Works matching IS 15250016 AND DT 2013 AND VI 21 AND IP 1

Results: 30

Gene Therapy for Hemophilia: Addressing the Coming Challenges of Affordability and Accessibility.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 1, doi. 10.1038/mt.2012.272

By:

Skinner, Mark W

Publication type:

Article

Targeting Gonadotropin-releasing Hormone Receptor Inhibits the Early Step of Ovarian Cancer Metastasis by Modulating Tumor-mesothelial Adhesion.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 78, doi. 10.1038/mt.2012.187

By:

Cheung, Lydia WT;
Yung, Susan;
Chan, Tak-Mao;
Leung, Peter CK;
Wong, Alice ST

Publication type:

Article

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 31, doi. 10.1038/mt.2012.66

By:

Spencer, Brian;
Michael, Sarah;
Shen, Jay;
Kosberg, Kori;
Rockenstein, Edward;
Patrick, Christina;
Adame, Anthony;
Masliah, Eliezer

Publication type:

Article

IL10 Released by a New Inflammation-regulated Lentiviral System Efficiently Attenuates Zymosan-induced Arthritis.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 119, doi. 10.1038/mt.2012.131

By:

Garaulet, Guillermo;
Alfranca, Arántzazu;
Torrente, María;
Escolano, Amelia;
López-Fontal, Raquel;
Hortelano, Sonsoles;
Redondo, Juan M;
Rodríguez, Antonio

Publication type:

Article

Regulating Cytokine Function Enhances Safety and Activity of Genetic Cancer Therapies.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 167, doi. 10.1038/mt.2012.225

By:

Chen, Hannah;
Sampath, Padma;
Hou, Weizhou;
Thorne, Stephen H.

Publication type:

Article

Intra-amniotic Transient Transduction of the Periderm With a Viral Vector Encoding TGFβ3 Prevents Cleft Palate in Tgfβ3−/− Mouse Embryos.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 8, doi. 10.1038/mt.2012.135

By:

Wu, Chadwick;
Endo, Masa;
Yang, Byung H;
Radecki, Melissa A;
Davis, Patrick F;
Zoltick, Philip W;
Spivak, Ryan M;
Flake, Alan W;
Kirschner, Richard E;
Nah, Hyun-Duck

Publication type:

Article

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 251, doi. 10.1038/mt.2012.202

By:

Pollard, Charlotte;
Rejman, Joanna;
De Haes, Winni;
Verrier, Bernard;
Van Gulck, Ellen;
Naessens, Thomas;
De Smedt, Stefaan;
Bogaert, Pieter;
Grooten, Johan;
Vanham, Guido;
De Koker, Stefaan

Publication type:

Article

Embedding siRNA sequences targeting Apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 217, doi. 10.1038/mt.2012.160

By:

Maczuga, Piotr;
Lubelski, Jacek;
van Logtenstein, Richard;
Borel, Florie;
Blits, Bas;
Fakkert, Erwin;
Costessi, Adalberto;
Butler, Derek;
van Deventer, Sander;
Petry, Harald;
Koornneef, Annemart;
Konstantinova, Pavlina

Publication type:

Article

In This Issue.

Published in:: Molecular Therapy, 2013, v. 21, n. 1, p. 3, doi. 10.1038/mt.2012.270
Publication type:: Article

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 101, doi. 10.1038/mt.2012.161

By:

Mizrak, Arda;
Bolukbasi, Mehmet Fatih;
Ozdener, Gokhan Baris;
Brenner, Gary J;
Madlener, Sibylle;
Erkan, Erdogan Pekcan;
Ströbel, Thomas;
Breakefield, Xandra O;
Saydam, Okay

Publication type:

Article

Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 240, doi. 10.1038/mt.2012.207

By:

Shao, Kaifeng;
Koch, Carmen;
Gupta, Manoj K;
Lin, Qiong;
Lenz, Michael;
Laufs, Stephanie;
Denecke, Bernd;
Schmidt, Manfred;
Linke, Matthias;
Hennies, Hans C;
Hescheler, Jürgen;
Zenke, Martin;
Zechner, Ulrich;
Šarić, Tomo;
Wagner, Wolfgang

Publication type:

Article

Inhibition of the Interaction Between NS3 Protease and HCV IRES With a Small Peptide: A Novel Therapeutic Strategy.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 57, doi. 10.1038/mt.2012.151

By:

Ray, Upasana;
Roy, Chaitrali L;
Kumar, Anuj;
Mani, Prashant;
Joseph, Agnel P;
Sudha, G;
Sarkar, Debi P;
Srinivasan, N;
Das, Saumitra

