Works matching IS 10966080 AND DT 2019 AND VI 167 AND IP 2

Results: 27

Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 385, doi. 10.1093/toxsci/kfy244
By:
- Giustarini, Giulio;
- Vrisekoop, Nienke;
- Kruijssen, Laura;
- Wagenaar, Laura;
- Staveren, Selma van;
- Roest, Manon van;
- Bleumink, Rob;
- Bol-Schoenmakers, Marianne;
- Weaver, Richard J;
- Koenderman, Leo;
- Smit, Joost;
- Pieters, Raymond
Publication type:
Article
Today's Challenges to De-Risk and Predict Drug Safety in Human "Mind-the-Gap".
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 307, doi. 10.1093/toxsci/kfy270
By:
- Weaver, Richard J;
- Valentin, Jean-Pierre
Publication type:
Article
Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 360, doi. 10.1093/toxsci/kfy239
By:
- Huo, Jianhua;
- Wei, Feng;
- Cai, Chengzhong;
- Lyn-Cook, Beverly;
- Pang, Li
Publication type:
Article
Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 573, doi. 10.1093/toxsci/kfy264
By:
- Zeng, Haoyu;
- Wang, Jixin;
- Clouse, Holly;
- Lagrutta, Armando;
- Sannajust, Frederick
Publication type:
Article
Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 593, doi. 10.1093/toxsci/kfy265
By:
- Deaton, Aimee M;
- Fan, Fan;
- Zhang, Wei;
- Nguyen, Phuong A;
- Ward, Lucas D;
- Nioi, Paul
Publication type:
Article
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 458, doi. 10.1093/toxsci/kfy253
By:
- Longo, Diane M;
- Woodhead, Jeffrey L;
- Walker, Paul;
- Herédi-Szabó, Krisztina;
- Mogyorósi, Károly;
- Wolenski, Francis S;
- Dragan, Yvonne P;
- Mosedale, Merrie;
- Siler, Scott Q;
- Watkins, Paul B;
- Howell, Brett A
Publication type:
Article
Proteomic and Metabolomic Profiling Identify Plasma Biomarkers for Exposure to Ultra-low Levels of Carfentanil.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 524, doi. 10.1093/toxsci/kfy259
By:
- Dhummakupt, Elizabeth S;
- Rizzo, Gabrielle M;
- Feasel, Michael;
- Mach, Phillip M;
- Tran, Bao Q;
- Carmany, Daniel O;
- Demond, Paul S;
- McBride, Ethan M;
- Maughan, Michele;
- Sekowski, Jennifer W;
- Glaros, Trevor
Publication type:
Article
Prenatal Bisphenol A Exposure Alters Epithelial Cell Composition in the Rhesus Macaque Fetal Oviduct.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 450, doi. 10.1093/toxsci/kfy251
By:
- Hung, Pei-Hsuan;
- Winkle, Laura S Van;
- Williams, Carmen J;
- Hunt, Patricia A;
- VandeVoort, Catherine A
Publication type:
Article
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 484, doi. 10.1093/toxsci/kfy255
By:
- Alberga, Domenico;
- Trisciuzzi, Daniela;
- Mansouri, Kamel;
- Mangiatordi, Giuseppe Felice;
- Nicolotti, Orazio
Publication type:
Article
Oxygen and Arsenite Synergize Phosphine Toxicity by Distinct Mechanisms.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 419, doi. 10.1093/toxsci/kfy248
By:
- Alzahrani, Saad M;
- Ebert, Paul R
Publication type:
Article
Nicotine Promotes Human Papillomavirus (HPV)-Immortalized Cervical Epithelial Cells (H8) Proliferation by Activating RPS27a-Mdm2-P53 Pathway In Vitro.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 408, doi. 10.1093/toxsci/kfy246
By:
- Chen, Lu;
- Wang, Huai
Publication type:
Article
linc00152 Controls Cell Cycle Progression by Regulating CCND1 in 16HBE Cells Malignantly Transformed by Cigarette Smoke Extract.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 496, doi. 10.1093/toxsci/kfy254
By:
- Liu, Zhenzhong;
- Liu, Anfei;
- Nan, Aruo;
- Cheng, Ying;
- Yang, Ti;
- Dai, Xin;
- Chen, Lijian;
- Li, Xin;
- Jia, Yangyang;
- Zhang, Nan;
- Jiang, Yiguo
Publication type:
Article
Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM).
