.;
Knibbe, Catherijne A. J.

Publication type:

Article

Parent and Metabolite Concentration-QT Modeling to Evaluate QT-Interval Prolongation at Savolitinib Therapeutic Doses.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00573-1

By:

Schalkwijk, Stein;
Sahota, Tarjinder;
Verheijen, Remy B.;
Harmer, Alexander R.;
Ahmed, Ghada F.

Publication type:

Article

Assessment of Drug Delivery Kinetics to Epidermal Targets In Vivo.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00571-3

By:

Hoppel, M.;
Tabosa, M. A. M.;
Bunge, A. L.;
Delgado-Charro, M. B.;
Guy, R. H.

Publication type:

Article

Assessing Food Effects on Oral Drug Absorption Based on the Degree of Renal Excretion.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00570-4

By:

Zhang, Tao;
Zou, Peng

Publication type:

Article

Can Pharmacokinetic Studies Assess the Pulmonary Fate of Dry Powder Inhaler Formulations of Fluticasone Propionate?

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00569-x

By:

Hochhaus, Günther;
Chen, Mong-Jen;
Kurumaddali, Abhinav;
Schilling, Uta;
Jiao, Yuanyuan;
Drescher, Stefanie K.;
Amini, Elham;
Kandala, Bhargava;
Tabulov, Christine;
Shao, Jie;
Seay, Brandon;
Abu-Hasan, Mutasim N.;
Baumstein, Sandra M.;
Winner, Lawrence;
Shur, Jagdeep;
Price, Robert;
Hindle, Michael;
Wei, Xiangyin;
Carrasco, Cynthia;
Sandell, Dennis

Publication type:

Article

Clinical Pharmacology Regulatory Sciences in Drug Development and Precision Medicine: Current Status and Emerging Trends.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00563-3

By:

Liu, Qi;
Ahadpour, Mitra;
Rocca, Mitra;
Huang, Shiew-Mei

Publication type:

Article

An Item Response Theory–Informed Strategy to Model Total Score Data from Composite Scales.

Published in:

AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00555-3

By:

Wellhagen, Gustaf J.;
Ueckert, Sebastian;
Kjellsson, Maria C.;
Karlsson, Mats O.

Publication type:

Article