Works in Drug Design, Development & Therapy, 2015, Vol 9

Results: 542

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6483, doi. 10.2147/DDDT.S97797

By:

Kazancioglu, Hakki Oguz;
Aksakalli, Sertac;
Ezirganli, Seref;
Birlik, Muhammet;
Esrefoglu, Mukaddes;
Acar, Ahmet Hüseyin

Publication type:

Article

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum].

Published in:: Drug Design, Development & Therapy, 2015, v. 9, p. 6509, doi. 10.2147/DDDT.S101194
Publication type:: Article

Study of bone-like hydroxyapatite/polyamino acid composite materials for their biological properties and effects on the reconstruction of long bone defects.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6497, doi. 10.2147/DDDT.S96207

By:

Ling Yan;
Dian-ming Jiang

Publication type:

Article

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6489, doi. 10.2147/DDDT.S95218

By:

Hyeong Jin Lee;
Bongjin Lee;
June Dong Park;
Hyung Joo Jeong;
Yu Hyeon Choi;
Hee Young Ju;
Che Ry Hong;
Ji Won Lee;
Hyery Kim;
Dong In Suh;
Kyung Duk Park;
Hyoung Jin Kang;
Hee Young Shin;
Hyo Seop Ahn

Publication type:

Article

Profile of deferasirox for the treatment of patients with non-transfusion-dependent thalassemia syndromes.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6475, doi. 10.2147/DDDT.S40694

By:

Ricchi, Paolo;
Marsella, Maria

Publication type:

Article

Effects of vitamin C treatment on collar-induced intimal thickening.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6461, doi. 10.2147/DDDT.S97020

By:

Arun, Mehmet Zuhuri;
Üstünes, Levent;
Sevin, Gülnur;
Özer, Erdener

Publication type:

Article

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6421, doi. 10.2147/DDDT.S95606

By:

Tao Wu;
Min-Cong Wang;
Li Jing;
Zhi-Yan Liu;
Hui Guo;
Ying Liu;
Yi-Yang Bai;
Yang-Zi Cheng;
Ke-Jun Nan;
Xuan Liang

Publication type:

Article

Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6379, doi. 10.2147/DDDT.S91823

By:

Jia-Qiang Zhang;
Jian-Qing Zhang;
Li-Zhou Fang;
Ling Liu;
Wei-Ping Fu;
Lu-Ming Dai

Publication type:

Article

The study on the preparation and characterization of gene-loaded immunomagnetic albumin nanospheres and their anti-cell proliferative effect combined with magnetic fluid hyperthermia on GLC-82 cells.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6445, doi. 10.2147/DDDT.S93481

By:

Hao Zhang;
Xinxin Hou;
Mei Lin;
Ling Wang;
Hongbo Li;
Chenyan Yuan;
Chen Liang;
Jia Zhang;
Dongsheng Zhang

Publication type:

Article

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6327, doi. 10.2147/DDDT.S92777

By:

Jing Sun;
Xueqi Fu;
Ye Liu;
Yongsen Wang;
Bo Huo;
Yidi Guo;
Xuefeng Gao;
Wannan Li;
Xin Hu

Publication type:

Article

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6319, doi. 10.2147/DDDT.S96893

By:

aus dem Siepen, Fabian;
Bauer, Ralf;
Aurich, Matthias;
Buss, Sebastian J.;
Steen, Henning;
Altland, Klaus;
Katus, Hugo A.;
Kristen, Arnt V.

Publication type:

Article

Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6401, doi. 10.2147/DDDT.S95946

By:

Pei-Jian Peng;
Bao-Jun Lv;
Con Tang;
Hai Liao;
Zhong Lin;
Yu-Meng Liu;
Zhi-Hui Wang;
Si-Yang Wang;
Zhi-Bin Cheng

Publication type:

Article

Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6433, doi. 10.2147/DDDT.S92273

By:

Melguizo, Consolación;
Cabeza, Laura;
Prados, Jose;
Ortiz, Raúl;
Caba, Octavio;
Rama, Ana R.;
Delgado, Ángel V.;
Arias, José L.

Publication type:

Article

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6407, doi. 10.2147/DDDT.S76648

By:

Bonella, Francesco;
Stowasser, Susanne;
Wollin, Lutz

Publication type:

Article

Identification of covalent active site inhibitors of dengue virus protease.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6389, doi. 10.2147/DDDT.S94207

By:

Koh-Stenta, Xiaoying;
Joy, Joma;
Si Fang Wang;
Kwek, Perlyn Zekui;
Wee, John Liang Kuan;
Kah Fei Wan;
Gayen, Shovanlal;
Chen, Angela Shuyi;
CongBao Kang;
Lee, May Ann;
Poulsen, Anders;
Vasudevan, Subhash G.;
Hill, Jeffrey;
Nacro, Kassoum

Publication type:

Article

Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6343, doi. 10.2147/DDDT.S79388

By:

Xianxie Zhang;
Yuguang Wang;
Zengchun Ma;
Qiande Liang;
Xianglin Tang;
Donghua Hu;
Hongling Tan;
Chengrong Xiao;
Yue Gao

Publication type:

Article

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6303, doi. 10.2147/DDDT.S93732

By:

Yuanyuan Wang;
Rong Wang;
Yujie Wang;
Ruqin Peng;
Yan Wu;
Yongfang Yuan

Publication type:

Article

Synthetic biology for pharmaceutical drug discovery.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6285, doi. 10.2147/DDDT.S58049

By:

Trosset, Jean-Yves;
Carbonell, Pablo

Publication type:

Article

Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 6275, doi. 10.2147/DDDT.S87973

By:

Rui Li;
Jing Xing;
Xaojing Mu;
Hui Wang;
Lei Zhang;
Yu Zhao;
Yu Zhang

Publication type:

Article

Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-β1/Smad7 signaling.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6269, doi. 10.2147/DDDT.S93964

By:

Chuanwei Xin;
Zhongni Xia;
Cheng Jiang;
Mengmeng Lin;
Gonghua Li

Publication type:

Article

Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6259, doi. 10.2147/DDDT.S88361

By:

Raczyńska, Dorota;
Lipowski, Paweł;
Zorena, Katarzyna;
Skorek, Andrzej;
Glasner, Paulina

Publication type:

Article

Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-κB signaling pathways in alloxan-induced mice.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6247, doi. 10.2147/DDDT.S96435

By:

Yong-Liang Yuan;
Chang-Run Guo;
Ling-Ling Cui;
Shi-Xia Ruan;
Chun-Feng Zhang;
De Ji;
Zhong-Lin Yang;
Fei Li

Publication type:

Article

The antiplasmodial and spleen protective role of crude Indigofera oblongifolia leaf extract traditionally used in the treatment of malaria in Saudi Arabia.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6235, doi. 10.2147/DDDT.S94673

By:

Dkhil, Mohamed A.;
Lubbad, Mahmoud Y.;
Al-Shaebi, Esam M.;
Delic, Denis;
Al-Quraishy, Saleh

Publication type:

Article

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6225, doi. 10.2147/DDDT.S91968

By:

Donejko, Magdalena;
Przylipiak, Andrzej;
Rysiak, Edyta;
Miltyk, Wojciech;
Galicka, Elzbieta;
Przylipiak, Jerzy;
Zareba, Ilona;
Surazynski, Arkadiusz

Publication type:

Article

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 5771, doi. 10.2147/DDDT.S92276

By:

Wenqin Liu;
Jian Shi;
Lijun Zhu;
Lingna Dong;
Feifei Luo;
Min Zhao;
Ying Wang;
Ming Hu;
Linlin Lu;
Zhongqiu Liu

Publication type:

Article

Different effects of statins on induction of diabetes mellitus: an experimental study.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6211, doi. 10.2147/DDDT.S87979

By:

Wang Zhao;
Shui-Ping Zhao

Publication type:

Article

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6191, doi. 10.2147/DDDT.S87064

By:

Fani, Somayeh;
Kamalidehghan, Behnam;
Kong Mun Lo;
Hashim, Najihah Mohd;
Chow, Kit May;
Ahmadipour, Fatemeh

Publication type:

Article

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxanepretreated patients.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6177, doi. 10.2147/DDDT.S89575

By:

Fabi, Alessandra;
Giannarelli, Diana;
Malaguti, Paola;
Ferretti, Gianluigi;
Vari, Sabrina;
Papaldo, Paola;
Nisticò, Cecilia;
Caterino, Mauro;
De Vita, Roy;
Mottolese, Marcella;
Iacorossi, Laura;
Cognetti, Francesco

Publication type:

Article

Spotlight on tavaborole for the treatment of onychomycosis.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6185, doi. 10.2147/DDDT.S81944

By:

Jinna, Sphoorthi;
Finch, Justin

Publication type:

Article

Pain relief and improved physical function in knee osteoarthritis patients receiving ongoing hylan G-F 20, a high-molecular-weight hyaluronan, versus other treatment options: data from a large real-world longitudinal cohort in Canada.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 5633, doi. 10.2147/DDDT.S88473

By:

Petrella, Robert J.;
Wakeford, Craig

Publication type:

Article

Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6203, doi. 10.2147/DDDT.S81488

By:

Fayette, Jérôme;
Molin, Yann;
Lavergne, Emilie;
Montbarbon, Xavier;
Racadot, Séverine;
Poupart, Marc;
Ramade, Antoine;
Zrounba, Philippe;
Ceruse, Philippe;
Pommier, Pascal

Publication type:

Article

Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6139, doi. 10.2147/DDDT.S92490

By:

Vollmar, Johanna;
Bellmann, Maren Christina;
Darstein, Felix;
Hoppe-Lotichius, Maria;
Mittler, Jens;
Heise, Michael;
Rüttger, Bernd;
Weyer, Veronika;
Zimmermann, Anca;
Lang, Hauke;
Galle, Peter R.;
Zimmermann, Tim

Publication type:

Article

Protective effects of alginate-chitosan microspheres loaded with alkaloids from Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. (Zuojin Pill) against ethanol-induced acute gastric mucosal injury in rats.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6151, doi. 10.2147/DDDT.S96056

By:

Qiang-Song Wang;
Xiao-Ning Zhu;
Heng-Li Jiang;
Gui-Fang Wang;
Yuan-Lu Cui

Publication type:

Article

Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6167, doi. 10.2147/DDDT.S91974

By:

Al-Kurdi, Zakieh I.;
Chowdhry, Babur Z.;
Leharne, Stephen A.;
Qinna, Nidal A.;
Al Omari, Mahmoud M. H.;
Badwan, Adnan A.

Publication type:

Article

Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6119, doi. 10.2147/DDDT.S92702

By:

Lin Wu;
Wei Yang;
Su-ning Zhang;
Ji-bin Lu

Publication type:

Article

Mechanisms underlying the perifocal neuroprotective effect of the Nrf2-ARE signaling pathway after intracranial hemorrhage.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 5973, doi. 10.2147/DDDT.S79399

By:

Xiao-ping Yin;
Zhi-ying Chen;
Jun Zhou;
Dan Wu;
Bing Bao

Publication type:

Article

Nanoethosomal transdermal delivery of vardenafil for treatment of erectile dysfunction: optimization, characterization, and in vivo evaluation.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6129, doi. 10.2147/DDDT.S94615

By:

Fahmy, Usama A.

Publication type:

Article

DNA zyme-based probe for circulating microRNA detection in peripheral blood.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6109, doi. 10.2147/DDDT.S89560

By:

Guoli Shao;
Shufeng Ji;
Aiguo Wu;
Cuiping Liu;
Mengchuan Wang;
Pusheng Zhang;
Qingli Jiao;
Yuzhan Kang

Publication type:

Article

Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6095, doi. 10.2147/DDDT.S92022

By:

Fan Yang;
Dongmei Wang;
Lingling Wu;
Ying Li

Publication type:

Article

Profile of paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6083, doi. 10.2147/DDDT.S80226

By:

Smith, Michael A.;
Lim, Alice

Publication type:

Article

A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6067, doi. 10.2147/DDDT.S94901

By:

Yoichiro Yoshida;
Keiji Hirata;
Hiroshi Matsuoka;
Shigeyoshi Iwamoto;
Masahito Kotaka;
Hideto Fujita;
Naoya Aisu;
Seiichiro Hoshino;
Takeo Kosaka;
Kotaro Maeda;
Fumiaki Kiyomi;
Yuichi Yamashita

Publication type:

Article

Apatinib for molecular targeted therapy in tumor.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6075, doi. 10.2147/DDDT.S97235

By:

Haijun Zhang

Publication type:

Article

Could the FDA-approved anti-HIV PR inhibitors be promising anticancer agents? An answer from enhanced docking approach and molecular dynamics analyses.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6055, doi. 10.2147/DDDT.S87653

By:

Arodola, Olayide A.;
Soliman, Mahmoud E. S.

Publication type:

Article

Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE 2 in rats.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6043, doi. 10.2147/DDDT.S95333

By:

Xue-Fen Pang;
Li-Hui Zhang;
Feng Bai;
Ning-Ping Wang;
Garner, Ron E.;
McKallip, Robert J.;
Zhi-Qing Zhao

Publication type:

Article

Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 5965, doi. 10.2147/DDDT.S93145

By:

Barbosa-Filho, Valter M.;
Waczuk, Emily P.;
Leite, Nadghia F.;
Menezes, Irwin R. A.;
da Costa, José G. M.;
Lacerda, Sírleis R.;
Adedara, Isaac A.;
Melo Coutinho, Henrique Douglas;
Posser, Thais;
Kamdem, Jean P.

Publication type:

Article

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 5851, doi. 10.2147/DDDT.S92943

By:

Lian Zhang;
Yingying Tong;
Xiuli Zhang;
Minggui Pan;
Siyu Chen

Publication type:

Article

Profile of suvorexant in the management of insomnia.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6035, doi. 10.2147/DDDT.S73224

By:

Sutton, Eliza L.

Publication type:

Article

The very-rapid and the ultra-rapid virologic response to two treatment options in patients with chronic hepatitis C: an interim report of a prospective randomized comparative effectiveness study.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6027, doi. 10.2147/DDDT.S95499

By:

Yakoot, Mostafa;
Abdo, Alaa M.;
Yousry, Ahmed;
Helmy, Sherine

Publication type:

Article

6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6019, doi. 10.2147/DDDT.S94346

By:

Ghareib, Salah A.;
El-Bassossy, Hany M.;
Elberry, Ahmed A.;
Azhar, Ahmad;
Watson, Malcolm L.;
Banjar, Zainy Mohammed

Publication type:

Article

Glucose abnormalities in Asian patients with chronic hepatitis C.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, n. 2015, p. 6009, doi. 10.2147/DDDT.S92060

By:

Qingyan Bo;
Orsenigo, Roberto;
Junyi Wang;
Griffel, Louis;
Brass, Clifford

Publication type:

Article