Works in Drug Design, Development & Therapy, 2022, Vol 16

Results: 316

Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of Diabetic Pediatrics via Trans Mucosal Delivery of Gliclazide.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4235, doi. 10.2147/DDDT.S394523

By:

Gaber, Dalia A;
Alburaykan, Abeer I;
Alruthea, Lama M;
Aldohan, Njoud S;
Alharbi, Raneem F;
Aljohani, Alhanoof R;
Albilaihi, Helah M;
Adogim, Somaiah S

Publication type:

Article

Network Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4325, doi. 10.2147/DDDT.S384927

By:

Xia, Ting;
Liang, Xiao;
Liu, Chang-Shun;
Hu, Yan-Nan;
Luo, Zhen-Ye;
Tan, Xiao-Mei

Publication type:

Article

Notoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4399, doi. 10.2147/DDDT.S387004

By:

Han, Ruiqi;
Zhang, Wenjuan;
Zhang, Lina;
Zou, Jinghua;
Yang, Yanran;
Li, Hongkun;
Zhang, Jun

Publication type:

Article

Pharmacokinetics of a Fixed-Dose Combination of Teneligliptin Hydrochloride Hydrate and Modified-Release Metformin Under Fasting and Fed Conditions in Healthy Subjects.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4439, doi. 10.2147/DDDT.S393675

By:

Goak, In Sun;
Lee, Jin A;
Jeong, Min Ho;
Moon, Seol Ju;
Kim, Min Gul

Publication type:

Article

Design and Optimization of Rivaroxaban-Cyclodextrin-Polymer Triple Complex Formulation with Improved Solubility.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4279, doi. 10.2147/DDDT.S389884

By:

Kang, Ji-Hyun;
Lee, Ji-Eun;
Jeong, So-Jeong;
Park, Chun-Woong;
Kim, Dong-Wook;
Weon, Kwon-Yeon

Publication type:

Article

Risk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4429, doi. 10.2147/DDDT.S386829

By:

Chen, Bowen;
Zhang, Linzhi;
Cheng, Jiamin;
Wu, Tong;
Lei, Jin;
Yang, Xu;
Zhang, Rongling;
Safadi, Rifaat;
Li, Yinyin;
Si, Tongguo;
Lu, Yinying

Publication type:

Article

A Novel Ocular Delivery of Brinzolamide Based on Gellan Gum: In vitro and in vivo Evaluation [Retraction].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4109, doi. 10.2147/DDDT.S399707

By:

Sun, Jingfen;
Zhou, Zhengshen

Publication type:

Article

Thalidomide Attenuates Skin Lesions and Inflammation in Rosacea-Like Mice Induced by Long-Term Exposure of LL-37.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4127, doi. 10.2147/DDDT.S393122

By:

Kang, Yumeng;
Zhang, Chuanxi;
He, Yang;
Zhang, Ziyan;
Liu, Heliang;
Wei, Zhongqiu;
Yang, Jie

Publication type:

Article

Molecular Mechanisms of Luteolin Against Atopic Dermatitis Based on Network Pharmacology and in vivo Experimental Validation.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4205, doi. 10.2147/DDDT.S387893

By:

Tang, Liu;
Gao, Jiefang;
Li, Xiaolei;
Cao, Xiaoqin;
Zhou, Benhong

Publication type:

Article

Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4179, doi. 10.2147/DDDT.S383054

By:

Arshad, Hafiza Maida;
Ahmad, Fiaz-ud-Din;
Lodhi, Arslan Hussain

Publication type:

Article

Metabolomics Study of Shaoyao Plants Decoction on the Proximal and Distal Colon in Mice with Dextran Sulfate Sodium-Induced Colitis by UPLC-Q-TOF-MS.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4343, doi. 10.2147/DDDT.S384607

By:

Luo, Yiting;
Wu, Jin;
Liu, Yingchao;
Shen, Yan;
Zhu, Fangyuan;
Wu, Jiaqian;
Hu, Yuyao

Publication type:

Article

Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4111, doi. 10.2147/DDDT.S386805

By:

