Works in Drug Design, Development & Therapy, 2018, Vol 12

Results: 380

Recent development in the strategies projected for chikungunya vaccine in humans.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4195, doi. 10.2147/DDDT.S181574

By:

Goyal, Manu;
Chauhan, Anil;
Goyal, Vishavdeep;
Jaiswal, Nishant;
Singh, Shreya;
Singh, Meenu

Publication type:

Article

HX575: established biosimilarity in the treatment of renal anemia and 10 years of clinical experience.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 9, doi. 10.2147/DDDT.S146147

By:

Dellanna, Frank;
Goldsmith, David;
Krendyukov, Andriy;
Seidl, Andreas;
Höbel, Nadja;
Combe, Christian

Publication type:

Article

Comment on the intravenous tranexamic acid use in revision total joint arthroplasty.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4191, doi. 10.2147/DDDT.S188844

By:

Jieyu He;
Youshuo Liu

Publication type:

Article

Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4149, doi. 10.2147/DDDT.S185618

By:

Cai, Wenting;
Yu, Donghui;
Fan, Jiaqi;
Liang, Xiuwei;
Jin, Huizi;
Liu, Chang;
Zhu, Meijiang;
Shen, Tianyi;
Zhang, Ruiling;
Hu, Weinan;
Wei, Qingquan;
Yu, Jing

Publication type:

Article

SREBP-2, a new target of metformin?

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4163, doi. 10.2147/DDDT.S190094

By:

Zhang, Fengxia;
Sun, Wenxiu;
Chen, Jianbo;
Jiang, Lusheng;
Yang, Ping;
Huang, Yufang;
Gong, Aihua;
Liu, Shudong;
Ma, Shizhan

Publication type:

Article

N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4117, doi. 10.2147/DDDT.S179227

By:

Zhou, Yuan;
Wang, Han-dong;
Zhou, Xiao-ming;
Fang, Jiang;
Zhu, Lin;
Ding, Ke

Publication type:

Article

MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4253, doi. 10.2147/DDDT.S188095

By:

He, Binchan;
Geng, Shen;
Zhou, Wei;
Rui, Yuwen;
Mu, Xianmin;
Zhang, Chen;
You, Qiang;
Su, Xin

Publication type:

Article

Development of a nanoliposomal formulation of erlotinib for lung cancer and in vitro/in vivo antitumoral evaluation.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 1, doi. 10.2147/DDDT.S146925

By:

Xiao Zhou;
H ui Tao;
Kai-Hu Shi

Publication type:

Article

Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4231, doi. 10.2147/DDDT.S187177

By:

Zhao, Xiangju;
Sun, Ying;
Li, Zhaoguo

Publication type:

Article

The role of various transporters in the placental uptake of ofloxacin in an in vitro model of human villous trophoblasts.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4129, doi. 10.2147/DDDT.S181493

By:

Polachek, Hana;
Debotton, Nir;
Feinshtein, Valeria;
Rubin, Mazal;
Ben-Zvi, Zvi;
Holcberg, Gershon;
Agbaria, Riad;
Dahan, Arik

Publication type:

Article

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4139, doi. 10.2147/DDDT.S186614

By:

Kostrzewa, Tomasz;
Sahu, Kamlesh K;
Gorska-Ponikowska, Magdalena;
Tuszynski, Jack A;
Kuban-Jankowska, Alicja

Publication type:

Article

Best tigecycline dosing for treatment of infections caused by multidrug-resistant pathogens in critically ill patients with different body weights.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4171, doi. 10.2147/DDDT.S181834

By:

Ibrahim, Mohamed M;
Abuelmatty, Abdulla M;
Mohamed, Gehan H;
Nasr, Mohsen A;
Hussein, Amal K;
Ebaed, Mohy El Deen;
Sarhan, Hatem A

Publication type:

Article

The therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3867, doi. 10.2147/DDDT.S181798

By:

Gao, Peiyang;
Zhao, Ziyi;
Zhang, Chuantao;
Wang, Chunxia;
Long, Kunlan;
Guo, Liuxue;
Li, Baixue

Publication type:

Article

3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4261, doi. 10.2147/DDDT.S189472

By:

Chen, Ningyuan;
Zhou, Zhibing;
Li, Ji;
Li, Bocheng;
Feng, Jihua;
He, Dan;
Luo, Yifeng;
Zheng, Xiaowen;
Luo, Jiefeng;
Zhang, Jianfeng

Publication type:

Article

Gamma linolic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced Hepatocellular carcinoma.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4241, doi. 10.2147/DDDT.S178519

By:

Cui, Hong;
Han, Feng;
Zhang, Ling;
Wang, Li;
Kumar, Mukesh

Publication type:

Article

Comparison of efficacy and safety between two different irbesartan, generic vs branded, in the treatment of Korean patients with mild-to-moderate hypertension: an 8-week, multicenter, randomized, open-label, Phase IV clinical study.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4217, doi. 10.2147/DDDT.S172046

By:

Han, Seung Hwan;
Oh, Gyu Chul;
Kwon, Hyuck Moon;
Park, Chang Gyu;
Kim, In Jai;
Hwang, Gyo-Seung;
Yoo, Byung Su;
Park, Seong Hoon;
Lee, Kwang Je;
Kim, Hyo-soo

Publication type:

Article

Iron oxide nanoparticles as nanocarriers to improve chlorin e6-based sonosensitivity in sonodynamic therapy.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4207, doi. 10.2147/DDDT.S184679

By:

Zhang, Peng;
Ren, Zhongyu;
Chen, Zhiqiang;
Zhu, Jinyong;
Liang, Jing;
Liao, Rujia;
Wen, Jian

Publication type:

Article

The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules [Corrigendum].

Published in:: Drug Design, Development & Therapy, 2018, v. 12, p. 3797, doi. 10.2147/DDDT.S191094
Publication type:: Article

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4107, doi. 10.2147/DDDT.S186726

By:

Mu, Mao;
Zuo, Shi;
Wu, Rong-Min;
Deng, Kai-Sheng;
Lu, Shuang;
Zhu, Juan-Juan;
Zou, Gao-Liang;
Yang, Jing;
Cheng, Ming-Liang;
Zhao, Xue-Ke

Publication type:

Article

Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4095, doi. 10.2147/DDDT.S175763

By:

Dai, Qiaoding;
Zhou, Di;
Xu, Liping;
Song, Xinwei

Publication type:

Article

Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3951, doi. 10.2147/DDDT.S186222

By:

Wu, Hongqiang;
Ding, Jian;
Wang, Lei;
Lin, Jinti;
Li, Shihen;
Xiang, Guangheng;
Jiang, Liangfu;
Xu, Huazi;
Gao, Weiyang;
Zhou, Kailiang

Publication type:

Article

Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3731, doi. 10.2147/DDDT.S140767

By:

Corado, Katya C;
Caplan, Margaret R;
Daar, Eric S

Publication type:

Article

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4181, doi. 10.2147/DDDT.S181312

By:

Jiang, Yun;
Wang, Zhancheng;
Chen, Xu;
Wang, Wei;
Wang, Xiaowei

Publication type:

Article

The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside combined with Adriamycin on MCF-7 breast cancer cells.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4083, doi. 10.2147/DDDT.S186028

By:

Shen, Jianfen;
Zhang, Youzhi;
Shen, Hui;
Pan, Hua;
Xu, Longsheng;
Yuan, Linna;
Ding, Zhiying

Publication type:

Article

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3741, doi. 10.2147/DDDT.S182444

By:

Atatreh, Noor;
Ghattas, Mohammad A;
Bardaweel, Sanaa K;
Rawashdeh, Sara Al;
Sorkhy, Mohammad Al

Publication type:

Article

Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4047, doi. 10.2147/DDDT.S178862

By:

Huang, Jie;
Fu, Cheng-xiao;
Yang, Xiao-yan;
Cui, Chan;
Yang, Shuang;
Kuang, Yun;
Guo, Cheng-xian;
Hu, Pei;
Pei, Qi;
Yang, Guo-ping

Publication type:

Article

Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3847, doi. 10.2147/DDDT.S174037

By:

Zhang, Hong-Mei;
Chen, Wei;
Liu, Rui-Ning;
Zhao, Yan

Publication type:

Article

The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3817, doi. 10.2147/DDDT.S175331

By:

Jiao, Hong;
Ren, Huan

Publication type:

Article

Spotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4059, doi. 10.2147/DDDT.S168014

By:

Chorepsima, Stamatia;
Kechagias, Konstantinos S;
Kalimeris, Georgios;
Triarides, Nikolaos A;
Falagas, Matthew E

Publication type:

Article

Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3879, doi. 10.2147/DDDT.S167149

By:

Haugh, Isabel M;
Preston, Allie K;
Kivelevitch, Dario N;
Menter, Alan M

Publication type:

Article

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3825, doi. 10.2147/DDDT.S183527

By:

Lei, Wei-Te;
Lin, Hsin Hui;
Tsai, Mu-Chieh;
Hung, Hua-His;
Cheng, Yu-Jyun;
Liu, Shu-Jung;
Lin, Chien Yu;
Yeh, Tzu-Lin

Publication type:

Article

Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3985, doi. 10.2147/DDDT.S184245

By:

Han, Jibo;
Shi, Xiaowen;
Zheng, Zhanxiong;
Zhang, Bin;
Shi, Fengjie;
Jiang, Liqin;
Xu, Jianjiang

Publication type:

Article

Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4033, doi. 10.2147/DDDT.S176561

By:

Feng, Shan;
Qiu, Bingxun;
Zou, Li;
Liu, Ke;
Xu, Xiaoyu;
Zhu, Huifeng

Publication type:

Article

Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3999, doi. 10.2147/DDDT.S173970

By:

Rad, Sima Kianpour;
Arya, Aditya;
Karimian, Hamed;
Madhavan, Priya;
Rizwan, Farzana;
Koshy, Shajan;
Prabhu, Girish

Publication type:

Article

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H<sub>2</sub>O<sub>2</sub>-induced apoptosis in PC12 cells.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3973, doi. 10.2147/DDDT.S178217

By:

Qi, Shimei;
Feng, Zunyong;
Li, Qiang;
Qi, Zhilin;
Zhang, Yao

Publication type:

Article

Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3653, doi. 10.2147/DDDT.S170764

By:

Regenthal, Ralf;
Voskanian, Margarita;
Baumann, Frank;
Teichert, Jens;
Brätter, Christian;
Aigner, Achim;
Abraham, Getu

Publication type:

Article

Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HI F-1α/CXCR 4 pathway.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 4023, doi. 10.2147/DDDT.S179989

By:

Zhu, Haiyan;
Wang, Xuxia;
Han, Yuanyuan;
Zhang, Wenjuan;
Xin, Wei;
Zheng, Xiaotao;
Zhang, Jun

Publication type:

Article

Hydralazine HCl rapidly disintegrating sublingual tablets: simple dosage form of higher bioavailability and enhanced clinical efficacy for potential rapid control on hypertensive preeclampsia.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3753, doi. 10.2147/DDDT.S173326

By:

Genedy, Samar;
Khames, Ahmed;
Hussein, Amal;
Sarhan, Hatem

Publication type:

Article

Effectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: a systematic review and meta-analysis.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3929, doi. 10.2147/DDDT.S179568

By:

Cheng, Lei;
Zhang, Keyan;
Zhang, Zhenyong

Publication type:

Article

Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3937, doi. 10.2147/DDDT.S178532

By:

Attia, Noha;
Mashal, Mohamed;
Soto-Sánchez, Cristina;
Martínez-Navarrete, Gema;
Fernández, Eduardo;
Grijalvo, Santiago;
Eritja, Ramón;
Puras, Gustavo;
Pedraz, Jose Luis

Publication type:

Article

Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3369, doi. 10.2147/DDDT.S179427

By:

Abe, Mitsuhiro;
Tsushima, Kenji;
Sakayori, Masashi;
Suzuki, Kenichi;
Ikari, Jun;
Terada, Jiro;
Tatsumi, Koichiro

Publication type:

Article

Efficacy evaluation of reteplase in a novel canine acute pulmonary thromboembolism model developed by minimally invasive surgery and digital subtraction angiography.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3717, doi. 10.2147/DDDT.S180151

By:

Zhang, Yinbing;
Liu, Haifeng;
Zhang, Yingqian;
Wu, Qiong;
Zhang, Yanyan;
Zhang, Jie;
Zhou, Xiangshan;
Jiao, He;
Fan, Feng;
Xue, Qi;
Wang, Xin;
Zhong, Zhihui

Publication type:

Article

Effect of intrathecal dexmedetomidine on preventing shivering in cesarean section after spinal anesthesia: a meta-analysis and trial sequential analysis.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3775, doi. 10.2147/DDDT.S178665

By:

Miao, Shuai;
Shi, Mengzhu;
Zou, Lan;
Wang, Guanglei

Publication type:

Article

Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3785, doi. 10.2147/DDDT.S182032

By:

Amraei, Mansour;
Mohamadpour, Mahmoud;
Ahmadi, Mohammad Reza Hafezi;
Azizi, Monireh;
Daemi, Ahmad;
Omidi, Mohammad;
Shirzadpour, Ehsan

Publication type:

Article

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3885, doi. 10.2147/DDDT.S138765

By:

Vairy, Stephanie;
Garcia, Julia Lopes;
Teira, Pierre;
Bittencourt, Henrique

Publication type:

Article

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3675, doi. 10.2147/DDDT.S180837

By:

Li, Teng;
Zhong, Yuanyuan;
Tang, Tao;
Luo, Jiekun;
Cui, Hanjin;
Fan, Rong;
Wang, Yang;
Wang, Dongsheng

Publication type:

Article

Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3645, doi. 10.2147/DDDT.S184053

By:

Lwin, Ei Mon Phyo;
Leggett, Catherine;
Ritchie, Usha;
Gerber, Cobus;
Song, Yunmei;
Hague, William;
Turner, Sean;
Upton, Richard;
Garg, Sanjay

Publication type:

Article

Lobaplatin inhibits breast cancer progression, cell proliferation while it induces cell apoptosis by downregulating MTDH expression.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3563, doi. 10.2147/DDDT.S163157

By:

Tian, Wuguo;
Hao, Shuai;
Gao, Bo;
Jiang, Yan;
Zhang, Xiaohua;
Zhang, Shu;
Guo, Lingji;
Zhao, Jianjie;
Zhang, Gang;
Chen, Yi;
Li, Zhirong;
Luo, Donglin

Publication type:

Article

Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3767, doi. 10.2147/DDDT.S181561

By:

Cho, Eun Ju;
Yu, Su Jong;
Kwon, So Young;
Kim, Ji-Hoon;
Kim, Do Young;
Kim, Won;
Lee, June Sung;
Lee, Jin Woo;
Lee, Youn Jae;
Chae, Hee Bok;
Yoon, Jung-Hwan

Publication type:

Article

Comparative pharmacokinetics of an adalimumab biosimilar SB5 administered via autoinjector or prefilled syringe in healthy subjects.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 3799, doi. 10.2147/DDDT.S169082

By:

Shin, Donghoon;
Lee, Younju;
Jeong, Deokyoon;
Ellis-Pegler, Rod

Publication type:

Article