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Results: 43

Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia.
Published in:
2014
By:
- Scherr, M;
- Elder, A;
- Battmer, K;
- Barzan, D;
- Bomken, S;
- Ricke-Hoch, M;
- Schröder, A;
- Venturini, L;
- Blair, H J;
- Vormoor, J;
- Ottmann, O;
- Ganser, A;
- Pich, A;
- Hilfiker-Kleiner, D;
- Heidenreich, O;
- Eder, M
Publication type:
journal article
Epigenetics of myelodysplastic syndromes.
Published in:
2014
By:
- Itzykson, R;
- Fenaux, P
Publication type:
journal article
Inherited genetic susceptibility to multiple myeloma.
Published in:
2014
By:
- Morgan, G J;
- Johnson, D C;
- Weinhold, N;
- Goldschmidt, H;
- Landgren, O;
- Lynch, H T;
- Hemminki, K;
- Houlston, R S
Publication type:
journal article
CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia.
Published in:
2014
By:
- Brault, L;
- Rovó, A;
- Decker, S;
- Dierks, C;
- Tzankov, A;
- Schwaller, J
Publication type:
journal article
Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 473, doi. 10.1038/leu.2013.255
By:
- Ratajczak, M Z;
- Zuba-Surma, E;
- Wojakowski, W;
- Suszynska, M;
- Mierzejewska, K;
- Liu, R;
- Ratajczak, J;
- Shin, D M;
- Kucia, M
Publication type:
Article
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.
Published in:
2014
By:
- Solary, E;
- Bernard, O A;
- Tefferi, A;
- Fuks, F;
- Vainchenker, W
Publication type:
journal article
KRas(G12D)-evoked leukemogenesis does not require β-catenin.
Published in:
2014
By:
- Ng, C E L;
- Sinha, A;
- Krivtsov, A;
- Dias, S;
- Chang, J;
- Armstrong, S A;
- Kalaitzidis, D
Publication type:
Letter
Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine.
Published in:
2014
By:
- Valencia, A;
- Masala, E;
- Rossi, A;
- Martino, A;
- Sanna, A;
- Buchi, F;
- Canzian, F;
- Cilloni, D;
- Gaidano, V;
- Voso, M T;
- Kosmider, O;
- Fontenay, M;
- Gozzini, A;
- Bosi, A;
- Santini, V
Publication type:
journal article
CD49d expression identifies a chronic-lymphocytic leukemia subset with high levels of mobilized circulating CD34(+) hemopoietic progenitors cells.
Published in:
2014
By:
- Rossi, F M;
- Zucchetto, A;
- Tissino, E;
- Dal Bo, M;
- Bomben, R;
- Caldana, C;
- Pozzo, F;
- Del Poeta, G;
- Rossi, D;
- Gaidano, G;
- Gattei, V
Publication type:
Letter
Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 589, doi. 10.1038/leu.2013.342
By:
- Kampen, K R;
- ter Elst, A;
- Mahmud, H;
- Scherpen, F J G;
- Diks, S H;
- Peppelenbosch, M P;
- de Haas, V;
- Guryev, V;
- de Bont, E S J M
Publication type:
Article
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 609, doi. 10.1038/leu.2013.354
By:
- Slamova, L;
- Starkova, J;
- Fronkova, E;
- Zaliova, M;
- Reznickova, L;
- van Delft, F W;
- Vodickova, E;
- Volejnikova, J;
- Zemanova, Z;
- Polgarova, K;
- Cario, G;
- Figueroa, M;
- Kalina, T;
- Fiser, K;
- Bourquin, J P;
- Bornhauser, B;
- Dworzak, M;
- Zuna, J;
- Trka, J;
- Stary, J
Publication type:
Article
Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 716, doi. 10.1038/leu.2013.347
By:
- Schaab, C;
- Oppermann, F S;
- Klammer, M;
- Pfeifer, H;
- Tebbe, A;
- Oellerich, T;
- Krauter, J;
- Levis, M;
- Perl, A E;
- Daub, H;
- Steffen, B;
- Godl, K;
- Serve, H
Publication type:
Article
Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 577, doi. 10.1038/leu.2013.264
By:
- Stankov, M V;
- El Khatib, M;
- Kumar Thakur, B;
- Heitmann, K;
- Panayotova-Dimitrova, D;
- Schoening, J;
- Bourquin, J P;
- Schweitzer, N;
- Leverkus, M;
- Welte, K;
- Reinhardt, D;
- Li, Z;
- Orkin, S H;
- Behrens, G M N;
- Klusmann, J H
Publication type:
Article
Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 680, doi. 10.1038/leu.2013.231
By:
- Minami, J;
- Suzuki, R;
- Mazitschek, R;
- Gorgun, G;
- Ghosh, B;
- Cirstea, D;
- Hu, Y;
- Mimura, N;
- Ohguchi, H;
- Cottini, F;
- Jakubikova, J;
- Munshi, N C;
- Haggarty, S J;
- Richardson, P G;
- Hideshima, T;
- Anderson, K C
Publication type:
Article
Cyclin D1 splice site variant triggers chromosomal aberrations in healthy humans.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 721, doi. 10.1038/leu.2013.353
By:
- Hemminki, K;
- Musak, L;
- Vymetalkova, V;
- Smerhovsky, Z;
- Halasova, E;
- Osina, O;
- Letkova, L;
- Försti, A;
- Vodickova, L;
- Buchancova, J;
- Vodicka, P
Publication type:
Article
Inherited genetic susceptibility to multiple myeloma.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 518, doi. 10.1038/leu.2013.344
By:
- Morgan, G J;
- Johnson, D C;
- Weinhold, N;
- Goldschmidt, H;
- Landgren, O;
- Lynch, H T;
- Hemminki, K;
- Houlston, R S
Publication type:
Article
Rapid rate of peripheral blood blast clearance accurately predicts complete remission in acute myeloid leukemia.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 713, doi. 10.1038/leu.2013.341
By:
- Vainstein, V;
- Buckley, S A;
- Shukron, O;
- Estey, E H;
- Abkowitz, J L;
- Wood, B L;
- Walter, R B
Publication type:
Article
BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 649, doi. 10.1038/leu.2013.358
By:
- Cheng, S;
- Ma, J;
- Guo, A;
- Lu, P;
- Leonard, J P;
- Coleman, M;
- Liu, M;
- Buggy, J J;
- Furman, R R;
- Wang, Y L
Publication type:
Article
Feasibility of targeted next-generation sequencing of the TP53 and ATM genes in chronic lymphocytic leukemia.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 694, doi. 10.1038/leu.2013.322
By:
- Mansouri, L;
- Sutton, L-A;
- Ljungström, V;
- Sörqvist, E F;
- Gunnarsson, R;
- Smedby, K E;
- Juliusson, G;
- Stamatopoulos, K;
- Nilsson, M;
- Rosenquist, R
Publication type:
Article
CD49d expression identifies a chronic-lymphocytic leukemia subset with high levels of mobilized circulating CD34<sup>+</sup> hemopoietic progenitors cells.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 705, doi. 10.1038/leu.2013.331
By:
- Rossi, F M;
- Zucchetto, A;
- Tissino, E;
- Dal Bo, M;
- Bomben, R;
- Caldana, C;
- Pozzo, F;
- Del Poeta, G;
- Rossi, D;
- Gaidano, G;
- Gattei, V
Publication type:
Article
Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: impact of tyrosine kinase inhibitor and minimal residual disease.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 658, doi. 10.1038/leu.2013.253
By:
- Bachanova, V;
- Marks, D I;
- Zhang, M-J;
- Wang, H;
- de Lima, M;
- Aljurf, M D;
- Arellano, M;
- Artz, A S;
- Bacher, U;
- Cahn, J-Y;
- Chen, Y-B;
- Copelan, E A;
- Drobyski, W R;
- Gale, R P;
- Greer, J P;
- Gupta, V;
- Hale, G A;
- Kebriaei, P;
- Lazarus, H M;
- Lewis, I D
Publication type:
Article
New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG).
