Works matching IS 01676997 AND DT 2019 AND VI 37 AND IP 2

Results: 22

IMRT combined with S-1 concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a prospective phase II study.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 352, doi. 10.1007/s10637-018-00720-0

By:

Lv, Tao;
Wang, Yujie;
Ou, Dan;
Liu, Peiyao;
Qin, Songbing;
Liu, Lidan;
Lou, Pengrong;
Wang, Xiaoshen

Publication type:

Article

Efficacy and safety of the combination of metformin, everolimus and exemestane in overweight and obese postmenopausal patients with metastatic, hormone receptor-positive, HER2-negative breast cancer: a phase II study.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 345, doi. 10.1007/s10637-018-0700-z

By:

Yam, Clinton;
Esteva, Francisco J.;
Patel, Miral M.;
Raghavendra, Akshara S.;
Ueno, Naoto T.;
Moulder, Stacy L.;
Hess, Kenneth R.;
Shroff, Girish S.;
Hodge, Silvia;
Koenig, Kimberly H.;
Chavez Mac Gregor, Mariana;
Griner, Robin L.;
Yeung, Sai-Ching J.;
Hortobagyi, Gabriel N.;
Valero, Vicente

Publication type:

Article

Pazopanib with low fat meal (PALM) in advanced renal cell carcinoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 323, doi. 10.1007/s10637-018-0692-8

By:

Reimers, Melissa A.;
Shango, Maryann M.;
Daignault-Newton, Stephanie;
Dedinsky, Rachel;
Karsies, Danielle;
Kraft, Shawna;
Riddle, Liam;
Felton, Jeremy A.;
Wen, Bo;
Gersch, Christina;
Rae, James M.;
Redman, Bruce G.;
Alva, Ajjai S.

Publication type:

Article

A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 338, doi. 10.1007/s10637-018-0691-9

By:

Saito, Kei;
Isayama, Hiroyuki;
Nakai, Yousuke;
Takahara, Naminatsu;
Ishigaki, Kazunaga;
Takeda, Tsuyoshi;
Hakuta, Ryunosuke;
Saito, Tomotaka;
Uchino, Rie;
Kishikawa, Takahiro;
Hamada, Tsuyoshi;
Mizuno, Suguru;
Sasaki, Takashi;
Kogure, Hirofumi;
Matsubara, Saburo;
Yamamoto, Natsuyo;
Ijichi, Hideaki;
Tateishi, Keisuke;
Tada, Minoru;
Koike, Kazuhiko

Publication type:

Article

Phase I/II study evaluating the safety and clinical efficacy of temsirolimus and bevacizumab in patients with chemotherapy refractory metastatic castration-resistant prostate cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 331, doi. 10.1007/s10637-018-0687-5

By:

Barata, Pedro C.;
Cooney, Matthew;
Mendiratta, Prateek;
Gupta, Ruby;
Dreicer, Robert;
Garcia, Jorge A.

Publication type:

Article

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 378, doi. 10.1007/s10637-018-0666-x

By:

Oppegard, Lisa M.;
Delgado, Justine L.;
Kulkarni, Chaitanya A.;
Towle, Tyrell R.;
Hart, Delaney E.;
Williams, Bridget P.;
Lentz, Sarah R. C.;
Norris, Beverly J.;
Flory, Craig M.;
Schumacher, Robert J.;
Murry, Daryl J.;
Kerns, Robert J.;
Hiasa, Hiroshi

Publication type:

Article

Identification of differentially expressed genes and signaling pathways using bioinformatics in interstitial lung disease due to tyrosine kinase inhibitors targeting the epidermal growth factor receptor.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 384, doi. 10.1007/s10637-018-0664-z

By:

Lu, Yuan;
Li, Ang;
Lai, Xiaofeng;
Jiang, Jun;
Zhang, Lihong;
Zhong, Zhicheng;
Zhao, Wen;
Tang, Ping;
Zhao, Hu;
Ren, Xinling

Publication type:

Article

Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 315, doi. 10.1007/s10637-018-0663-0

By:

Goff, Laura W.;
Azad, Nilofer S.;
Stein, Stacey;
Whisenant, Jennifer G.;
Koyama, Tatsuki;
Vaishampayan, Ulka;
Hochster, Howard;
Connolly, Roisin;
Weise, Amy;
LoRusso, Patricia M.;
Salaria, Safia N.;
El-Rifai, Wael;
Berlin, Jordan D.

Publication type:

Article

A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 307, doi. 10.1007/s10637-018-0662-1

By:

Jazieh, Khalid;
Molina, Julian;
Allred, Jacob;
Yin, Jun;
Reid, Joel;
Goetz, Matthew;
Lim, Vun-Sin;
Kaufmann, Scott H.;
Adjei, Alex

Publication type:

Article

Long-term adverse event: inflammatory orbitopathy induced by pembrolizumab in a patient with metastatic melanoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 375, doi. 10.1007/s10637-018-0659-9

By:

Nardin, Charlée;
Borot, Sophie;
Beaudoin, Marie-Astride;
Cattin, Françoise;
Puzenat, Eve;
Gauthier, Anne-Sophie;
Schillo, Franck;
Borg, Christophe;
Aubin, François

Publication type:

Article

Phase I study of S-1 plus paclitaxel combination therapy as a first-line treatment in elderly patients with advanced non-small cell lung cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 291, doi. 10.1007/s10637-018-0656-z

