Works matching IS 15507416 AND DT 2016 AND VI 18 AND IP 5

Results: 25

Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1159, doi. 10.1208/s12248-016-9922-1

By:

Leung, Cassandra;
Tong, Zhenbo;
Zhou, Qi;
Chan, John;
Tang, Patricia;
Sun, Siping;
Yang, Runyu;
Chan, Hak-Kim

Publication type:

Article

A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1182, doi. 10.1208/s12248-016-9923-0

By:

An, Guohua;
Widness, John;
Mock, Donald;
Veng-Pedersen, Peter

Publication type:

Article

Optimal Design for Informative Protocols in Xenograft Tumor Growth Inhibition Experiments in Mice.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1233, doi. 10.1208/s12248-016-9924-z

By:

Lestini, Giulia;
Mentré, France;
Magni, Paolo

Publication type:

Article

Clinical Predictors of Venetoclax Pharmacokinetics in Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphoma Patients: a Pooled Population Pharmacokinetic Analysis.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1192, doi. 10.1208/s12248-016-9927-9

By:

Jones, Aksana;
Freise, Kevin;
Agarwal, Suresh;
Humerickhouse, Rod;
Wong, Shekman;
Salem, Ahmed

Publication type:

Article

Preclinical to Clinical Translation of Antibody-Drug Conjugates Using PK/PD Modeling: a Retrospective Analysis of Inotuzumab Ozogamicin.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1101, doi. 10.1208/s12248-016-9929-7

By:

Betts, Alison;
Haddish-Berhane, Nahor;
Tolsma, John;
Jasper, Paul;
King, Lindsay;
Sun, Yongliang;
Chakrapani, Subramanyam;
Shor, Boris;
Boni, Joseph;
Johnson, Theodore

Publication type:

Article

Examining the Use of a Mechanistic Model to Generate an In Vivo/ In Vitro Correlation: Journey Through a Thought Process.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1144, doi. 10.1208/s12248-016-9930-1

By:

Mistry, Bipin;
Patel, Nikunjkumar;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Martinez, Marilyn

Publication type:

Article

Modeling the Disease Progression from Healthy to Overt Diabetes in ZDSD Rats.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1203, doi. 10.1208/s12248-016-9931-0

By:

Choy, Steve;
Winter, Willem;
Karlsson, Mats;
Kjellsson, Maria

Publication type:

Article

How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder?

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1213, doi. 10.1208/s12248-016-9934-x

By:

Zhou, Qi;
Loh, Zhi;
Yu, Jiaqi;
Sun, Si-ping;
Gengenbach, Thomas;
Denman, John;
Li, Jian;
Chan, Hak-Kim

Publication type:

Article

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1262, doi. 10.1208/s12248-016-9936-8

By:

Pierrillas, Philippe;
Tod, Michel;
Amiel, Magali;
Chenel, Marylore;
Henin, Emilie

Publication type:

Article

Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1225, doi. 10.1208/s12248-016-9937-7

By:

Mensink, Maarten;
Nethercott, Matthew;
Hinrichs, Wouter;
van der Voort Maarschalk, Kees;
Frijlink, Henderik;
Munson, Eric;
Pikal, Michael

Publication type:

Article

Defining Patient Centric Pharmaceutical Drug Product Design.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1047, doi. 10.1208/s12248-016-9938-6

By:

Stegemann, Sven;
Ternik, Robert;
Onder, Graziano;
Khan, Mansoor;
Riet-Nales, Diana

Publication type:

Article

Investigation of Polymer-Surfactant and Polymer-Drug-Surfactant Miscibility for Solid Dispersion.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1131, doi. 10.1208/s12248-016-9939-5

By:

Gumaste, Suhas;
Gupta, Simerdeep;
Serajuddin, Abu

Publication type:

Article

Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1117, doi. 10.1208/s12248-016-9940-z

By:

Cilliers, Cornelius;
Guo, Hans;
Liao, Jianshan;
Christodolu, Nikolas;
Thurber, Greg

