Works matching IS 01676997 AND DT 2014 AND VI 32 AND IP 5

Results: 29

A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations.

Published in:

2014

By:

Plimack, E.;
Desai, J.;
Issa, J.;
Jelinek, J.;
Sharma, P.;
Vence, L.;
Bassett, R.;
Ilagan, J.;
Papadopoulos, N.;
Hwu, W.

Publication type:

Journal Article

In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3)

Published in:

2014

By:

Kikuchi, Aya;
Furutani, Takashi;
Azami, Hidenori;
Watanabe, Kazushi;
Niimi, Tatsuya;
Kamiyama, Yoshiteru;
Kuromitsu, Sadao;
Baskin-Bey, Edwina;
Heeringa, Marten;
Ouatas, Taoufik;
Enjo, Kentaro

Publication type:

Journal Article

Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 995, doi. 10.1007/s10637-014-0101-x

By:

Loriot, Yohann;
Fizazi, Karim;
Jones, Robert;
Brande, Jan;
Molife, Rhoda;
Omlin, Aurelius;
James, Nicholas;
Baskin-Bey, Edwina;
Heeringa, Marten;
Baron, Benoit;
Holtkamp, Gertjan;
Ouatas, Taoufik;
Bono, Johann

Publication type:

Article

Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 795, doi. 10.1007/s10637-014-0102-9

By:

Chien, Wei-Wen;
Allas, Soraya;
Rachinel, Nicolas;
Sahakian, Pierre;
Julien, Michel;
Le Beux, Céline;
Lacroix, Claire-Emmanuelle;
Abribat, Thierry;
Salles, Gilles

Publication type:

Article

Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 913, doi. 10.1007/s10637-014-0103-8

By:

Hasselt, J.;
Schellens, Jan;
Beijnen, Jos;
Huitema, Alwin

Publication type:

Article

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 806, doi. 10.1007/s10637-014-0105-6

By:

Wong, Charng;
Periasamy, Nagarajan;
Sagineedu, Sreenivasa;
Sidik, Shiran;
Sumon, Shariful;
Loadman, Paul;
Phillips, Roger;
Lajis, Nordin;
Stanslas, Johnson

Publication type:

Article

A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 1005, doi. 10.1007/s10637-014-0106-5

By:

Spreafico, Anna;
Chi, Kim;
Sridhar, Srikala;
Smith, David;
Carducci, Michael;
Kavsak, Peter;
Wong, Tracy;
Wang, Lisa;
Ivy, S.;
Mukherjee, Som;
Kollmannsberger, Christian;
Sukhai, Mahadeo;
Takebe, Naoko;
Kamel-Reid, Suzanne;
Siu, Lillian;
Hotte, Sebastien

Publication type:

Article

The novel kinase inhibitor EMD1214063 is effective against neuroblastoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 815, doi. 10.1007/s10637-014-0107-4

By:

Scorsone, Kathy;
Zhang, Linna;
Woodfield, Sarah;
Hicks, John;
Zage, Peter

Publication type:

Article

Phase I study on the safety, pharmacokinetic profile, and efficacy of the combination of TSU-68, an oral antiangiogenic agent, and S-1 in patients with advanced hepatocellular carcinoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 928, doi. 10.1007/s10637-014-0109-2

By:

Ikeda, Masafumi;
Shiina, Shuichiro;
Nakachi, Kohei;
Mitsunaga, Shuichi;
Shimizu, Satoshi;
Kojima, Yasushi;
Ueno, Hideki;
Morizane, Chigusa;
Kondo, Shunsuke;
Sakamoto, Yasunari;
Asaoka, Yoshinari;
Tateishi, Ryosuke;
Koike, Kazuhiko;
Arioka, Hitoshi;
Okusaka, Takuji

Publication type:

Article

A phase I clinical trial of navitoclax, a targeted high-affinity Bcl-2 family inhibitor, in combination with gemcitabine in patients with solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 937, doi. 10.1007/s10637-014-0110-9

By:

