Works matching IS 08990042 AND DT 2007 AND VI 19 AND IP 9
Results: 9
Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery—Building chiral technology toolboxesIn contrast to previous usage, Chiral Technology is defined in this review as the use of techniques or tools for the determination of absolute stereochemistry, the chiral analysis or preparative separation of racemic small molecules containing one or more asymmetric centers into (all of) their enantiomers (= enantiomeric or chiral separation), and the facilitation of asymmetric transformations, but not asymmetric transformations themselves. The terms Chiral Technology and Chirotechnology have often been used as a general category for asymmetric transformations using enzymes, chiral building blocks, chiral auxiliaries, and chiral catalysts, as well as chiral salt resolution.1–13
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- Chirality, 2007, v. 19, n. 9, p. 658
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Prologue: Chirality in the Pharmaceutical Industry.
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- Chirality, 2007, v. 19, n. 9, p. 657
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Rapid screening of enzymes for the enzymatic hydrolysis of chiral esters in drug discovery.
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- Chirality, 2007, v. 19, n. 9, p. 701
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An investigation of the absolute configuration of the potent histamine H3 receptor antagonist GT‐2331 using vibrational circular dichroism.
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- Chirality, 2007, v. 19, n. 9, p. 731
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Simulated moving columns technique for enantioselective supercritical fluid chromatography.
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- Chirality, 2007, v. 19, n. 9, p. 683
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Strategic use of preparative chiral chromatography for the synthesis of a preclinical pharmaceutical candidate.
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- Chirality, 2007, v. 19, n. 9, p. 693
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Preparative chiral chromatography and chiroptical characterization of enantiomers of omeprazole and related benzimidazoles.
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- Chirality, 2007, v. 19, n. 9, p. 706
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Application of chiral technology in a pharmaceutical company. Enantiomeric separation and spectroscopic studies of key asymmetric intermediates using a combination of techniques. PhenylglycidolsMuch of the material in this manuscript was presented previously in a poster presentation at the ISCD‐17/Chirality‐2005, September 11–14, Parma, Italy.
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- Chirality, 2007, v. 19, n. 9, p. 716
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Stereochemical identification of (R)‐ and (S)‐ibuprofen using residual dipolar couplings, NMR, and modeling.
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- Chirality, 2007, v. 19, n. 9, p. 741
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