Precise and broad scope genome editing based on high-specificity Cas9 nickases.
- Published in:
- Nucleic Acids Research, 2021, v. 49, n. 2, p. 1, doi. 10.1093/nar/gkaa1236
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- Article
Works matching IS 03051048 AND DT 2021 AND VI 49 AND IP 2
Results: 33
1
2
Targeting alternative splicing by RNAi: from the differential impact on splice variants to triggering artificial pre-mRNA splicing.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 1133, doi. 10.1093/nar/gkaa1260
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- Article
3
Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 954, doi. 10.1093/nar/gkaa1241
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- Article
4
A deafness-associated tRNA mutation caused pleiotropic effects on the m<sup>1</sup>G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 1075, doi. 10.1093/nar/gkaa1225
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- Article
5
Arabidopsis mTERF9 protein promotes chloroplast ribosomal assembly and translation by establishing ribonucleoprotein interactions in vivo
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 1114, doi. 10.1093/nar/gkaa1244
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- Article
6
Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 1046, doi. 10.1093/nar/gkaa1248
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7
Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 1065, doi. 10.1093/nar/gkaa1263
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8
Expansion and re-classification of the extracytoplasmic function (ECF) factor family.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 986, doi. 10.1093/nar/gkaa1229
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9
Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 969, doi. 10.1093/nar/gkaa1251
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- Article
10
The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 847, doi. 10.1093/nar/gkaa1273
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11
IncC helper dependent plasmid-like replication of Salmonella Genomic Island 1.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 832, doi. 10.1093/nar/gkaa1257
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- Article
12
Effects of codon usage on gene expression are promoter context dependent.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 818, doi. 10.1093/nar/gkaa1253
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- Article
13
Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 713, doi. 10.1093/nar/gkaa1249
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- Article
14
A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 700, doi. 10.1093/nar/gkaa1247
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- Article
15
The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 805, doi. 10.1093/nar/gkaa1243
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- Article
16
Partition of tRNA<sup>Gly</sup> isoacceptors between protein and cell-wall peptidoglycan synthesis in Staphylococcus aureus.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 684, doi. 10.1093/nar/gkaa1242
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17
In vitro selections with RNAs of variable length converge on a robust catalytic core.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 674, doi. 10.1093/nar/gkaa1238
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- Article
18
The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 657, doi. 10.1093/nar/gkaa1235
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- Article
19
SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 928, doi. 10.1093/nar/gkaa1232
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20
Mapping DNA conformations and interactions within the binding cleft of bacteriophage T4 single-stranded DNA binding protein (gp32) at single nucleotide resolution.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 916, doi. 10.1093/nar/gkaa1230
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21
Intestinal differentiation involves cleavage of histone H3 N-terminal tails by multiple proteases.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 791, doi. 10.1093/nar/gkaa1228
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22
The nucleoid-associated protein IHF acts as a 'transcriptional domainin' protein coordinating the bacterial virulence traits with global transcription.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 776, doi. 10.1093/nar/gkaa1227
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- Article
23
A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 902, doi. 10.1093/nar/gkaa1224
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- Article
24
A pan-cancer atlas of somatic mutations in miRNA biogenesis genes.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 601, doi. 10.1093/nar/gkaa1223
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- Article
25
Dynamics of TRF1 organizing a single human telomere.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 760, doi. 10.1093/nar/gkaa1222
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26
Differential activation mechanisms of two isoforms of Gcr1 transcription factor generated from spliced and un-spliced transcripts in Saccharomyces cerevisiae.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 745, doi. 10.1093/nar/gkaa1221
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27
Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 891, doi. 10.1093/nar/gkaa1219
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28
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 646, doi. 10.1093/nar/gkaa1215
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29
Splicing at the phase-separated nuclear speckle interface: a model.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 636, doi. 10.1093/nar/gkaa1209
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30
Factors that mold the nuclear landscape of HIV-1 integration.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 621, doi. 10.1093/nar/gkaa1207
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31
A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 879, doi. 10.1093/nar/gkaa1205
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32
Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model.
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- Nucleic Acids Research, 2021, v. 49, n. 2, p. 726, doi. 10.1093/nar/gkaa1204
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33
Chromatin structure restricts origin utilization when quiescent cells re-enter the cell cycle.
- Published in:
- Nucleic Acids Research, 2021, v. 49, n. 2, p. 864, doi. 10.1093/nar/gkaa1148
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- Article