Works matching IS 01676997 AND DT 2022 AND VI 40 AND IP 5

Results: 31

An open-label, crossover study to compare different formulations and evaluate effect of food on pharmacokinetics of pimitespib in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1011, doi. 10.1007/s10637-022-01285-9

By:

Komatsu, Yoshito;
Shimokawa, Tsuneo;
Akiyoshi, Kohei;
Karayama, Masato;
Shimomura, Akihiko;
Kawamoto, Yasuyuki;
Yuki, Satoshi;
Tambo, Yuichi;
Kasahara, Kazuo

Publication type:

Article

Clinical features, diagnosis, and management of dasatinib-induced nephrotic syndrome.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1153, doi. 10.1007/s10637-022-01288-6

By:

He, Yang;
Fang, Weijin;
Li, Zuojun;
Wang, Chunjiang

Publication type:

Article

Phase I study of envafolimab (KN035), a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1021, doi. 10.1007/s10637-022-01287-7

By:

Shimizu, Toshio;
Nakajima, Takako Eguchi;
Yamamoto, Noboru;
Yonemori, Kan;
Koyama, Takafumi;
Kondo, Shunsuke;
Sunakawa, Yu;
Izawa, Naoki;
Horie, Yoshiki;
Xiang, Silong;
Xu, Siying;
Qin, Lan;
Gong, John;
Liu, David

Publication type:

Article

Phase 1 study to evaluate the effects of rifampin on pharmacokinetics of pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1042, doi. 10.1007/s10637-022-01286-8

By:

Zhou, Xiaofei;
Vaishampayan, Ulka;
Mahalingam, Devalingam;
Harvey, R. Donald;
Chung, Ki Young;
Sedarati, Farhad;
Dong, Cassie;
Faller, Douglas V.;
Venkatakrishnan, Karthik;
Gupta, Neeraj

Publication type:

Article

Antitumor activity of mianserin (a tetracyclic antidepressant) primarily driven by the inhibition of SLC1A5-mediated glutamine transport.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 977, doi. 10.1007/s10637-022-01284-w

By:

Duan, Zelin;
Zhou, Zhiyun;
Lu, Feifei;
Zhang, Yawen;
Guo, Xvqin;
Gui, Chunshan;
Zhang, Hongjian

Publication type:

Article

Real-world data on efficacy and safety of azacitidine therapy in chronic myelomonocytic leukemia in China: results from a multicenter, retrospective study.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1117, doi. 10.1007/s10637-022-01283-x

By:

Xu, Yu;
Guo, Rong;
Miao, Miao;
Zhang, Guangsen;
Lan, Jianping;
Jin, Jie

Publication type:

Article

Improved delivery of Mcl-1 and survivin siRNA combination in breast cancer cells with additive siRNA complexes.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 962, doi. 10.1007/s10637-022-01282-y

By:

Santadkha, Tinnabhop;
Skolpap, Wanwisa;
K.C., Remant;
Ansari, Aysha;
Kucharski, Cezary;
Atz Dick, Teo;
Uludağ, Hasan

Publication type:

Article

3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 953, doi. 10.1007/s10637-022-01280-0

By:

Bär, Sofia I.;
Biersack, Bernhard;
Schobert, Rainer

Publication type:

Article

Anlotinib plus etoposide and cisplatin/carboplatin as first-line therapy for extensive-stage small cell lung cancer (ES-SCLC): a single-arm, phase II study.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1095, doi. 10.1007/s10637-022-01279-7

By:

Kong, Tiandong;
Chen, Lu;
Zhao, Xiaoli;
Duan, Fangfang;
Zhou, Hanli;
Wang, Lei;
Liu, Danna

Publication type:

Article

Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 944, doi. 10.1007/s10637-022-01278-8

By:

Desai, Janki M.;
Karve, Aniruddha S.;
Gudelsky, Gary A.;
Gawali, Mruniya V.;
Seibel, William;
Sallans, Larry;
DasGupta, Biplab;
Desai, Pankaj B.

Publication type:

Article

First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1001, doi. 10.1007/s10637-022-01277-9

By:

Janku, Filip;
Beom, Seung-Hoon;
Moon, Yong Wha;
Kim, Tae Won;
Shin, Young G.;
Yim, Dong-Seok;
Kim, Gun Min;
Kim, Hyo Song;
Kim, Sun Young;
Cheong, Jae-Ho;
Lee, Young Woo;
Geiger, Barb;
Yoo, Sanghee;
Thurston, Archie;
Welsch, Dean;
Rudoltz, Marc S.;
Rha, Sun Young

Publication type:

Article

A phase II study assessing the safety and efficacy of ASP1650 in male patients with relapsed refractory germ cell tumors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1087, doi. 10.1007/s10637-022-01276-w

By:

Adra, Nabil;
Vaughn, David J.;
Einhorn, Lawrence H.;
Hanna, Nasser H.;
Funt, Samuel A.;
Rosales, Matt;
Arozullah, Ahsan;
Feldman, Darren R.

