Works matching IS 15507416 AND DT 2020 AND VI 22 AND IP 4

Results: 20

Facilitating Longitudinal Exposure-Response Modeling of a Composite Endpoint Using the Joint Modeling of Sparsely and Frequently Collected Subcomponents.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00452-1
By:
- Hu, Chuanpu;
- Zhou, Honghui;
- Sharma, Amarnath
Publication type:
Article
Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00474-9
By:
- Xie, Zhiliang;
- Chen, Min;
- Goswami, Swagata;
- Mani, Rajes;
- Wang, Dasheng;
- Kulp, Samuel K.;
- Coss, Chris C.;
- Schaaf, Larry J.;
- Cui, Fengyu;
- Byrd, John C.;
- Jennings, Ryan N.;
- Schober, Karsten K.;
- Freed, Carrie;
- Lewis, Stephanie;
- Malbrue, Raphael;
- Muthusamy, Natarajan;
- Bennett, Chad;
- Kisseberth, William C.;
- Phelps, Mitch A.
Publication type:
Article
Comparison of Fraction Unbound Between Liver Homogenate and Hepatocytes at 4°C.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00476-7
By:
- Riccardi, Keith;
- Ryu, Sangwoo;
- Tess, David;
- Li, Rui;
- Luo, Lina;
- Johnson, Nathaniel;
- Jordan, Samantha;
- Patel, Roshan;
- Di, Li
Publication type:
Article
A Cautionary Tale: Quantitative LC-HRMS Analytical Procedures for the Analysis of N-Nitrosodimethylamine in Metformin.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00473-w
By:
- Yang, Jingyue;
- Marzan, Tim Andres;
- Ye, Wei;
- Sommers, Cynthia D.;
- Rodriguez, Jason D.;
- Keire, David A.
Publication type:
Article
Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00471-y
By:
- Bjugård Nyberg, Henrik;
- Hooker, Andrew C.;
- Bauer, Robert J.;
- Aoki, Yasunori
Publication type:
Article
The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00468-7
By:
- Cristea, Sînziana;
- Krekels, Elke Henriëtte Josephina;
- Rostami-Hodjegan, Amin;
- Allegaert, Karel;
- Knibbe, Catherijne Annette Jantine
Publication type:
Article
Nano-delivery of Gemcitabine Derivative as a Therapeutic Strategy in a Desmoplastic KRAS Mutant Pancreatic Cancer.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00467-8
By:
- Das, Manisit;
- Li, Jun;
- Bao, Michelle;
- Huang, Leaf
Publication type:
Article
In Vitro and In Vivo Efficacy of AZD3965 and Alpha-Cyano-4-Hydroxycinnamic Acid in the Murine 4T1 Breast Tumor Model.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00466-9
By:
- Guan, Xiaowen;
- Morris, Marilyn E.
Publication type:
Article
Intracellular ABCB1 as a Possible Mechanism to Explain the Synergistic Effect of Hydroxychloroquine-Azithromycin Combination in COVID-19 Therapy.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00465-w
By:
- Scherrmann, JM.
Publication type:
Article
Protein Corona-Enabled Systemic Delivery and Targeting of Nanoparticles.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00464-x
By:
- Chen, Dongyu;
- Ganesh, Shanthi;
- Wang, Weimin;
- Amiji, Mansoor
Publication type:
Article
Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00463-y
By:
- Parrott, Neil;
- Stillhart, Cordula;
- Lindenberg, Marc;
- Wagner, Bjoern;
- Kowalski, Karey;
- Guerini, Elena;
- Djebli, Nassim;
- Meneses-Lorente, Georgina
Publication type:
Article
Development of a Highly Specific Anti-drug Antibody Assay in Support of a Nanoparticle-based Therapeutic.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00462-z
By:
- Wang, Ying;
- Smith, Judith F.;
- Araya, Marcela M.;
- Liao, Kai-Hsin (Ken);
- Gorovits, Boris
Publication type:
Article
High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00461-0
By:
- Xu, Hui;
- Feldman, Gerald M.;
- Max, Edward E.
Publication type:
Article
Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00460-1
By:
- Pan, Xian;
- Stader, Felix;
- Abduljalil, Khaled;
- Gill, Katherine L.;
- Johnson, Trevor N.;
- Gardner, Iain;
- Jamei, Masoud
Publication type:
Article
Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00459-8
By:
- Sun, Duxin
Publication type:
Article
In Vitro Dissolution Profiles Similarity Assessment in Support of Drug Product Quality: What, How, When—Workshop Summary Report.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00458-9
By:
- Suarez-Sharp, Sandra;
- Abend, Andreas;
- Hoffelder, Thomas;
- Leblond, David;
- Delvadia, Poonam;
- Kovacs, Elisabeth;
- Diaz, Dorys Argelia
Publication type:
Article
Evaluation of Heat Effects on Transdermal Nicotine Delivery In Vitro and In Silico Using Heat-Enhanced Transport Model Analysis.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00457-w
By:
- La Count, Terri D.;
- Zhang, Qian;
- Murawsky, Michael;
- Hao, Jinsong;
- Ghosh, Priyanka;
- Dave, Kaushalkumar;
- Raney, Sam G.;
- Talattof, Arjang;
- Kasting, Gerald B.;
- Li, S. Kevin
Publication type:
Article
Population Pharmacokinetics of Sertraline in Healthy Subjects: a Model-Based Meta-analysis.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00455-y
By:
- Alhadab, Ali A.;
- Brundage, Richard C.
Publication type:
Article
A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00450-3
By:
- Ma, Huilin;
- Wang, Hanwen;
- Sove, Richard J.;
- Jafarnejad, Mohammad;
- Tsai, Chia-Hung;
- Wang, Jun;
- Giragossian, Craig;
- Popel, Aleksander S.
Publication type:
Article
Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties.
Published in:
AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00449-w
By:
- Zarmpi, P.;
- Flanagan, T.;
- Meehan, E.;
- Mann, J.;
- Fotaki, Nikoletta
Publication type:
Article