Cleary, James;
Lima, Caio;
Hurwitz, Herbert;
Montero, Alberto;
Franklin, Catherine;
Yang, Jianning;
Graham, Alison;
Busman, Todd;
Mabry, Mack;
Holen, Kyle;
Shapiro, Geoffrey;
Uronis, Hope

Publication type:

Article

Phase II trial of bortezomib plus doxorubicin in hepatocellular carcinoma (E6202): a trial of the Eastern Cooperative Oncology Group.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 1017, doi. 10.1007/s10637-014-0111-8

By:

Ciombor, Kristen;
Feng, Yang;
Benson, Al;
Su, Yingjun;
Horton, Linda;
Short, Sarah;
Kauh, John;
Staley, Charles;
Mulcahy, Mary;
Powell, Mark;
Amiri, Katayoun;
Richmond, Ann;
Berlin, Jordan

Publication type:

Article

Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: Phase I study in Japanese patients with advanced solid malignancies and advanced breast cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 946, doi. 10.1007/s10637-014-0112-7

By:

Kurata, Takayasu;
Tsurutani, Junji;
Fujisaka, Yasuhito;
Okamoto, Wataru;
Hayashi, Hidetoshi;
Kawakami, Hisato;
Shin, Eisei;
Hayashi, Nobuya;
Nakagawa, Kazuhiko

Publication type:

Article

Atypical reversible posterior leukoencephalopathy syndrome (RPLS) induced by cediranib in a patient with metastatic rectal cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 1036, doi. 10.1007/s10637-014-0113-6

By:

Kim, Christina;
Price-Hiller, Julie;
Chu, Quincy;
Tankel, Keith;
Hennig, Ron;
Sawyer, Michael;
Spratlin, Jennifer

Publication type:

Article

Preclinical analyses and phase I evaluation of LY2603618 administered in combination with Pemetrexed and cisplatin in patients with advanced cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 955, doi. 10.1007/s10637-014-0114-5

By:

Calvo, Emiliano;
Chen, Victor;
Marshall, Mark;
Ohnmacht, Ute;
Hynes, Scott;
Kumm, Elizabeth;
Diaz, H.;
Barnard, Darlene;
Merzoug, Farhana;
Huber, Lysiane;
Kays, Lisa;
Iversen, Philip;
Calles, Antonio;
Voss, Beatrice;
Lin, Aimee;
Dickgreber, Nicolas;
Wehler, Thomas;
Sebastian, Martin

Publication type:

Article

A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 969, doi. 10.1007/s10637-014-0115-4

By:

Plimack, E.;
Desai, J.;
Issa, J.;
Jelinek, J.;
Sharma, P.;
Vence, L.;
Bassett, R.;
Ilagan, J.;
Papadopoulos, N.;
Hwu, W.

Publication type:

Article

A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 976, doi. 10.1007/s10637-014-0116-3

By:

Vlahovic, Gordana;
Karantza, Vassiliki;
Wang, Ding;
Cosgrove, David;
Rudersdorf, Nikita;
Yang, Jianning;
Xiong, Hao;
Busman, Todd;
Mabry, Mack

Publication type:

Article

Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 985, doi. 10.1007/s10637-014-0118-1

By:

Chalret du Rieu, Quentin;
Fouliard, Sylvain;
White-Koning, Mélanie;
Kloos, Ioana;
Chatelut, Etienne;
Chenel, Marylore

Publication type:

Article

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 825, doi. 10.1007/s10637-014-0120-7

By:

Gelbert, Lawrence;
Cai, Shufen;
Lin, Xi;
Sanchez-Martinez, Concepcion;
Prado, Miriam;
Lallena, Maria;
Torres, Raquel;
Ajamie, Rose;
Wishart, Graham;
Flack, Robert;
Neubauer, Blake;
Young, Jamie;
Chan, Edward;
Iversen, Philip;
Cronier, Damien;
Kreklau, Emiko;
Dios, Alfonso

Publication type:

Article

Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 838, doi. 10.1007/s10637-014-0126-1

By:

Raja, Vijay;
Lim, Kuan-Hon;
Leong, Chee-Onn;
Kam, Toh-Seok;
Bradshaw, Tracey

Publication type:

Article

Effects of the combination of TRC105 and bevacizumab on endothelial cell biology.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 851, doi. 10.1007/s10637-014-0129-y

By:

Liu, Yingmiao;
Tian, Hongyu;
Blobe, Gerard;
Theuer, Charles;
Hurwitz, Herbert;
Nixon, Andrew

Publication type:

Article

In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 860, doi. 10.1007/s10637-014-0130-5

By:

Kikuchi, Aya;
Furutani, Takashi;
Azami, Hidenori;
Watanabe, Kazushi;
Niimi, Tatsuya;
Kamiyama, Yoshiteru;
Kuromitsu, Sadao;
Baskin-Bey, Edwina;
Heeringa, Marten;
Ouatas, Taoufik;
Enjo, Kentaro

Publication type:

Article

Growth hormone-releasing hormone antagonists abolish the transactivation of human epidermal growth factor receptors in advanced prostate cancer models.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 871, doi. 10.1007/s10637-014-0131-4

By:

Muñoz-Moreno, Laura;
Arenas, M.;
Carmena, M.;
Schally, Andrew;
Prieto, Juan;
Bajo, Ana

Publication type:

Article

Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 883, doi. 10.1007/s10637-014-0132-3

By:

Leblond, Pierre;
Boulet, Elodie;
Bal-Mahieu, Christine;
Pillon, Arnaud;
Kruczynski, Anna;
Guilbaud, Nicolas;
Bailly, Christian;
Sarrazin, Thierry;
Lartigau, Eric;
Lansiaux, Amélie;
Meignan, Samuel

Publication type:

Article

The use of everolimus to reverse tamoxifen resistance in men with metastatic breast cancer: a case report.

Published in:

2014

By:

Kattan, Joseph;
Kourie, Hampig

Publication type:

Report

Resistance mechanisms of cancer cells to the novel vacuolar H-ATPase inhibitor archazolid B.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 893, doi. 10.1007/s10637-014-0134-1

By:

Hamm, Rebecca;
Sugimoto, Yoshikazu;
Steinmetz, Heinrich;
Efferth, Thomas

Publication type:

Article

Rituximab for treating CD20+ prostate cancer with generalized lymphadenopathy: a case report and review of the literature.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 1048, doi. 10.1007/s10637-014-0063-z

By:

Dalgleish, Angus;
Featherstone, Peter;
Vlassov, Viatcheslav;
Rogosnitzky, Moshe

Publication type:

Article

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 783, doi. 10.1007/s10637-014-0090-9

By:

Izetti, Patricia;
Hautefeuille, Agnes;
Abujamra, Ana;
Farias, Caroline;
Giacomazzi, Juliana;
Alemar, Bárbara;
Lenz, Guido;
Roesler, Rafael;
Schwartsmann, Gilberto;
Osvaldt, Alessandro;
Hainaut, Pierre;
Ashton-Prolla, Patricia

Publication type:

Article

Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 904, doi. 10.1007/s10637-014-0099-0

By:

Hussain, Maha;
Carducci, Michael;
Slovin, Susan;
Cetnar, Jeremy;
Qian, Jiang;
McKeegan, Evelyn;
Refici-Buhr, Marion;
Chyla, Brenda;
Shepherd, Stacie;
Giranda, Vincent;
Alumkal, Joshi

Publication type:

Article

Gemcitabine and oxaliplatin chemotherapy for advanced hepatocellular carcinoma after failure of anti-angiogenic therapies.

Published in:

Investigational New Drugs, 2014, v. 32, n. 5, p. 1028, doi. 10.1007/s10637-014-0100-y

By:

Patrikidou, Anna;
Sinapi, Isabelle;
Regnault, Hélène;
Fayard, Florence;
Bouattour, Mohamed;
Fartoux, Laetitia;
Faivre, Sandrine;
Malka, David;
Ducreux, Michel;
Boige, Valerie

Publication type:

Article