Works matching IS 01676997 AND DT 2020 AND VI 38 AND IP 4

Results: 30

Matteucinol, isolated from Miconia chamissois, induces apoptosis in human glioblastoma lines via the intrinsic pathway and inhibits angiogenesis and tumor growth in vivo.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1044, doi. 10.1007/s10637-019-00878-1

By:

Silva, Ana Gabriela;
Silva, Viviane Aline O.;
Oliveira, Renato J. S.;
de Rezende, Allisson Rodrigues;
Chagas, Rafael César Russo;
Pimenta, Lúcia Pinheiro Santos;
Romão, Wanderson;
Santos, Hélio Batista;
Thomé, Ralph Gruppi;
Reis, Rui Manuel;
de Azambuja Ribeiro, Rosy Iara Maciel

Publication type:

Article

Phase I study of the mTOR inhibitor everolimus in combination with the histone deacetylase inhibitor panobinostat in patients with advanced clear cell renal cell carcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1108, doi. 10.1007/s10637-019-00864-7

By:

Wood, Anthony;
George, Saby;
Adra, Nabil;
Chintala, Sreenivasulu;
Damayanti, Nur;
Pili, Roberto

Publication type:

Article

Risk factors for cancer-associated thrombosis in patients undergoing treatment with immune checkpoint inhibitors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1200, doi. 10.1007/s10637-019-00881-6

By:

Ando, Yosuke;
Hayashi, Takahiro;
Sugimoto, Reiko;
Nishibe, Seira;
Ito, Kaori;
Kawada, Kenji;
Ikeda, Yoshiaki;
Yamada, Shigeki;
Imaizumi, Kazuyoshi

Publication type:

Article

Factors affecting symptom presentation in an early-phase clinical trials clinic patient population.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1166, doi. 10.1007/s10637-019-00879-0

By:

George, Goldy C.;
Mendoza, Tito R.;
Iwuanyanwu, Eucharia C.;
Manandhar, Meryna;
Afshar, Solmaz F.;
Piha-Paul, Sarina A.;
Tsimberidou, Apostolia;
Naing, Aung;
Cleeland, Charles S.;
Hong, David S.

Publication type:

Article

Therapeutic efficacy and imaging assessment of the HER2-targeting chemotherapy drug ZHER2:V2-pemetrexed in lung adenocarcinoma Xenografts.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1031, doi. 10.1007/s10637-019-00876-3

By:

Han, Jingya;
Zhao, Yan;
Zhao, Xinming;
Ma, Tuo;
Hao, Tiancheng;
Liu, Jiahui;
Zhang, Zhaoqi;
Zhang, Jingmian;
Wang, Jianfang

Publication type:

Article

A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1145, doi. 10.1007/s10637-019-00873-6

By:

Bendell, Johanna C.;
Bischoff, Helge G.;
Hwang, Jimmy;
Reinhardt, Hans Christian;
Zander, Thomas;
Wang, Xuejing;
Hynes, Scott;
Pitou, Celine;
Campbell, Robert;
Iversen, Philip;
Farrington, Daphne L.;
Bell-McGuinn, Katherine;
Thomas, Michael

Publication type:

Article

Epigallocatechin-3-gallate mouthwash protects mucosa from radiation-induced mucositis in head and neck cancer patients: a prospective, non-randomised, phase 1 trial.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1129, doi. 10.1007/s10637-019-00871-8

By:

Zhu, Wanqi;
Mei, Hui;
Jia, Li;
Zhao, Hanxi;
Li, Xiaolin;
Meng, Xiangjiao;
Zhao, Xianguang;
Xing, Ligang;
Yu, Jinming

Publication type:

Article

A phase 1 study of the MDM2 antagonist RO6839921, a pegylated prodrug of idasanutlin, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1156, doi. 10.1007/s10637-019-00869-2

By:

Abdul Razak, Albiruni R.;
Miller, Wilson H.;
Uy, Geoffrey L.;
Blotner, Steven;
Young, Anne-Marie;
Higgins, Brian;
Chen, Lin-Chi;
Gore, Lia

Publication type:

Article

Prolonged response to 177Lu-DOTATATE therapy of a bone marrow infiltration in a refractory thymic neuro endocrine tumor.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1196, doi. 10.1007/s10637-019-00865-6

By:

Cottereau, Anne Ségolène;
Bricaire, Léopoldine;
Arrondeau, Jennifer;
Dechmi, Amina;
Montravers, Françoise;
Coriat, Romain;
Clerc, Jerome;
Groussin, Lionel;
Tenenbaum, Florence

Publication type:

Article

A phase I study of vistusertib (dual mTORC1/2 inhibitor) in patients with previously treated glioblastoma multiforme: a CCTG study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1137, doi. 10.1007/s10637-019-00875-4

By:

Lapointe, Sarah;
Mason, Warren;
MacNeil, Mary;
Harlos, Craig;
Tsang, Roger;
Sederias, Joana;
Luchman, H. Artee;
Weiss, Samuel;
Rossiter, John P.;
Tu, Dongsheng;
Seymour, Lesley;
Smoragiewicz, Martin

Publication type:

Article

Naked antisense double-stranded DNA oligonucleotide efficiently suppresses BCR-ABL positive leukemic cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1012, doi. 10.1007/s10637-019-00862-9

By:

Hoshiko, Toshimi;
Kubota, Yasushi;
Akisawa, Takuya;
Watanabe, Tatsuro;
Tanigawara, Kazuaki;
Yano, Junichi;
Kimura, Shinya

Publication type:

Article

7-Chloroquinoline-1,2,3-triazoyl carboxamides induce cell cycle arrest and apoptosis in human bladder carcinoma cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1020, doi. 10.1007/s10637-019-00861-w

By:

Sonego, Mariana S.;
Segatto, Natália V.;
Damé, Lucas;
Fronza, Mariana;
Gomes, Carolina B.;
Oliveira, Thais Larré;
Seixas, Fabiana Kömmling;
Savegnago, Lucielli;
Schachtschneider, Kyle M.;
Alves, Diego;
Collares, Tiago

Publication type:

Article

Phase I study of TAS-115, a novel oral multi-kinase inhibitor, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1175, doi. 10.1007/s10637-019-00859-4

By:

Doi, Toshihiko;
Matsubara, Nobuaki;
Kawai, Akira;
Naka, Norifumi;
Takahashi, Shunji;
Uemura, Hiroji;
Yamamoto, Noboru

Publication type:

Article

Phase II study of apatinib, a novel tyrosine kinase inhibitor targeting tumor angiogenesis, as second-line treatment for recurrent or advanced cervical cancer patients.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1186, doi. 10.1007/s10637-019-00858-5

By:

Zhang, Linlin;
Chen, Liang;
Yu, Hao

Publication type:

Article

Osimertinib in a patient with non-small cell lung cancer and renal failure undergoing hemodialysis: a case report.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1192, doi. 10.1007/s10637-019-00851-y

By:

Matsunashi, Atsushi;
Fujimoto, Daichi;
Hosoya, Kazutaka;
Irie, Kei;
Fukushima, Shoji;
Tomii, Keisuke

Publication type:

Article

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1).

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1117, doi. 10.1007/s10637-019-00856-7

By:

van der Noll, Ruud;
Jager, Agnes;
Ang, Joo Ern;
Marchetti, Serena;
Mergui-Roelvink, Marja W. J.;
Lolkema, Martijn P.;
de Jonge, Maja J. A.;
van der Biessen, Diane A.;
Brunetto, Andre T.;
Arkenau, Hendrik-Tobias;
Tchakov, Ilian;
Beijnen, Jos H.;
de Bono, Johann S.;
Schellens, Jan H. M.

Publication type:

Article

Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1085, doi. 10.1007/s10637-019-00854-9

By:

Roosendaal, Jeroen;
Rosing, Hilde;
Lucas, Luc;
Gebretensae, Abadi;
Huitema, Alwin D. R.;
van Dongen, Marloes G.;
Beijnen, Jos H.;
Oganesian, Aram

Publication type:

Article

Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1003, doi. 10.1007/s10637-019-00853-w

By:

Sun, Jingjie;
Du, Yuping;
Zhang, Xinxin;
Wang, Zhuoya;
Lin, Yuxi;
Song, Qiaoling;
Wang, Xiao;
Guo, Jihui;
Li, Shanshan;
Nan, Jing;
Yang, Jinbo

Publication type:

Article

Radiosensitizing effects of trabectedin on human A549 lung cancer cells and HT-29 colon cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 967, doi. 10.1007/s10637-019-00852-x

By:

Manda, Katrin;
Präkelt, Tina;
Schröder, Tonja;
Kriesen, Stephan;
Hildebrandt, Guido

Publication type:

Article

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2).

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1096, doi. 10.1007/s10637-019-00857-6

By:

van der Noll, Ruud;
Jager, Agnes;
Ang, Joo Ern;
Marchetti, Serena;
Mergui-Roelvink, Marja W. J.;
de Bono, Johann S.;
Lolkema, Martijn P.;
de Jonge, Maja J. A.;
van der Biessen, Diane A.;
Brunetto, Andre T.;
Arkenau, Hendrik-Tobias;
Tchakov, Ilian;
Beijnen, Jos H.;
De Grève, Jacques;
Schellens, Jan H. M.

Publication type:

Article

A Phase 1 study of BAL101553, a novel tumor checkpoint controller targeting microtubules, administered as 48-h infusion in adult patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1067, doi. 10.1007/s10637-019-00850-z

By:

Joerger, Markus;
Stathis, Anastasios;
Metaxas, Yannis;
Hess, Dagmar;
Mantiero, Mara;
Mark, Michael;
Volden, Matthias;
Kaindl, Thomas;
Engelhardt, Marc;
Larger, Patrice;
Lane, Heidi;
Hafner, Peter;
Levy, Nicole;
Stuedeli, Silvia;
Sessa, Cristiana;
von Moos, Roger

Publication type:

Article

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 977, doi. 10.1007/s10637-019-00849-6

By:

Segat, Gabriela C.;
Moreira, Camila G.;
Santos, Evelyn C.;
Heller, Melina;
Schwanke, Raquel C.;
Aksenov, Alexander V.;
Aksenov, Nicolai A.;
Aksenov, Dmitrii A.;
Kornienko, Alexander;
Marcon, Rodrigo;
Calixto, João B.

Publication type:

Article

Benzothiazole derivative bearing amide moiety induces p53-mediated apoptosis in HPV16 positive cervical cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 934, doi. 10.1007/s10637-019-00848-7

By:

Modi, Arusha;
Singh, Meenakshi;
Gutti, Gopichand;
Shanker, Ozasvi R.;
Singh, Vinay Kumar;
Singh, Sunita;
Singh, Sushil Kumar;
Pradhan, Satyajit;
Narayan, Gopeshwar

Publication type:

Article

Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 946, doi. 10.1007/s10637-019-00847-8

By:

Hochmair, Maximilian;
Rath, Barbara;
Klameth, Lukas;
Ulsperger, Ernst;
Weinlinger, Christoph;
Fazekas, Andreas;
Plangger, Adelina;
Zeillinger, Robert;
Hamilton, Gerhard

Publication type:

Article

A phase I study of enfortumab vedotin in Japanese patients with locally advanced or metastatic urothelial carcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1056, doi. 10.1007/s10637-019-00844-x

By:

Takahashi, Shunji;
Uemura, Motohide;
Kimura, Tomokazu;
Kawasaki, Yoshihide;
Takamoto, Atsushi;
Yamaguchi, Akito;
Melhem-Bertrandt, Amal;
Gartner, Elaina M.;
Inoue, Takashi;
Akazawa, Rio;
Kadokura, Takeshi;
Tanikawa, Toshiki

Publication type:

Article

The tumor suppressor NDRG2 cooperates with an mTORC1 inhibitor to suppress the Warburg effect in renal cell carcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 956, doi. 10.1007/s10637-019-00839-8

By:

Li, Xi'an;
Hou, Guangdong;
Zhu, Zheng;
Yan, Fei;
Wang, Fuli;
Wei, Di;
Zheng, Yu;
Yuan, Jiarui;
Zheng, Wanxiang;
Zhang, Geng;
Meng, Ping;
Guo, Yan;
Li, Xia;
Yao, Libo;
Shen, Lan;
Yuan, Jianlin

Publication type:

Article

Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 990, doi. 10.1007/s10637-019-00838-9

By:

Wróbel, Agnieszka;
Kolesińska, Beata;
Frączyk, Justyna;
Kamiński, Zbigniew J.;
Tankiewicz-Kwedlo, Anna;
Hermanowicz, Justyna;
Czarnomysy, Robert;
Maliszewski, Dawid;
Drozdowska, Danuta

Publication type:

Article

Ibrutinib as a potential therapeutic option for HER2 overexpressing breast cancer – the role of STAT3 and p21.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 909, doi. 10.1007/s10637-019-00837-w

By:

Prabaharan, Chandra Bose;
Yang, Allan Boyao;
Chidambaram, Divya;
Rajamanickam, Karthic;
Napper, Scott;
Sakharkar, Meena Kishore

Publication type:

Article

Identification of HGF as a novel target of miR-15a/16/195 in gastric cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 922, doi. 10.1007/s10637-019-00834-z

By:

Liu, Dongying;
Zhang, Haiyang;
Ge, Shaohua;
Lin, Dan;
Han, Jiayi;
Ying, Guoguang;
Ba, Yi

Publication type:

Article

A phase Ib study of a PI3Kinase inhibitor BKM120 in combination with panitumumab in patients with KRAS wild-type advanced colorectal cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 4, p. 1077, doi. 10.1007/s10637-019-00814-3

By:

Goodwin, Rachel;
Jonker, Derek;
Chen, Eric;
Kennecke, Hagen;
Cabanero, Michael;
Tsao, Ming-Sound;
Vickers, Michael;
Bohemier, Caryn;
Lim, Howard;
Ritter, Heather;
Tu, Dongsheng;
Seymour, Lesley

Publication type:

Article