Works matching IS 11778881 AND DT 2025 AND VI 19

Results: 214

Young, Healthy, Underweight Women Require Higher Effective Doses of Propofol for Successful Gastroscope Insertion: a Dose-Finding Study Using Dixon's Up-and-Down Method.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3017, doi. 10.2147/DDDT.S512554

By:

Zhu, Qian;
Cui, Lingli;
Li, Xinyue;
Li, Qipei;
Wang, Yun

Publication type:

Article

Utilizing Physiologically Based Pharmacokinetic Models to Support Rational Medication in Chinese Elderly Population.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3077, doi. 10.2147/DDDT.S501143

By:

Wu, Xiaofei;
Wang, Ziyang;
Liu, Shupeng;
Wang, Hongyun

Publication type:

Article

Comparison of Remimazolam and Propofol on Post-Induction Hypotension in Elderly Hypertensive Patients: A Randomized Controlled Trial.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3425, doi. 10.2147/DDDT.S510431

By:

Zhou, Chunyan;
Wang, Xinghe;
Zhou, Meiyan;
Guo, Songhai;
Qi, Yu;
Sun, Jia;
Wang, Liwei

Publication type:

Article

Therapeutic Challenges of Diabetes Mellitus-Related Erectile Dysfunction and The Potential Therapeutic Role of Medicinal Plants: A Narrative Review.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3209, doi. 10.2147/DDDT.S515403

By:

Wang, Hao;
Chang, Hongyuan;
Sun, Di;
Wang, Anmin;
Yan, Bin;
Chung, Eric

Publication type:

Article

Antimicrobial Effects of Kelisha Capsule on Escherichia coli Induced Diarrhea in Mice.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2779, doi. 10.2147/DDDT.S511158

By:

Shi, Guolin;
Lu, Xiao;
Wang, Guowei;
Qian, Kai;
Peng, Xiaokang;
Zhu, Yangyang;
Wu, Jiaxu;
Ke, Haiyong;
Chen, Li;
Zheng, Yuanhang;
Yang, Tao;
Shi, Xiaoying;
Huang, Pintong

Publication type:

Article

Potential Application of Origanum majorana Stabilized Silver Nanoparticles for Coating of Urinary Catheter.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2941, doi. 10.2147/DDDT.S512320

By:

Rugaie, Osamah Al;
Abdulbaqi, Mustafa R;
Danial, Amal W;
Mohammed, Hamdoon A;
Alsharidah, Mansour;
Tawfeek, Hesham M;
Abdellatif, Ahmed AH

Publication type:

Article

Effect of Esketamine Compared with Sufentanil Combined with Propofol in Patients Undergoing First Trimester Surgical Abortion: A Randomized, Double-Blinded Clinical Trial.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2873, doi. 10.2147/DDDT.S515006

By:

Guan, Yingchao;
Wang, Haochen;
Cong, Xiaojing;
Zhang, Beibei;
Lin, Yusong;
Wang, Xiaodong

Publication type:

Article

pH-Sensitive Porphyrin Metal-Organic Frameworks for Controlled Delivery of Para-Toluenesulfonamide and Photodynamic Cancer Therapy.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2351, doi. 10.2147/DDDT.S504891

By:

Zhou, Wei;
Feng, Fan;
Zhang, Jieli;
Cao, Shuang;
Zhou, Yunzhi;
Li, Yanming

Publication type:

Article

New Drug Approvals in China: An International Comparative Analysis, 2019-2023.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2629, doi. 10.2147/DDDT.S514132

By:

Yan, Yilong;
Guo, Xiangyu;
Li, Ziming;
Shi, Weilin;
Long, Min;
Yue, Xiaolin;
Kong, Fanpu;
Zhao, Zhigang

Publication type:

Article

Optimal Effect-Site Concentration of Propofol for Hemodynamic Stability During Intubation with Dexmedetomidine: A Randomized Controlled Study.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3129, doi. 10.2147/DDDT.S508736