Publication type:

Article

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 109, doi. 10.1038/mt.2012.186

By:

Münch, Robert C;
Janicki, Hanna;
Völker, Iris;
Rasbach, Anke;
Hallek, Michael;
Büning, Hildegard;
Buchholz, Christian J

Publication type:

Article

Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 91, doi. 10.1038/mt.2012.184

By:

Yang, Xuanming;
Zhang, Xunmin;
Mortenson, Eric D;
Radkevich-Brown, Olga;
Wang, Yang;
Fu, Yang-Xin

Publication type:

Article

Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 192, doi. 10.1038/mt.2012.226

By:

Zhou, Jiehua;
Neff, C Preston;
Swiderski, Piotr;
Li, Haitang;
Smith, David D;
Aboellail, Tawfik;
Remling-Mulder, Leila;
Akkina, Ramesh;
Rossi, John J

Publication type:

Article

Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 42, doi. 10.1038/mt.2012.203

By:

D'Souza, Anthony D;
Parish, Ian A;
Krause, Diane S;
Kaech, Susan M;
Shadel, Gerald S

Publication type:

Article

Small but Significant: Inter- and Intrapatient Variations in iPS Cell-based Disease Modeling.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 5, doi. 10.1038/mt.2012.273

By:

Sgodda, Malte;
Cantz, Tobias

Publication type:

Article

Minicircle DNA Vectors Achieve Sustained Expression Reflected by Active Chromatin and Transcriptional Level.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 131, doi. 10.1038/mt.2012.244

By:

Gracey Maniar, Lia E.;
Maniar, Jay M.;
Chen, Zhi-Ying;
Lu, Jiamiao;
Fire, Andrew Z.;
Kay, Mark A.

Publication type:

Article

Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 68, doi. 10.1038/mt.2012.175

By:

Tamura, Kaoru;
Wakimoto, Hiroaki;
Agarwal, Aayush S;
Rabkin, Samuel D;
Bhere, Deepak;
Martuza, Robert L;
Kuroda, Toshihiko;
Kasmieh, Randa;
Shah, Khalid

Publication type:

Article

Virus-mediated shRNA Knockdown of Nav1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-induced Neuropathic Pain.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 49, doi. 10.1038/mt.2012.169

By:

Samad, Omar A;
Tan, Andrew M;
Cheng, Xiaoyang;
Foster, Edmund;
Dib-Hajj, Sulayman D;
Waxman, Stephen G

Publication type:

Article

Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 158, doi. 10.1038/mt.2012.167

By:

Ciesielska, Agnieszka;
Hadaczek, Piotr;
Mittermeyer, Gabriele;
Zhou, Shangzhen;
Wright, J Fraser;
Bankiewicz, Krystof S;
Forsayeth, John

Publication type:

Article

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 185, doi. 10.1038/mt.2012.180

By:

Ohno, Shin-ichiro;
Takanashi, Masakatsu;
Sudo, Katsuko;
Ueda, Shinobu;
Ishikawa, Akio;
Matsuyama, Nagahisa;
Fujita, Koji;
Mizutani, Takayuki;
Ohgi, Tadaaki;
Ochiya, Takahiro;
Gotoh, Noriko;
Kuroda, Masahiko

Publication type:

Article

Polyethylenimine-modified Pluronics (PCMs) Improve Morpholino Oligomer Delivery in Cell Culture and Dystrophic mdx Mice.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 210, doi. 10.1038/mt.2012.236

By:

Wang, Mingxing;
Wu, Bo;
Lu, Peijuan;
Cloer, Caryn;
Tucker, Jay D;
Lu, Qilong

Publication type:

Article

Intrapatient Variations in Type 1 Diabetes-specific iPS Cell Differentiation Into Insulin-producing Cells.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 228, doi. 10.1038/mt.2012.245

By:

Thatava, Tayaramma;
Kudva, Yogish C;
Edukulla, Ramakrishna;
Squillace, Karen;
De Lamo, Josep Genebriera;
Khan, Yulia Krotova;
Sakuma, Toshie;
Ohmine, Seiga;
Terzic, Andre;
Ikeda, Yasuhiro

Publication type:

Article

Research Highlights.

