Works matching IS 15507416 AND DT 2012 AND VI 14 AND IP 4

Results: 30

Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 872, doi. 10.1208/s12248-012-9401-2

By:

Rozewski, Darlene M.;
Herman, Sarah E. M.;
Towns II, William H.;
Mahoney, Emilia;
Stefanovski, Matthew R.;
Shin, Jungook D.;
Xiaoxia Yang;
Yue Gao;
Xiaobai Li;
Jarjoura, David;
Byrd, John C.;
Johnson, Amy J.;
Phelps, Mitch A.

Publication type:

Article

Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 927, doi. 10.1208/s12248-012-9407-9

By:

Xu Steven Xu;
Min Yuan;
Karlsson, Mats O.;
Dunne, Adrian;
Nandy, Partha;
Vermeulen, An

Publication type:

Article

Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 904, doi. 10.1208/s12248-012-9405-y

By:

de Mendizábal, Nieves Vélez;
Vásquez-Bahena, Dalia;
Jiménez-Andrade, Juan M.;
Ortiz, Mario I.;
Castañeda-Hernández, Gilberto;
Trocóniz, Iñaki F.

Publication type:

Article

Regulatory Pathways for ATP-binding Cassette Transport Proteins in Kidney Proximal Tubules.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 883, doi. 10.1208/s12248-012-9404-z

By:

Masereeuw, Rosalinde;
Russel, Frans G. M.

Publication type:

Article

Universal Immunoassay Applied During Early Development of Large Molecules to Understand Impact of Immunogenicity on Biotherapeutic Exposure.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 843, doi. 10.1208/s12248-012-9403-0

By:

Bautista, Ami C.;
Salimi-Moosavi, Hossein;
Jawa, Vibha

Publication type:

Article

Effective Absorption Modeling in Relative Bioavailability Study Risk Assessment.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 895, doi. 10.1208/s12248-012-9402-1

By:

Rose, John P.

Publication type:

Article

Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Generic Drug Products by the US Food and Drug Administration.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 915, doi. 10.1208/s12248-012-9406-x

By:

Davit, Barbara M.;
Mei-Ling Chen;
Conner, Dale P.;
Haidar, Sam H.;
Kim, Stephanie;
Lee, Christina H.;
Lionberger, Robert A.;
Makhlouf, Fairouz T.;
Nwakama, Patrick E.;
Patel, Devvrat T.;
Schuirmann, Donald J.;
Yu, Lawrence X.

Publication type:

Article

Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 806, doi. 10.1208/s12248-012-9400-3

By:

Mohammed, Diar;
Matts, Paul J.;
Hadgraft, Jonathan;
Lane, Majella E.

Publication type:

Article

Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 832, doi. 10.1208/s12248-012-9399-5

By:

Vadlapudi, Aswani Dutt;
Vadlapatla, Ramya Krishna;
Pal, Dhananjay;
Mitra, Ashim K.

Publication type:

Article

Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 860, doi. 10.1208/s12248-012-9398-6

By:

Thomas, Nicky;
Holm, René;
Rades, Thomas;
Müllertz, Anette

Publication type:

Article

Guidelines for the Quality Control of Population Pharmacokinetic-Pharmacodynamic Analyses: an Industry Perspective.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 749, doi. 10.1208/s12248-012-9387-9

By:

Bonate, P. L.;
Strougo, A.;
Desai, A.;
Roy, M.;
Yassen, A.;
van der Walt, J. S.;
Kaibara, A.;
Tannenbaum, S.

Publication type:

Article

Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 813, doi. 10.1208/s12248-012-9396-8

By:

Endrenyi, Laszlo;
Tothfalusi, Laszlo

Publication type:

Article

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 850, doi. 10.1208/s12248-012-9395-9

By:

Yang Chen;
Balthasar, Joseph P.

