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Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma.
Published in:
2016
By:
- Bechter, Oliver;
- Dumez, Herlinde;
- Costermans, Jo;
- Punie, Kevin;
- Hsu, Karl;
- Dedieu, Jean-François;
- Ghuysen, Anne-Frédérique;
- Francesconi, Elisa;
- Sharma, Jyoti;
- Liu, Li;
- Schöffski, Patrick;
- Bechter, Oliver E;
- Dedieu, Jean-François;
- Ghuysen, Anne-Frédérique;
- Schöffski, Patrick
Publication type:
journal article
Everolimus pharmacokinetics and its exposure-toxicity relationship in patients with thyroid cancer.
Published in:
2016
By:
- Wit, D.;
- Schneider, T.;
- Moes, D.;
- Roozen, C.;
- Hartigh, J.;
- Gelderblom, H.;
- Guchelaar, H.;
- Hoeven, J.;
- Links, T.;
- Kapiteijn, E.;
- Erp, N.;
- de Wit, D;
- Schneider, T C;
- Moes, D J A R;
- Roozen, C F M;
- den Hartigh, J;
- Guchelaar, H J;
- van der Hoeven, J J;
- Links, T P;
- van Erp, N P
Publication type:
journal article
Gibberellin derivative GA-13315 sensitizes multidrug-resistant cancer cells by antagonizing ABCB1 while agonizes ABCC1.
Published in:
2016
By:
- Mo, Jiao;
- Kang, Min;
- Ye, Jun-Xian;
- Chen, Jing-Bo;
- Zhang, Hong-bin;
- Qing, Chen
Publication type:
journal article
Developing more effective, non-neurotoxic, methotrexate-based therapy in infants with brain tumors.
Published in:
2016
By:
- Cohen, Ian;
- Cohen, Ian J
Publication type:
Letter
Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective.
Published in:
2016
By:
- Ciccolini, Joseph;
- Serdjebi, Cindy;
- Peters, Godefridus;
- Giovannetti, Elisa;
- Peters, Godefridus J
Publication type:
journal article
A clinical drug-drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib.
Published in:
2016
By:
- Malhi, Vikram;
- Colburn, Dawn;
- Williams, Sarah;
- Hop, Cornelis;
- Dresser, Mark;
- Chandra, Priya;
- Graham, Richard;
- Williams, Sarah J;
- Hop, Cornelis E C A;
- Dresser, Mark J;
- Graham, Richard A
Publication type:
journal article
Combinational strategies of metformin and chemotherapy in cancers.
Published in:
2016
By:
- Zhang, Hui-Hui;
- Guo, Xiu-Li
Publication type:
journal article
Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites.
Published in:
2016
By:
- Mahipal, Amit;
- Klapman, Jason;
- Vignesh, Shivakumar;
- Yang, Chung;
- Neuger, Anthony;
- Chen, Dung-Tsa;
- Malafa, Mokenge;
- Yang, Chung S;
- Malafa, Mokenge P
Publication type:
journal article
Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.
Published in:
2016
By:
- Campbell, Jared;
- Bateman, Emma;
- Stephenson, Matthew;
- Bowen, Joanne;
- Keefe, Dorothy;
- Peters, Micah;
- Campbell, Jared M;
- Stephenson, Matthew D;
- Bowen, Joanne M;
- Keefe, Dorothy M;
- Peters, Micah D J
Publication type:
journal article
UGT1A1 gene polymorphism is associated with toxicity and clinical efficacy of irinotecan-based chemotherapy in patients with advanced colorectal cancer.
Published in:
2016
By:
- Xu, Chunlei;
- Tang, Xushan;
- Qu, Yanli;
- Keyoumu, Saifuding;
- Zhou, Ning;
- Tang, Yong
Publication type:
journal article
Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals.
Published in:
2016
By:
- Martin, Emma;
- Aarons, Leon;
- Yates, James;
- Martin, Emma C;
- Yates, James W T
Publication type:
journal article
Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation.
Published in:
2016
By:
- Yamashita, Takaya;
- Fujishima, Naohito;
- Miura, Masatomo;
- Niioka, Takenori;
- Abumiya, Maiko;
- Shinohara, Yoshinori;
- Ubukawa, Kumi;
- Nara, Miho;
- Fujishima, Masumi;
- Kameoka, Yoshihiro;
- Tagawa, Hiroyuki;
- Hirokawa, Makoto;
- Takahashi, Naoto
Publication type:
journal article
Reply to Prof Ian J. Cohen.
Published in:
2016
By:
- Lucchesi, Maurizio;
- Sardi, Iacopo
Publication type:
Letter
Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency.
Published in:
2016
By:
- Saif, Muhammad;
- Diasio, Robert;
- Saif, Muhammad Wasif;
- Diasio, Robert B
Publication type:
journal article
A prospective, multicenter phase I/II study of induction chemotherapy with docetaxel, cisplatin and fluorouracil (DCF) followed by chemoradiotherapy in patients with unresectable locally advanced esophageal carcinoma.
