Works matching IS 15507416 AND DT 2013 AND VI 15 AND IP 1

Results: 27

Mechanistic Models Describing Active Renal Reabsorption and Secretion: A Simulation-Based Study.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 278, doi. 10.1208/s12248-012-9437-3

By:

Felmlee, Melanie A.;
Dave, Rutwij A.;
Morris, Marilyn E.

Publication type:

Article

The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 258, doi. 10.1208/s12248-012-9429-3

By:

Mingming Gao;
Dexi Liu

Publication type:

Article

In Vitro and In Vivo Evaluation of a Water-in-Oil Microemulsion System for Enhanced Peptide Intestinal Delivery.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 288, doi. 10.1208/s12248-012-9441-7

By:

Dongyun Liu;
Taku Kobayashi;
Russo, Steven;
Fengling Li;
Plevy, Scott E.;
Gambling, Todd M.;
Carson, Johnny L.;
Mumper, Russell J.

Publication type:

Article

A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 267, doi. 10.1208/s12248-012-9422-x

By:

Klančar, Uroš;
Markun, Boštjan;
Baumgartner, Saša;
Legen, Igor

Publication type:

Article

Integrated Pharmacokinetic-Driven Approach to Screen Candidate Anticancer Drugs for Brain Tumor Chemotherapy.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 250, doi. 10.1208/s12248-012-9428-4

By:

Hua Lv;
Xiaoping Zhang;
Sharma, Jyoti;
Reddy, M. V. Ramana;
Reddy, E. Premkumar;
Gallo, James M.

Publication type:

Article

In Vivo Quantification of Active Decitabine-Triphosphate Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 242, doi. 10.1208/s12248-012-9427-5

By:

Hongyan Wang;
Ping Chen;
Jiang Wang;
Santhanam, Ramasamy;
Aimiuwu, Josephine;
Saradhi, U. V. Vijaya;
Zhongfa Liu;
Schwind, Sebastian;
Mims, Alice;
Byrd, John C.;
Grever, Michael R.;
Villalona-Calero, Miguel A.;
Klisovic, Rebecca;
Walker, Alison;
Garzon, Ramiro;
Blum, William;
Chan, Kenneth K.;
Marcucci, Guido

Publication type:

Article

Pocket-Based Drug Design: Exploring Pocket Space.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 228, doi. 10.1208/s12248-012-9426-6

By:

Xiliang Zheng;
LinFeng Gan;
Erkang Wang;
Jin Wang

Publication type:

Article

Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) Enhance the Bioavailability of the Poorly Water-Soluble Drug Simvastatin in Dogs.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 219, doi. 10.1208/s12248-012-9433-7

By:

Thomas, Nicky;
Holm, René;
Garmer, Mats;
Karlsson, Jens Jakob;
Müllertz, Anette;
Rades, Thomas

Publication type:

Article

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 195, doi. 10.1208/s12248-012-9432-8

By:

Gupta, Subash C.;
Patchva, Sridevi;
Aggarwal, Bharat B.

Publication type:

Article

Target-Mediated Disposition Model Describing the Dynamics of IL12 and IFN<sub>γ</sub> after Administration of a Mifepristone-Inducible Adenoviral Vector for IL-12 Expression in Mice.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 183, doi. 10.1208/s12248-012-9423-9

By:

Parra-Guillen, Zinnia Patricia;
Janda, Alvaro;
Alzuguren, Pilar;
Berraondo, Pedro;
Hernandez-Alcoceba, Ruben;
Troconiz, Iñaki F.

Publication type:

Article

The Utility of Modeling and Simulation Approaches to Evaluate Immunogenicity Effect on the Therapeutic Protein Pharmacokinetics.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 172, doi. 10.1208/s12248-012-9424-8

By:

Ruixo, Juan Jose Perez;
Peiming Ma;
Chow, Andrew T.

Publication type:

Article

A Pharmacokinetic Simulation Tool for Inhaled Corticosteroids.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 159, doi. 10.1208/s12248-012-9420-z

By:

Weber, Benjamin;
Hochhaus, Guenther

Publication type:

Article

Case Studies for Practical Food Effect Assessments across BCS/BDDCS Class Compounds using In Silico, In Vitro, and Preclinical In Vivo Data.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 143, doi. 10.1208/s12248-012-9419-5

By:

Heimbach, Tycho;
Binfeng Xia;
Tsu-han Lin;
Handan He

Publication type:

Article

Amino-Terminated Generation 2 Poly(amidoamine) Dendrimer as a Potential Broad-Spectrum, Nonresistance-Inducing Antibacterial Agent.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 132, doi. 10.1208/s12248-012-9416-8

By:

Xiaoyan Xue;
Xiaoqing Chen;
Xinggang Mao;
Zheng Hou;
Ying Zhou;
Hui Bai;
Jingru Meng;
Fei Da;
Guojun Sang;
Yukun Wang;
Xiaoxing Luo

Publication type:

Article

Validation of a Ligand Binding Assay Using Dried Blood Spot Sampling.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 123, doi. 10.1208/s12248-012-9430-x

By:

Burns, Daniel;
Brunner, Laura;
Rajendran, Surendran;
Johnson, Beth;
Ma, Mark;
Jin Wang

Publication type:

Article

Determination of the Dominant Arachidonic Acid Cytochrome P450 Monooxygenases in Rat Heart, Lung, Kidney, and Liver: Protein Expression and Metabolite Kinetics.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 112, doi. 10.1208/s12248-012-9425-7

By:

El-Sherbeni, Ahmed A.;
Aboutabl, Mona E.;
Zordoky, Beshay N. M.;
Anwar-Mohamed, Anwar;
El-Kadi, Ayman O. S.

Publication type:

Article

How Promiscuous Are Pharmaceutically Relevant Compounds? A Data-Driven Assessment.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 104, doi. 10.1208/s12248-012-9421-y

By:

Ye Hu;
Bajorath, Jürgen

Publication type:

Article

Pilot Investigation on Long-Term Subcutaneous Microdialysis: Proof of Principle in Humans.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 95, doi. 10.1208/s12248-012-9412-z

By:

Simmel, Franziska;
Kirbs, Claudia;
Erdogan, Zeynep;
Lackner, Edith;
Zeitlinger, Markus;
Kloft, Charlotte

Publication type:

Article

Biodegradable Particles as Vaccine Delivery Systems: Size Matters.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 85, doi. 10.1208/s12248-012-9418-6

By:

Joshi, Vijaya B.;
Geary, Sean M.;
Salem, Aliasger K.

Publication type:

Article

Common Reasons for "For-Cause" Inspections in Bioequivalence Studies Submitted to the Food and Drug Administration.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 10, doi. 10.1208/s12248-012-9415-9

By:

Li, Bing V.;
Davit, Barbara M.;
Lee, Christina H.;
Pabba, Santhosh K.;
Mahadevan, Chitra;
Caramenico, Hoainhon T.;
Haidar, Sam H.;
Sanchez, Aida L.;
Sigler, Aaron W.;
Stier, Ethan M.;
Conner, Dale P.

Publication type:

Article

Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 78, doi. 10.1208/s12248-012-9417-7

By:

Pawaskar, Dipti K.;
Straubinger, Robert M.;
Fetterly, Gerald J.;
Ma, Wen W.;
Jusko, William J.

Publication type:

Article

Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 53, doi. 10.1208/s12248-012-9413-y

By:

Li Wang;
Sweet, Douglas H.

Publication type:

Article

Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 41, doi. 10.1208/s12248-012-9411-0

By:

Rong-Kun Chang;
Raw, Andre;
Lionberger, Robert;
Yu, Lawrence

Publication type:

Article

Stratification of Antibody-Positive Subjects by Antibody Level Reveals an Impact of Immunogenicity on Pharmacokinetics.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 30, doi. 10.1208/s12248-012-9408-8

By:

Lei Zhou;
Hoofring, Sarah A.;
Yu Wu;
Vu, Thuy;
Peiming Ma;
Swanson, Steven J.;
Chirmule, Narendra;
Starcevic, Marta

Publication type:

Article

Study Reanalysis Using a Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 15, doi. 10.1208/s12248-012-9409-7

By:

Jing Fang;
Landersdorfer, Cornelia B.;
Cirincione, Brenda;
Jusko, William J.

Publication type:

Article

Specific Method Validation and Sample Analysis Approaches for Biocomparability Studies of Denosumab Addressing Method and Manufacture Site Changes.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 70, doi. 10.1208/s12248-012-9414-x

By:

Pourvasei, Ramak;
Lee, Ed;
Eschenberg, Michael;
Patel, Vimal;
Macaraeg, Chris;
Pandya, Kinnari;
Shih, Judy;
Ma, Mark;
Lee, Jean W.;
DeSilva, Binodh

Publication type:

Article

A Stability Analysis of a Modified Version of the Chi-Square Ratio Statistic: Implications for Equivalence Testing of Aerodynamic Particle Size Distribution.

Published in:

AAPS Journal, 2013, v. 15, n. 1, p. 1, doi. 10.1208/s12248-012-9410-1

By:

Weber, Benjamin;
Hochhaus, Guenther;
Adams, Wallace;
Lionberger, Robert;
Bing Li;
Yi Tsong;
Lee, Sau L.

Publication type:

Article