Works matching IS 15507416 AND DT 2018 AND VI 20 AND IP 3

Results: 21

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0217-6

By:

Hens, Bart;
Talattof, Arjang;
Paixão, Paulo;
Bermejo, Marival;
Tsume, Yasuhiro;
Löbenberg, Raimar;
Amidon, Gordon L.

Publication type:

Article

Generic Anti-PEG Antibody Assay on ProterixBio’s (Formerly BioScale) ViBE Platform Shows Poor Reproducibility.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0228-3

By:

Chilewski, Shannon D.;
Shields, Julie;
Mora, Johanna R.;
Myler, Heather

Publication type:

Article

Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0226-5

By:

Papathanasiou, Theodoros;
Strathe, Anders;
Hooker, Andrew C.;
Lund, Trine Meldgaard;
Overgaard, Rune Viig

Publication type:

Article

Investigation of the Mechanism of Therapeutic Protein-Drug Interaction Between Methotrexate and Golimumab, an Anti-TNFα Monoclonal Antibody.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0219-4

By:

Wang, Weirong;
Leu, Jocelyn;
Watson, Rebecca;
Xu, Zhenhua;
Zhou, Honghui

Publication type:

Article

Computational Fragment-Based Drug Design: Current Trends, Strategies, and Applications.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0216-7

By:

Bian, Yuemin;
Xie, Xiang-Qun (Sean)

Publication type:

Article

Improved Prediction of Blood–Brain Barrier Permeability Through Machine Learning with Combined Use of Molecular Property-Based Descriptors and Fingerprints.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0215-8

By:

Yuan, Yaxia;
Zheng, Fang;
Zhan, Chang-Guo

Publication type:

Article

Development of Fc-Fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0214-9

By:

Chen, Xiabin;
Deng, Jing;
Cui, Wenpeng;
Hou, Shurong;
Zhang, Jinling;
Zheng, Xirong;
Ding, Xin;
Wei, Huimei;
Zhou, Ziyuan;
Kim, Kyungbo;
Zhan, Chang-Guo;
Zheng, Fang

Publication type:

Article

Equivalence Testing of Complex Particle Size Distribution Profiles Based on Earth Mover’s Distance.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0212-y

By:

Hu, Meng;
Jiang, Xiaohui;
Absar, Mohammad;
Choi, Stephanie;
Kozak, Darby;
Shen, Meiyu;
Weng, Yu-Ting;
Zhao, Liang;
Lionberger, Robert

Publication type:

Article

Deep Learning for Drug Design: an Artificial Intelligence Paradigm for Drug Discovery in the Big Data Era.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0210-0

By:

Jing, Yankang;
Bian, Yuemin;
Hu, Ziheng;
Wang, Lirong;
Xie, Xiang-Qun Sean

Publication type:

Article

A Simple Approach to Determine a Curve Fitting Model with a Correct Weighting Function for Calibration Curves in Quantitative Ligand Binding Assays.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0208-7

By:

Xiang, Yuhong;
Donley, Jean;
Seletskaia, Elena;
Shingare, Sonal;
Kamerud, John;
Gorovits, Boris

Publication type:

Article

Dissolution and Translational Modeling Strategies Enabling Patient-Centric Drug Product Development: the M-CERSI Workshop Summary Report.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0213-x

By:

Abend, Andreas;
Heimbach, Tycho;
Cohen, Michael;
Kesisoglou, Filippos;
Pepin, Xavier;
Suarez-Sharp, Sandra

Publication type:

Article

Comparison of Model Averaging and Model Selection in Dose Finding Trials Analyzed by Nonlinear Mixed Effect Models.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0205-x

By:

Buatois, Simon;
Ueckert, Sebastian;
Frey, Nicolas;
Retout, Sylvie;
Mentré, France

Publication type:

Article

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0199-4

By:

Patel, Nikunjkumar;
Hatley, Oliver;
Berg, Alexander;
Romero, Klaus;
Wisniowska, Barbara;
Hanna, Debra;
Hermann, David;
Polak, Sebastian

Publication type:

Article

Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0186-9

By:

Nitta, Shin-ichiro;
Hashimoto, Mari;
Kazuki, Yasuhiro;
Takehara, Shoko;
Suzuki, Hiraku;
Oshimura, Mitsuo;
Akita, Hidetaka;
Chiba, Kan;
Kobayashi, Kaoru

Publication type:

Article

A Minimal Physiologically Based Pharmacokinetic Model with a Nested Endosome Compartment for Novel Engineered Antibodies.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-017-0183-4

By:

Yuan, Dongfen;
Rode, Frederik;
Cao, Yanguang

Publication type:

Article

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0218-5

By:

Pierrillas, Philippe B.;
Fouliard, Sylvain;
Chenel, Marylore;
Hooker, Andrew C.;
Friberg, Lena E.;
Karlsson, Mats O.

Publication type:

Article

PharmTeX: a LaTeX-Based Open-Source Platform for Automated Reporting Workflow.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0202-0

By:

Rasmussen, Christian Hove;
Smith, Mike K.;
Ito, Kaori;
Sundararajan, Vijayakumar;
Magnusson, Mats O.;
Niclas Jonsson, E.;
Fostvedt, Luke;
Burger, Paula;
McFadyen, Lynn;
Tensfeldt, Thomas G.;
Nicholas, Timothy

Publication type:

Article

Detection of Memory B Activity Against a Therapeutic Protein in Treatment-Naïve Subjects.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0198-5

By:

Liao, Karen;
Derbyshire, Stacy;
Wang, Kai-fen;
Caucci, Cherilyn;
Tang, Shuo;
Holland, Claire;
Loercher, Amy;
Gunn, George R.

Publication type:

Article

Therapeutic Potential of Engineered Extracellular Vesicles.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0211-z

By:

Mentkowski, Kyle I.;
Snitzer, Jonathan D.;
Rusnak, Sarah;
Lang, Jennifer K.

Publication type:

Article

Selection of a Ligand-Binding Neutralizing Antibody Assay for Benralizumab: Comparison with an Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Cell-Based Assay.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0207-8

By:

Yuling Wu;
Akhgar, Ahmad;
Li, Jia J.;
Binbing Yu;
Cecil Chen;
Nancy Lee;
White, Wendy I.;
Roskos, Lorin K.

Publication type:

Article

Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0204-y

By:

Parasrampuria, Dolly A.;
Benet, Leslie Z.;
Sharma, Amarnath

Publication type:

Article