Publication type:

Article

A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3' n-1 Metabolite from Rat Plasma by uHPLC-MS/MS.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 772, doi. 10.1208/s12248-012-9394-x

By:

Buyun Chen;
Bartlett, Michael

Publication type:

Article

International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 792, doi. 10.1208/s12248-012-9393-y

By:

Lainesse, Chantal

Publication type:

Article

Use of Partial Area under the Curve Metrics to Assess Bioequivalence of Methylphenidate Multiphasic Modified Release Formulations.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 925, doi. 10.1208/s12248-012-9397-7

By:

Stier, Ethan M.;
Davit, Barbara M.;
Chandaroy, Parthapratim;
Mei-Ling Chen;
Fourie-Zirkelbach, Jeanne;
Jackson, Andre;
Kim, Stephanie;
Lionberger, Robert;
Mehta, Mehul;
Uppoor, Ramana S.;
Yaning Wang;
Yu, Lawrence;
Conner, Dale P.

Publication type:

Article

Monoamine Transporter Structure, Function, Dynamics, and Drug Discovery: A Computational Perspective.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 820, doi. 10.1208/s12248-012-9391-0

By:

Manepalli, Sankar;
Surratt, Christopher K.;
Madura, Jeffry D.;
Nolan, Tammy L.

Publication type:

Article

Drug Repurposing: Far Beyond New Targets for Old Drugs.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 759, doi. 10.1208/s12248-012-9390-1

By:

Oprea, T. I.;
Mestres, J.

Publication type:

Article

Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 703, doi. 10.1208/s12248-012-9389-7

By:

Ping Gao;
Yi Shi

Publication type:

Article

Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 781, doi. 10.1208/s12248-012-9388-8

By:

Xin Xu;
Vugmeyster, Yulia

Publication type:

Article

Rationalizing Structure and Target Relationships between Current Drugs.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 764, doi. 10.1208/s12248-012-9392-z

By:

Ye Hu;
Bajorath, Jürgen

Publication type:

Article

ADME of Antibody-Maytansinoid Conjugates.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 799, doi. 10.1208/s12248-012-9386-x

By:

Erickson, Hans K.;
Lambert, John M.

Publication type:

Article

Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 714, doi. 10.1208/s12248-012-9385-y

By:

Vugmeyster, Yulia;
Harrold, John;
Xin Xu

Publication type:

Article

Statistics on BCS Classification of Generic Drug Products Approved Between 2000 and 2011 in the USA.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 664, doi. 10.1208/s12248-012-9384-z

By:

Nair, Anil K.;
Anand, Om;
Chun, Nam;
Conner, Dale P.;
Mehta, Mehul U.;
Nhu, Duong T.;
Polli, James E.;
Yu, Lawrence X.;
Davit, Barbara M.

Publication type:

Article

Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 677, doi. 10.1208/s12248-012-9383-0

By:

Kesisoglou, Filippos;
Mitra, Amitava

Publication type:

Article

Bioequivalence Requirements in the European Union: Critical Discussion.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 738, doi. 10.1208/s12248-012-9382-1

By:

García-Arieta, Alfredo;
Gordon, John

Publication type:

Article

Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 728, doi. 10.1208/s12248-012-9381-2

By:

Erb, Robert;
Leithner, Katharina;
Bernkop-Schnürch, Andreas;
Oberacher, Herbert

Publication type:

Article

Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 657, doi. 10.1208/s12248-012-9380-3

By:

Viberg, Anders;
Martino, Giovanni;
Lessard, Etienne;
Laird, Jennifer M. A.

Publication type:

Article

Effect of Device Design on the In Vitro Performance and Comparability for Capsule-Based Dry Powder Inhalers.

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 667, doi. 10.1208/s12248-012-9379-9

By:

Shur, Jagdeep;
Sau Lee;
Adams, Wallace;
Lionberger, Robert;
Tibbatts, James;
Price, Robert

Publication type:

Article

Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?

Published in:

AAPS Journal, 2012, v. 14, n. 4, p. 688, doi. 10.1208/s12248-012-9377-y

By:

Diab, Roudayna;
Jaafar-Maalej, Chiraz;
Fessi, Hatem;
Maincent, Philippe

Publication type:

Article