Works matching IS 02678357 AND DT 2016 AND VI 31 AND IP 3

Results: 14

A proposal for a novel rationale for critical effect size in dose--response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 239, doi. 10.1093/mutage/gev077

By:

Zeller, Andreas;
Leilei Tang;
Dertinger, Stephen D.;
Funk, Juergen;
Duran-Pacheco, Gonzalo;
Guérard, Melanie

Publication type:

Article

Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 265, doi. 10.1093/mutage/gew009

By:

Wills, John W.;
Long, Alexandra S.;
Johnson, George E.;
Bemis, Jeffrey C.;
Dertinger, Stephen D.;
Slob, Wout;
White, Paul A.

Publication type:

Article

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 255, doi. 10.1093/mutage/gev085

By:

Wills, John W.;
Johnson, George E.;
Doak, Shareen H.;
Soeteman-Hernández, Lya G.;
Slob, Wout;
White, Paul A.

Publication type:

Article

Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 233, doi. 10.1093/mutage/gew011

By:

White, Paul A.;
Johnson, George E.

Publication type:

Article

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 309, doi. 10.1093/mutage/gev070

By:

Tweats, David J.;
Johnson, George E.;
Scandale, Ivan;
Whitwell, James;
Evans, Dean B.

Publication type:

Article

Estimating the carcinogenic potency of chemicals from the in vivo micronucleus test.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 347, doi. 10.1093/mutage/gev043

By:

Lya, G.;
Soeteman-Hernández;
Johnson, George E.;
Slob, Wout

Publication type:

Article

Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 359, doi. 10.1093/mutage/gev081

By:

Sahota, Tarjinder;
Danhof, Meindert;
Della Pasqua, Oscar

Publication type:

Article

Dose--Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 297, doi. 10.1093/mutage/gev035

By:

Zhiying Ji;
LeBaron, Matthew J.;
Schisler, Melissa R.;
Fagen Zhang;
Bartels, Michael J.;
Bhaskar Gollapudi, B.;
Pottenger, Lynn H.

Publication type:

Article

Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 287, doi. 10.1093/mutage/gev039

By:

Xiaoqing Guo;
Heflich, Robert H.;
Dial, Stacey L.;
Richter, Patricia A.;
Moore, Martha M.;
Nan Mei

Publication type:

Article

Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 333, doi. 10.1093/mutage/gev078

By:

Clewell, Rebecca A.;
Andersen, Melvin E.

Publication type:

Article

The use of dose-response data in a margin of exposure approach to carcinogenic risk assessment for genotoxic chemicals in food.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 329, doi. 10.1093/mutage/gev064

By:

Benford, Diane J.

Publication type:

Article

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 277, doi. 10.1093/mutage/gev041

By:

Bemis, Jeffrey C.;
Wills, John W.;
Bryce, Steven M.;
Torous, Dorothea K.;
Dertinger, Stephen D.;
Slob, Wout

Publication type:

Article

MutAIT: an online genetic toxicology data portal and analysis tools.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 323, doi. 10.1093/mutage/gev050

By:

Avancini, Daniele;
Menzies, Georgina E.;
Morgan, Claire;
Wills, John;
Johnson, George E.;
White, Paul A.;
Lewis, Paul D.

Publication type:

Article

Qualitative and quantitative approaches in the dose--response assessment of genotoxic carcinogens.

Published in:

Mutagenesis, 2016, v. 31, n. 3, p. 341, doi. 10.1093/mutage/gev049

By:

Shoji Fukushima;
Min Gi;
Kakehashi, Anna;
Hideki Wanibuchi;
Michiharu Matsumoto

Publication type:

Article