Works matching IS 0344-5704 AND VI 69 AND IP 1 AND DT 2012

Results: 50

Safety and pharmacokinetics of high-dose gefitinib in patients with solid tumors: results of a phase I study.

Published in:

2012

By:

Gross ME;
Leichman L;
Lowe ES;
Swaisland A;
Agus DB

Publication type:

Journal Article

A randomized phase II trial of two different 4-drug combinations in advanced pancreatic adenocarcinoma: cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel (PEXG or PDXG regimen)

Published in:

2012

By:

Reni M;
Cereda S;
Rognone A;
Belli C;
Ghidini M;
Longoni S;
Fugazza C;
Rezzonico S;
Passoni P;
Slim N;
Balzano G;
Nicoletti R;
Cappio S;
Doglioni C;
Villa E

Publication type:

Journal Article

Pharmacokinetic drug interaction between AEE788 and RAD001 causing thrombocytopenia in patients with glioblastoma.

Published in:

2012

By:

Reardon DA;
Cloughesy T;
Rich J;
Alfred Yung WK;
Yung L;
Dilea C;
Huang J;
Dugan M;
Mietlowski W;
Maes A;
Conrad C

Publication type:

Journal Article

Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer.

Published in:

2012

By:

Hong J;
Jung M;
Kim YJ;
Sym SJ;
Kyung SY;
Park J;
Lee SP;
Park JW;
Cho EK;
Jeong SH;
Shin DB;
Lee JH

Publication type:

Journal Article

5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells.

Published in:

2012

By:

Yang JF;
Cao JG;
Tian L;
Liu F

Publication type:

Journal Article

Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor.

Published in:

2012

By:

Wang D;
Tang F;
Wang S;
Jiang Z;
Zhang L

Publication type:

Journal Article

A systematic approach to the management of patients with brain metastases of known or unknown primary site.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 1, doi. 10.1007/s00280-011-1775-9

By:

Kyritsis, Athanassios;
Markoula, Sofia;
Levin, Victor

Publication type:

Article

A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects.

Published in:

2012

By:

Abbas R;
Hug BA;
Leister C;
Gaaloul ME;
Chalon S;
Sonnichsen D

Publication type:

Journal Article

Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.

Published in:

2012

By:

Tavecchio M;
Munck JM;
Cano C;
Newell DR;
Curtin NJ

Publication type:

Journal Article

Factors affecting the pharmacokinetics of pegylated liposomal doxorubicin in patients.

Published in:

2012

By:

La-Beck NM;
Zamboni BA;
Gabizon A;
Schmeeda H;
Amantea M;
Gehrig PA;
Zamboni WC

Publication type:

Journal Article

A drug interaction study evaluating the pharmacokinetics and toxicity of sorafenib in combination with capecitabine.

Published in:

2012

By:

Infante JR;
Jones SF;
Bendell JC;
Greco FA;
Yardley DA;
Lane CM;
Spigel DR;
Hainsworth JD;
Burris Iii HA

Publication type:

Journal Article

A phase I trial of oral metronomic vinorelbine plus capecitabine in patients with metastatic breast cancer.

Published in:

2012

By:

Saridaki Z;
Malamos N;
Kourakos P;
Polyzos A;
Ardavanis A;
Androulakis N;
Kalbakis K;
Vamvakas L;
Georgoulias V;
Mavroudis D

Publication type:

Journal Article

Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells.

Published in:

2012

By:

Cheng CY;
Cherng SH;
Wu WJ;
Yang TY;
Huang XY;
Liao FT;
Wu MF;
Sheu GT

Publication type:

Journal Article

Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test.

Published in:

2012

By:

Michael M;
Cullinane C;
Hatzimihalis A;
O'Kane C;
Milner A;
Booth R;
Schlicht S;
Clarke SJ;
Francis P

Publication type:

Journal Article

A phase I trial of oral metronomic vinorelbine plus capecitabine in patients with metastatic breast cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 35, doi. 10.1007/s00280-011-1663-3

By:

Saridaki, Zacharenia;
Malamos, Nikolaos;
Kourakos, Panagiotis;
Polyzos, Aristides;
Ardavanis, Alexandros;
Androulakis, Nikolaos;
Kalbakis, Kostas;
Vamvakas, Lambros;
Georgoulias, Vassilis;
Mavroudis, Dimitris

Publication type:

Article

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine.