Published in:: Molecular Therapy, 2013, v. 21, n. 1, p. 4, doi. 10.1038/mt.2012.271
Publication type:: Article

Preclinical Safety and Efficacy of Human CD34+ Cells Transduced With Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 175, doi. 10.1038/mt.2012.23

By:

Scaramuzza, Samantha;
Biasco, Luca;
Ripamonti, Anna;
Castiello, Maria C;
Loperfido, Mariana;
Draghici, Elena;
Hernandez, Raisa J;
Benedicenti, Fabrizio;
Radrizzani, Marina;
Salomoni, Monica;
Ranzani, Marco;
Bartholomae, Cynthia C;
Vicenzi, Elisa;
Finocchi, Andrea;
Bredius, Robbert;
Bosticardo, Marita;
Schmidt, Manfred;
von Kalle, Christof;
Montini, Eugenio;
Biffi, Alessandra

Publication type:

Article

Improved Survival and Reduced Phenotypic Severity Following AAV9/MECP2 Gene Transfer to Neonatal and Juvenile Male Mecp2 Knockout Mice.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 18, doi. 10.1038/mt.2012.200

By:

Gadalla, Kamal KE;
Bailey, Mark ES;
Spike, Rosemary C;
Ross, Paul D;
Woodard, Kenton T;
Kalburgi, Sahana Nagabhushan;
Bachaboina, Lavanya;
Deng, Jie V;
West, Anne E;
Samulski, R Jude;
Gray, Steven J;
Cobb, Stuart R

Publication type:

Article

The Possible 'Proton Sponge ' Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 149, doi. 10.1038/mt.2012.185

By:

Benjaminsen, Rikke V;
Mattebjerg, Maria A;
Henriksen, Jonas R;
Moghimi, S Moein;
Andresen, Thomas L

Publication type:

Article

Infectivity-selective Oncolytic Adenovirus Developed by High-throughput Screening of Adenovirus-formatted Library.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 139, doi. 10.1038/mt.2012.205

By:

Miura, Yoshiaki;
Yamasaki, Satoshi;
Davydova, Julia;
Brown, Eric;
Aoki, Kazunori;
Vickers, Selwyn;
Yamamoto, Masato

Publication type:

Article

Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells.

Published in:

Molecular Therapy, 2013, v. 21, n. 1, p. 201, doi. 10.1038/mt.2012.209

By:

Tezgel, A. Özgül;
Gonzalez-Perez, Gabriela;
Telfer, Janice C.;
Osborne, Barbara A.;
Minter, Lisa M.;
Tew, Gregory N.

Publication type:

Article

Works matching IS 15250016 AND DT 2013 AND VI 21 AND IP 1

Gene Therapy for Hemophilia: Addressing the Coming Challenges of Affordability and Accessibility.

Targeting Gonadotropin-releasing Hormone Receptor Inhibits the Early Step of Ovarian Cancer Metastasis by Modulating Tumor-mesothelial Adhesion.

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD.

IL10 Released by a New Inflammation-regulated Lentiviral System Efficiently Attenuates Zymosan-induced Arthritis.

Regulating Cytokine Function Enhances Safety and Activity of Genetic Cancer Therapies.

Intra-amniotic Transient Transduction of the Periderm With a Viral Vector Encoding TGFβ3 Prevents Cleft Palate in Tgfβ3<sup>−/−</sup> Mouse Embryos.

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines.

Embedding siRNA sequences targeting Apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy.

In This Issue.

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth.

Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles.

Inhibition of the Interaction Between NS3 Protease and HCV IRES With a Small Peptide: A Novel Therapeutic Strategy.

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer.

Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses.

Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge.

Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia.

Small but Significant: Inter- and Intrapatient Variations in iPS Cell-based Disease Modeling.

Minicircle DNA Vectors Achieve Sustained Expression Reflected by Active Chromatin and Transcriptional Level.

Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors.

Virus-mediated shRNA Knockdown of Na<sub>v</sub>1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-induced Neuropathic Pain.

Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses.

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells.

Polyethylenimine-modified Pluronics (PCMs) Improve Morpholino Oligomer Delivery in Cell Culture and Dystrophic mdx Mice.

Intrapatient Variations in Type 1 Diabetes-specific iPS Cell Differentiation Into Insulin-producing Cells.

Research Highlights.

Preclinical Safety and Efficacy of Human CD34<sup>+</sup> Cells Transduced With Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome.

Improved Survival and Reduced Phenotypic Severity Following AAV9/MECP2 Gene Transfer to Neonatal and Juvenile Male Mecp2 Knockout Mice.

The Possible 'Proton Sponge ' Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH.

Infectivity-selective Oncolytic Adenovirus Developed by High-throughput Screening of Adenovirus-formatted Library.

Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells.