Works matching IS 15507416 AND DT 2017 AND VI 19 AND IP 4

Results: 30

The Two Main Goals of Bioequivalence Studies.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 885, doi. 10.1208/s12248-017-0048-x

By:

Endrenyi, Laszlo;
Blume, Henning;
Tothfalusi, Laszlo

Publication type:

Article

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 891, doi. 10.1208/s12248-017-0050-3

By:

Yamamoto, Yumi;
Danhof, Meindert;
Lange, Elizabeth

Publication type:

Article

Dissolution comparisons using a Multivariate Statistical Distance (MSD) test and a comparison of various approaches for calculating the measurements of dissolution profile comparison.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1091, doi. 10.1208/s12248-017-0063-y

By:

Cardot, J-M.;
Roudier, B.;
Schütz, H.

Publication type:

Article

The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1084, doi. 10.1208/s12248-017-0065-9

By:

Sutton, Steven;
Nause, Richard;
Gandelman, Kuan

Publication type:

Article

In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1102, doi. 10.1208/s12248-017-0070-z

By:

Watanabe, Shimpei;
Vikingsson, Svante;
Roman, Markus;
Green, Henrik;
Kronstrand, Robert;
Wohlfarth, Ariane

Publication type:

Article

Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1054, doi. 10.1208/s12248-017-0071-y

By:

Singh, Aman;
Shah, Dhaval

Publication type:

Article

Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1029, doi. 10.1208/s12248-017-0072-x

By:

Ali Akbari Ghavimi, Soheila;
Tata, Rama;
Greenwald, Andrew;
Allen, Brittany;
Grant, David;
Grant, Sheila;
Lee, Mark;
Ulery, Bret

Publication type:

Article

Controlled Release of Vanadium from a Composite Scaffold Stimulates Mesenchymal Stem Cell Osteochondrogenesis.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1017, doi. 10.1208/s12248-017-0073-9

By:

Schussler, S.;
Uske, K.;
Marwah, P.;
Kemp, F.;
Bogden, J.;
Lin, S.;
Livingston Arinzeh, Treena

Publication type:

Article

Physiologically Based Pharmacokinetic and Absorption Modeling for Osmotic Pump Products.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1045, doi. 10.1208/s12248-017-0075-7

By:

Ni, Zhanglin;
Talattof, Arjang;
Fan, Jianghong;
Tsakalozou, Eleftheria;
Sharan, Satish;
Sun, Dajun;
Wen, Hong;
Zhao, Liang;
Zhang, Xinyuan

Publication type:

Article

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 910, doi. 10.1208/s12248-017-0076-6

By:

Lochhead, Jeffrey;
Ronaldson, Patrick;
Davis, Thomas

Publication type:

Article

Neurovascular Alterations in Alzheimer's Disease: Transporter Expression Profiles and CNS Drug Access.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 940, doi. 10.1208/s12248-017-0077-5

By:

McInerney, Mitchell;
Short, Jennifer;
Nicolazzo, Joseph

Publication type:

Article

Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 by Cunninghamella elegans.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1148, doi. 10.1208/s12248-017-0078-4

By:

Watanabe, Shimpei;
Kuzhiumparambil, Unnikrishnan;
Nguyen, My;
Cameron, Jane;
Fu, Shanlin

Publication type:

Article

Blood-Brain Barriers in Obesity.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 921, doi. 10.1208/s12248-017-0079-3

By:

Rhea, Elizabeth;
Salameh, Therese;
Logsdon, Aric;
Hanson, Angela;
Erickson, Michelle;
Banks, William

Publication type:

Article

Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Published in:

2017

By:

Yamamoto, Yumi;
Danhof, Meindert;
Lange, Elizabeth

Publication type:

Erratum

Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 931, doi. 10.1208/s12248-017-0081-9

By:

Abdullahi, Wazir;
Davis, Thomas;
Ronaldson, Patrick

Publication type:

Article

Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example for In Silico Assessment of Adaptive Dosing Strategies.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1136, doi. 10.1208/s12248-017-0082-8

By:

Wojciechowski, Jessica;
Upton, Richard;
Mould, Diane;
Wiese, Michael;
Foster, David

Publication type:

Article

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1123, doi. 10.1208/s12248-017-0083-7

By:

Tumey, L.;
Li, Fengping;
Rago, Brian;
Han, Xiaogang;
Loganzo, Frank;
Musto, Sylvia;
Graziani, Edmund;
Puthenveetil, Sujiet;
Casavant, Jeffrey;
Marquette, Kimberly;
Clark, Tracey;
Bikker, Jack;
Bennett, Eric;
Barletta, Frank;
Piche-Nicholas, Nicole;
Tam, Amy;
O'Donnell, Christopher;
Gerber, Hans;
Tchistiakova, Lioudmila

Publication type:

Article

How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1071, doi. 10.1208/s12248-017-0084-6

By:

Tyner, Katherine;
Zheng, Nan;
Choi, Stephanie;
Xu, Xiaoming;
Zou, Peng;
Jiang, Wenlei;
Guo, Changning;
Cruz, Celia

Publication type:

Article

Evolution of Choice of Solubility and Dissolution Media After Two Decades of Biopharmaceutical Classification System.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 989, doi. 10.1208/s12248-017-0085-5

By:

Bou-Chacra, Nadia;
Melo, Katherine;
Morales, Ivan;
Stippler, Erika;
Kesisoglou, Filippos;
Yazdanian, Mehran;
Löbenberg, Raimar

Publication type:

Article

Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1186, doi. 10.1208/s12248-017-0086-4

By:

Gu, Jian-Ming;
Zhao, Xiao-Yan;
Schwarz, Thomas;
Schuhmacher, Joachim;
Baumann, Andreas;
Ho, Elena;
Subramanyan, Babu;
Tran, Kathy;
Myles, Timothy;
Patel, Chandra;
Koellnberger, Maria

Publication type:

Article

Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro- In Vivo Comparisons.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1163, doi. 10.1208/s12248-017-0087-3

By:

Wilkinson, David;
Southall, Rosalind;
Li, Mingguang;
Wright, Lisa;
Corfield, Lindsay;
Heeley, Thomas;
Bratby, Benjamin;
Mannu, Ranbir;
Johnson, Sarah;
Shaw, Victoria;
Friett, Holly;
Blakeburn, Louise;
Kendrick, John;
Otteneder, Michael

Publication type:

Article

Controlled Release of Second Generation mTOR Inhibitors to Restrain Inflammation in Primary Immune Cells.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1175, doi. 10.1208/s12248-017-0089-1

By:

Gosselin, Emily;
Tostanoski, Lisa;
Jewell, Christopher

Publication type:

Article

Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1196, doi. 10.1208/s12248-017-0090-8

By:

Lee, Jieon;
Kim, Andrew;
Yi, SoJeong;
Lee, SeungHwan;
Yoon, Seo;
Yu, Kyung-Sang;
Jang, In-Jin;
Cho, Joo-Youn

Publication type:

Article

Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 957, doi. 10.1208/s12248-017-0091-7

By:

Sifat, Ali;
Vaidya, Bhuvaneshwar;
Abbruscato, Thomas

Publication type:

Article

Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1235, doi. 10.1208/s12248-017-0093-5

By:

Bian, Yuemin;
Feng, Zhiwei;
Yang, Peng;
Xie, Xiang-Qun

Publication type:

Article

Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1218, doi. 10.1208/s12248-017-0094-4

By:

Soderstrom, Catherine;
Berstein, Gabriel;
Zhang, Weidong;
Valdez, Hernan;
Fitz, Lori;
Kuhn, Max;
Fraser, Stephanie

Publication type:

Article

Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 973, doi. 10.1208/s12248-017-0096-2

By:

Han, Hadas;
Mann, Aniv;
Ekstein, Dana;
Eyal, Sara

Publication type:

Article

Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1223, doi. 10.1208/s12248-017-0098-0

By:

Loebrich, Sven;
Shen, Mingfang;
Cohen, Erika;
Payne, Gillian;
Chen, Ying;
Bogalhas, Megan;
Zhao, Yiwei

Publication type:

Article

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1205, doi. 10.1208/s12248-017-0099-z

By:

Rose, Rachel;
Turner, David;
Neuhoff, Sibylle;
Jamei, Masoud

Publication type:

Article

QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models.

Published in:

AAPS Journal, 2017, v. 19, n. 4, p. 1002, doi. 10.1208/s12248-017-0100-x

By:

Cheng, Yougan;
Thalhauser, Craig;
Smithline, Shepard;
Pagidala, Jyotsna;
Miladinov, Marko;
Vezina, Heather;
Gupta, Manish;
Leil, Tarek;
Schmidt, Brian

Publication type:

Article