Works matching IS 15507416 AND DT 2019 AND VI 21 AND IP 5

Results: 25

Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0365-3

By:

Papathanasiou, Theodoros;
Strathe, Anders;
Overgaard, Rune Viig;
Lund, Trine Meldgaard;
Hooker, Andrew C.

Publication type:

Article

Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0364-4

By:

Martinez, Marilyn N.;
El-Kattan, Ayman;
Awji, Elias;
Papich, Mark

Publication type:

Article

Cellular Uptake and Distribution of Gemini Surfactant Nanoparticles Used as Gene Delivery Agents.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0367-1

By:

Jin, Wei;
Al-Dulaymi, Mays;
Badea, Ildiko;
Leary, Scot C.;
Rehman, Jeveria;
El-Aneed, Anas

Publication type:

Article

Evaluation of Assumptions Underpinning Pharmacometric Models.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0366-2

By:

Ooi, Qing-Xi;
Wright, Daniel F. B.;
Isbister, Geoffrey K.;
Duffull, Stephen B.

Publication type:

Article

TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0368-0

By:

Yogurtcu, Osman N.;
Sauna, Zuben E.;
McGill, Joseph R.;
Tegenge, Million A.;
Yang, Hong

Publication type:

Article

Correction to: Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation.

Published in:

2019

By:

Cui, Yonglei;
Tian, Xiangge;
Ning, Jing;
Wang, Chao;
Yu, Zhenlong;
Wang, Yan;
Huo, Xiaokui;
Jin, Lingling;
Deng, Sa;
Zhang, Baojing;
Ma, Xiaochi

Publication type:

Correction Notice

Model-Informed Drug Development Approach Supporting Approval of Adalimumab (HUMIRA) in Adolescent Patients with Hidradenitis Suppurativa: a Regulatory Perspective.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0363-5

By:

Bi, Youwei;
Liu, Jiang;
Wang, Jie;
Epps, Roselyn E.;
Kettl, David;
Marcus, Kendall;
Seo, Shirley;
Zhu, Hao;
Wang, Yaning

Publication type:

Article

Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0362-6

By:

Yu, Ruihong;
Song, Dawei;
DuBois, Debra C;
Almon, Richard R.;
Jusko, William J.

Publication type:

Article

Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0361-7

By:

Hamuro, Lora;
Tirucherai, Giridhar S.;
Crawford, Sean M.;
Nayeem, Akbar;
Pillutla, Renuka C.;
DeSilva, Binodh S.;
Leil, Tarek A.;
Thalhauser, Craig J.

Publication type:

Article

A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0360-8

By:

Kavita, Uma;
Miller, Wendy;
Ji, Qin C.;
Pillutla, Renuka C.

Publication type:

Article

Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0359-1

By:

Li, Cindy Yanfei;
Hosey-Cojocari, Chelsea;
Basit, Abdul;
Unadkat, Jashvant D.;
Leeder, J. Steven;
Prasad, Bhagwat

Publication type:

Article

Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0358-2

By:

Misra, Sandeep K.;
Orlando, Ron;
Weinberger, Scot R.;
Sharp, Joshua S.

Publication type:

Article

Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0357-3

By:

Ren, Tianjing;
Xiao, Min;
Yang, Mengbi;
Zhao, Jiajia;
Zhang, Yufeng;
Hu, Mengyun;
Cheng, Yan;
Xu, Hong;
Zhang, Chunbo;
Yan, Xiaoyu;
Zuo, Zhong

Publication type:

Article

Characterization and Quantification of an Fc-FGF21 Fusion Protein in Rat Serum Using Immunoaffinity LC-MS.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0356-4

By:

Li, Fengping;
Weng, Yan;
Zhang, Guodong;
Han, Xiaogang;
Li, Dongmei;
Neubert, Hendrik

Publication type:

Article

Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0355-5

By:

Kuo, Hsiao-Chen Dina;
Wu, Renyi;
Li, Shanyi;
Yang, Anne Yuqing;
Kong, Ah-Ng

Publication type:

Article

Quality Controls in Ligand Binding Assays: Recommendations and Best Practices for Preparation, Qualification, Maintenance of Lot to Lot Consistency, and Prevention of Assay Drift.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0354-6

By:

Azadeh, Mitra;
Sondag, Perceval;
Wang, Ying;
Raines, Maribeth;
Sailstad, Jeffrey

Publication type:

Article

Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0353-7

By:

Ueshima, Satoshi;
Hira, Daiki;
Tomitsuka, Chiho;
Nomura, Miki;
Kimura, Yuuma;
Yamane, Takuya;
Tabuchi, Yohei;
Ozawa, Tomoya;
Itoh, Hideki;
Horie, Minoru;
Terada, Tomohiro;
Katsura, Toshiya

Publication type:

Article

Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0352-8

By:

Zhang, Ting-Ting;
Ma, Junli;
Durbin, Kenneth R.;
Montavon, Timothy;
Lacy, Susan E.;
Jenkins, Gary J.;
Doktor, Stella;
Kalvass, J. Cory

Publication type:

Article

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0351-9

By:

Brussee, Janneke M.;
Krekels, Elke H. J.;
Calvier, Elisa A. M.;
Palić, Semra;
Rostami-Hodjegan, Amin;
Danhof, Meindert;
Barrett, Jeffrey S.;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0350-x

By:

Jafarnejad, Mohammad;
Gong, Chang;
Gabrielson, Edward;
Bartelink, Imke H.;
Vicini, Paolo;
Wang, Bing;
Narwal, Rajesh;
Roskos, Lorin;
Popel, Aleksander S.

Publication type:

Article

Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0349-3

By:

Brekkan, Ari;
Lopez-Lazaro, Luis;
Plan, Elodie L.;
Nyberg, Joakim;
Kankanwadi, Suresh;
Karlsson, Mats O.

Publication type:

Article

Anti-drug Antibody Assay Validation: Improved Reporting of the Assay Selectivity via Simpler Positive Control Recovery Data Analysis.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0347-5

By:

Gorovits, Boris;
Roldan, Marcela Araya;
Baltrukonis, Daniel;
Cai, Chun-Hua;
Donley, Jean;
Jani, Darshana;
Kamerud, John;
McCush, Frederick;
Thomas, Jeffrey S.;
Wang, Ying

Publication type:

Article

A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0345-7

By:

Wei, Guor-Jien;
Chao, Yen-Hsiang;
Tung, Yen-Chen;
Wu, Tien-Yuan;
Su, Zheng-Yuan

Publication type:

Article

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0344-8

By:

Treyer, Andrea;
Ullah, Mohammed;
Parrott, Neil;
Molitor, Birgit;
Fowler, Stephen;
Artursson, Per

Publication type:

Article

Guidance for Rifampin and Midazolam Dosing Protocols To Study Intestinal and Hepatic Cytochrome P450 (CYP) 3A4 Induction and De-induction.

Published in:

AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0341-y

By:

Kapetas, Asha J;
Sorich, Michael J;
Rodrigues, A David;
Rowland, Andrew

Publication type:

Article