Works matching IS 14741776 AND DT 2015 AND VI 14 AND IP 7

Results: 25

An analysis of the attrition of drug candidates from four major pharmaceutical companies.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 475, doi. 10.1038/nrd4609

By:

Waring, Michael J.;
Arrowsmith, John;
Leach, Andrew R.;
Leeson, Paul D.;
Mandrell, Sam;
Owen, Robert M.;
Pairaudeau, Garry;
Pennie, William D.;
Pickett, Stephen D.;
Wang, Jibo;
Wallace, Owen;
Weir, Alex

Publication type:

Article

Regulatory watch: Why do oncology drugs fail to gain US regulatory approval?

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 450, doi. 10.1038/nrd4651

By:

Khozin, Sean;
Liu, Ke;
Jarow, Jonathan P.;
Pazdur, Richard

Publication type:

Article

Rational drug design: Tuning kinase inhibitor residence time.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 457, doi. 10.1038/nrd4673

By:

Cully, Megan

Publication type:

Article

Improving R&D productivity.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 455, doi. 10.1038/nrd4650

By:

Smietana, Katarzyna;
Ekstrom, Leeland;
Jeffery, Barbara;
Møller, Martin

Publication type:

Article

Assessing the relative efficacy of new drugs: an emerging opportunity.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 443, doi. 10.1038/nrd4664

By:

Eichler, Hans-Georg;
Thomson, Andrew;
Eichler, Irmgard;
Schneeweiss, Sebastian

Publication type:

Article

Asthma: DNAzyme attenuates allergic asthma.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 460, doi. 10.1038/nrd4677

By:

Crunkhorn, Sarah

Publication type:

Article

Oncolytic viruses get a boost with first FDA-approval recommendation.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 510, doi. 10.1038/nrd4680

By:

Dolgin, Elie

Publication type:

Article

Anticancer drugs: Selectively targeting proteins for degradation.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 459, doi. 10.1038/nrd4670

By:

Crunkhorn, Sarah

Publication type:

Article

Robust biotech sector increases R&D spend.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 449, doi. 10.1038/nrd4687

By:

Mullard, Asher

Publication type:

Article

Cancer: LOX does some prepping.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 458, doi. 10.1038/nrd4674

By:

Villanueva, M. Teresa

Publication type:

Article

Prospects for the development of epigenetic drugs for CNS conditions.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 461, doi. 10.1038/nrd4580

By:

Szyf, Moshe

Publication type:

Article

Infectious disease: Fragment screening identifies novel HIV-1 RT inhibitors.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 460, doi. 10.1038/nrd4678

By:

Crunkhorn, Sarah

Publication type:

Article

The pharmacology of second-generation chimeric antigen receptors.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 499, doi. 10.1038/nrd4597

By:

van der Stegen, Sjoukje J. C.;
Hamieh, Mohamad;
Sadelain, Michel

Publication type:

Article

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 487, doi. 10.1038/nrd4506

By:

Childs, Richard W.;
Carlsten, Mattias

Publication type:

Article

Autoimmune disease: SIRT1 inhibition suppresses multiple sclerosis.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 460, doi. 10.1038/nrd4679

By:

Crunkhorn, Sarah

Publication type:

Article

Moncef Slaoui.

Published in:: Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 452, doi. 10.1038/nrd4669
Publication type:: Article

Obesity: Reversing resistance to leptin in obesity.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 458, doi. 10.1038/nrd4671

By:

Bray, Natasha

Publication type:

Article

The NASH drug dash.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 447, doi. 10.1038/nrd4667

By:

Chi, Kelly Rae

Publication type:

Article

Fibrotic diseases: New tools to target an elusive integrin.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 460, doi. 10.1038/nrd4672

By:

Kingwell, Katie

Publication type:

Article

Market watch: Upcoming market catalysts in Q3 2015.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 451, doi. 10.1038/nrd4668

By:

Tan, Clara

Publication type:

Article

Academic drug discovery within the United Kingdom: a reassessment.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 510, doi. 10.1038/nrd4661

By:

Shanks, Emma;
Ketteler, Robin;
Ebner, Daniel

Publication type:

Article

FDA approves two IBS drugs.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 449, doi. 10.1038/nrd4688

By:

Mullard, Asher

Publication type:

Article

A β-lactamase inhibitor revival provides new hope for old antibiotics.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 445, doi. 10.1038/nrd4666

By:

Garber, Ken

Publication type:

Article

Chronic kidney disease: Targeting dynamin oligomerization.

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 460, doi. 10.1038/nrd4676

By:

Crunkhorn, Sarah

Publication type:

Article

Should the FDA disclose complete response letters?

Published in:

Nature Reviews Drug Discovery, 2015, v. 14, n. 7, p. 449, doi. 10.1038/nrd4686

By:

Mullard, Asher

Publication type:

Article