Publication type:

Article

Genetic variations in the ATP-binding cassette transporter ABCC10 are associated with neutropenia in Japanese patients with lung cancer treated with nanoparticle albumin-bound paclitaxel.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 934, doi. 10.1007/s10637-022-01275-x

By:

Horiuchi, Minoru;
Uemura, Takehiro;
Oguri, Tetsuya;
Toda, Sanae;
Yamamoto, Sayaka;
Suzuki, Yuto;
Kagawa, Yusuke;
Sone, Kazuki;
Fukuda, Satoshi;
Mori, Yuta;
Fukumitsu, Kensuke;
Kanemitsu, Yoshihiro;
Tajiri, Tomoko;
Ohkubo, Hirotsugu;
Takemura, Masaya;
Ito, Yutaka;
Maeno, Ken;
Niimi, Akio

Publication type:

Article

First-in-human phase 1/1b study to evaluate sitravatinib in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 990, doi. 10.1007/s10637-022-01274-y

By:

Bauer, Todd;
Cho, Byong Chul;
Heist, Rebecca;
Bazhenova, Lyudmila;
Werner, Theresa;
Goel, Sanjay;
Kim, Dong-Wan;
Adkins, Douglas;
Carvajal, Richard D.;
Alva, Ajjai;
Eaton, Keith;
Wang, Judy;
Liu, Yong;
Yan, Xiaohong;
Christensen, Jamie;
Neuteboom, Saskia;
Chao, Richard;
Pant, Shubham

Publication type:

Article

Author Correction: The 45-month therapy outcomes of permanent seed implantation and radical prostatectomy for prostate cancer patients.

Published in:

2022

By:

Li, Chao;
Zhang, Mengdong;
Wang, Jianwen;
Zhang, Xiaodong

Publication type:

Correction Notice

MY11 exerts antitumor effects through activation of the NF-κB/PUMA signaling pathway in breast cancer.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 922, doi. 10.1007/s10637-022-01272-0

By:

Ye, Qun;
Jiang, Ziwei;
Xie, Ying;
Xu, Yuanhong;
Ye, Yiyi;
Ma, Lei;
Pei, Lixia

Publication type:

Article

Phase II study of Disulfiram and Cisplatin in Refractory Germ Cell Tumors. The GCT-SK-006 phase II trial.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1080, doi. 10.1007/s10637-022-01271-1

By:

Mego, M;
Svetlovska, D;
Angelis V, De;
Kalavska, K;
Lesko, P;
Makovník, M;
Obertova, J;
Orszaghova, Z;
Palacka, P;
Rečková, M;
Rejlekova, K;
Z, Sycova-Mila;
Mardiak, J;
Chovanec, M

Publication type:

Article

Pulmonary granulomatous inflammation after ceritinib treatment in advanced ALK-rearranged pulmonary adenocarcinoma.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1141, doi. 10.1007/s10637-022-01270-2

By:

Liao, Juanyan;
Guan, Hui;
Yu, Min;
Zhou, Ping;
Han, Yao;
Peng, Xingchen;
Zhang, Shuang

Publication type:

Article

A comprehensive analysis of the microbiota composition and host driver gene mutations in colorectal cancer.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 884, doi. 10.1007/s10637-022-01263-1

By:

Yuan, Danping;
Tao, Yong;
Wang, Haoyi;
Wang, Jiawei;
Cao, Yuepeng;
Cao, Wen;
Pan, Shou;
Yu, Zhaonan

Publication type:

Article

Phase I study of aflibercept in combination with docetaxel in Japanese patients with advanced solid malignancies.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1032, doi. 10.1007/s10637-022-01267-x

By:

Sunakawa, Yu;
Takahashi, Keishiro;
Kawaguchi, Osamu;
Yamamoto, Nobuyuki

Publication type:

Article

Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 905, doi. 10.1007/s10637-022-01266-y

By:

Swain, Risa Mia;
Contreras, Lisett;
Varela-Ramirez, Armando;
Hossain, Mohammad;
Das, Umashankar;
Valenzuela, Carlos A.;
Penichet, Manuel L.;
Dimmock, Jonathan R.;
Aguilera, Renato J

Publication type:

Article

Mono-PEGylated thermostable Bacillus caldovelox arginase mutant (BCA-M-PEG20) induces apoptosis, autophagy, cell cycle arrest and growth inhibition in gastric cancer cells.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 895, doi. 10.1007/s10637-022-01265-z

