Works matching IS 15507416 AND DT 2017 AND VI 19 AND IP 4

Results: 30

The Two Main Goals of Bioequivalence Studies.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 885, doi. 10.1208/s12248-017-0048-x
By:
- Endrenyi, Laszlo;
- Blume, Henning;
- Tothfalusi, Laszlo
Publication type:
Article
Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 891, doi. 10.1208/s12248-017-0050-3
By:
- Yamamoto, Yumi;
- Danhof, Meindert;
- Lange, Elizabeth
Publication type:
Article
Dissolution comparisons using a Multivariate Statistical Distance (MSD) test and a comparison of various approaches for calculating the measurements of dissolution profile comparison.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1091, doi. 10.1208/s12248-017-0063-y
By:
- Cardot, J-M.;
- Roudier, B.;
- Schütz, H.
Publication type:
Article
The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1084, doi. 10.1208/s12248-017-0065-9
By:
- Sutton, Steven;
- Nause, Richard;
- Gandelman, Kuan
Publication type:
Article
In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1102, doi. 10.1208/s12248-017-0070-z
By:
- Watanabe, Shimpei;
- Vikingsson, Svante;
- Roman, Markus;
- Green, Henrik;
- Kronstrand, Robert;
- Wohlfarth, Ariane
Publication type:
Article
Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1054, doi. 10.1208/s12248-017-0071-y
By:
- Singh, Aman;
- Shah, Dhaval
Publication type:
Article
Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 by Cunninghamella elegans.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1148, doi. 10.1208/s12248-017-0078-4
By:
- Watanabe, Shimpei;
- Kuzhiumparambil, Unnikrishnan;
- Nguyen, My;
- Cameron, Jane;
- Fu, Shanlin
Publication type:
Article
Controlled Release of Vanadium from a Composite Scaffold Stimulates Mesenchymal Stem Cell Osteochondrogenesis.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1017, doi. 10.1208/s12248-017-0073-9
By:
- Schussler, S.;
- Uske, K.;
- Marwah, P.;
- Kemp, F.;
- Bogden, J.;
- Lin, S.;
- Livingston Arinzeh, Treena
Publication type:
Article
Physiologically Based Pharmacokinetic and Absorption Modeling for Osmotic Pump Products.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1045, doi. 10.1208/s12248-017-0075-7
By:
- Ni, Zhanglin;
- Talattof, Arjang;
- Fan, Jianghong;
- Tsakalozou, Eleftheria;
- Sharan, Satish;
- Sun, Dajun;
- Wen, Hong;
- Zhao, Liang;
- Zhang, Xinyuan
Publication type:
Article
Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 910, doi. 10.1208/s12248-017-0076-6
By:
- Lochhead, Jeffrey;
- Ronaldson, Patrick;
- Davis, Thomas
Publication type:
Article
Neurovascular Alterations in Alzheimer's Disease: Transporter Expression Profiles and CNS Drug Access.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 940, doi. 10.1208/s12248-017-0077-5
By:
- McInerney, Mitchell;
- Short, Jennifer;
- Nicolazzo, Joseph
Publication type:
Article
Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1029, doi. 10.1208/s12248-017-0072-x
By:
- Ali Akbari Ghavimi, Soheila;
- Tata, Rama;
- Greenwald, Andrew;
- Allen, Brittany;
- Grant, David;
- Grant, Sheila;
- Lee, Mark;
- Ulery, Bret
Publication type:
Article
Blood-Brain Barriers in Obesity.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 921, doi. 10.1208/s12248-017-0079-3
By:
- Rhea, Elizabeth;
- Salameh, Therese;
- Logsdon, Aric;
- Hanson, Angela;
- Erickson, Michelle;
- Banks, William
Publication type:
Article
Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.
