Works matching IS 15507416 AND DT 2016 AND VI 18 AND IP 4

Results: 25

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 898, doi. 10.1208/s12248-016-9888-z

By:

Feng, Zhiwei;
Pearce, Larry;
Zhang, Yu;
Xing, Changrui;
Herold, Brienna;
Ma, Shifan;
Hu, Ziheng;
Turcios, Noe;
Yang, Peng;
Tong, Qin;
McCall, Anna;
Blumberg, Peter;
Xie, Xiang-Qun

Publication type:

Article

Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 933, doi. 10.1208/s12248-016-9896-z

By:

Villiger, Angela;
Stillhart, Cordula;
Parrott, Neil;
Kuentz, Martin

Publication type:

Article

Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 861, doi. 10.1208/s12248-016-9904-3

By:

Singh, Aman;
Maass, Katie;
Betts, Alison;
Wittrup, K.;
Kulkarni, Chethana;
King, Lindsay;
Khot, Antari;
Shah, Dhaval

Publication type:

Article

Evolutionary Dynamics of Chronic Myeloid Leukemia Progression: the Progression-Inhibitory Effect of Imatinib.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 914, doi. 10.1208/s12248-016-9905-2

By:

Jackson, Robert;
Radivoyevitch, Tomas

Publication type:

Article

Environmental Risk Assessment of Pharmaceutical Mixtures: Demands, Gaps, and Possible Bridges.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 804, doi. 10.1208/s12248-016-9907-0

By:

Backhaus, Thomas

Publication type:

Article

Monitoring Quality of Biotherapeutic Products Using Multivariate Data Analysis.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 793, doi. 10.1208/s12248-016-9908-z

By:

Rathore, Anurag;
Pathak, Mili;
Jain, Renu;
Jadaun, Gaurav

Publication type:

Article

Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 923, doi. 10.1208/s12248-016-9909-y

By:

Thomas, Veena;
Balthasar, Joseph

Publication type:

Article

Critical Importance and Quality Evaluation of Drug Delivery Autoinjectors in the FDA-DOD Shelf Life Extension Program (SLEP).

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 801, doi. 10.1208/s12248-016-9910-5

By:

Khan, Saeed;
Mohammad, Adil;
Khan, Mansoor;
Faustino, Patrick

Publication type:

Article

Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG Antibody in Cynomolgus Monkey.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 948, doi. 10.1208/s12248-016-9911-4

By:

Ng, Chee;
Fielder, Paul;
Jin, Jin;
Deng, Rong

Publication type:

Article

Development and Validation of Electrochemiluminescence Assays to Measure Free and Total sSLAMF7 in Human Serum in the Absence and Presence of Elotuzumab.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 989, doi. 10.1208/s12248-016-9912-3

By:

Postelnek, Jennifer;
Neely, Robert;
Robbins, Michael;
Gleason, Carol;
Peterson, Jon;
Piccoli, Steven

Publication type:

Article

Use of Modeling and Simulation Tools for Understanding the Impact of Formulation on the Absorption of a Low Solubility Compound: Ciprofloxacin.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 886, doi. 10.1208/s12248-016-9913-2

By:

Martinez, Marilyn;
Mistry, Bipin;
Lukacova, Viera;
Polli, Jim;
Hoag, Stephen;
Dowling, Thomas;
Kona, Ravikanth;
Fahmy, Raafat

Publication type:

Article

The Use of Cellulose Membrane to Eliminate Burst Release from Intravaginal Rings.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 960, doi. 10.1208/s12248-016-9914-1

By:

Helbling, Ignacio;
Ibarra, Juan;
Luna, Julio

Publication type:

Article

Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended Approaches.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 1039, doi. 10.1208/s12248-016-9915-0

By:

Cardot, J.-M.;
Garcia Arieta, A.;
Paixao, P.;
Tasevska, I.;
Davit, B.

Publication type:

Article

Synthesis and Physicochemical Characterization of a Diethyl Ester Prodrug of DTPA and Its Investigation as an Oral Decorporation Agent in Rats.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 972, doi. 10.1208/s12248-016-9916-z

By:

Huckle, James;
Sadgrove, Matthew;
Leed, Marina;
Yang, Yu-Tsai;
Mumper, Russell;
Semelka, Richard;
Jay, Michael

Publication type:

Article

The FDA's Experience with Emerging Genomics Technologies-Past, Present, and Future.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 814, doi. 10.1208/s12248-016-9917-y

By:

Xu, Joshua;
Thakkar, Shraddha;
Gong, Binsheng;
Tong, Weida

Publication type:

Article

Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 981, doi. 10.1208/s12248-016-9918-x

By:

Nader, Ahmed;
Quinney, Sara;
Fadda, Hala;
Foster, David

Publication type:

Article

Dual Outcomes of Rosiglitazone Treatment on Fatty Liver.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 1023, doi. 10.1208/s12248-016-9919-9

By:

Gao, Mingming;
Ma, Yongjie;
Alsaggar, Mohammad;
Liu, Dexi

Publication type:

Article

Clinical, Pharmacokinetic, and In Vitro Studies to Support Bioequivalence of Ophthalmic Drug Products.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 1032, doi. 10.1208/s12248-016-9932-z

By:

Choi, Stephanie;
Lionberger, Robert

Publication type:

Article

A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 1013, doi. 10.1208/s12248-016-9921-2

By:

Juul, Rasmus;
Knøsgaard, Katrine;
Olesen, Anne;
Pedersen, Katja;
Kreilgaard, Mads;
Christrup, Lona;
Osther, Palle;
Drewes, Asbjørn;
Lund, Trine

Publication type:

Article

Quantifying Trace Amounts of Aggregates in Biopharmaceuticals Using Analytical Ultracentrifugation Sedimentation Velocity: Bayesian Analyses and F Statistics.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 849, doi. 10.1208/s12248-016-9925-y

By:

Wafer, Lucas;
Kloczewiak, Marek;
Luo, Yin

Publication type:

Article

Therapeutic Application of Pharmacogenomics in Oncology.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 819, doi. 10.1208/s12248-016-9926-x

By:

Zhang, Yingqi;
Somtakoune, Seumsack;
Cheung, Christina;
Listiawan, Mario;
Feng, Xiaodong

Publication type:

Article

The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters-an Update.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 830, doi. 10.1208/s12248-016-9928-8

By:

Zhang, Wenpeng;
Li, Yanyan;
Zou, Peng;
Wu, Man;
Zhang, Zhenqing;
Zhang, Tao

Publication type:

Article

PK/PD Modelling of the QT Interval: a Step Towards Defining the Translational Relationship Between In Vitro, Awake Beagle Dogs, and Humans.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 1000, doi. 10.1208/s12248-016-9920-3

By:

Marostica, Eleonora;
Van Ammel, Karel;
Teisman, Ard;
Gallacher, David;
Van Bocxlaer, Jan;
De Ridder, Filip;
Boussery, Koen;
Vermeulen, An

Publication type:

Article

Cell-Based Therapies Formulations: Unintended components.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 844, doi. 10.1208/s12248-016-9935-9

By:

Atouf, Fouad

Publication type:

Article

Porous Silica-Supported Solid Lipid Particles for Enhanced Solubilization of Poorly Soluble Drugs.

Published in:

AAPS Journal, 2016, v. 18, n. 4, p. 876, doi. 10.1208/s12248-015-9864-z

By:

Yasmin, Rokhsana;
Rao, Shasha;
Bremmell, Kristen;
Prestidge, Clive

Publication type:

Article