Published in:

2012

By:

Joerger M;
Burgers JA;
Baas P;
Doodeman VD;
Smits PH;
Jansen RS;
Vainchtein LD;
Rosing H;
Huitema AD;
Beijnen JH;
Schellens JH

Publication type:

Journal Article

Meta-analysis of docetaxel-based doublet versus docetaxel alone as second-line treatment for advanced non-small-cell lung cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 99, doi. 10.1007/s00280-011-1678-9

By:

Qi, Wei-Xiang;
Shen, Zan;
Yao, Yang

Publication type:

Article

Factors affecting the pharmacokinetics of pegylated liposomal doxorubicin in patients.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 43, doi. 10.1007/s00280-011-1664-2

By:

La-Beck, Ninh;
Zamboni, Beth;
Gabizon, Alberto;
Schmeeda, Hilary;
Amantea, Michael;
Gehrig, Paola;
Zamboni, William

Publication type:

Article

Population pharmacokinetics of PM00104 (Zalypsis((R))) in cancer patients.

Published in:

2012

By:

Pérez-Ruixo C;
Valenzuela B;
Fernández Teruel C;
González-Sales M;
Miguel-Lillo B;
Soto-Matos A;
Pérez-Ruixo JJ

Publication type:

Journal Article

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.

Published in:

2012

By:

Kanai M;
Imaizumi A;
Otsuka Y;
Sasaki H;
Hashiguchi M;
Tsujiko K;
Matsumoto S;
Ishiguro H;
Chiba T

Publication type:

Journal Article

5-Fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity.

Published in:

2012

By:

Jensen SA;
Sørensen JB

Publication type:

Journal Article

Meta-analysis of docetaxel-based doublet versus docetaxel alone as second-line treatment for advanced non-small-cell lung cancer.

Published in:

2012

By:

Qi WX;
Shen Z;
Yao Y

Publication type:

Journal Article

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 25, doi. 10.1007/s00280-011-1670-4

By:

Joerger, M.;
Burgers, J.;
Baas, P.;
Doodeman, V.;
Smits, P.;
Jansen, R.;
Vainchtein, L.;
Rosing, H.;
Huitema, A.;
Beijnen, J.;
Schellens, J.

Publication type:

Article

Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 85, doi. 10.1007/s00280-011-1675-z

By:

Effenberger-Neidnicht, Katharina;
Breyer, Sandra;
Mahal, Katharina;
Sasse, Florenz;
Schobert, Rainer

Publication type:

Article

Population pharmacokinetics of PM00104 (Zalypsis) in cancer patients.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 15, doi. 10.1007/s00280-011-1644-6

By:

Pérez-Ruixo, Carlos;
Valenzuela, Belén;
Fernández Teruel, Carlos;
González-Sales, Mario;
Miguel-Lillo, Bernardo;
Soto-Matos, Arturo;
Pérez-Ruixo, Juan

Publication type:

Article

5-Fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 57, doi. 10.1007/s00280-011-1669-x

By:

Jensen, Søren;
Sørensen, Jens

Publication type:

Article

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 65, doi. 10.1007/s00280-011-1673-1

By:

Kanai, Masashi;
Imaizumi, Atsushi;
Otsuka, Yoshihiko;
Sasaki, Hiroki;
Hashiguchi, Momo;
Tsujiko, Kazu;
Matsumoto, Shigemi;
Ishiguro, Hiroshi;
Chiba, Tsutomu

Publication type:

Article

The marine sponge toxin agelasine B increases the intracellular Ca concentration and induces apoptosis in human breast cancer cells (MCF-7).