Published in:
2017
By:
- Yamamoto, Yumi;
- Danhof, Meindert;
- Lange, Elizabeth
Publication type:
Erratum
Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 931, doi. 10.1208/s12248-017-0081-9
By:
- Abdullahi, Wazir;
- Davis, Thomas;
- Ronaldson, Patrick
Publication type:
Article
Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example for In Silico Assessment of Adaptive Dosing Strategies.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1136, doi. 10.1208/s12248-017-0082-8
By:
- Wojciechowski, Jessica;
- Upton, Richard;
- Mould, Diane;
- Wiese, Michael;
- Foster, David
Publication type:
Article
Controlled Release of Second Generation mTOR Inhibitors to Restrain Inflammation in Primary Immune Cells.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1175, doi. 10.1208/s12248-017-0089-1
By:
- Gosselin, Emily;
- Tostanoski, Lisa;
- Jewell, Christopher
Publication type:
Article
How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1071, doi. 10.1208/s12248-017-0084-6
By:
- Tyner, Katherine;
- Zheng, Nan;
- Choi, Stephanie;
- Xu, Xiaoming;
- Zou, Peng;
- Jiang, Wenlei;
- Guo, Changning;
- Cruz, Celia
Publication type:
Article
Evolution of Choice of Solubility and Dissolution Media After Two Decades of Biopharmaceutical Classification System.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 989, doi. 10.1208/s12248-017-0085-5
By:
- Bou-Chacra, Nadia;
- Melo, Katherine;
- Morales, Ivan;
- Stippler, Erika;
- Kesisoglou, Filippos;
- Yazdanian, Mehran;
- Löbenberg, Raimar
Publication type:
Article
Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1186, doi. 10.1208/s12248-017-0086-4
By:
- Gu, Jian-Ming;
- Zhao, Xiao-Yan;
- Schwarz, Thomas;
- Schuhmacher, Joachim;
- Baumann, Andreas;
- Ho, Elena;
- Subramanyan, Babu;
- Tran, Kathy;
- Myles, Timothy;
- Patel, Chandra;
- Koellnberger, Maria
Publication type:
Article
Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro- In Vivo Comparisons.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1163, doi. 10.1208/s12248-017-0087-3
By:
- Wilkinson, David;
- Southall, Rosalind;
- Li, Mingguang;
- Wright, Lisa;
- Corfield, Lindsay;
- Heeley, Thomas;
- Bratby, Benjamin;
- Mannu, Ranbir;
- Johnson, Sarah;
- Shaw, Victoria;
- Friett, Holly;
- Blakeburn, Louise;
- Kendrick, John;
- Otteneder, Michael
Publication type:
Article
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1123, doi. 10.1208/s12248-017-0083-7
By:
- Tumey, L.;
- Li, Fengping;
- Rago, Brian;
- Han, Xiaogang;
- Loganzo, Frank;
- Musto, Sylvia;
- Graziani, Edmund;
- Puthenveetil, Sujiet;
- Casavant, Jeffrey;
- Marquette, Kimberly;
- Clark, Tracey;
- Bikker, Jack;
- Bennett, Eric;
- Barletta, Frank;
- Piche-Nicholas, Nicole;
- Tam, Amy;
- O'Donnell, Christopher;
- Gerber, Hans;
- Tchistiakova, Lioudmila
Publication type:
Article
Distribution of Exogenous and Endogenous CYP3A Markers and Related Factors in Healthy Males and Females.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1196, doi. 10.1208/s12248-017-0090-8
By:
- Lee, Jieon;
- Kim, Andrew;
- Yi, SoJeong;
- Lee, SeungHwan;
- Yoon, Seo;
- Yu, Kyung-Sang;
- Jang, In-Jin;
- Cho, Joo-Youn
Publication type:
Article
Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 957, doi. 10.1208/s12248-017-0091-7
By:
- Sifat, Ali;
- Vaidya, Bhuvaneshwar;
- Abbruscato, Thomas
Publication type:
Article
Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1235, doi. 10.1208/s12248-017-0093-5
By:
- Bian, Yuemin;
- Feng, Zhiwei;
- Yang, Peng;
- Xie, Xiang-Qun
Publication type:
Article
Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1218, doi. 10.1208/s12248-017-0094-4
By:
- Soderstrom, Catherine;
- Berstein, Gabriel;
- Zhang, Weidong;
- Valdez, Hernan;
- Fitz, Lori;
- Kuhn, Max;
- Fraser, Stephanie
Publication type:
Article
Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 973, doi. 10.1208/s12248-017-0096-2
By:
- Han, Hadas;
- Mann, Aniv;
- Ekstein, Dana;
- Eyal, Sara
Publication type:
Article
Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1223, doi. 10.1208/s12248-017-0098-0
By:
- Loebrich, Sven;
- Shen, Mingfang;
- Cohen, Erika;
- Payne, Gillian;
- Chen, Ying;
- Bogalhas, Megan;
- Zhao, Yiwei
Publication type:
Article
Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1205, doi. 10.1208/s12248-017-0099-z
By:
- Rose, Rachel;
- Turner, David;
- Neuhoff, Sibylle;
- Jamei, Masoud
Publication type:
Article
QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models.
Published in:
AAPS Journal, 2017, v. 19, n. 4, p. 1002, doi. 10.1208/s12248-017-0100-x
By:
- Cheng, Yougan;
- Thalhauser, Craig;
- Smithline, Shepard;
- Pagidala, Jyotsna;
- Miladinov, Marko;
- Vezina, Heather;
- Gupta, Manish;
- Leil, Tarek;
- Schmidt, Brian
Publication type:
Article