Works matching IS 01676997 AND DT 2015 AND VI 33 AND IP 5

Results: 19

A phase I/Ib study of trametinib (GSK1120212) alone and in combination with gemcitabine in Japanese patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1058, doi. 10.1007/s10637-015-0270-2

By:

Kasuga, Akiyoshi;
Nakagawa, Kazuhiko;
Nagashima, Fumio;
Shimizu, Toshio;
Naruge, Daisuke;
Nishina, Shinichi;
Kitamura, Hiroshi;
Kurata, Takayasu;
Takasu, Atsuko;
Fujisaka, Yasuhito;
Okamoto, Wataru;
Nishimura, Yuichiro;
Mukaiyama, Akihira;
Matsushita, Hideki;
Furuse, Junji

Publication type:

Article

First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1048, doi. 10.1007/s10637-015-0262-2

By:

Kim, Kyu-pyo;
Park, Seong;
Kim, Jeong-Eun;
Hong, Yong;
Lee, Jae-Lyun;
Bae, Kyun-Seop;
Cha, Hyunju;
Kwon, Sool-Ki;
Ro, Seonggu;
Cho, JoongMyung;
Kim, Tae

Publication type:

Article

P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1012, doi. 10.1007/s10637-015-0266-y

By:

Gooijer, Mark;
Zhang, Ping;
Thota, Nishita;
Mayayo-Peralta, Isabel;
Buil, Levi;
Beijnen, Jos;
Tellingen, Olaf

Publication type:

Article

Topotecan plus cyclophosphamide in adults with relapsed or refractory pediatric-type sarcoma: a retrospective analysis from the German Sarcoma Medical Oncology Group (AIO).

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1115, doi. 10.1007/s10637-015-0267-x

By:

Hartmann, Jörg;
Issels, R.;
Nicolo, K.;
Grünwald, V.;
Hertenstein, B.;
Papesch, E.;
Krause, S.;
Sturm, I.

Publication type:

Article

Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1108, doi. 10.1007/s10637-015-0269-8

By:

Tolaney, Sara;
Tan, Sally;
Guo, Hao;
Barry, William;
Allen, Eliezer;
Wagle, Nikhil;
Brock, Jane;
Larrabee, Katherine;
Paweletz, Cloud;
Ivanova, Elena;
Janne, Pasi;
Overmoyer, Beth;
Wright, John;
Shapiro, Geoffrey;
Winer, Eric;
Krop, Ian

Publication type:

Article

Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1040, doi. 10.1007/s10637-015-0261-3

By:

Zibelman, Matthew;
Wong, Yu-Ning;
Devarajan, Karthik;
Malizzia, Lois;
Corrigan, Alycia;
Olszanski, Anthony;
Denlinger, Crystal;
Roethke, Susan;
Tetzlaff, Colleen;
Plimack, Elizabeth

Publication type:

Article

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1068, doi. 10.1007/s10637-015-0271-1

By:

Doi, Toshihiko;
Yoshino, Takayuki;
Fuse, Nozomu;
Boku, Narikazu;
Yamazaki, Kentaro;
Koizumi, Wasaburo;
Shimada, Ken;
Takinishi, Yasutaka;
Ohtsu, Atsushi

Publication type:

Article

Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1078, doi. 10.1007/s10637-015-0272-0

By:

Gustavsson, Bengt;
Carlsson, Göran;
Swartling, Torbjörn;
Kurlberg, Göran;
Derwinger, Kristoffer;
Björkqvist, Hillevi;
Odin, Elisabeth;
Gibson, Fernando

Publication type:

Article

Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1086, doi. 10.1007/s10637-015-0273-z

By:

Cercek, Andrea;
Wheler, Jennifer;
Murray, Peter;
Zhou, Shawn;
Saltz, Leonard

Publication type:

Article

Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1123, doi. 10.1007/s10637-015-0274-y

By:

Koubkova, Lucie;
Vyzula, Rostislav;
Karban, Jindrich;
Pinkas, Jiri;
Ondrouskova, Eva;
Vojtesek, Borivoj;
Hrstka, Roman

Publication type:

Article

Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1020, doi. 10.1007/s10637-015-0275-x

By:

Roy, Laurent-Olivier;
Poirier, Marie-Belle;
Fortin, David

Publication type:

Article

Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1032, doi. 10.1007/s10637-015-0276-9

By:

Studzian, Kazimierz;
Kik, Krzysztof;
Lukawska, Malgorzata;
Oszczapowicz, Irena;
Strek, Malgorzata;
Szmigiero, Leszek

Publication type:

Article

Phase I trial of combination of FOLFIRI and pasireotide, a somatostatin analogue, in advanced gastrointestinal malignancies.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1093, doi. 10.1007/s10637-015-0277-8

By:

Mahipal, Amit;
Shibata, Dave;
Siegel, Erin;
Springett, Gregory;
Almhanna, Khaldoun;
Fulp, William;
Williams-Elson, Irene;
Kim, Richard

Publication type:

Article

Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1003, doi. 10.1007/s10637-015-0259-x

By:

Heuvel, John;
Thompson, Jerry;
Albrecht, Prajakta;
Mandetta, Donald;
Kamerow, Harry;
Ford, John

Publication type:

Article

BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1136, doi. 10.1007/s10637-015-0280-0

By:

Protsenko, Svetlana;
Semionova, Anna;
Komarov, Yuri;
Aleksakhina, Svetlana;
Ivantsov, Alexandr;
Iyevleva, Aglaya;
Imyanitov, Evgeny

Publication type:

Article

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1100, doi. 10.1007/s10637-015-0282-y

By:

Jones, Suzanne;
Siu, Lillian;
Bendell, Johanna;
Cleary, James;
Razak, Albiruni;
Infante, Jeffrey;
Pandya, Shuchi;
Bedard, Philippe;
Pierce, Kristen;
Houk, Brett;
Roberts, W.;
Shreeve, S.;
Shapiro, Geoffrey

Publication type:

Article

Long term exposure to antiangiogenic therapy, bevacizumab, induces osteonecrosis.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1144, doi. 10.1007/s10637-015-0283-x

By:

Tabouret, Tessa;
Gregory, Thomas;
Dhooge, Marion;
Brezault, Catherine;
Mir, Olivier;
Dréanic, Johann;
Chaussade, Stanislas;
Coriat, Romain

Publication type:

Article

Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement-positive non-small cell lung cancer treated with alectinib.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1148, doi. 10.1007/s10637-015-0284-9

By:

Yamamoto, Yuzo;
Okamoto, Isamu;
Otsubo, Kohei;
Iwama, Eiji;
Hamada, Naoki;
Harada, Taishi;
Takayama, Koichi;
Nakanishi, Yoichi

Publication type:

Article

Ulcerative colitis in a patient with non-small-cell lung cancer receiving bevacizumab.

Published in:

Investigational New Drugs, 2015, v. 33, n. 5, p. 1133, doi. 10.1007/s10637-015-0279-6

By:

Tanaka, Midori;
Ishii, Hidenobu;
Azuma, Koichi;
Saisho, Chika;
Matsuo, Norikazu;
Imamura, Yohei;
Tokito, Takaaki;
Kinoshita, Takashi;
Yamada, Kazuhiko;
Takedatsu, Hidetoshi;
Mitsuyama, Keiichi;
Hoshino, Tomoaki

Publication type:

Article