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ONC212, alone or in synergistic conjunction with Navitoclax (ABT-263), promotes cancer cell apoptosis via unconventional mitochondrial-independent caspase-3 activation.
- Published in:
- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01817-1
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- Article
TMEM100 acts as a TAK1 receptor that prevents pathological cardiac hypertrophy progression.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01816-2
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- Article
Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4<sup>+</sup> cells.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01814-4
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- Article
Correction: Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1.
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- 2024
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- Correction Notice
A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01813-5
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- Article
Lipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implications.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01792-7
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- Article
Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01819-z
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- Article
Interactions between hedgehog signaling pathway and the complex tumor microenvironment in breast cancer: current knowledge and therapeutic promises.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01812-6
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- Article
Targeting the EphA2 pathway: could it be the way for bone sarcomas?
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01811-7
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- Article
Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01785-6
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- Article
Protein disulfide isomerase plays a crucial role in mediating chemically-induced, glutathione depletion-associated hepatocyte injury in vitro and in vivo.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01798-1
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- Article
NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01805-5
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- Article
Emerging roles of liquid-liquid phase separation in liver innate immunity.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01787-4
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- Article
The mTOR pathway controls phosphorylation of BRAF at T401.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01808-2
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- Article
Correction: ASIC3-activated key enzymes of de novo lipid synthesis supports lactate-driven EMT and the metastasis of colorectal cancer cells.
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- 2024
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- Publication type:
- Correction Notice
Role of G protein coupled receptors in acute kidney injury.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01802-8
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- Article
Polyoxometalate inhibition of SOX2-mediated tamoxifen resistance in breast cancer.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01800-w
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- Article
RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01796-3
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- Article
Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01795-4
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- Article
Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01777-6
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- Article
ASIC3-activated key enzymes of de novo lipid synthesis supports lactate-driven EMT and the metastasis of colorectal cancer cells.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01762-z
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- Publication type:
- Article
Misfolding and aggregation in neurodegenerative diseases: protein quality control machinery as potential therapeutic clearance pathways.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01791-8
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- Article
OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01789-2
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- Article
ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01794-5
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- Article
Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01769-6
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- Article
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01746-z
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- Article
Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01741-4
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- Article
Endometrial senescence is mediated by interleukin 17 receptor B signaling.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01740-5
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- Article
Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01733-4
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- Article
Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01732-5
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- Article
Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01710-x
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- Article
Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01731-6
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- Article
Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01708-5
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- Article
Hypoxic extracellular vesicles from hiPSCs protect cardiomyocytes from oxidative damage by transferring antioxidant proteins and enhancing Akt/Erk/NRF2 signaling.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01722-7
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- Article
Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01729-0
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- Article
tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01730-7
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- Article
Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01734-3
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- Article
TonEBP inhibits ciliogenesis by controlling aurora kinase A and regulating centriolar satellite integrity.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01721-8
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- Article
The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01726-3
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- Article
Context-dependent T-BOX transcription factor family: from biology to targeted therapy.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01719-2
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- Article
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01718-3
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- Article
Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01728-1
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- Article
piRNA associates with immune diseases.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01724-5
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- Article
Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01720-9
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- Article
Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01715-6
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- Publication type:
- Article
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01701-y
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- Article
Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01716-5
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- Article
Identification of the central role of RNA polymerase mitochondrial for angiogenesis.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01712-9
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- Article
Short-term response of primary human meniscus cells to simulated microgravity.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01684-w
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- Article
Extracellular vesicles released by host epithelial cells during Pseudomonas aeruginosa infection function as homing beacons for neutrophils.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01609-7
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- Article