Works in Drug Design, Development & Therapy, 2014, Vol 8

Results: 260

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2321, doi. 10.2147/DDDT.S65495

By:

Konofal, Eric;
Wei Zhao;
Laouénan, Cédric;
Lecendreux, Michel;
Kaguelidou, Florentia;
Benadjaoud, Lila;
Mentré, France;
Jacqz-Aigrain, Evelyne

Publication type:

Article

Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2555, doi. 10.2147/DDDT.S73476

By:

Junhui Su;
Cui Chang;
Qi Xiang;
Zhi-Wei Zhou;
Rong Luo;
Lun Yang;
Zhi-Xu He;
Hongtu Yang;
Jianan Li;
Yu Bei;
Jinmei Xu;
Minjing Zhang;
Qihao Zhang;
Zhijian Su;
Yadong Huang;
Jiyan Pang;
Shu-Feng Zhou

Publication type:

Article

Curative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2549, doi. 10.2147/DDDT.S70451

By:

Guenne, Clémence;
Fayette, Jérôme;
Cosmidis, Alain;
Fuchsmann, Carine;
Tartas, Sophie;
Favrel, Véronique;
Céruse, Philippe

Publication type:

Article

Stevens-Johnson Syndrome and toxic epidermal necrolysis: a multi-aspect comparative 7-year study from the People's Republic of China.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2539, doi. 10.2147/DDDT.S71736

By:

Jie Sun;
Jin Liu;
Qing-Li Gong;
Gao-Zhong Ding;
Li-Wen Ma;
Li-Chao Zhang;
Yan Lu

Publication type:

Article

Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People's Republic of China.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2531, doi. 10.2147/DDDT.S71710

By:

Wenhao Shi;
Jinliang Wang;
Yan Lin;
Jianhui Geng;
Haixia Wang;
Yueqin Gong;
Huaxu Liu;
Furen Zhang

Publication type:

Article

Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/ apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2517, doi. 10.2147/DDDT.S71432

By:

Tao Ren;
Jinlu Shan;
Yi Qing;
Chengyuan Qian;
Qing Li;
Guoshou Lu;
Mengxia Li;
Chongyi Li;
Yu Peng;
Hao Luo;
Shiheng Zhang;
Weiwei Zhang;
Dong Wang;
Shu-Feng Zhou

Publication type:

Article

Dapagliflozin for the treatment of type 2 diabetes: a review of the literature.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2493, doi. 10.2147/DDDT.S50963

By:

Saeed, Mujahid A.;
Narendran, Parth

Publication type:

Article

Functional characterization of a competitive peptide antagonist of p65 in human macrophagelike cells suggests therapeutic potential for chronic inflammation.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2409, doi. 10.2147/DDDT.S59722

By:

Srinivasan, Mythily;
Blackburn, Corinne;
Lahiri, Debomoy K.

Publication type:

Article

Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 127, doi. 10.2147/DDDT.S68501

By:

Jin-Lian He;
Zhi-Wei Zhou;
Juan-Juan Yin;
Chang-Qiang He;
Shu-Feng Zhou;
Yang Yu

Publication type:

Article

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 103, doi. 10.2147/DDDT.S51476

By:

Gardiner, Katheleen J.

Publication type:

Article

Arsenic sulfide, the main component of realgar, a traditional Chinese medicine, induces apoptosis of gastric cancer cells in vitro and in vivo.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 79, doi. 10.2147/DDDT.S74379

By:

Lian Zhang;
Wei Tian;
Sungkyoung Kim;
Wenping Ding;
Yingying Tong;
Siyu Chen

Publication type:

Article

A new recombinant factor VIII: from genetics to clinical use.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2507, doi. 10.2147/DDDT.S73241

By:

Santagostino, Elena

Publication type:

Article

Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2401, doi. 10.2147/DDDT.S71419

By:

Nobuaki Ochi;
Hiromichi Yamane;
Katsuyuki Hotta;
Hiromi Fujii;
Hideko Isozaki;
Yoshihiro Honda;
Tomoko Yamagishi;
Toshio Kubo;
Mitsune Tanimoto;
Katsuyuki Kiura;
Nagio Takigawa

Publication type:

Article

Optimizing iron delivery in the management of anemia: patient considerations and the role of ferric carboxymaltose.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2475, doi. 10.2147/DDDT.S55499

By:

Toblli, Jorge Eduardo;
Angerosa, Margarita

Publication type:

Article

Scientometrics of anesthetic drugs and their techniques of administration, 1984-2013.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2463, doi. 10.2147/DDDT.S73862

By:

Vlassakov, Kamen V.;
Kissin, Igor

Publication type:

Article

Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2449, doi. 10.2147/DDDT.S71466

By:

Yin Zhu;
Ming Cheng;
Zhen Yang;
Chun-Yan Zeng;
Jiang Chen;
Yong Xie;
Shi-Wen Luo;
Kun-He Zhang;
Shu-Feng Zhou;
Nong-Hua Lu

Publication type:

Article

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2439, doi. 10.2147/DDDT.S71356

By:

Zhongwen Zhang;
Xin Zhong;
Huiru Ji;
Zibin Tang;
Jianpeng Bai;
Minmin Yao;
Jianlei Hou;
Minghao Zheng;
Wood, David J.;
Jiazhi Sun;
Shu-Feng Zhou;
Aibing Liu

Publication type:

Article

Design real-time reversal of tumor multidrug resistance cleverly with shortened carbon nanotubes.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2431, doi. 10.2147/DDDT.S74962

By:

Pingping Wu;
Shang Li;
Haijun Zhang

Publication type:

Article

Clinicopathological significance and potential drug target of RUNX3 in breast cancer.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2423, doi. 10.2147/DDDT.S71815

By:

Ying-Ying Yu;
Chao Chen;
Fan-fei Kong;
Wei Zhang

Publication type:

Article

Designing biologic selectivity for inflammatory bowel disease - role of vedolizumab.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 147, doi. 10.2147/DDDT.S50348

By:

Krupka, Niklas;
Baumgart, Daniel C.

Publication type:

Article

Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2391, doi. 10.2147/DDDT.S53129

By:

Barja-Fernandez, S.;
Leis, R.;
Casanueva, F. F.;
Seoane, L. M.

Publication type:

Article

Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2377, doi. 10.2147/DDDT.S74061

By:

Jiao-Yu He;
Cheng Li;
Guo Wu

Publication type:

Article

Comparison of peginterferon alfa-2a and alfa-2b for treatment of patients with chronic hepatitis C: a retrospective study using the Japanese Interferon Database.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 283, doi. 10.2147/DDDT.S72245

By:

Izumi Sato;
Takuro Shimbo;
Yohei Kawasaki;
Naohiko Masaki

Publication type:

Article

Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 241, doi. 10.2147/DDDT.S71106

By:

Li-Fang Zhang;
Zhi-Wei Zhou;
Zhen-Hai Wang;
Yan-Hui Du;
Zhi-Xu He;
Chuanhai Cao;
Shu-Feng Zhou

Publication type:

Article

Synthesis and characterization of a novel chemically designed (Globo)<sub>3</sub>-DTPA-KLH antigen.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 217, doi. 10.2147/DDDT.S72530

By:

Hajmohammadi, Mehdi;
Siadat, Seyed Davar;
Ghorbani, Masoud;
Ardestani, Mehdi Shafiee;
Teimourian, Shahram;
Asgari, Vahid;
Cohan, Reza Ahangari;
Hajmohammadi, Mostafa;
Hajmohammadi, Akram;
Behzadi, Ramezan;
Nezhad, Saied Rajab;
Asl, Nabiollah Namvar

Publication type:

Article

Clinicopathological significance and potential drug target of T-cadherin in NSCLC.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 207, doi. 10.2147/DDDT.S74259

By:

Zhidong Wang;
Bin Wang;
Huanchen Guo;
Guoyu Shi;
Xiuqin Hong

Publication type:

Article

Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2137, doi. 10.2147/DDDT.S72305

By:

Yong-Yeon cho;
Hyeon-Uk Jeong;
Jeong-Han Kim;
Hye Suk Lee

Publication type:

Article

Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 199, doi. 10.2147/DDDT.S75495

By:

Maowen Ba;
Min Kong;
Guozhao Ma

Publication type:

Article

Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease: a pharmacoinformatics study.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 187, doi. 10.2147/DDDT.S72794

By:

Mirza, Muhammad Usman;
Mirza, A. Hammad;
Ghori, Noor-Ul-Huda;
Ferdous, Saba

Publication type:

Article

A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 175, doi. 10.2147/DDDT.S75565

By:

Hoch, Matthias;
Darpo, Borje;
Remenova, Tatiana;
Stoltz, Randall;
Meijian Zhou;
Kaufmann, Priska;
Bruderer, Shirin;
Dingemanse, Jasper

Publication type:

Article

Clinical effect of a positive surgical margin after hepatectomy on survival of patients with intrahepatic cholangiocarcinoma.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 163, doi. 10.2147/DDDT.S74940

By:

Chun-Nan Yeh;
Feng-Jen Hsieh;
Kun-Chun Chiang;
Jen-Shi Chen;
Ta-Sen Yeh;
Yi-Yin Jan;
Miin-Fu Chen

Publication type:

Article

Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV).

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 155, doi. 10.2147/DDDT.S76158

By:

Navari, Rudolph M.

Publication type:

Article

Women taking the "blue pill" (sildenafil citrate): such a big deal?

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2251, doi. 10.2147/DDDT.S71227

By:

Monte, Giuseppe Lo;
Graziano, Angela;
Piva, Isabella;
Marci, Roberto

Publication type:

Article

Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2255, doi. 10.2147/DDDT.S70383

By:

Xue-Jiao Wang;
Jun Zhang;
Shu-Qing Wang;
Wei-Ren Xu;
Xian-Chao Cheng;
Run-Ling Wang

Publication type:

Article

Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2283, doi. 10.2147/DDDT.S70945

By:

Qingwei Zhao;
Dongsheng Hong;
Dongsheng Zheng;
Yao Xiao;
Baohua Wu

Publication type:

Article

Analysis of malignancies in patients after heart transplantation with subsequent immunosuppressive therapy.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 93, doi. 10.2147/DDDT.S75464

By:

Rivinius, Rasmus;
Helmschrott, Matthias;
Ruhparwar, Arjang;
Schmack, Bastian;
Klein, Berthold;
Erbel, Christian;
Gleissner, Christian A.;
Akhavanpoor, Mohammadreza;
Frankenstein, Lutz;
Darche, Fabrice F.;
Thomas, Dierk;
Ehlermann, Philipp;
Bruckner, Tom;
Katus, Hugo A.;
Doesch, Andreas O.

Publication type:

Article

Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2333, doi. 10.2147/DDDT.S70650

By:

Tan, Julia M.;
Karthivashan, Govindarajan;
Arulselvan, Palanisamy;
Fakurazi, Sharida;
Hussein, Mohd Zobir

Publication type:

Article

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 33, doi. 10.2147/DDDT.S72892

By:

Jiang Cheng;
Zhi-Wei Zhou;
Hui-Ping Sheng;
Lan-Jie He;
Xue-Wen Fan;
Zhi-Xu He;
Tao Sun;
Xueji Zhang;
Ruan Jin Zhao;
Ling Gu;
Chuanhai Cao;
Shu-Feng Zhou

Publication type:

Article

Microemulsion of babassu oil as a natural product to improve human immune system function.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 21, doi. 10.2147/DDDT.S73756

By:

Pessoa, Rafael Souza;
França, Eduardo Luzia;
Ribeiro, Elton Brito;
Dias Lanes, Patrícia Kelly;
Abud Chaud, Natalina Galdeano;
Albuquerque Moraes, Lucélia Campelo;
Honorio-França, Adenilda Cristina

Publication type:

Article

Temsirolimus for patients with metastatic renal cell carcinoma: outcomes in patients receiving temsirolimus within a compassionate use program in a tertiary referral center.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 13, doi. 10.2147/DDDT.S73686

By:

Afshar, Mehran;
Pascoe, Jennifer;
Whitmarsh, Sue;
James, Nicholas;
Porfiri, Emilio

Publication type:

Article

Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 1, doi. 10.2147/DDDT.S72572

By:

Blandizzi, Corrado;
Viscomi, Giuseppe Claudio;
Scarpignato, Carmeto

Publication type:

Article

Interleukin I inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2345, doi. 10.2147/DDDT.S73428

By:

Dongsheng Hong;
Zhihai Yang;
Shuyin Han;
Xingguang Liang;
Kuifen Ma;
Xingguo Zhang

Publication type:

Article

Choosing preclinical study models of diabetic retinopathy: key problems for consideration.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2311, doi. 10.2147/DDDT.S72797

By:

Xue-Song Mi;
Ti-Fei Yuan;
Yong Ding;
Jing-Xiang Zhong;
Kwok-Fai So

Publication type:

Article

CCLI9 and CCL2I modulate the inflammatory milieu in atherosclerotic lesions.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2359, doi. 10.2147/DDDT.S72394

By:

Mohammadreza;
Akhavanpoor;
Gleissner, Christian A.;
Gorbatsch, Stephanie;
Doesch, Andreas O.;
Akhavanpoor, Hamidreza;
Wangler, Susanne;
Jahn, Frederik;
Lasitschka, Felix;
Katus, Hugo A.;
Erbel, Christian

Publication type:

Article

Caval filters in intensive care: a retrospective study.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2213, doi. 10.2147/DDDT.S68026

By:

Ferraro, F.;
Di Gennaro, T. L.;
Torino, A.;
Petruzzi, J.;
d'Elia, A.;
Fusco, P.;
Marfella, R.;
Lettieri, B.

Publication type:

Article

Inhibition of cardiac Kvl.5 potassium current by the anesthetic midazolam: mode of action.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2263, doi. 10.2147/DDDT.S70461

By:

Vonderlin, Nadine;
Fischer, Fathima;
Zitron, Edgar;
Seyler, Claudia;
Scherer, Daniel;
Thomas, Dierk;
Katus, Hugo A.;
Scholz, Eberhard P.

Publication type:

Article

Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease I/redox factor-I.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2147, doi. 10.2147/DDDT.S71124

By:

Jiangdong Sui;
Mengxia Li;
Chengyuan Qian;
Shufeng Wang;
Yi Cheng;
Benjamin PC Chen;
Dong Wang

Publication type:

Article

Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2161, doi. 10.2147/DDDT.S69914

By:

Yali Zhang;
Xin Jiang;
Kesong Peng;
Chengwei Chen;
Lili Fu;
Zhe Wang;
Jianpeng Feng;
Zhiguo Liu;
Huajie Zhang;
Guang Liang;
Zheer Pan

Publication type:

Article

Leptin signaling molecular actions and drug target in hepatocellular carcinoma.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2295, doi. 10.2147/DDDT.S69004

By:

Nan Jiang;
Rongtong Sun;
Qing Sun

Publication type:

Article

Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients.

Published in:

Drug Design, Development & Therapy, 2014, v. 8, p. 2241, doi. 10.2147/DDDT.S70595

By:

Hyunjeong Baek;
Seunghoon Han;
Dong-Seok Yim;
Sung Joo Kim;
Soo-Youn Lee;
Hye Ryoun Jang;
Jung Eun Lee;
Dae Joong Kim;
Yoon-Goo Kim;
Ha Young Oh;
Wooseong Huh

Publication type:

Article