By:

Gao, Huayuan;
Wu, Junmei;
Chen, Youwen;
Wang, Chengyu;
Yao, Minmin;
Yang, Yan;
Miao, Changhong;
Liang, Chao

Publication type:

Article

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Administration of a Novel Anti-NGF Monoclonal Antibody (AK115) in Healthy Participants: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase I Clinical Trial

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3225, doi. 10.2147/DDDT.S500902

By:

Zhang, Juan;
Fan, Yu-Xin;
Huang, Yu;
Guan, Runfang;
Li, Ruixia;
Long, Shuxian;
Yang, Mei;
Yu, Binge;
Wang, Guo Qin;
Chen, Peng;
Gong, Xia;
Li, Baiyong;
Xia, Michelle;
He, Jianchang

Publication type:

Article

The Mechanism of Xuanyu Tongjing Decoction Regulating NOD/NFκB Pathway to Inhibit Ectopic Tissue Inflammation to Reduce Ovarian Damage in Rats with Ovarian Endometriosis.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2717, doi. 10.2147/DDDT.S500129

By:

Fan, Weisen;
Zhai, Fengting;
Yuan, Zheng;
Hu, Guotao;
Wang, Li

Publication type:

Article

The Jieduan-Niwan Formula Reduces Inflammatory Responses in Acute-on-Chronic Liver Failure Rats by Inhibiting HMGB1-Induced Hepatocyte Pyroptosis.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2503, doi. 10.2147/DDDT.S488659

By:

Hou, Weixin;
Fang, Peng;
Liang, Jiajun;
Wei, Xiaoyi;
Ma, Chongyang;
Gao, Yanbin;
Zhang, Qiuyun;
Li, Jingnan

Publication type:

Article

Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2667, doi. 10.2147/DDDT.S506262

By:

Han, Guangtao;
Ye, Yuna;
Kang, Pengde

Publication type:

Article

The Changing Landscape of Heart Failure Drug Clinical Trials in China, 2013–2023.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2597, doi. 10.2147/DDDT.S511608

By:

Zhang, Wenjie;
Zhang, Yinming;
Tang, Jiawei;
Wang, Xuejiao;
Meng, Chao;
Wu, Ji;
Li, Jun

Publication type:

Article

The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2693, doi. 10.2147/DDDT.S514498

By:

Song, Zhicong;
Bu, Shuai;
Sang, Suzhen;
Li, Jie;
Zhang, Xihai;
Song, Xu;
Ran, Yuqin

Publication type:

Article

Study of the Chemical Composition and Anti-Inflammatory Mechanism of Shiyiwei Golden Pill Based on UPLC-Q-TOF/MS and Network Pharmacology.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3159, doi. 10.2147/DDDT.S505880

By:

Han, Cong;
Chen, Jing;
Shen, Chuanlin;
Liang, Qiuxia;
An, Ying;
Zhou, Chaoyi;
Liu, Kechun;
Xia, Qing;
He, Qiuxia;
Zhang, Huazheng

Publication type:

Article

Single-Cell Transcriptional Analysis Reveals the Mechanism of AZD6738 in HCC Immunotherapy via EZH2 Targeting.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2897, doi. 10.2147/DDDT.S508709

By:

Li, Ren-peng;
Wu, Guo-zhi;
Fang, Xi-dong;
Yang, Wen-wen;
Zhang, Hui-yun;
Yue, Han-xun;
Zheng, Ya;
Wang, Yu-ping;
Zhou, Yong-ning

Publication type:

Article

Role of Curcumin in Chronic Liver Diseases: A Comprehensive Review.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3395, doi. 10.2147/DDDT.S518547

By:

Sun, Heyuan;
Liu, Tong;
Wang, Zijian;
Shen, Wenjuan;
Yuan, Xingxing;
Xie, Jingri;
Zhang, Yang

Publication type:

Article

Rho Kinase Inhibitors in Glaucoma Management: Current Perspectives and Future Directions.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2519, doi. 10.2147/DDDT.S515166

By:

Chatzimichail, Eleftherios;
Christodoulaki, Eirini;
Konstas, Panagiotis AG;
Tsiropoulos, Georgios N;
Amaxilati, Efstratia;
Gugleta, Konstantin;
Gatzioufas, Zisis;
Panos, Georgios D

Publication type:

Article

Review of the Efficacy and Mechanisms of Traditional Chinese Medicine for Treating Multi-Organ Damage in Wilson's Disease.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2453, doi. 10.2147/DDDT.S515123

By:

Chen, Hong;
Wang, Xie;
Tang, Le;
Pu, Yue;
Ma, Ying;
Ye, Hao;
Zhang, Juan

Publication type:

Article

Research Progress on the Treatment of Related Diseases With Astragalus.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2845, doi. 10.2147/DDDT.S494915

By:

Zhang, Xinyu;
Lin, Bingying;
Wang, Xiaoqian;
Fanɡ, Ninɡji;
Wu, Lifei;
Wan, Haitong;
Zhou, Huifen

Publication type:

Article

Recombinant Hydrophobic Polypeptide MBAY Loaded Into SPION-Exosome Realizes Sustained-Release to Improve Type 2 Diabetes Mellitus.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3103, doi. 10.2147/DDDT.S499641

By:

Zong, Xinyu;
Xiao, Shangying;
Xia, Haishan;
Guo, Dan;
Wu, Jiaping;
Zhuang, Manjiao;
Rao, Lei

Publication type:

Article

Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2979, doi. 10.2147/DDDT.S501318

By:

Pang, Xueyi;
Bai, Siqiong;
Feng, Zhinan;
Zhang, Yumin;
Hu, Bojie;
Zhang, Yan

Publication type:

Article

Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3351, doi. 10.2147/DDDT.S514209

By:

Su, Yudong;
Shui, Jinman;
Qi, Danshi;
Bai, Jie;
Xu, Xiaoxia;
Huang, Yongchun;
Li, Ruilian;
Wu, Qiong;
Wang, Haiyan;
Cao, Chengzhu;
Su, Zhanhai;
Zhang, Shoude

Publication type:

Article

Preclinical Investigations of a Novel PEGylated Long-Acting Human Growth Hormone.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3497, doi. 10.2147/DDDT.S517485

By:

Wang, Jun;
Wang, He;
Wang, Rong;
Zhuang, Yu;
Jiang, Chenyang;
Zhao, Baixue;
Xu, Zhen;
Ma, Bruce Yong

Publication type:

Article

Opioid-Free Anesthesia with Esketamine Combined with Iliac Fascia Block in Elderly Patients Undergoing Hip Surgery.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3337, doi. 10.2147/DDDT.S508805

By:

Luo, Lai-Lin;
Xiao, Rui;
Zhang, Jin-Peng;
Xi, Wen-Feng;
Xu, Guang-Hong;
Yuan, Hao

Publication type:

Article

Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial Cells.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2921, doi. 10.2147/DDDT.S512752

By:

Gao, Hongguo;
Liu, Te;
Liu, Junfeng;
Yang, Lian;
Liu, Luxi;
Cui, Zeyu;
Du, Xiling;
Gu, Yun;
Huang, Peirong

Publication type:

Article

Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2959, doi. 10.2147/DDDT.S492033

By:

Sun, Jinpeng;
Qi, Xinmeng;
Yang, Cuiyuan;
Wang, Shanpeng;
Jiang, Jingwen;
Wang, Lijie;
Song, Jiacheng;
Yu, Bin;
Sun, Min

Publication type:

Article

Model-Informed Precision Dosing of Levamlodipine Besylate in Smoking Patients.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3193, doi. 10.2147/DDDT.S501762