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 71, doi. 10.1007/s00280-011-1677-x

By:

Pimentel, Adriana;
Felibertt, Pimali;
Sojo, Felipe;
Colman, Laura;
Mayora, Adriana;
Silva, May;
Rojas, Hector;
Dipolo, Reinaldo;
Suarez, Alírica;
Compagnone, Reinaldo;
Arvelo, Francisco;
Galindo-Castro, Ivan;
Sanctis, Juan;
Chirino, Perla;
Benaim, Gustavo

Publication type:

Article

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 51, doi. 10.1007/s00280-011-1672-2

By:

Gan, Jinping;
Liu-Kreyche, Peggy;
Humphreys, W.

Publication type:

Article

Combining capecitabine, oxaliplatin, and gemcitabine (XELOXGEM) for colorectal carcinoma patients pretreated with irinotecan: a multicenter phase I/II trial.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 91, doi. 10.1007/s00280-011-1668-y

By:

Kim, Se;
Shin, Sang;
Kim, Sun;
Lee, Se;
Park, Young;
Park, Se;
Lee, Kyung;
Kim, Tae;
Hong, Yong;
Ahn, Joong

Publication type:

Article

Hematologic adverse events associated with temozolomide.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 107, doi. 10.1007/s00280-011-1679-8

By:

Villano, J.;
Letarte, Nathalie;
Yu, Janny;
Abdur, Shakir;
Bressler, Linda

Publication type:

Article

A randomized phase II trial of two different 4-drug combinations in advanced pancreatic adenocarcinoma: cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel (PEXG or PDXG regimen).

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 115, doi. 10.1007/s00280-011-1680-2

By:

Reni, Michele;
Cereda, Stefano;
Rognone, Alessia;
Belli, Carmen;
Ghidini, Michele;
Longoni, Simonetta;
Fugazza, Clara;
Rezzonico, Sara;
Passoni, Paolo;
Slim, Najla;
Balzano, Giampaolo;
Nicoletti, Roberto;
Cappio, Stefano;
Doglioni, Claudio;
Villa, Eugenio

Publication type:

Article

A drug interaction study evaluating the pharmacokinetics and toxicity of sorafenib in combination with capecitabine.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 137, doi. 10.1007/s00280-011-1674-0

By:

Infante, Jeffrey;
Jones, Suzanne;
Bendell, Johanna;
Greco, F.;
Yardley, Denise;
Lane, Cassie;
Spigel, David;
Hainsworth, John;
Burris III, Howard

Publication type:

Article

Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C-erythromycin breath test and the antipyrine clearance test.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 125, doi. 10.1007/s00280-011-1676-y

By:

Michael, M.;
Cullinane, C.;
Hatzimihalis, A.;
O'Kane, C.;
Milner, A.;
Booth, R.;
Schlicht, S.;
Clarke, S.;
Francis, P.

Publication type:

Article

Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 145, doi. 10.1007/s00280-011-1682-0

By:

Cheng, Ching-Yuan;
Cherng, Shur-Hueih;
Wu, Wen-Jun;
Yang, Tsung-Ying;
Huang, Xin-Yi;
Liao, Fu-Tien;
Wu, Ming-Fang;
Sheu, Gwo-Tarng

Publication type:

Article

Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 155, doi. 10.1007/s00280-011-1662-4

By:

Tavecchio, Michele;
Munck, Joanne;
Cano, Celine;
Newell, David;
Curtin, Nicola

Publication type:

Article

Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 173, doi. 10.1007/s00280-011-1681-1

By:

Wang, Dongchun;
Tang, Feng;
Wang, Sen;
Jiang, Zhenzhou;
Zhang, Luyong

Publication type:

Article

Pharmacokinetic drug interaction between AEE788 and RAD001 causing thrombocytopenia in patients with glioblastoma.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 281, doi. 10.1007/s00280-011-1754-1

By:

Reardon, David;
Cloughesy, Timothy;
Rich, Jeremy;
Alfred Yung, W.;
Yung, Lotus;
DiLea, Clifford;
Huang, Jerry;
Dugan, Margaret;
Mietlowski, William;
Maes, Andrea;
Conrad, Charles

Publication type:

Article

A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 221, doi. 10.1007/s00280-011-1688-7

By:

Abbas, Richat;
Hug, Bruce;
Leister, Cathie;
Gaaloul, Myriam;
Chalon, Stephan;
Sonnichsen, Daryl

Publication type:

Article

A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 165, doi. 10.1007/s00280-011-1667-z

By:

Infante, J.;
Kurzrock, R.;
Spratlin, J.;
Burris, H.;
Eckhardt, S.;
Li, J.;
Wu, K.;
Skolnik, J.;
Hylander-Gans, L.;
Osmukhina, A.;
Huszar, D.;
Herbst, R.