Han, Xue;
Yang, Yakun;
Zhang, Muqing;
Li, Li;
Xue, Yucong;
Jia, Qingzhong;
Wang, Xiangting;
Guan, Shengjiang

Publication type:

Article

Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4411, doi. 10.2147/DDDT.S391010

By:

Xiao, Shilin;
Zhou, Ying;
Wang, Qianyu;
Yang, Dong

Publication type:

Article

Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4223, doi. 10.2147/DDDT.S386786

By:

Hu, Huan;
Mao, Guangyu;
Zheng, Jianghong;
Guo, Feng

Publication type:

Article

Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4449, doi. 10.2147/DDDT.S365416

By:

Chao, Ariana M;
Tronieri, Jena Shaw;
Amaro, Anastassia;
Wadden, Thomas A

Publication type:

Article

Dual-Drug Nanosystem: Etoposide Prodrug and Cisplatin Coloaded Nanostructured Lipid Carriers for Lung Cancer Therapy.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4139, doi. 10.2147/DDDT.S386100

By:

Du, Min;
Yin, Jianbo

Publication type:

Article

Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4291, doi. 10.2147/DDDT.S392784

By:

Zhu, Min;
Xu, Siqi;
Ju, Xia;
Wang, Shengbin;
Yu, Xitong

Publication type:

Article

Efficiency and Safety of Baofei Granules in Chronic Obstructive Pulmonary Disease (Lung and Spleen Qi Deficiency Syndrome): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4251, doi. 10.2147/DDDT.S382285

By:

Sun, Yuan;
Chen, Xuan;
Zhang, Lei;
Yuan, Wei-an;
Chen, Qi;
Zhang, Yi-bao;
Liu, Lu-jiong;
Zhang, Wei;
Sun, Meng

Publication type:

Article

Efficacy and Safety of the PD-1 Inhibitor Combined with Albumin-Bound Paclitaxel and Nedaplatin in Preoperative Neoadjuvant Therapy of Unresectable Stage III Lung Squamous Cell Carcinoma.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4269, doi. 10.2147/DDDT.S388777

By:

Xu, Hongyan;
Wang, Wenjing;
Yin, Junlei;
Song, Chengcun;
Li, Lin;
Sun, Zhi

Publication type:

Article

Effect of Rifampicin on the Pharmacokinetics of Evogliptin in Healthy Volunteers.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4301, doi. 10.2147/DDDT.S383157

By:

Shin, Yesong;
Choi, Chungam;
Oh, Eun Sil;
Kim, Choon Ok;
Park, Kyungsoo;
Park, Min Soo

Publication type:

Article

Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4151, doi. 10.2147/DDDT.S391147

By:

Hu, Bailong;
Jiang, Ke;
Shi, Wenyan;
Xiao, Shixiang;
Zhang, Shili;
Zhang, Yongguo;
Zhou, Yuancheng;
Tan, Chengwei;
Tan, Songjiang;
Zou, Xiaohua

Publication type:

Article

Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4385, doi. 10.2147/DDDT.S393816

By:

Jeon, Jae-Ho;
Im, Somyoung;
Kim, Hyo Shin;
Lee, Dongyun;
Jeong, Kwiwan;
Ku, Jin-Mo;
Nam, Tae-Gyu

Publication type:

Article

Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4161, doi. 10.2147/DDDT.S388823

By:

Zuo, Qingjuan;
Zhang, Guorui;
He, Lili;
Ma, Sai;
Ma, Huijuan;
Zhai, Jianlong;
Wang, Zhongli;
Zhang, Tingting;
Wang, Yan;
Guo, Yifang

Publication type:

Article

Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4311, doi. 10.2147/DDDT.S387885

By:

Jiang, Kai;
Feng, Jing;
Qi, Xia;
Ran, Lili;
Xie, Lixin

Publication type:

Article

Anti-Inflammatory Activation of Phellodendri Chinensis Cortex is Mediated by Berberine Erythrocytes Self-Assembly Targeted Delivery System.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4365, doi. 10.2147/DDDT.S385301

By:

Li, Minhua;
Qin, Zehui;
Yu, Qiuxia;
Huang, Ziwei;
Cheng, Juanjuan;
Zhong, Linjiang;
Liu, Yuhong;
Xie, Jianhui;
Li, Yucui;
Chen, Jiannan;
Zhan, Ruoting;
Su, Ziren

Publication type:

Article

Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4061, doi. 10.2147/DDDT.S386031

By:

Zhang, Ping Na;
Tang, Jing Yi;
Yang, Ke Zhen;
Zheng, Qi Yan;
Dong, Zhao Cheng;
Geng, Yun Ling;
Liu, Yu Ning;
Liu, Wei Jing

Publication type:

Article

Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3893, doi. 10.2147/DDDT.S383537

By:

Chen, Xing;
Chen, Shuchun;
Ren, Qingjuan;
Niu, Shu;
Pan, Xiaoyu;
Yue, Lin;
Li, Zelin;
Zhu, Ruiyi;
Jia, Zhuoya;
Chen, Xiaoyi;
Zhen, Ruoxi;
Ban, Jiangli

Publication type:

Article

Targeting mTOR Complex 2 in Castration-Resistant Prostate Cancer with Acquired Docetaxel Resistance.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3817, doi. 10.2147/DDDT.S376474

By:

Huang, Yujie;
Zhai, You;
Wu, Meijia;
Chang, Chengdong;
Luo, Jindan;
Hong, Dongsheng;
Zhao, Qingwei;
Dai, Yao;
Liu, Jian

Publication type:

Article

Effects of Salidroside Combined with Paclitaxel on Proliferation, Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4079, doi. 10.2147/DDDT.S384151

By:

Hao, Yanjiao;
Li, Zhiyu;
Chang, Mingzhi;
Zhang, Xiaoli

Publication type:

Article

Preparation of Novel Pirfenidone Microspheres for Lung-Targeted Delivery: In vitro and in vivo Study [Retraction].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4017, doi. 10.2147/DDDT.S398022

By:

Li, Dianbo;
Gong, Liping

Publication type:

Article

Development of a Nanoliposomal Formulation of Erlotinib for Lung Cancer and in vitro/In vivo Antitumoral Evaluation [Retraction].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4019, doi. 10.2147/DDDT.S398024

By:

Zhou, Xiao;
Tao, Hui;
Shi, Kai-Hu

Publication type:

Article

Coffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4041, doi. 10.2147/DDDT.S397859

By:

Zhang, Li-Fang;
Zhou, Zhi-Wei;
Wang, Zhen-Hai;
Du, Yan-Hui;
He, Zhi-Xu;
Cao, Chuanhai;
Zhou, Shu-Feng

Publication type:

Article

A Novel Tetrandrine-Loaded Chitosan Microsphere: Characterization and in vivo Evaluation [Retraction].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4015, doi. 10.2147/DDDT.S398021

By:

Guo, Kefang;
Cang, Jing

Publication type:

Article

A Novel Glycyrrhetinic Acid-Modified Oxaliplatin Liposome for Liver-Targeting and in vitro/vivo Evaluation [Retraction].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4013, doi. 10.2147/DDDT.S398020

By:

Chen, Jingde;
Jiang, Hong;
Wu, Yin;
Li, Yandong;
Gao, Yong

Publication type:

Article

Remimazolam: An Updated Review of a New Sedative and Anaesthetic.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3957, doi. 10.2147/DDDT.S384155

By:

Hu, Qinxue;
Liu, Xing;
Wen, Chengli;
Li, Duo;
Lei, Xianying

Publication type:

Article

Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4101, doi. 10.2147/DDDT.S390403

By:

Zhang, Fan;
Chang, Huan;
Qing, Wenxiang;
Yu, Rili;
Liao, Qin;
Tong, Jianbin

Publication type:

Article

Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3975, doi. 10.2147/DDDT.S387677

By:

Xia, Mengdi;
Ai, Na;
Pang, Junjie

Publication type:

Article

Decoding the Key Functional Combined Components Group and Uncovering the Molecular Mechanism of Longdan Xiegan Decoction in Treating Uveitis.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3991, doi. 10.2147/DDDT.S385136