By:

Li, Guoxing;
Guan, Ying;
Yang, YingYing;
Xiang, Qiulin;
Chen, Song;
Shao, Jiaqi;
Chen, Yue;
Yu, Xian

Publication type:

Article

Study on the Protective Effect of Methyl Rosmarinate on Hypoxic Mice and Their Erythrocytes.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3179, doi. 10.2147/DDDT.S493866

By:

Guo, Qianwen;
Yin, Ziyue;
Wang, Rong;
Sun, Yuemei;
Zhao, Anpeng;
Yao, Wanteng;
Li, Wenbin

Publication type:

Article

Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2795, doi. 10.2147/DDDT.S487898

By:

Zhao, Xinyu;
Su, Sijia;
Zhou, Jingna;
Gao, Junfeng;
Tang, Xu;
Wen, Binyu

Publication type:

Article

Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2609, doi. 10.2147/DDDT.S495366

By:

Liu, Yuanyuan;
Sun, Dalin;
Xing, Dong;
Rui, Yiqi;
Jin, Yihan;
Wang, Peng;
Cai, Bin;
Li, Chuyu;
Gao, Chao;
Cui, Yugui;
Jin, Baofang

Publication type:

Article

Mechanisms of Total Glucosides of Paeony in Alleviating Methotrexate-Induced Liver Injury.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3407, doi. 10.2147/DDDT.S521740

By:

Chen, Guang-Yao;
Ji, Xiang-Yu;
Li, Ying;
Zheng, Si-Si;
Jin, Qi;
Tao, Qing-Wen

Publication type:

Article

Lean Six Sigma as a Management Tool Helps Standardize Antimicrobial Use in Hospital Settings.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3539, doi. 10.2147/DDDT.S510926

By:

Wang, Qian;
Han, Xinru;
Zhang, Xiang;
Guo, Lubo

Publication type:

Article

LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3253, doi. 10.2147/DDDT.S503483

By:

Zhang, Yongli;
Liu, Jiali;
Zhang, Dan;
Qian, Haihua

Publication type:

Article

Knowledge Mapping and Global Research Trends of Ginseng Polysaccharides: a Bibliometric Analysis with Visualizations from 1985 to 2023.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2749, doi. 10.2147/DDDT.S508387

By:

Mo, Pingli;
Gao, Bowen;
Wang, Rui;
Huang, Shiying;
Chen, Qiugu;
Li, Muxia;
Wu, Jiazhen;
Zhang, Shangbin;
Chen, Jianping

Publication type:

Article

Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2393, doi. 10.2147/DDDT.S501823

By:

Huang, Zhiguang;
Li, Yuanyuan;
Xie, Yixin;
Fu, Hangjie;
Weng, Zhiwei;
Yuan, Jianchang;
Wu, Lan;
Lin, Weizhou;
Cao, Yi;
Ding, Bin

Publication type:

Article

Curcumin Analog J7 Attenuates Liver Fibrosis and Metabolic Dysregulation in a Rat Model of Type 2 Diabetes via Modulation of TGF-β/Smad and NF-κB/BCL-2/BAX Pathways.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2411, doi. 10.2147/DDDT.S511372

By:

Ma, Jun;
Chen, Wei;
Vaishnani, Deep K;
Wang, Congying;
Xue, Shuman;
Yang, Qiuqin;
Tong, Yuheng;
Lei, Ningjia;
Zhao, Zhichao;
Ying, Furong

Publication type:

Article

Investigating Remedial Strategies for Missed or Delayed Dose of Sertraline in Chinese Adolescent Patients with Depressive Disorders via Population Pharmacokinetics Modeling and Simulation Approaches.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3001, doi. 10.2147/DDDT.S504521

By:

Xia, Hui;
Deng, Guowei;
Liang, Fengtao;
Zhang, Zi;
Huang, Wanting;
Guo, Zhihao;
Song, Qi;
Wen, Yuguan;
Shang, Dewei;
Tan, Yaqian

