Works matching IS 15507416 AND DT 2019 AND VI 21 AND IP 4

Results: 24

Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0339-5

By:

Bai, Jane P. F.;
Earp, Justin C.;
Pillai, Venkateswaran C.

Publication type:

Article

Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0340-z

By:

Nicolas, Jean-Marie;
de Lange, Elizabeth C. M.

Publication type:

Article

A Bounded Integer Model for Rating and Composite Scale Data.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0343-9

By:

Wellhagen, Gustaf J.;
Kjellsson, Maria C.;
Karlsson, Mats O.

Publication type:

Article

Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®.

Published in:

2019

By:

Betts, Alison;
Haddish-Berhane, Nahor;
Shah, Dhaval K.;
van der Graaf, Piet H.;
Barletta, Frank;
King, Lindsay;
Clark, Tracey;
Kamperschroer, Cris;
Root, Adam;
Hooper, Andrea;
Chen, Xiaoying

Publication type:

Correction Notice

Anti-drug Antibody Assay Conditions Significantly Impact Assay Screen and Confirmatory Cut-Points.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0342-x

By:

Gorovits, Boris;
Wang, Ying;
Zhu, Liang;
Araya, Marcela;
Kamerud, John;
Lepsy, Christopher

Publication type:

Article

Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®.

Published in:

2019

By:

Betts, Alison;
Haddish-Berhane, Nahor;
Shah, Dhaval K.;
van der Graaf, Piet H.;
Barletta, Frank;
King, Lindsay;
Clark, Tracey;
Kamperschroer, Cris;
Root, Adam;
Hooper, Andrea;
Chen, Xiaoying

Publication type:

Correction Notice

“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0346-6

By:

Hens, Bart;
Corsetti, Maura;
Bermejo, Marival;
Löbenberg, Raimar;
González, Pablo M.;
Mitra, Amitava;
Desai, Divyakant;
Chilukuri, Dakshina Murthy;
Aceituno, Alexis

Publication type:

Article

In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0338-6

By:

Davidsen, Anders Bork;
Mardal, Marie;
Linnet, Kristian

Publication type:

Article

Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0337-7

By:

Li, Rui

Publication type:

Article

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0336-8

By:

Lagassé, H. A. Daniel;
Hengel, Hartmut;
Golding, Basil;
Sauna, Zuben E.

Publication type:

Article

Skin Delivery and Irritation Potential of Phenmetrazine as a Candidate Transdermal Formulation for Repurposed Indications.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0335-9

By:

Jiang, Ying;
Murnane, Kevin S.;
Bhattaccharjee, Sonalika A.;
Blough, Bruce E.;
Banga, Ajay K.

Publication type:

Article

Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: "Drug Products, Including Biological Products, that Contain Nanomaterials".

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0329-7

By:

de Vlieger, Jon S. B.;
Crommelin, Daan J. A.;
Tyner, Katherine;
Drummond, Daryl C.;
Jiang, Wenlei;
McNeil, Scott E.;
Neervannan, Sesha;
Crist, Rachael M.;
Shah, Vinod P.

Publication type:

Article

Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. 1, doi. 10.1208/s12248-019-0333-y

By:

Le, Quoc-Viet;
Suh, Juhan;
Oh, Yu-Kyoung

Publication type:

Article

A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART<sup>®</sup>.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0332-z

By:

Betts, Alison;
Haddish-Berhane, Nahor;
Shah, Dhaval K.;
van der Graaf, Piet H.;
Barletta, Frank;
King, Lindsay;
Clark, Tracey;
Kamperschroer, Cris;
Root, Adam;
Hooper, Andrea;
Chen, Xiaoying

Publication type:

Article

Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0331-0

By:

Krzyzanski, Wojciech;
Cook, Sarah F.;
Wilbaux, Melanie;
Sherwin, Catherine M. T.;
Allegaert, Karel;
Vermeulen, An;
van den Anker, John N.

Publication type:

Article

Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0330-1

By:

Gjestad, Caroline;
Hole, Kristine;
Haslemo, Tore;
Diczfalusy, Ulf;
Molden, Espen

Publication type:

Article

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. 1, doi. 10.1208/s12248-019-0334-x

By:

Le Merdy, Maxime;
Fan, Jianghong;
Bolger, Michael B.;
Lukacova, Viera;
Spires, Jessica;
Tsakalozou, Eleftheria;
Patel, Vikram;
Xu, Lin;
Stewart, Sharron;
Chockalingam, Ashok;
Narayanasamy, Suresh;
Rouse, Rodney;
Matta, Murali;
Babiskin, Andrew;
Kozak, Darby;
Choi, Stephanie;
Zhang, Lei;
Lionberger, Robert;
Zhao, Liang

Publication type:

Article

Report on the AAPS Immunogenicity Guidance Forum.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0328-8

By:

Myler, Heather;
Gorovits, Boris;
Phillips, Kelli;
Devanarayan, Viswanath;
Clements-Egan, Adrienne;
Gunn, George R.;
Kirshner, Susan;
DeSilva, Binodh;
Shah, Vinod P.

Publication type:

Article

In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0327-9

By:

Mohammed, Ahmed Fouad Abdelwahab;
Higashi, Taishi;
Motoyama, Keiichi;
Ohyama, Ayumu;
Onodera, Risako;
Khaled, Khaled Ali;
Sarhan, Hatem Abdelmonsef;
Hussein, Amal Kamal;
Arima, Hidetoshi

Publication type:

Article

Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. 1, doi. 10.1208/s12248-019-0326-x

By:

Chan, Pui Shan;
Xian, Jia Wen;
Li, Qingqing;
Chan, Chun Wai;
Leung, Sharon S. Y.;
To, Kenneth K. W.

Publication type:

Article

Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. 1, doi. 10.1208/s12248-019-0325-y

By:

Santos, Ana Cláudia;
Pereira, Irina;
Magalhães, Mariana;
Pereira-Silva, Miguel;
Caldas, Mariana;
Ferreira, Laura;
Figueiras, Ana;
Ribeiro, António J.;
Veiga, Francisco

Publication type:

Article

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. 1, doi. 10.1208/s12248-019-0323-0

By:

Hernández Lozano, Irene;
Karch, Rudolf;
Bauer, Martin;
Blaickner, Matthias;
Matsuda, Akihiro;
Wulkersdorfer, Beatrix;
Hacker, Marcus;
Zeitlinger, Markus;
Langer, Oliver

Publication type:

Article

A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT® Daily Diary Data from COPD Patients.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0319-9

By:

Germovsek, Eva;
Ambery, Claire;
Yang, Shuying;
Beerahee, Misba;
Karlsson, Mats O.;
Plan, Elodie L.

Publication type:

Article

Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice.

Published in:

AAPS Journal, 2019, v. 21, n. 4, p. N.PAG, doi. 10.1208/s12248-019-0313-2

By:

Zaidi, Syedsaoud;
Chen, Mong-Jen;
Lee, Daniel T.;
Neubart, Elsa;
Ewing, Pär;
Miller-Larsson, Anna;
Hochhaus, Günther

Publication type:

Article