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Author’s overview: identifying SARS-CoV-2 antiviral compounds.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2533, doi. 10.1042/BCJ20210426
By:
- Diffley, John F. X.
Publication type:
Article
Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2715, doi. 10.1042/BCJ20210401
By:
- de Oliveira, Hamine C.;
- da Silva, Tainá D.;
- Salvador, Guilherme H. M.;
- Moraes, Ivan R.;
- Fukuda, Cíntia A.;
- de Barros, Andrea C.;
- Fontes, Marcos R. M.
Publication type:
Article
Characterization of caspase-7 interaction with RNA.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2681, doi. 10.1042/BCJ20210366
By:
- Desroches, Alexandre;
- Denault, Jean-Bernard
Publication type:
Article
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2571, doi. 10.1042/BCJ20210295
By:
- Conter, Carolina;
- Bombardi, Luca;
- Pedretti, Marco;
- Favretto, Filippo;
- Matteo, Adele Di;
- Dominici, Paola;
- Astegno, Alessandra
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2405, doi. 10.1042/BCJ20210201
By:
- Jingkun Zeng;
- Weissmann, Florian;
- Bertolin, Agustina P.;
- Posse, Viktor;
- Canal, Berta;
- Ulferts, Rachel;
- Wu, Mary;
- Harvey, Ruth;
- Hussain, Saira;
- Milligan, Jennifer C.;
- Roustan, Chloe;
- Borg, Annabel;
- McCoy, Laura;
- Drury, Lucy S.;
- Kjaer, Svend;
- McCauley, John;
- Howell, Michael;
- Beale, Rupert;
- Diffley, John F. X.
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2465, doi. 10.1042/bcj20210198
By:
- Canal, Berta;
- Fujisawa, Ryo;
- McClure, Allison W.;
- Deegan, Tom D.;
- Wu, Mary;
- Ulferts, Rachel;
- Weissmann, Florian;
- Drury, Lucy S.;
- Bertolin, Agustina P.;
- Jingkun Zeng;
- Beale, Rupert;
- Howell, Michael;
- Labib, Karim;
- Diffley, John F. X.
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/ nsp10 exoribonuclease.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2445, doi. 10.1042/BCJ20210198
By:
- Canal, Berta;
- McClure, Allison W.;
- Curran, Joseph F.;
- Wu, Mary;
- Ulferts, Rachel;
- Weissmann, Florian;
- Jingkun Zeng;
- Bertolin, Agustina P.;
- Milligan, Jennifer C.;
- Basu, Souradeep;
- Drury, Lucy S.;
- Deegan, Tom D.;
- Fujisawa, Ryo;
- Roberts, Emma L.;
- Basier, Clovis;
- Labib, Karim;
- Beale, Rupert;
- Howell, Michael;
- Diffley, John F. X.
Publication type:
Article
SMCHD1’s ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2555, doi. 10.1042/BCJ20210278
By:
- Gurzau, Alexandra D.;
- Horne, Christopher R.;
- Mok, Yee-Foong;
- Iminitoff, Megan;
- Willson, Tracy A.;
- Young, Samuel N.;
- Blewitt, Marnie E.;
- Murphy, James M.
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2481, doi. 10.1042/BCJ20210219
By:
- Basu, Souradeep;
- Mak, Tiffany;
- Ulferts, Rachel;
- Wu, Mary;
- Deegan, Tom;
- Fujisawa, Ryo;
- Kang Wei Tan;
- Chew Theng Lim;
- Basier, Clovis;
- Canal, Berta;
- Curran, Joseph F.;
- Drury, Lucy S.;
- McClure, Allison W.;
- Roberts, Emma L.;
- Weissmann, Florian;
- Zeisner, Theresa U.;
- Beale, Rupert;
- Cowling, Victoria H.;
- Howell, Michael;
- Labib, Karim
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2425, doi. 10.1042/BCJ20210200
By:
- Bertolin, Agustina P.;
- Weissmann, Florian;
- Jingkun Zeng;
- Posse, Viktor;
- Milligan, Jennifer C.;
- Canal, Berta;
- Ulferts, Rachel;
- Wu, Mary;
- Drury, Lucy S.;
- Howell, Michael;
- Beale, Rupert;
- Diffley, John F. X.