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 347, doi. 10.1093/toxsci/kfy236
By:
- Kenyon, Elaina M;
- Lipscomb, John C;
- Pegram, Rex A;
- George, Barbara J;
- Hines, Ronald N
Publication type:
Article
Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 468, doi. 10.1093/toxsci/kfy261
By:
- Catron, Tara R;
- Keely, Scott P;
- Brinkman, Nichole E;
- Zurlinden, Todd J;
- Wood, Charles E;
- Wright, Justin R;
- Phelps, Drake;
- Wheaton, Emily;
- Kvasnicka, Allison;
- Gaballah, Shaza;
- Lamendella, Regina;
- Tal, Tamara
Publication type:
Article
From the Editor's Desk, Editor's Highlights.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 305, doi. 10.1093/toxsci/kfz018
Publication type:
Article
Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 322, doi. 10.1093/toxsci/kfy279
By:
- Wikoff, Daniele S;
- Rager, Julia E;
- Chappell, Grace A;
- Fitch, Seneca;
- Haws, Laurie;
- Borghoff, Susan J
Publication type:
Article
Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 375, doi. 10.1093/toxsci/kfy245
By:
- Dent, Matthew P;
- Li, Hequn;
- Carmichael, Paul L;
- Martin, Francis L
Publication type:
Article
Differential Toxicity of Alkylphenols in JEG-3 Human Placental Cells: Alteration of P450 Aromatase and Cell Lipid Composition.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 336, doi. 10.1093/toxsci/kfy243
By:
- Pérez-Albaladejo, Elisabet;
- Lacorte, Silvia;
- Porte, Cinta
Publication type:
Article
Dichloroacetate Ameliorates Cardiac Dysfunction Caused by Ischemic Insults Through AMPK Signal Pathway—Not Only Shifts Metabolism.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 604, doi. 10.1093/toxsci/kfy272
By:
- Li, Xuan;
- Liu, Jia;
- Hu, Haiyan;
- Lu, Shaoxin;
- Lu, Qingguo;
- Quan, Nanhu;
- Rousselle, Thomas;
- Patel, Mulchand S;
- Li, Ji
Publication type:
Article
Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in Zebrafish (Danio rerio).
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 536, doi. 10.1093/toxsci/kfy257
By:
- Ulin, Alexandra;
- Henderson, Jake;
- Pham, Minh-Tam;
- Meyo, James;
- Chen, Yuying;
- Karchner, Sibel I;
- Goldstone, Jared V;
- Hahn, Mark E;
- Williams, Larissa M
Publication type:
Article
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 581, doi. 10.1093/toxsci/kfy263
By:
- Lu, Peipei;
- Cai, Xinran;
- Guo, Yan;
- Xu, Meishu;
- Tian, Jianmin;
- Locker, Joseph;
- Xie, Wen
Publication type:
Article
Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 509, doi. 10.1093/toxsci/kfy256
By:
- Truong, Kim M;
- Pessah, Isaac N
Publication type:
Article
Benzene Exposure Induces Insulin Resistance in Mice.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 426, doi. 10.1093/toxsci/kfy252
By:
- Abplanalp, Wesley T;
- Wickramasinghe, Nalinie S;
- Sithu, Srinivas D;
- Conklin, Daniel J;
- Xie, Zhengzhi;
- Bhatnagar, Aruni;
- Srivastava, Sanjay;
- O'Toole, Timothy E
Publication type:
Article
Automated Morphological Feature Assessment for Zebrafish Embryo Developmental Toxicity Screens.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 438, doi. 10.1093/toxsci/kfy250
By:
- Teixidó, Elisabet;
- Kießling, Tobias R;
- Krupp, Eckart;
- Quevedo, Celia;
- Muriana, Arantza;
- Scholz, Stefan
Publication type:
Article
Ambient Particulate Matter and Acrolein Co-Exposure Increases Myocardial Dyssynchrony in Mice via TRPA1.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 559, doi. 10.1093/toxsci/kfy262
By:
- Thompson, Leslie C;
- Walsh, Leon;
- Martin, Brandi L;
- McGee, John;
- Wood, Charles;
- Kovalcik, Kasey;
- Pancras, Joseph Patrick;
- Haykal-Coates, Najwa;
- Ledbetter, Allen D;
- Davies, David;
- Cascio, Wayne E;
- Higuchi, Mark;
- Hazari, Mehdi S;
- Farraj, Aimen K
Publication type:
Article
Allyl Sulfide Counteracts 1-Bromopropane-Induced Neurotoxicity by Inhibiting Neuroinflammation and Oxidative Stress.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 397, doi. 10.1093/toxsci/kfy240
By:
- Suo, Jinning;
- Zhang, Cuili;
- Wang, Pin;
- Hou, Liyan;
- Wang, Qingshan;
- Zhao, Xiulan
Publication type:
Article
All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate.
Published in:
Toxicological Sciences, 2019, v. 167, n. 2, p. 546, doi. 10.1093/toxsci/kfy260
By:
- Spade, Daniel J;
- Dere, Edward;
- Hall, Susan J;
- Schorl, Christoph;
- Freiman, Richard N;
- Boekelheide, Kim
Publication type:
Article