By:

Chung, Sai-Fung;
Tam, Suet-Ying;
Kim, Chi-Fai;
Chong, Hiu-Chi;
Lee, Leo Man-Yuen;
Leung, Yun-Chung

Publication type:

Article

Dacomitinib overcomes afatinib-refractory carcinomatous meningitis in a lung cancer patient harbouring EGFR Ex.19 deletion and G724S mutation; a case report.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1137, doi. 10.1007/s10637-022-01264-0

By:

Kunimasa, Kei;
Sugimoto, Naotoshi;
Tamiya, Motohiro;
Inoue, Takako;
Kawamura, Takahisa;
Kanzaki, Ryu;
Okami, Jiro;
Nishino, Kazumi

Publication type:

Article

Efficacy and safety of amrubicin monotherapy after atezolizumab plus carboplatin and etoposide in patients with relapsed small-cell lung cancer.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1066, doi. 10.1007/s10637-022-01269-9

By:

Imai, Hisao;
Nagai, Yoshiaki;
Minemura, Hiroyuki;
Tsuda, Takeshi;
Yamada, Yutaka;
Wasamoto, Satoshi;
Kishikawa, Takayuki;
Shiono, Ayako;
Shiihara, Jun;
Yamaguchi, Ou;
Mouri, Atsuto;
Kaira, Kyoichi;
Kanazawa, Kenya;
Taniguchi, Hirokazu;
Minato, Koichi;
Kagamu, Hiroshi

Publication type:

Article

The efficacy of transarterial chemoembolization in downstaging unresectable hepatocellular carcinoma to curative therapy: a predicted regression model.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1146, doi. 10.1007/s10637-022-01261-3

By:

Lin, Haomin;
Luo, Bin;
Peng, Fangyi;
Fang, Cheng;
Gan, Yu;
Yang, Xiaoli;
Li, Bo;
Li, Yaling;
Su, Song

Publication type:

Article

Dramatic response to alectinib in a lung adenocarcinoma patient harboring a Novel SSFA2-ALK fusion.

Published in:

2022

By:

Lin, Xinyi;
Yang, Xiaojuan;
Tan, Yuan;
Duan, Qianqian;
He, Mei

Publication type:

Letter

The return of RET GateKeeper mutations? an in-silico exploratory analysis of potential resistance mechanisms to novel RET macrocyclic inhibitor TPX-0046.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1133, doi. 10.1007/s10637-022-01259-x

By:

Repetto, Matteo;
Crimini, Edoardo;
Ascione, Liliana;
Boscolo Bielo, Luca;
Belli, Carmen;
Curigliano, Giuseppe

Publication type:

Article

ZL-n-91, a specific Phosphodiesterase-4 inhibitor, suppresses the growth of triple-negative breast cancer.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 875, doi. 10.1007/s10637-022-01258-y

By:

Liang, Longming;
Chen, Hansi;
Mao, Ping;
Li, Yuyu;
Xu, Lijun;
He, Yujie;
Mu, Yunping;
Zhao, Allan Z.;
Zhou, Sujin;
Zhao, Zhenggang;
Li, Fanghong

Publication type:

Article

Combination of TACE and Lenvatinib as a promising option for downstaging to surgery of initially unresectable intrahepatic cholangiocarcinoma.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1125, doi. 10.1007/s10637-022-01257-z

By:

Yuan, Peng;
Song, Jinhua;
Wang, Fei;
Zhu, Guangyu;
Chen, Baoan

Publication type:

Article

Targeting wild-type TP53 using AMG 232 in combination with MAPK inhibition in Metastatic Melanoma; a phase 1 study.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1051, doi. 10.1007/s10637-022-01253-3

By:

Moschos, Stergios J.;
Sandhu, Shahneen;
Lewis, Karl D.;
Sullivan, Ryan J.;
Puzanov, Igor;
Johnson, Douglas B.;
Henary, Haby A.;
Wong, Hansen;
Upreti, Vijay V.;
Long, Georgina V.;
Flaherty, Keith T.

Publication type:

Article

Effectiveness and safety of gemcitabine plus nab-paclitaxel in elderly patients with advanced pancreatic cancer: a single-center retrospective cohort study.

Published in:

Investigational New Drugs, 2022, v. 40, n. 5, p. 1106, doi. 10.1007/s10637-022-01221-x

By:

Ohwada, Sae;
Todaka, Akiko;
Nakase, Hiroshi;
Shirasu, Hiromichi;
Kawakami, Takeshi;
Hamauchi, Satoshi;
Tsushima, Takahiro;
Yokota, Tomoya;
Onozawa, Yusuke;
Yasui, Hirofumi;
Yamazaki, Kentaro

Publication type:

Article