Publication type:
Article
Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2539, doi. 10.1042/BCJ20210264
By:
- Brunetta, Henver S.;
- Petrick, Heather L.;
- Vachon, Bayley;
- Nunes, Everson A.;
- Holloway, Graham P.
Publication type:
Article
An all-out assault on SARS-CoV-2 replication.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2399, doi. 10.1042/BCJ20210256
By:
- Hay, Ronald T.
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2517, doi. 10.1042/BCJ20210244
By:
- Chew Theng Lim;
- Kang Wei Tan;
- Wu, Mary;
- Ulferts, Rachel;
- Armstrong, Lee A.;
- Eiko Ozono;
- Drury, Lucy S.;
- Milligan, Jennifer C.;
- Zeisner, Theresa U.;
- Jingkun Zeng;
- Weissmann, Florian;
- Canal, Berta;
- Bineva-Todd, Ganka;
- Howell, Michael;
- O’Reilly, Nicola;
- Beale, Rupert;
- Kulathu, Yogesh;
- Labib, Karim;
- Diffley, John F. X.
Publication type:
Article
Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables realtime enzyme analysis of carbohydrate sulfatase activity.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2537, doi. 10.1042/bcj-2020-0952_cor
By:
- Byrne, Dominic P.;
- London, James A.;
- Eyers, Patrick A.;
- Yates, Edwin A.;
- Cartmell, Alan
Publication type:
Article
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2697, doi. 10.1042/BCJ20210172
By:
- Malcolm, Tess R.;
- Swiderska, Karolina W.;
- Hayes, Brooke K.;
- Webb, Chaille T.;
- Drag, Marcin;
- Drinkwater, Nyssa;
- McGowan, Sheena
Publication type:
Article
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2601, doi. 10.1042/BCJ20210160
By:
- Day, Martin A.;
- Jarrom, David;
- Christofferson, Andrew J.;
- Graziano, Antonio E.;
- Ross Anderson, J. L.;
- Searle, Peter F.;
- Hyde, Eva I.;
- White, Scott A.
Publication type:
Article
Hetero-oligomerization of Bacillus thuringiensis Cry1A proteins enhance binding to the ABCC2 transporter of Spodoptera exigua.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2589, doi. 10.1042/BCJ20210137
By:
- Pinos, Daniel;
- Joya, Noelia;
- Herrero, Salvador;
- Ferré, Juan;
- Hernández-Martínez, Patricia
Publication type:
Article
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2499, doi. 10.1042/BCJ20210197
By:
- Milligan, Jennifer C.;
- Zeisner, Theresa U.;
- Papageorgiou, George;
- Joshi, Dhira;
- Soudy, Christelle;
- Ulferts, Rachel;
- Wu, Mary;
- Chew Theng Lim;
- Kang Wei Tan;
- Weissmann, Florian;
- Canal, Berta;
- Fujisawa, Ryo;
- Deegan, Tom;
- Nagaraj, Hema;
- Bineva-Todd, Ganka;
- Basier, Clovis;
- Curran, Joseph F.;
- Howell, Michael;
- Beale, Rupert;
- Labib, Karim
Publication type:
Article
Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2665, doi. 10.1042/BCJ20200922
By:
- Juarez-Quintero, Víctor;
- Peralta-Castro, Antolín;
- Benítez Cardoza, Claudia G.;
- Ellenberger, Tom;
- Brieba, Luis G.
Publication type:
Article
Inhibitory feedback control of NF-κB signalling in health and disease.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2619, doi. 10.1042/BCJ20210139
By:
- Prescott, Jack A.;
- Mitchell, Jennifer P.;
- Cook, Simon J.
Publication type:
Article

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