Publication type:

Article

Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3269, doi. 10.2147/DDDT.S492044

By:

Yu, Zhengyao;
Wang, Yingying;
Guo, Yingxue;
Zhu, Ruotong;
Fang, Yimiao;
Yao, Qinghua;
Fu, Huiying;
Zhou, Ang;
Ma, Lili;
Shou, Qiyang

Publication type:

Article

Inhibition of TRPM3 by Primidone Provides a Potential Therapeutic Method for Adenomyosis Management.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2533, doi. 10.2147/DDDT.S494981

By:

Jin, Zhixing;
Peng, Yaoming;
Zhang, He;
He, Xiaoping;
Zhang, Yi;
Pan, Xin;
Li, Min;
Yang, Qianqian

Publication type:

Article

Comparative Analysis of Clinical Efficacy and Safety of Pyrotinib Plus Capecitabine versus Trastuzumab Emtansine (T-DM1) as Second-Line Treatment for HER2-Positive Advanced Breast Cancer: A Retrospective Study.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2885, doi. 10.2147/DDDT.S516394

By:

Han, Hao;
Wang, Congcong;
Jiang, Fenge;
Sun, Ping;
Liu, Jiannan

Publication type:

Article

The Role of Radiosensitizing Drugs in Osteosarcoma Treatment: Mechanisms and Clinical Perspectives.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 1927, doi. 10.2147/DDDT.S512479

By:

Zhang, Yilei;
Xie, Yuhuan;
Wang, Yiwen;
Huang, Panpan;
Lu, Yao

Publication type:

Article

Identifying Antihepatocellular Carcinoma Compounds in Gansui Banxia Decoction Using Live Cell Adsorption.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3437, doi. 10.2147/DDDT.S513086

By:

Huang, Jiahao;
Mao, Hongyu;
Wu, Weidong;
Jiang, Siliang;
Chen, Lanru;
Ma, Tianyu;
Zhai, Chunmei;
Meng, Yonghai

Publication type:

Article

Huyang Yangkun Formula Enhances Ovarian Function and Delays Reproductive Aging by Influencing Hypothalamic GnRH/LH Pulse Release Through GAT-1/GABA/GABAAR2.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2677, doi. 10.2147/DDDT.S504610

By:

Li, Yang;
Peng, Yin;
Nie, Guangning;
Cheng, Fangping;
Zhou, Yuling;
Liu, Jian;
Yang, Hongyan

Publication type:

Article

Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 3059, doi. 10.2147/DDDT.S509046

By:

Cai, Changjiu;
Wang, Manying;
Yang, Dan;
Jing, Chenxu;
Li, Yingna;
Xu, Hanying;
Liu, Fangbing;
Zhao, Daqing

Publication type:

Article

Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2491, doi. 10.2147/DDDT.S485240

By:

Lu, Xinxing;
Zhang, Yan;
Wang, Ran;
Li, Ziyu

Publication type:

Article

GA-LDV: A Promising Derivative of 18β-Glycyrrhetinic Acid with Enhanced in vitro and in vivo Anti-Cancer Properties.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2641, doi. 10.2147/DDDT.S492303

By:

Zheng, Jiaying;
Feng, Qiqi;
Gao, Qi;
Wang, Yaonan;
Zhao, Shurui;
Zhang, Xiaoyi;
Zhao, Ming

Publication type:

Article

From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism Avoidance.

Published in:

Drug Design, Development & Therapy, 2025, v. 19, p. 2551, doi. 10.2147/DDDT.S504291

By:

Asar, Turky Omar;
Al-hejaili, Omar D;
El-Sawy, Hossam S;
Abd-Allah, Fathy I;
Omar, Abdelsattar M;
Ahmed, Tarek A;
El-Say, Khalid M

Publication type:

Article