Published in:
2016
By:
- Satake, Hironaga;
- Tahara, Makoto;
- Mochizuki, Satoshi;
- Kato, Ken;
- Hara, Hiroki;
- Yokota, Tomoya;
- Kiyota, Naomi;
- Kii, Takayuki;
- Chin, Keisho;
- Zenda, Sadamoto;
- Kojima, Takashi;
- Bando, Hideaki;
- Yamazaki, Tomoko;
- Iwasa, Satoru;
- Honma, Yoshitaka;
- Hamauchi, Satoru;
- Tsushima, Takahiro;
- Ohtsu, Atsushi
Publication type:
journal article
A phase I study of mTOR inhibitor everolimus in association with cisplatin and radiotherapy for the treatment of locally advanced cervix cancer: PHOENIX I.
Published in:
2016
By:
- Melo, Andréia;
- Grazziotin-Reisner, Rachele;
- Erlich, Felipe;
- Fontes Dias, Mariane;
- Moralez, Giulliana;
- Carneiro, Michel;
- Ingles Garces, Álvaro;
- Guerra Alves, Flávia;
- Novaes Neto, Bruna;
- Fuchshuber-Moraes, Mateus;
- Morando, Juliane;
- Suarez-Kurtz, Guilherme;
- Ferreira, Carlos;
- de Melo, Andréia Cristina;
- Fontes Dias, Mariane S;
- Ingles Garces, Álvaro Henrique;
- Guerra Alves, Flávia Vieira;
- Ferreira, Carlos Gil
Publication type:
journal article
Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study.
Published in:
2016
By:
- Pilancı, Kezban;
- Saglam, Sezer;
- Okyar, Alper;
- Yucel, Serap;
- Pala-Kara, Zeliha;
- Ordu, Cetin;
- Namal, Esat;
- Ciftci, Rumeysa;
- Iner-Koksal, Ulkuhan;
- Kaytan-Saglam, Esra;
- Pilancı, Kezban Nur
Publication type:
journal article
Pharmacokinetics, safety, and efficacy of lenalidomide plus dexamethasone in patients with multiple myeloma and renal impairment.
Published in:
2016
By:
- Bridoux, Frank;
- Chen, Nianhang;
- Moreau, Stephane;
- Arnulf, Bertrand;
- Moumas, Eric;
- Abraham, Julie;
- Desport, Estelle;
- Jaccard, Arnaud;
- Fermand, Jean;
- Fermand, Jean Paul
Publication type:
journal article
Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma.
Published in:
2016
By:
- Ogura, Michinori;
- Ishida, Takashi;
- Tsukasaki, Kunihiro;
- Takahashi, Takeshi;
- Utsunomiya, Atae
Publication type:
journal article
Monte Carlo simulations of the clinical benefits from therapeutic drug monitoring of sunitinib in patients with gastrointestinal stromal tumours.
Published in:
2016
By:
- Goulooze, Sebastiaan;
- Galettis, Peter;
- Boddy, Alan;
- Martin, Jennifer;
- Goulooze, Sebastiaan C;
- Boddy, Alan V;
- Martin, Jennifer H
Publication type:
journal article
Association between new-onset hypothyroidism and clinical response in patients treated with tyrosine kinase inhibitor therapy in phase I clinical trials.
Published in:
2016
By:
- Bilen, Mehmet;
- Patel, Amy;
- Hess, Kenneth;
- Munoz, Javier;
- Busaidy, Naifa;
- Wheler, Jennifer;
- Janku, Filip;
- Falchook, Gerald;
- Hong, David;
- Meric-Bernstam, Funda;
- Habra, Mouhammed;
- Naing, Aung;
- Bilen, Mehmet Asim;
- Hess, Kenneth R;
- Busaidy, Naifa L;
- Wheler, Jennifer J;
- Falchook, Gerald S;
- Hong, David S;
- Habra, Mouhammed Amir
Publication type:
journal article
Atrial natriuretic peptide protects against cisplatin-induced granulocytopenia.
Published in:
2016
By:
- Nojiri, Takashi;
- Hosoda, Hiroshi;
- Zenitani, Masahiro;
- Tokudome, Takeshi;
- Kimura, Toru;
- Miura, Koichi;
- Miyazato, Mikiya;
- Okumura, Meinoshin;
- Kangawa, Kenji
Publication type:
journal article
Effect of renal function on pemetrexed-induced haematotoxicity.
Published in:
2016
By:
- Ando, Yosuke;
- Hayashi, Takahiro;
- Ujita, Moeko;
- Murai, Sumie;
- Ohta, Hideki;
- Ito, Kaori;
- Yamaguchi, Teppei;
- Funatsu, Minori;
- Ikeda, Yoshiaki;
- Imaizumi, Kazuyoshi;
- Kawada, Kenji;
- Yasuda, Kimio;
- Yamada, Shigeki
Publication type:
journal article
Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors.
Published in:
2016
By:
- Kummar, Shivaani;
- Chen, Alice;
- Gutierrez, Martin;
- Pfister, Thomas;
- Wang, Lihua;
- Redon, Christophe;
- Bonner, William;
- Yutzy, William;
- Zhang, Yiping;
- Kinders, Robert;
- Ji, Jiuping;
- Allen, Deborah;
- Covey, Joseph;
- Eiseman, Julie;
- Holleran, Julianne;
- Beumer, Jan;
- Rubinstein, Larry;
- Collins, Jerry;
- Tomaszewski, Joseph;
- Parchment, Ralph
Publication type:
journal article

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