Publication type:

Article

Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 185, doi. 10.1007/s00280-011-1684-y

By:

Holland, William;
Tepper, Clifford;
Pietri, Jose;
Chinn, Danielle;
Gandara, David;
Mack, Philip;
Lara, Primo

Publication type:

Article

The plasma and cerebrospinal fluid pharmacokinetics of the platinum analog satraplatin after intravenous administration in non-human primates.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 247, doi. 10.1007/s00280-011-1659-z

By:

Marcus, Leigh;
Murphy, Robert;
Fox, Elizabeth;
McCully, Cynthia;
Cruz, Raphael;
Warren, Katherine;
Meyer, Thorsten;
McNiff, Edward;
Balis, Frank;
Widemann, Brigitte

Publication type:

Article

5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 195, doi. 10.1007/s00280-011-1686-9

By:

Yang, Jian-Feng;
Cao, Jian-Guo;
Tian, Li;
Liu, Fei

Publication type:

Article

Pharmacokinetic characterization of a natural product-inspired novel MEK1 inhibitor E6201 in preclinical species.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 229, doi. 10.1007/s00280-011-1687-8

By:

Kumar, Vipul;
Schuck, Edgar;
Pelletier, Robert;
Farah, Nadia;
Condon, Krista;
Ye, Meng;
Rowbottom, Christopher;
King, Belinda;
Zhang, Zhi-Yi;
Saxton, Philip;
Wong, Y.

Publication type:

Article

Montelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male rats.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 207, doi. 10.1007/s00280-011-1692-y

By:

Beytur, Ali;
Ciftci, Osman;
Oguz, Fatih;
Oguzturk, Hakan;
Yılmaz, Fethi

Publication type:

Article

Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 215, doi. 10.1007/s00280-011-1689-6

By:

Hong, Junshik;
Jung, Minkyu;
Kim, Yu;
Sym, Sun;
Kyung, Sun;
Park, Jinny;
Lee, Sang;
Park, Jeong;
Cho, Eun;
Jeong, Sung;
Shin, Dong;
Lee, Jae

Publication type:

Article

Different combination schedules of gemcitabine with endostar affect antitumor efficacy.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 239, doi. 10.1007/s00280-011-1695-8

By:

Peng, Xing-Chen;
Qiu, Meng;
Wei, Meng;
Tan, Ben-Xu;
Ge, Jun;
Zhao, Yu;
Chen, Ye;
Cheng, Ke;
Zhou, Yi;
Wu, Yang;
Gong, Feng-Ming;
Li, Qiu;
Xu, Feng;
Bi, Feng;
Liu, Ji-Yan

Publication type:

Article

Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 253, doi. 10.1007/s00280-011-1698-5

By:

Ding, Xiaoling;
Zhou, Xiaorong;
Zhang, Haifeng;
Qing, Jingdan;
Qiang, Hui;
Zhou, Guoxiong

Publication type:

Article

A pilot pharmacologic biomarker study of busulfan and fludarabine in hematopoietic cell transplant recipients.

Published in:

2012

By:

McCune, Jeannine;
Woodahl, Erica;
Furlong, Terry;
Storer, Barry;
Wang, Joanne;
Heimfeld, Shelly;
Deeg, H.;
O'Donnell, Paul

Publication type:

Report

Safety and pharmacokinetics of high-dose gefitinib in patients with solid tumors: results of a phase I study.

Published in:

2012

By:

Gross, Mitchell;
Leichman, Lawrence;
Lowe, Elizabeth;
Swaisland, Alan;
Agus, David

Publication type:

Report