Works matching IS 01676997 AND DT 2019 AND VI 37 AND IP 4

Results: 25

Phase II study of avelumab in multiple relapsed/refractory germ cell cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 748, doi. 10.1007/s10637-019-00805-4

By:

Mego, M.;
Svetlovska, D.;
Chovanec, M.;
Rečkova, M.;
Rejlekova, K.;
Obertova, J.;
Palacka, P.;
Sycova-Mila, Z.;
De Giorgi, U.;
Mardiak, J.

Publication type:

Article

A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 755, doi. 10.1007/s10637-019-00797-1

By:

Xie, Hao;
Yin, Jun;
Shah, Manisha H.;
Menefee, Michael E.;
Bible, Keith C.;
Reidy-Lagunes, Diane;
Kane, Madeleine A.;
Quinn, David I.;
Gandara, David R.;
Erlichman, Charles;
Adjei, Alex A.

Publication type:

Article

A phase 2, open-label study of brentuximab vedotin in patients with CD30-expressing solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 738, doi. 10.1007/s10637-019-00768-6

By:

Sharman, Jeffrey P.;
Wheler, Jennifer J.;
Einhorn, Lawrence;
Dowlati, Afshin;
Shapiro, Geoffrey I.;
Hilton, John;
Burke, John M.;
Siddiqi, Tanya;
Whiting, Nancy;
Jalal, Shadia I.

Publication type:

Article

Correction to: Phase Ib/II study of gemcitabine, nab-paclitaxel, and pembrolizumab in metastatic pancreatic adenocarcinoma.

Published in:

2019

By:

Weiss, Glen J.;
Blaydorn, Lisa;
Beck, Julia;
Bornemann-Kolatzki, Kirsten;
Urnovitz, Howard;
Schütz, Ekkhard;
Khemka, Vivek

Publication type:

Correction Notice

Correction to: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-<sub>XL</sub>.

Published in:

2019

By:

Hwang, Jung Jin;
Kim, Yong Sook;
Kim, Taelim;
Kim, Mi Joung;
Jeong, In Gab;
Lee, Je-Hwan;
Choi, Jene;
Jang, Sejin;
Ro, Seonggu;
Kim, Choung-Soo

Publication type:

Correction Notice

Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1–ALK fusion: a case report.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 791, doi. 10.1007/s10637-019-00742-2

By:

Honda, Kazunori;
Kadowaki, Shigenori;
Kato, Kyoko;
Hanai, Nobuhiro;
Hasegawa, Yasuhisa;
Yatabe, Yasushi;
Muro, Kei

Publication type:

Article

An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 784, doi. 10.1007/s10637-019-00737-z

By:

Yan, Wang;
Xiangyu, Chen;
Ya, Li;
Yu, Wang;
Feng, Xu

Publication type:

Article

Apatinib, a novel VEGFR inhibitor plus docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR: a phase I trial.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 731, doi. 10.1007/s10637-019-00735-1

By:

Duan, Jian-Chun;
Wang, Zhi-Jie;
Lin, Lin;
Li, Jun-Ling;
Wang, Yan;
Bai, Hua;
Hu, Xing-Sheng;
Liu, Yu-Tao;
Hao, Xue-Zhi;
Wang, Hong-Yu;
Wan, Rui;
Wang, Xin;
Wang, Jie

Publication type:

Article

Inhibition of AKT signalling by benzoxazine derivative LTUR6 through the modulation of downstream kinases.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 779, doi. 10.1007/s10637-019-00726-2

By:

Suraj, Rejitha;
Al-Rawi, Jasim;
Bradley, Christopher

Publication type:

Article

A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 722, doi. 10.1007/s10637-018-0714-6

By:

Smith, David C.;
Chugh, Rashmi;
Patnaik, Amita;
Papadopoulos, Kyriakos P.;
Wang, Min;
Kapoun, Ann M.;
Xu, Lu;
Dupont, Jakob;
Stagg, Robert J.;
Tolcher, Anthony

Publication type:

Article

Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 771, doi. 10.1007/s10637-018-0711-9

By:

Viale, Maurizio;
Tosto, Rita;
Giglio, Valentina;
Pappalardo, Giuseppe;
Oliveri, Valentina;
Maric, Irena;
Mariggiò, Maria Addolorata;
Vecchio, Graziella

Publication type:

Article

Efficacy and safety of lanreotide in Korean patients with metastatic, well-differentiated gastroenteropancreatic-neuroendocrine tumors: a retrospective analysis.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 763, doi. 10.1007/s10637-018-0710-x

By:

Kang, Junho;
Yoo, Changhoon;
Hwang, Hee-Sang;
Hong, Seung-Mo;
Kim, Kyu-pyo;
Kim, Sun Young;
Hong, Yong-Sang;
Kim, Tae Won;
Ryoo, Baek-Yeol

Publication type:

Article

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 711, doi. 10.1007/s10637-018-0706-6

By:

Seitz, Lisa;
Jin, Lixia;
Leleti, Manmohan;
Ashok, Devika;
Jeffrey, Jenna;
Rieger, Aimee;
Tiessen, Renger G.;
Arold, Gerhard;
Tan, Joanne B. L.;
Powers, Jay P.;
Walters, Matthew J.;
Karakunnel, Joyson

Publication type:

Article

A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 684, doi. 10.1007/s10637-018-0703-9

By:

Mody, Kabir;
Mansfield, Aaron S.;
Vemireddy, Lalitha;
Nygren, Peter;
Gulbo, Joachim;
Borad, Mitesh

Publication type:

Article

E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 636, doi. 10.1007/s10637-018-0668-8

By:

Babiker, Hani M.;
Byron, Sara A.;
Hendricks, William P. D.;
Elmquist, William F.;
Gampa, Gautham;
Vondrak, Jessica;
Aldrich, Jessica;
Cuyugan, Lori;
Adkins, Jonathan;
De Luca, Valerie;
Tibes, Raoul;
Borad, Mitesh J.;
Marceau, Katie;
Myers, Thomas J.;
Paradiso, Linda J.;
Liang, Winnie S.;
Korn, Ronald L.;
Cridebring, Derek;
Von Hoff, Daniel D.;
Carpten, John D.

Publication type:

Article

Mass balance, routes of excretion, and pharmacokinetics of investigational oral [<sup>14</sup>C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 666, doi. 10.1007/s10637-018-0693-7

By:

Zhou, Xiaofei;
Pusalkar, Sandeepraj;
Chowdhury, Swapan K.;
Searle, Shawn;
Li, Yuexian;
Ullmann, Claudio Dansky;
Venkatakrishnan, Karthik

Publication type:

Article

A phase I study of the vascular endothelial growth factor inhibitor Vatalanib in combination with Pemetrexed disodium in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 658, doi. 10.1007/s10637-018-0690-x

By:

Wang, Fen;
Molina, Julian;
Satele, Daniel;
Yin, Jun;
Lim, Vun-Sin;
Adjei, Alex A.

Publication type:

Article

Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 693, doi. 10.1007/s10637-018-0688-4

By:

Leary, Alexandra;
Le Tourneau, Christophe;
Varga, Andrea;
Sablin, Marie-Paule;
Gomez-Roca, Carlos;
Guilbaud, Nicolas;
Petain, Aurelie;
Pavlyuk, Mariya;
Delord, Jean-Pierre

Publication type:

Article

First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 674, doi. 10.1007/s10637-018-0674-x

By:

Elez, Elena;
Gomez-Roca, Carlos;
Soto Matos-Pita, Arturo;
Argiles, Guillem;
Valentin, Thibaud;
Coronado, Cinthya;
Iglesias, Jorge;
Macarulla, Teresa;
Betrian, Sarah;
Fudio, Salvador;
Zaragoza, Katrin;
Tabernero, Josep;
Delord, Jean-Pierre

Publication type:

Article

A phase 1 trial of Vorinostat in combination with concurrent chemoradiation therapy in the treatment of advanced staged head and neck squamous cell carcinoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 702, doi. 10.1007/s10637-018-0696-4

By:

Teknos, Theodoros N.;
Grecula, J.;
Agrawal, A.;
Old, M. O.;
Ozer, E.;
Carrau, R.;
Kang, S.;
Rocco, J.;
Blakaj, D.;
Diavolitsis, V.;
Kumar, B.;
Kumar, P.;
Pan, Q.;
Palettas, M.;
Wei, L.;
Baiocchi, R.;
Savvides, P.

Publication type:

Article

Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 646, doi. 10.1007/s10637-018-0667-9

By:

Mei, Peng-jin;
Bai, Jin;
Miao, Fa-an;
Li, Zhong-lin;
Chen, Chen;
Zheng, Jun-nian;
Fan, Yue-chao

Publication type:

Article

CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 625, doi. 10.1007/s10637-018-0661-2

By:

Rahaman, Muhammed H.;
Yu, Yingyi;
Zhong, Longjin;
Adams, Julian;
Lam, Frankie;
Li, Peng;
Noll, Ben;
Milne, Robert;
Peng, Jun;
Wang, Shudong

Publication type:

Article

Hexane partition from Annona crassiflora Mart. promotes cytotoxity and apoptosis on human cervical cancer cell lines.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 602, doi. 10.1007/s10637-018-0657-y

By:

Silva, Viviane A. O.;
Alves, Ana Laura V.;
Rosa, Marcela N.;
Silva, Larissa R. V.;
Melendez, Matias E.;
Cury, Fernanda P.;
Gomes, Izabela N. F.;
Tansini, Aline;
Longato, Giovanna B.;
Martinho, Olga;
Oliveira, Bruno G.;
Pinto, Fernanda E.;
Romão, Wanderson;
Ribeiro, Rosy I. M. A.;
Reis, Rui M.

Publication type:

Article

Preclinical assessment of histone deacetylase inhibitor quisinostat as a therapeutic agent against esophageal squamous cell carcinoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 616, doi. 10.1007/s10637-018-0651-4

By:

Zhong, Lei;
Zhou, Shu;
Tong, Rongsheng;
Shi, Jianyou;
Bai, Lan;
Zhu, Yuxuan;
Duan, Xingmei;
Liu, Wenzhao;
Bao, Jinku;
Su, Lingyu;
Peng, Qian

Publication type:

Article

The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging.

Published in:

Investigational New Drugs, 2019, v. 37, n. 4, p. 595, doi. 10.1007/s10637-018-0644-3

By:

Albatany, Mohammed;
Meakin, Susan;
Bartha, Robert

Publication type:

Article