By:

Zheng, Yi-Xu;
Wang, Ke-Xin;
Chen, Si-Jin;
Liao, Mu-Xi;
Chen, Yu-Peng;
Guan, Dao-Gang;
Wu, Jing;
Xiong, Ke

Publication type:

Article

Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3793, doi. 10.2147/DDDT.S383632

By:

Fu, Xuejie;
He, Shuangjian;
Wang, Liang;
Xue, Yangyang;
Qiao, Shigang;
An, Jianzhong;
Xia, Tingting

Publication type:

Article

Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice with Methotrexate-Induced Hepatoxicity.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3877, doi. 10.2147/DDDT.S381667

By:

Wang, Changshui;
Zhao, Shuzhen;
Xu, Yuan;
Sun, Wenxue;
Feng, Yuanyuan;
Liang, Deshuai;
Guan, Yun

Publication type:

Article

Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3947, doi. 10.2147/DDDT.S387920

By:

Zhao, Dehua;
Long, Xiaoqing;
Wang, Jisheng

Publication type:

Article

Evaluation of the Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Perampanel in Rats by Isotope-Dilution-UHPLC-MS/MS.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4091, doi. 10.2147/DDDT.S392934

By:

Liu, Ping;
An, Jing;
Wu, Huizhen

Publication type:

Article

ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3929, doi. 10.2147/DDDT.S377001

By:

Rong, Xing;
Kou, Yuying;
Zhang, Yuan;
Yang, Panpan;
Tang, Rong;
Liu, Hongrui;
Li, Minqi

Publication type:

Article

Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4043, doi. 10.2147/DDDT.S379205

By:

Rashid, Fatima;
Ahmad, Matloob;
Ashfaq, Usman Ali;
Al-Mutairi, Aamal A;
Al-Hussain, Sami A

Publication type:

Article

Ropivacaine with Dexmedetomidine or Dexamethasone in a Thoracic Paravertebral Nerve Block Combined with an Erector Spinae Plane Block for Thoracoscopic Lobectomy Analgesia: A Randomized Controlled Trial [Corrigendum].

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4077, doi. 10.2147/DDDT.S398198

By:

Yang, Jing;
Zhao, Min;
Zhang, Xiao-Rui;
Wang, Xiao-Rui;
Wang, Zhi-Hao;
Feng, Xiao-Yue;
Lei, Ya-Juan;
Zhang, Jian-Wen

Publication type:

Article

Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3805, doi. 10.2147/DDDT.S379335

By:

Li, Huimin;
Wang, Shue;
Wang, Shuai;
Yu, Hai;
Yu, Wenhao;
Ma, Xiaomin;
He, Xiaodong

Publication type:

Article

Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 4021, doi. 10.2147/DDDT.S357604

By:

Akbar, Idhayadhulla;
Radhakrishnan, Surendrakumar;
Meenakshisundaram, Karpakavalli;
Manilal, Aseer;
Hatamleh, Ashraf Atef;
Alnafisi, Bassam Khalid;
Ahamed, Anis;
Balasubramani, Ravindran

Publication type:

Article

Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3865, doi. 10.2147/DDDT.S387508

By:

Yang, Ling;
Shen, Qi;
Hu, Chao;
Wang, Ying;
Zhu, Xiaohong;
Shu, Shiqing;
Luo, Zhu

Publication type:

Article

Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3829, doi. 10.2147/DDDT.S386982

By:

Feng, Yanan;
Sun, Wenxiu;
Sun, Fengcui;
Yin, Guoliang;
Liang, Pengpeng;
Chen, Suwen;
Liu, Xiangyi;
Jiang, Tongfei;
Zhang, Fengxia

Publication type:

Article

Diroximel Fumarate as a Novel Oral Immunomodulating Therapy for Relapsing Forms of Multiple Sclerosis: A Review on the Emerging Data.

Published in:

Drug Design, Development & Therapy, 2022, v. 16, p. 3915, doi. 10.2147/DDDT.S236926

By:

Hauer, Larissa;
Sellner, Johann

Publication type:

Article