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 525, doi. 10.1038/leu.2013.350
By:
- Ocio, E M;
- Richardson, P G;
- Rajkumar, S V;
- Palumbo, A;
- Mateos, M V;
- Orlowski, R;
- Kumar, S;
- Usmani, S;
- Roodman, D;
- Niesvizky, R;
- Einsele, H;
- Anderson, K C;
- Dimopoulos, M A;
- Avet-Loiseau, H;
- Mellqvist, U-H;
- Turesson, I;
- Merlini, G;
- Schots, R;
- McCarthy, P;
- Bergsagel, L
Publication type:
Article
Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 621, doi. 10.1038/leu.2013.330
By:
- Valencia, A;
- Masala, E;
- Rossi, A;
- Martino, A;
- Sanna, A;
- Buchi, F;
- Canzian, F;
- Cilloni, D;
- Gaidano, V;
- Voso, M T;
- Kosmider, O;
- Fontenay, M;
- Gozzini, A;
- Bosi, A;
- Santini, V
Publication type:
Article
Differential expression of miR-17∼92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 554, doi. 10.1038/leu.2013.361
By:
- Scherr, M;
- Elder, A;
- Battmer, K;
- Barzan, D;
- Bomken, S;
- Ricke-Hoch, M;
- Schröder, A;
- Venturini, L;
- Blair, H J;
- Vormoor, J;
- Ottmann, O;
- Ganser, A;
- Pich, A;
- Hilfiker-Kleiner, D;
- Heidenreich, O;
- Eder, M
Publication type:
Article
Elevated PTPN2 expression is associated with inferior molecular response in de-novo chronic myeloid leukaemia patients.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 702, doi. 10.1038/leu.2013.329
By:
- Kok, C H;
- Leclercq, T;
- Watkins, D B;
- Saunders, V;
- Wang, J;
- Hughes, T P;
- White, D L
Publication type:
Article
High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 719, doi. 10.1038/leu.2013.348
By:
- Kraan, W;
- van Keimpema, M;
- Horlings, H M;
- Schilder-Tol, E J M;
- Oud, M E C M;
- Noorduyn, L A;
- Kluin, P M;
- Kersten, M J;
- Spaargaren, M;
- Pals, S T
Publication type:
Article
Deletion of the 1p32 region is a major independent prognostic factor in young patients with myeloma: the IFM experience on 1195 patients.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 726, doi. 10.1038/leu.2013.352
By:
- Hebraud, B;
- Leleu, X;
- Lauwers-Cances, V;
- Roussel, M;
- Caillot, D;
- Marit, G;
- Karlin, L;
- Hulin, C;
- Gentil, C;
- Guilhot, F;
- Garderet, L;
- Lamy, T;
- Brechignac, S;
- Pegourie, B;
- Jaubert, J;
- Dib, M;
- Stoppa, A-M;
- Sebban, C;
- Fohrer, C;
- Fontan, J
Publication type:
Article
On the way towards a 'CLL prognostic index': focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 710, doi. 10.1038/leu.2013.333
By:
- Cortese, D;
- Sutton, L-A;
- Cahill, N;
- Smedby, K E;
- Geisler, C;
- Gunnarsson, R;
- Juliusson, G;
- Mansouri, L;
- Rosenquist, R
Publication type:
Article
Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 666, doi. 10.1038/leu.2013.346
By:
- Montes, R;
- Ayllón, V;
- Prieto, C;
- Bursen, A;
- Prelle, C;
- Romero-Moya, D;
- Real, P J;
- Navarro-Montero, O;
- Chillón, C;
- Marschalek, R;
- Bueno, C;
- Menendez, P
Publication type:
Article
Rituximab maintenance therapy after autologous stem cell transplantation prolongs progression-free survival in patients with mantle cell lymphoma.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 708, doi. 10.1038/leu.2013.332
By:
- Dietrich, S;
- Weidle, J;
- Rieger, M;
- Meissner, J;
- Radujkovic, A;
- Ho, A D;
- Dreger, P;
- Witzens-Harig, M
Publication type:
Article
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 629, doi. 10.1038/leu.2013.351
By:
- Berger, A;
- Hoelbl-Kovacic, A;
- Bourgeais, J;
- Hoefling, L;
- Warsch, W;
- Grundschober, E;
- Uras, I Z;
- Menzl, I;
- Putz, E M;
- Hoermann, G;
- Schuster, C;
- Fajmann, S;
- Leitner, E;
- Kubicek, S;
- Moriggl, R;
- Gouilleux, F;
- Sexl, V
Publication type:
Article
CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 566, doi. 10.1038/leu.2013.201
By:
- Brault, L;
- Rovó, A;
- Decker, S;
- Dierks, C;
- Tzankov, A;
- Schwaller, J
Publication type:
Article
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 485, doi. 10.1038/leu.2013.337
By:
- Solary, E;
- Bernard, O A;
- Tefferi, A;
- Fuks, F;
- Vainchenker, W
Publication type:
Article
Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 600, doi. 10.1038/leu.2013.345
By:
- Kaindl, U;
- Morak, M;
- Portsmouth, C;
- Mecklenbräuker, A;
- Kauer, M;
- Zeginigg, M;
- Attarbaschi, A;
- Haas, O A;
- Panzer-Grümayer, R
Publication type:
Article
Deletion of the 1p32 region is a major independent prognostic factor in young patients with myeloma: the IFM experience on 1195 patients.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 675, doi. 10.1038/leu.2013.225
By:
- Hebraud, B;
- Leleu, X;
- Lauwers-Cances, V;
- Roussel, M;
- Caillot, D;
- Marit, G;
- Karlin, L;
- Hulin, C;
- Gentil, C;
- Guilhot, F;
- Garderet, L;
- Lamy, T;
- Brechignac, S;
- Pegourie, B;
- Jaubert, J;
- Dib, M;
- Stoppa, A-M;
- Sebban, C;
- Fohrer, C;
- Fontan, J
Publication type:
Article
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 543, doi. 10.1038/leu.2013.349
By:
- Buontempo, F;
- Orsini, E;
- Martins, L R;
- Antunes, I;
- Lonetti, A;
- Chiarini, F;
- Tabellini, G;
- Evangelisti, C;
- Melchionda, F;
- Pession, A;
- Bertaina, A;
- Locatelli, F;
- McCubrey, J A;
- Cappellini, A;
- Barata, J T;
- Martelli, A M
Publication type:
Article
Immunotherapy for chronic lymphocytic leukemia in the era of BTK inhibitors.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 507, doi. 10.1038/leu.2013.311
By:
- Kharfan-Dabaja, M A;
- Wierda, W G;
- Cooper, L J N
Publication type:
Article
Epigenetics of myelodysplastic syndromes.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 497, doi. 10.1038/leu.2013.343
By:
- Itzykson, R;
- Fenaux, P
Publication type:
Article
Phase 2 study of oral panobinostat (LBH589) with or without erythropoietin in heavily transfusion-dependent IPSS low or int-1 MDS patients.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 696, doi. 10.1038/leu.2013.325
By:
- Platzbecker, U;
- Al-Ali, H K;
- Gattermann, N;
- Haase, D;
- Janzen, V;
- Krauter, J;
- Götze, K;
- Schlenk, R;
- Nolte, F;
- Letsch, A;
- Ottmann, O G;
- Kündgen, A;
- Lübbert, M;
- Germing, U;
- Wermke, M;
- Reinhard, H;
- Weiss, C;
- Lieder, K;
- Ehninger, G;
- Leismann, O
Publication type:
Article
Bendamustine in combination with Ofatumumab in relapsed or refractory chronic lymphocytic leukemia: a GIMEMA Multicenter Phase II Trial.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 642, doi. 10.1038/leu.2013.334
By:
- Cortelezzi, A;
- Sciumè, M;
- Liberati, A M;
- Vincenti, D;
- Cuneo, A;
- Reda, G;
- Laurenti, L;
- Zaja, F;
- Marasca, R;
- Chiarenza, A;
- Gritti, G;
- Orsucci, L;
- Storti, S;
- Angelucci, E;
- Cascavilla, N;
- Gobbi, M;
- Mauro, F R;
- Morabito, F;
- Fabris, S;
- Piciocchi, A
Publication type:
Article
Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 690, doi. 10.1038/leu.2013.335
By:
- Nooka, A K;
- Kaufman, J L;
- Muppidi, S;
- Langston, A;
- Heffner, L T;
- Gleason, C;
- Casbourne, D;
- Saxe, D;
- Boise, L H;
- Lonial, S
Publication type:
Article
Impact of the revised International Prognostic Scoring System on the outcome of patients with acute myeloid leukemia with or without antecedent myelodysplastic syndrome.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 723, doi. 10.1038/leu.2013.356
By:
- Stölzel, F;
- Kramer, M;
- Mohr, B;
- Wermke, M;
- Bornhäuser, M;
- Ehninger, G;
- Schaich, M;
- Platzbecker, U
Publication type:
Article
KRas<sup>G12D</sup>-evoked leukemogenesis does not require β-catenin.
Published in:
Leukemia (08876924), 2014, v. 28, n. 3, p. 698, doi. 10.1038/leu.2013.328
By:
- Ng, C E L;
- Sinha, A;
- Krivtsov, A;
- Dias, S;
- Chang, J;
- Armstrong, S A;
- Kalaitzidis, D
Publication type:
Article