Works matching IS 15507416 AND DT 2017 AND VI 19 AND IP 6

Results: 30

Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1600, doi. 10.1208/s12248-017-0120-6

By:

Mohamed, Loqman;
Markandaiah, Shashirekha;
Bonanno, Silvia;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1615, doi. 10.1208/s12248-017-0123-3

By:

Rodriguez-Grande, Beatriz;
Ichkova, Aleksandra;
Lemarchant, Sighild;
Badaut, Jerome

Publication type:

Article

Comparison of NMR and Dynamic Light Scattering for Measuring Diffusion Coefficients of Formulated Insulin: Implications for Particle Size Distribution Measurements in Drug Products.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1760, doi. 10.1208/s12248-017-0127-z

By:

Patil, Sharadrao;
Keire, David;
Chen, Kang

Publication type:

Article

Advancements in Understanding Immunogenicity of Biotherapeutics in the Intraocular Space.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1656, doi. 10.1208/s12248-017-0128-y

By:

Wakshull, Eric;
Quarmby, Valerie;
Mahler, Hanns-Christian;
Rivers, Hongwen;
Jere, Dhananjay;
Ramos, Meg;
Szczesny, Piotr;
Bechtold-Peters, Karoline;
Masli, Sharmila;
Gupta, Swati

Publication type:

Article

Submicron Matrices Embedded in a Polymeric Caplet for Extended Intravaginal Delivery of Zidovudine.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1745, doi. 10.1208/s12248-017-0130-4

By:

Mashingaidze, Felix;
Choonara, Yahya;
Kumar, Pradeep;
Toit, Lisa;
Maharaj, Vinesh;
Buchmann, Eckhart;
Pillay, Viness

Publication type:

Article

Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1715, doi. 10.1208/s12248-017-0131-3

By:

Khot, Antari;
Tibbitts, Jay;
Rock, Dan;
Shah, Dhaval

Publication type:

Article

Pharmacokinetics of Mephedrone and Its Metabolites in Human by LC-MS/MS.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1767, doi. 10.1208/s12248-017-0132-2

By:

Olesti, Eulàlia;
Farré, Magí;
Papaseit, Esther;
Krotonoulas, Aristotelis;
Pujadas, Mitona;
de la Torre, Rafael;
Pozo, Óscar

Publication type:

Article

Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1703, doi. 10.1208/s12248-017-0133-1

By:

Cao, Mingnan;
Wang, Huixia;
Guo, Limei;
Yang, Simin;
Liu, Chun;
Khor, Tin;
Yu, Siwang;
Kong, Ah-Ng

Publication type:

Article

A Flavonoid Glycoside Compound from Murraya paniculata (L.) Interrupts Metastatic Characteristics of A549 Cells by Regulating STAT3/NF-κB/COX-2 and EGFR Signaling Pathways.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1779, doi. 10.1208/s12248-017-0134-0

By:

Shi, Qing;
Jiang, Zhou;
Yang, Jingyi;
Cheng, Yunlong;
Pang, Yaqiong;
Zheng, Ning;
Chen, Jiahang;
Chen, Wenge;
Jia, Lee

Publication type:

Article

Investigation of the Influence of Protein-Losing Enteropathy on Monoclonal Antibody Pharmacokinetics in Mice.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1791, doi. 10.1208/s12248-017-0135-z

By:

Yang, Yujie;
Li, Tommy;
Balthasar, Joseph

Publication type:

Article

siRNA-Mediated RNA Interference in Precision-Cut Tissue Slices Prepared from Mouse Lung and Kidney.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1855, doi. 10.1208/s12248-017-0136-y

By:

Ruigrok, Mitchel;
Maggan, Nalinie;
Willaert, Delphine;
Frijlink, Henderik;
Melgert, Barbro;
Olinga, Peter;
Hinrichs, Wouter

Publication type:

Article

In vitro Approaches to Support Bioequivalence and Substitutability of Generic Proton Pump Inhibitors via Nasogastric Tube Administration.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1593, doi. 10.1208/s12248-017-0137-x

By:

Ren, Ping;
Cui, Minglei;
Anand, Om;
Xia, Li;
Zhao, Zhuojun;
Sun, Dajun;
Sharp, Trueman;
Conner, Dale;
Peters, John;
Jiang, Wenlei;
Stier, Ethan;
Jiang, Xiaojian

Publication type:

Article

Development of an Enantioselective and Biomarker-Informed Translational Population Pharmacokinetic/Pharmacodynamic Model for Etodolac.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1814, doi. 10.1208/s12248-017-0138-9

By:

Miranda Silva, Carolina;
Rocha, Adriana;
Tozatto, Eduardo;
Silva, Lucienir;
Donadi, Eduardo;
Dalla Costa, Teresa;
Lanchote, Vera;
Schmidt, Stephan;
Bulitta, Jürgen

Publication type:

Article

Determination of Critical Quality Attributes for a Biotherapeutic in the QbD Paradigm: GCSF as a Case Study.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1826, doi. 10.1208/s12248-017-0139-8

By:

Singh, Sumit;
Kumar, Deepak;
Rathore, Anurag

Publication type:

Article

Quantification of the Pharmacodynamic Interaction of Morphine and Gabapentin Using a Response Surface Approach.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1804, doi. 10.1208/s12248-017-0140-2

By:

Papathanasiou, Theodoros;
Juul, Rasmus;
Gabel-Jensen, Charlotte;
Kreilgaard, Mads;
Heegaard, Anne-Marie;
Lund, Trine

Publication type:

Article

Population Pharmacokinetic and Pharmacodynamic Modeling of Artemisinin Resistance in Southeast Asia.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1842, doi. 10.1208/s12248-017-0141-1

By:

Lohy Das, Jesmin;
Dondorp, Arjen;
Nosten, Francois;
Phyo, Aung;
Hanpithakpong, Warunee;
Ringwald, Pascal;
Lim, Pharath;
White, Nicholas;
Karlsson, Mats;
Bergstrand, Martin;
Tarning, Joel

Publication type:

Article

Role of In Vitro Release Methods in Liposomal Formulation Development: Challenges and Regulatory Perspective.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1669, doi. 10.1208/s12248-017-0142-0

By:

Solomon, Deepak;
Gupta, Nilesh;
Mulla, Nihal;
Shukla, Snehal;
Guerrero, Yadir;
Gupta, Vivek

Publication type:

Article

How Close Are We to Profiling Immunogenicity Risk Using In Silico Algorithms and In Vitro Methods?: an Industry Perspective.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1587, doi. 10.1208/s12248-017-0143-z

By:

Gokemeijer, Jochem;
Jawa, Vibha;
Mitra-Kaushik, Shibani

Publication type:

Article

New Botanical Anxiolytics for Use in Companion Animals and Humans.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1626, doi. 10.1208/s12248-017-0144-y

By:

Liu, Rui;
Ahmed, Fida;
Cayer, Christian;
Mullally, Martha;
Carballo, Ana;
Rojas, Marco;
Garcia, Mario;
Baker, John;
Masic, Aleksandar;
Sanchez, Pablo;
Poveda, Luis;
Merali, Zul;
Durst, Tony;
Arnason, John

Publication type:

Article

Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1682, doi. 10.1208/s12248-017-0145-x

By:

Yu, Alex;
Jackson, Trachette;
Tsume, Yasuhiro;
Koenigsknecht, Mark;
Wysocki, Jeffrey;
Marciani, Luca;
Amidon, Gordon;
Frances, Ann;
Baker, Jason;
Hasler, William;
Wen, Bo;
Pai, Amit;
Sun, Duxin

Publication type:

Article

Recommendations for Selection and Characterization of Protein Biomarker Assay Calibrator Material.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1550, doi. 10.1208/s12248-017-0146-9

By:

Cowan, Kyra;
Amaravadi, Lakshmi;
Cameron, Mark;
Fink, Damien;
Jani, Darshana;
Kamat, Medha;
King, Lindsay;
Neely, Robert;
Ni, Yan;
Rhyne, Paul;
Riffon, Renee;
Zhu, Yuda

Publication type:

Article

Drug Target Interference in Immunogenicity Assays: Recommendations and Mitigation Strategies.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1564, doi. 10.1208/s12248-017-0148-7

By:

Zhong, Zhandong;
Clements-Egan, Adrienne;
Gorovits, Boris;
Maia, Mauricio;
Sumner, Giane;
Theobald, Valerie;
Wu, Yuling;
Rajadhyaksha, Manoj

Publication type:

Article

Investigating Oral Absorption of Carbamazepine in Pediatric Populations.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1864, doi. 10.1208/s12248-017-0149-6

By:

Kohlmann, Philip;
Stillhart, Cordula;
Kuentz, Martin;
Parrott, Neil

Publication type:

Article

Alternative Splicing: Expanding Diversity in Major ABC and SLC Drug Transporters.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1643, doi. 10.1208/s12248-017-0150-0

By:

Park, Ji;
Ryoo, Gongmi;
Lee, Wooin

Publication type:

Article

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1878, doi. 10.1208/s12248-017-0151-z

By:

Morse, Bridget;
MacGuire, Jamus;
Marino, Anthony;
Zhao, Yue;
Fox, Maxine;
Zhang, Yueping;
Shen, Hong;
Griffith Humphreys, W.;
Marathe, Punit;
Lai, Yurong

Publication type:

Article

Nanotechnology as a Delivery Tool for Precision Cancer Therapies.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1632, doi. 10.1208/s12248-017-0152-y

By:

Sharma, Bhawna;
Crist, Rachael;
Adiseshaiah, Pavan

Publication type:

Article

Recommendations for the Assessment and Management of Pre-existing Drug-Reactive Antibodies During Biotherapeutic Development.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1576, doi. 10.1208/s12248-017-0153-x

By:

Xue, Li;
Clements-Egan, Adrienne;
Amaravadi, Lakshmi;
Birchler, Mary;
Gorovits, Boris;
Liang, Meina;
Myler, Heather;
Purushothama, Shobha;
Manning, Marta;
Sung, Crystal

Publication type:

Article

Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1691, doi. 10.1208/s12248-017-0154-9

By:

Aqil, Farrukh;
Munagala, Radha;
Jeyabalan, Jeyaprakash;
Agrawal, Ashish;
Gupta, Ramesh

Publication type:

Article

Characterization of Apolipoprotein C3 (Apo C3) LNA/DNA Impurities and Degradation Products by LC-MS/MS.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1735, doi. 10.1208/s12248-017-0088-2

By:

Friese, Olga;
Sperry, Justin;
He, Yan;
Joseph, Liji;
Carroll, James;
Rouse, Jason

Publication type:

Article

Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1537, doi. 10.1208/s12248-017-0117-1

By:

Hermans, Andre;
Abend, Andreas;
Kesisoglou, Filippos;
Flanagan, Talia;
Cohen, Michael;
Diaz, Dorys;
Mao, Y.;
Zhang, Limin;
Webster, Gregory;
Lin, Yiqing;
Hahn, David;
Coutant, Carrie;
Grady, Haiyan

Publication type:

Article