Works matching IS 15507416 AND DT 2018 AND VI 20 AND IP 1

Results: 25

The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0180-7

By:

Felmlee, Melanie A.;
Morse, Bridget L.;
Follman, Kristin E.;
Morris, Marilyn E.

Publication type:

Article

Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0179-0

By:

Wang, Qianwen;
Zhang, Yufeng;
Wong, Chun-Ho;
Edwin Chan, H.Y.;
Zuo, Zhong

Publication type:

Article

In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0177-2

By:

Ramirez, Christina N.;
Li, Wenji;
Zhang, Chengyue;
Wu, Renyi;
Su, Shan;
Wang, Chao;
Gao, Linbo;
Yin, Ran;
Kong, Ah-Ng

Publication type:

Article

Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0176-3

By:

Manickavasagam, Dharani;
Novak, Kimberly;
Oyewumi, Moses O.

Publication type:

Article

Balancing Antibacterial Efficacy and Reduction in Renal Function to Optimise Initial Gentamicin Dosing in Paediatric Oncology Patients.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0173-6

By:

Llanos-Paez, Carolina Consuelo;
Staatz, Christine;
Hennig, Stefanie

Publication type:

Article

Transporter-Mediated Interaction Between Platinum Drugs and Sorafenib at the Cellular Level.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0169-2

By:

Schneider, Verena;
Chaib, Selim;
Spanier, Claudia;
Knapp, Mandy;
Moscvin, Violeta;
Scordovillo, Laura;
Ewertz, Alessandra;
Jaehde, Ulrich;
Kalayda, Ganna V.

Publication type:

Article

ABCB6, an ABC Transporter Impacting Drug Response and Disease.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0165-6

By:

Boswell-Casteel, Rebba C.;
Fukuda, Yu;
Schuetz, John D.

Publication type:

Article

The Na+/Cl−-Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0164-7

By:

Sikder, Mohd Omar F.;
Yang, Shengping;
Ganapathy, Vadivel;
Bhutia, Yangzom D.

Publication type:

Article

Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0163-8

By:

Nakanishi, Takeo;
Tamai, Ikumi

Publication type:

Article

Demonstration of Nucleoside Transporter Activity in the Nose-to-Brain Distribution of [18F]Fluorothymidine Using PET Imaging.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0158-5

By:

Ponto, Laura L. Boles;
Huang, Jiangeng;
Walsh, Susan A.;
Acevedo, Michael R.;
Mundt, Christine;
Sunderland, John;
Donovan, Maureen

Publication type:

Article

Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0157-6

By:

Ponto, Laura L. Boles;
Walsh, Susan;
Huang, Jiangeng;
Mundt, Christine;
Thede-Reynolds, Katherine;
Leonard Watkins, G.;
Sunderland, John;
Acevedo, Michael;
Donovan, Maureen

Publication type:

Article

A Multi-site In-depth Evaluation of the Quanterix Simoa from a User’s Perspective.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0156-7

By:

Chunyk, Allison Given;
Joyce, Alison;
Fischer, Saloumeh K.;
Dysinger, Mark;
Mikulskis, Alvydas;
Jeromin, Andreas;
Lawrence-Henderson, Rosemary;
Baker, Dana;
Yeung, David

Publication type:

Article

Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0181-6

By:

Gouty, D.;
Cai, C. C.;
Cai, X. Y.;
Kasinath, A.;
Kumar, V.;
Alvandkouhi, S.;
Yang, J.;
Pederson, S.;
Babbitt, B.;
Peritt, D.;
Rudy, A.;
Koppenburg, V.;
Dasilva, A.;
Ullmann, M.;
Liu, S.;
Satterwhite, C.

Publication type:

Article

Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0166-5

By:

Ryeznik, Yevgen;
Sverdlov, Oleksandr;
Hooker, Andrew C.

Publication type:

Article

Calibration Curves in Quantitative Ligand Binding Assays: Recommendations and Best Practices for Preparation, Design, and Editing of Calibration Curves.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0159-4

By:

Azadeh, Mitra;
Gorovits, Boris;
Kamerud, John;
MacMannis, Stephen;
Safavi, Afshin;
Sailstad, Jeffrey;
Sondag, Perceval

Publication type:

Article

Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0171-8

By:

Meseguer-Ripolles, Jose;
Khetani, Salman R.;
Blanco, Javier G.;
Iredale, Mairi;
Hay, David C.

Publication type:

Article

Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0178-1

By:

Mochel, Jonathan P.;
Jergens, Albert E.;
Kingsbury, Dawn;
Kim, Hyun Jung;
Martín, Martín G.;
Allenspach, Karin

Publication type:

Article

A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0168-3

By:

Rogers, Richard S.;
Abernathy, Michael;
Richardson, Douglas D.;
Rouse, Jason C.;
Sperry, Justin B.;
Swann, Patrick;
Wypych, Jette;
Yu, Christopher;
Zang, Li;
Deshpande, Rohini

Publication type:

Article

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0172-7

By:

Vlot, Anna H. C.;
de Witte, Wilhelmus E. A.;
Danhof, Meindert;
van der Graaf, Piet H.;
van Westen, Gerard J. P.;
de Lange, Elizabeth C. M.

Publication type:

Article

Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0160-y

By:

Jeyaram, Anjana;
Jay, Steven M.

Publication type:

Article

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0161-x

By:

Lauschke, Volker M.;
Milani, Lili;
Ingelman-Sundberg, Magnus

Publication type:

Article

Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0162-9

By:

Goulooze, Sebastiaan C.;
Välitalo, Pyry A. J.;
Knibbe, Catherijne A. J.;
Krekels, Elke H. J.

Publication type:

Article

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0167-4

By:

Zheng, Xirong;
Zhou, Ziyuan;
Zhang, Ting;
Jin, Zhenyu;
Chen, Xiabin;
Deng, Jing;
Zhan, Chang-Guo;
Zheng, Fang

Publication type:

Article

Selection and Qualification of Simplified QSP Models When Using Model Order Reduction Techniques.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0170-9

By:

Hasegawa, Chihiro;
Duffull, Stephen B.

Publication type:

Article

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.

Published in:

AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0155-8

By:

Patel, Nikunjkumar;
Wiśniowska, Barbara;
Jamei, Masoud;
Polak, Sebastian

Publication type:

Article

Works matching IS 15507416 AND DT 2018 AND VI 20 AND IP 1

The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution.

Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling.

In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention.

Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia.

Balancing Antibacterial Efficacy and Reduction in Renal Function to Optimise Initial Gentamicin Dosing in Paediatric Oncology Patients.

Transporter-Mediated Interaction Between Platinum Drugs and Sorafenib at the Cellular Level.

ABCB6, an ABC Transporter Impacting Drug Response and Disease.

The Na<sup>+</sup>/Cl<sup>−</sup>-Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB<sup>0,+</sup>): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis.

Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins.

Demonstration of Nucleoside Transporter Activity in the Nose-to-Brain Distribution of [<sup>18</sup>F]Fluorothymidine Using PET Imaging.

Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration.

A Multi-site In-depth Evaluation of the Quanterix Simoa from a User’s Perspective.

Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment.

Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes.

Calibration Curves in Quantitative Ligand Binding Assays: Recommendations and Best Practices for Preparation, Design, and Editing of Calibration Curves.

Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research.

A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy.

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications.

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments.

Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models.

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats.

Selection and Qualification of Simplified QSP Models When Using Model Order Reduction Techniques.

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.