Works matching IS 08936692 AND DT 2007 AND VI 48 AND IP 3/4
Results: 18
Plasma and cellular markers of 3′‐azido‐3′‐dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIsInvited article on the genotoxicity of perinatal NRTI therapy.Contributing investigators at clinical sites for the protocol entitled “A study of the potential mutagenicity of ZDV/nucleoside analogues in perinatal HIV prophylaxis” were Alan Bateman (Harlem Hospital Center, New York, NY), Eleanor Jimenez and Jorge Gandia (Centro Medico, San Juan, Puerto Rico), Renee Samelson (Albany Medical Center, Albany, NY), Sohail Rana (Howard University Hospital, Washington, DC), Andrea Kovacs and Alice Stek (University of Southern California Medical Center, Los Angeles, CA), and Mobeen H. Rathore and Isaac Delke (University of Florida Health Science Center, Jacksonville, FL).
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 307
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Transplacental carcinogenicity of 3′‐azido‐3′‐deoxythymidine in B6C3F1 mice and F344 ratsInvited article on the genotoxicity of perinatal NTRI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 283, doi. 10.1002/em.20297
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Special issue on health risks of perinatal exposure to nucleoside reverse transcriptase inhibitorsInvited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 159, doi. 10.1002/em.20296
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Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother–child pairs to AZT or AZT‐3TCInvited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 330
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Does perinatal antiretroviral therapy create an iatrogenic cancer risk?Invited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 210, doi. 10.1002/em.20283
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Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cellsInvited article on the genotoxicity of perinatal NRTI therapy.The contents of this communication are the sole responsibility of the authors and do not necessarily represent the official views of the NCI, NHLBI, or NIH.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 239, doi. 10.1002/em.20282
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Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53‐haplodeficient mice treated perinatally with AZT and AZT in combination with 3TCThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 270, doi. 10.1002/em.20280
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Clinical mitochondrial dysfunction in uninfected children born to HIV‐infected mothers following perinatal exposure to nucleoside analoguesInvited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 173
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Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother‐to‐child transmission of HIVInvited article on the genotoxicity of perinatal NRTI therapyThis article is a US Government work and, as such, is in the public domain in the United States of America.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 322, doi. 10.1002/em.20266
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Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD‐1 mice to single agents or drug combinationsThe contents of this communication are the sole responsibility of the authors and do not necessarily represent official views of the NCI or the NIH.Invited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 224, doi. 10.1002/em.20264
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3′‐azido‐3′‐deoxythymidine induces deletions in L5178Y mouse lymphoma cellsThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRT1 therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 248, doi. 10.1002/em.20263
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Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long‐term to ZidovudineThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRTI therapy
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 179, doi. 10.1002/em.20245
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Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudineInvited article on the genotoxicity of perinatal NRTI therapy.The views expressed in this article do not necessarily reflect those of the Food and Drug Administration.This article is a US Government work and, as such, is in the public domain in the United States of America.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 258, doi. 10.1002/em.20237
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A brief overview of mechanisms of mitochondrial toxicity from NRTIsInvited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 166, doi. 10.1002/em.20223
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Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor‐induced mitochondrial toxicityInvited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 201, doi. 10.1002/em.20201
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Genetic alterations in K‐ras and p53 cancer genes in lung neoplasms from Swiss (CD‐1) male mice exposed transplacentally to AZTThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 299, doi. 10.1002/em.20197
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Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitorsInvited article on the genotoxicity of perinatal NRTI therapy.This article is a US Government work and, as such, is in the public domain in the United States of America.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 215, doi. 10.1002/em.20195
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Mitochondrial toxicity in hearts of CD‐1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combinationThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRTI therapy.
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- Environmental & Molecular Mutagenesis, 2007, v. 48, n. 3/4, p. 190, doi. 10.1002/em.20191
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