Publication type:

Article

Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1254, doi. 10.1208/s12248-016-9941-y

By:

Shin, Kwang-Hee;
Ahn, Li;
Choi, Man;
Moon, Ju-Yeon;
Lee, Jieon;
Jang, In-Jin;
Yu, Kyung-Sang;
Cho, Joo-Youn

Publication type:

Article

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1067, doi. 10.1208/s12248-016-9942-x

By:

Scotcher, Daniel;
Jones, Christopher;
Posada, Maria;
Rostami-Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

The Impact of Model-Misspecification on Model Based Personalised Dosing.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1244, doi. 10.1208/s12248-016-9943-9

By:

McDougall, David;
Martin, Jennifer;
Playford, E.;
Green, Bruce

Publication type:

Article

Feasibility of Singlet Analysis for Ligand Binding Assays: a Retrospective Examination of Data Generated Using the Gyrolab Platform.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1300, doi. 10.1208/s12248-016-9944-8

By:

Clark, Tracey;
Yates, Phillip;
Chunyk, Allison;
Joyce, Alison;
Wu, Aidong;
Pop-Damkov, Petar;
Zhang, Yiqun;
Dreher, Elizabeth;
Tylaska, Laurie;
Wentland, Jo-Ann;
Pelletier, Kathleen;
King, Lindsay;
Ray, Chad

Publication type:

Article

Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1273, doi. 10.1208/s12248-016-9945-7

By:

Cui, Yonglei;
Tian, Xiangge;
Ning, Jing;
Wang, Chao;
Yu, Zhenlong;
Wang, Yan;
Huo, Xiaokui;
Jin, Lingling;
Deng, Sa;
Zhang, Baojing;
Ma, Xiaochi

Publication type:

Article

Lipophilicity in Drug Development: Too Much or Not Enough?

Published in:

2016

By:

Bergström, Christel;
Yazdanian, Mehran

Publication type:

Report

Di-Peptide-Modified Gemini Surfactants as Gene Delivery Vectors: Exploring the Role of the Alkyl Tail in Their Physicochemical Behavior and Biological Activity.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1168, doi. 10.1208/s12248-016-9906-1

By:

Al-Dulaymi, Mays;
Chitanda, Jackson;
Mohammed-Saeid, Waleed;
Araghi, Hessamaddin;
Verrall, Ronald;
Grochulski, Pawel;
Badea, Ildiko

Publication type:

Article

In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1289, doi. 10.1208/s12248-016-9951-9

By:

Zheng, Liang;
Zhu, Lijun;
Zhao, Min;
Shi, Jian;
Li, Yuhuan;
Yu, Jia;
Jiang, Huangyu;
Wu, Jinjun;
Tong, Yunli;
Liu, Yuting;
Hu, Ming;
Lu, Linlin;
Liu, Zhongqiu

Publication type:

Article

A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption-Part I: Gastrointestinal pH.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1309, doi. 10.1208/s12248-016-9952-8

By:

Abuhelwa, Ahmad;
Foster, David;
Upton, Richard

Publication type:

Article

A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1322, doi. 10.1208/s12248-016-9953-7

By:

Abuhelwa, Ahmad;
Foster, David;
Upton, Richard

Publication type:

Article

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1082, doi. 10.1208/s12248-016-9959-1

By:

Scotcher, Daniel;
Jones, Christopher;
Posada, Maria;
Galetin, Aleksandra;
Rostami-Hodjegan, Amin

Publication type:

Article

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity.

Published in:

AAPS Journal, 2016, v. 18, n. 5, p. 1056, doi. 10.1208/s12248-016-9949-3

By:

Aubry, Anne-Françoise;
Dean, Brian;
Diczfalusy, Ulf;
Goodenough, Angela;
Iffland, André;
McLeod, James;
Weng, Naidong;
Yang, Ziping

Publication type:

Article