Works matching IS 15507416 AND DT 2020 AND VI 22 AND IP 4

Results: 20

Facilitating Longitudinal Exposure-Response Modeling of a Composite Endpoint Using the Joint Modeling of Sparsely and Frequently Collected Subcomponents.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00452-1

By:

Hu, Chuanpu;
Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00474-9

By:

Xie, Zhiliang;
Chen, Min;
Goswami, Swagata;
Mani, Rajes;
Wang, Dasheng;
Kulp, Samuel K.;
Coss, Chris C.;
Schaaf, Larry J.;
Cui, Fengyu;
Byrd, John C.;
Jennings, Ryan N.;
Schober, Karsten K.;
Freed, Carrie;
Lewis, Stephanie;
Malbrue, Raphael;
Muthusamy, Natarajan;
Bennett, Chad;
Kisseberth, William C.;
Phelps, Mitch A.

Publication type:

Article

In Vitro and In Vivo Efficacy of AZD3965 and Alpha-Cyano-4-Hydroxycinnamic Acid in the Murine 4T1 Breast Tumor Model.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00466-9

By:

Guan, Xiaowen;
Morris, Marilyn E.

Publication type:

Article

A Cautionary Tale: Quantitative LC-HRMS Analytical Procedures for the Analysis of N-Nitrosodimethylamine in Metformin.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00473-w

By:

Yang, Jingyue;
Marzan, Tim Andres;
Ye, Wei;
Sommers, Cynthia D.;
Rodriguez, Jason D.;
Keire, David A.

Publication type:

Article

Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00471-y

By:

Bjugård Nyberg, Henrik;
Hooker, Andrew C.;
Bauer, Robert J.;
Aoki, Yasunori

Publication type:

Article

The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00468-7

By:

Cristea, Sînziana;
Krekels, Elke Henriëtte Josephina;
Rostami-Hodjegan, Amin;
Allegaert, Karel;
Knibbe, Catherijne Annette Jantine

Publication type:

Article

Nano-delivery of Gemcitabine Derivative as a Therapeutic Strategy in a Desmoplastic KRAS Mutant Pancreatic Cancer.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00467-8

By:

Das, Manisit;
Li, Jun;
Bao, Michelle;
Huang, Leaf

Publication type:

Article

Comparison of Fraction Unbound Between Liver Homogenate and Hepatocytes at 4°C.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00476-7

By:

Riccardi, Keith;
Ryu, Sangwoo;
Tess, David;
Li, Rui;
Luo, Lina;
Johnson, Nathaniel;
Jordan, Samantha;
Patel, Roshan;
Di, Li

Publication type:

Article

Intracellular ABCB1 as a Possible Mechanism to Explain the Synergistic Effect of Hydroxychloroquine-Azithromycin Combination in COVID-19 Therapy.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00465-w

By:

Scherrmann, JM.

Publication type:

Article

Protein Corona-Enabled Systemic Delivery and Targeting of Nanoparticles.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00464-x

By:

Chen, Dongyu;
Ganesh, Shanthi;
Wang, Weimin;
Amiji, Mansoor

Publication type:

Article

Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00463-y

By:

Parrott, Neil;
Stillhart, Cordula;
Lindenberg, Marc;
Wagner, Bjoern;
Kowalski, Karey;
Guerini, Elena;
Djebli, Nassim;
Meneses-Lorente, Georgina

Publication type:

Article

Development of a Highly Specific Anti-drug Antibody Assay in Support of a Nanoparticle-based Therapeutic.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00462-z

By:

Wang, Ying;
Smith, Judith F.;
Araya, Marcela M.;
Liao, Kai-Hsin (Ken);
Gorovits, Boris

Publication type:

Article

High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00461-0

By:

Xu, Hui;
Feldman, Gerald M.;
Max, Edward E.

Publication type:

Article

Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00460-1

By:

Pan, Xian;
Stader, Felix;
Abduljalil, Khaled;
Gill, Katherine L.;
Johnson, Trevor N.;
Gardner, Iain;
Jamei, Masoud

Publication type:

Article

Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00459-8

By:

Sun, Duxin

Publication type:

Article

In Vitro Dissolution Profiles Similarity Assessment in Support of Drug Product Quality: What, How, When—Workshop Summary Report.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00458-9

By:

Suarez-Sharp, Sandra;
Abend, Andreas;
Hoffelder, Thomas;
Leblond, David;
Delvadia, Poonam;
Kovacs, Elisabeth;
Diaz, Dorys Argelia

Publication type:

Article

Evaluation of Heat Effects on Transdermal Nicotine Delivery In Vitro and In Silico Using Heat-Enhanced Transport Model Analysis.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00457-w

By:

La Count, Terri D.;
Zhang, Qian;
Murawsky, Michael;
Hao, Jinsong;
Ghosh, Priyanka;
Dave, Kaushalkumar;
Raney, Sam G.;
Talattof, Arjang;
Kasting, Gerald B.;
Li, S. Kevin

Publication type:

Article

Population Pharmacokinetics of Sertraline in Healthy Subjects: a Model-Based Meta-analysis.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00455-y

By:

Alhadab, Ali A.;
Brundage, Richard C.

Publication type:

Article

A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00450-3

By:

Ma, Huilin;
Wang, Hanwen;
Sove, Richard J.;
Jafarnejad, Mohammad;
Tsai, Chia-Hung;
Wang, Jun;
Giragossian, Craig;
Popel, Aleksander S.

Publication type:

Article

Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00449-w

By:

Zarmpi, P.;
Flanagan, T.;
Meehan, E.;
Mann, J.;
Fotaki, Nikoletta

Publication type:

Article