By:

Chihara, Yusuke;
Date, Koji;
Takemura, Yoshizumi;
Tamiya, Nobuyo;
Kohno, Yoshihito;
Imabayashi, Tatsuya;
Kaneko, Yoshiko;
Yamada, Tadaaki;
Ueda, Mikio;
Arimoto, Taichiro;
Uchino, Junji;
Iwasaki, Yoshinobu;
Takayama, Koichi

Publication type:

Article

A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 297, doi. 10.1007/s10637-018-0655-0

By:

Phillips, Tycel;
Barr, Paul M.;
Park, Steven I.;
Kolibaba, Kathryn;
Caimi, Paolo F.;
Chhabra, Saurabh;
Kingsley, Edwin C.;
Boyd, Thomas;
Chen, Robert;
Carret, Anne-Sophie;
Gartner, Elaina M.;
Li, Hong;
Yu, Cindy;
Smith, David C.

Publication type:

Article

Sarcoid-like reaction mimicking disease progression in an ALK-positive lung cancer patient receiving lorlatinib.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 360, doi. 10.1007/s10637-018-0652-3

By:

Facchinetti, Francesco;
Gnetti, Letizia;
Balestra, Valeria;
Silva, Mario;
Silini, Enrico Maria;
Ventura, Luigi;
Majori, Maria;
Bordi, Paola;
Tiseo, Marcello

Publication type:

Article

A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 282, doi. 10.1007/s10637-018-0648-z

By:

Kelly, Ciara M.;
Shoushtari, Alexander N.;
Qin, Li-Xuan;
D'Angelo, Sandra P.;
Dickson, Mark A.;
Gounder, Mrinal M.;
Keohan, Mary Louise;
Mcfadyen, Chloe;
Sjoberg, Ana;
Singer, Samuel;
DeMatteo, Ronald P.;
Hwang, Sinchun;
Heinemann, M. H.;
Francis, Jasmine H.;
Antonescu, Cristina R.;
Chi, Ping;
Tap, William D.

Publication type:

Article

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 364, doi. 10.1007/s10637-018-0647-0

By:

Cai, Weijing;
Ratnayake, Ranjala;
Gerber, Michael H.;
Chen, Qi-Yin;
Yu, Yichao;
Derendorf, Hartmut;
Trevino, Jose G.;
Luesch, Hendrik

Publication type:

Article

The marine natural product Scalarin inhibits the receptor for advanced glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 262, doi. 10.1007/s10637-018-0635-4

By:

Guzmán, Esther Amalia;
Pitts, Tara Peterson;
Diaz, Maria Cristina;
Wright, Amy Elizabeth

Publication type:

Article

Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 271, doi. 10.1007/s10637-018-0627-4

By:

Harding, James J.;
Bauer, Todd M.;
Tan, Daniel S. W.;
Bedard, Philippe L.;
Rodon, Jordi;
Doi, Toshihiko;
Schnell, Christian;
Iyer, Varsha;
Baffert, Fabienne;
Radhakrishnan, Rajkumar;
Fabre, Claire;
Juric, Dejan

Publication type:

Article

Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 252, doi. 10.1007/s10637-018-0626-5

By:

Vazhappilly, Cijo George;
Saleh, Ekram;
Ramadan, Wafaa;
Menon, Varsha;
Al-Azawi, Aya Mudhafar;
Tarazi, Hamadeh;
Abdu-Allah, Hajjaj;
El-Shorbagi, Abdel-Nasser;
El-Awady, Raafat

Publication type:

Article

Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 210, doi. 10.1007/s10637-018-0623-8

By:

Takimoto-Shimomura, Tomoko;
Tsukamoto, Taku;
Maegawa, Saori;
Fujibayashi, Yuto;
Matsumura-Kimoto, Yayoi;
Mizuno, Yoshimi;
Chinen, Yoshiaki;
Shimura, Yuji;
Mizutani, Shinsuke;
Horiike, Shigeo;
Taniwaki, Masafumi;
Kobayashi, Tsutomu;
Kuroda, Junya

Publication type:

Article

Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc<sup>Min/+</sup> mouse model of colon carcinogenesis.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 238, doi. 10.1007/s10637-018-0622-9

By:

Huderson, Ashley C.;
Rekha Devi, P. V.;
Niaz, Mohammad S.;
Adunyah, Samuel E.;
Ramesh, Aramandla

Publication type:

Article

Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 223, doi. 10.1007/s10637-018-0620-y

By:

Silva, Viviane A. O.;
Rosa, Marcela N.;
Miranda-Gonçalves, Vera;
Costa, Angela M.;
Tansini, Aline;
Evangelista, Adriane F.;
Martinho, Olga;
Carloni, Adriana C.;
Jones, Chris;
Lima, João Paulo;
Pianowski, Luiz F.;
Reis, Rui Manuel

Publication type:

Article

Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.

Published in:

Investigational New Drugs, 2019, v. 37, n. 2, p. 201, doi. 10.1007/s10637-018-0619-4

By:

Pokrovsky, V. S.;
Yu Anisimova, N.;
Zh Davydov, D.;
Bazhenov, S. V.;
Bulushova, N. V.;
Zavilgelsky, G. B.;
Kotova, V. Y.;
Manukhov, I. V.

Publication type:

Article