Works matching IS 01676997 AND DT 2014 AND VI 32 AND IP 4

Results: 27

Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors.

Published in:

2014

By:

Salazar, Ramón;
Calles, Antonio;
Gil, Marta;
Durán, Ignacio;
García, Margarita;
Hidalgo, Manuel;
Coronado, Cinthya;
Alfaro, Vicente;
Siguero, Mariano;
Fernández-Teruel, Carlos;
Prados, Raquel;
Calvo, Emiliano

Publication type:

Journal Article

A phase I/II trial of capecitabine combined with peginterferon α-2a in Patients with sorafenib-refractory advanced hepatocellular carcinoma.

Published in:

2014

By:

Ogasawara, Sadahisa;
Chiba, Tetsuhiro;
Ooka, Yoshihiko;
Kanogawa, Naoya;
Motoyama, Tenyu;
Suzuki, Eiichiro;
Tawada, Akinobu;
Kanai, Fumihiko;
Yokosuka, and

Publication type:

Journal Article

A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naïve castration-resistant prostate cancer.

Published in:

2014

By:

Azad, Arun;
Beardsley, Emma;
Hotte, Sebastian;
Ellard, Susan;
Klotz, Lawrence;
Chin, Joseph;
Kollmannsberger, Christian;
Mukherjee, Som;
Chi, Kim

Publication type:

Journal Article

The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein-a well-known, yet poorly understood drug transporter.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 618, doi. 10.1007/s10637-014-0098-1

By:

Zeino, Maen;
Saeed, Mohamed;
Kadioglu, Onat;
Efferth, Thomas

Publication type:

Article

Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 644, doi. 10.1007/s10637-014-0072-y

By:

Salazar, Ramón;
Calles, Antonio;
Gil, Marta;
Durán, Ignacio;
García, Margarita;
Hidalgo, Manuel;
Coronado, Cinthya;
Alfaro, Vicente;
Siguero, Mariano;
Fernández-Teruel, Carlos;
Prados, Raquel;
Calvo, Emiliano

Publication type:

Article

Combination of docetaxel and TSU-68, an oral antiangiogenic agent, in patients with metastatic breast cancer previously treated with anthracycline: Randomized phase II multicenter trial.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 753, doi. 10.1007/s10637-014-0093-6

By:

Kim, Sung-Bae;
Yoo, Changhoon;
Ro, Jungsil;
Im, Seock-Ah;
Im, Young-Hyuck;
Kim, Jee;
Ahn, Jin-Hee;
Jung, Kyung;
Song, Hong;
Kang, Seok;
Park, Hee;
Chung, Hyun-Cheol

Publication type:

Article

Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 604, doi. 10.1007/s10637-014-0084-7

By:

Grogan, Patrick;
Sarkaria, Jann;
Timmermann, Barbara;
Cohen, Mark

Publication type:

Article

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 670, doi. 10.1007/s10637-014-0082-9

By:

Rodon, Jordi;
Braña, Irene;
Siu, Lillian;
Jonge, Maja;
Homji, Natasha;
Mills, David;
Tomaso, Emmanuelle;
Sarr, Celine;
Trandafir, Lucia;
Massacesi, Cristian;
Eskens, Ferry;
Bendell, Johanna

Publication type:

Article

The combination of RAF265, SB590885, ZSTK474 on thyroid cancer cell lines deeply impact on proliferation and MAPK and PI3K/Akt signaling pathways.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 626, doi. 10.1007/s10637-014-0108-3

By:

Barollo, Susi;
Bertazza, Loris;
Baldini, Enke;
Ulisse, Salvatore;
Cavedon, Elisabetta;
Boscaro, Marco;
Pezzani, Raffaele;
Mian, Caterina

Publication type:

Article

Evaluation of a novel blood pressure scoring method and its association with clinical response in cancer patients treated with anti-vascular endothelial growth factor therapy.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 717, doi. 10.1007/s10637-014-0104-7

By:

Bilen, Mehmet;
Durand, Jean-Bernard;
McQuinn, Lacey;
Hess, Kenneth;
Fu, Siqing;
Falchook, Gerald;
Hong, David;
Wheler, Jennifer;
Said, Rabih;
Ewer, Michael;
Kurzrock, Razelle;
Naing, Aung

Publication type:

Article

An assessment of the pharmacokinetics, pharmacodynamics, and tolerability of GCPGC, a novel pegylated granulocyte colony-stimulating factor (G-CSF), in healthy subjects.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 636, doi. 10.1007/s10637-014-0068-7

By:

Shin, Kwang-Hee;
Lim, Kyoung;
Lee, Howard;
Jang, In-Jin;
Yu, Kyung-Sang

Publication type:

Article

Randomized phase II trial of sorafenib alone or in combination with carboplatin/paclitaxel in women with recurrent platinum sensitive epithelial ovarian, peritoneal, or fallopian tube cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 729, doi. 10.1007/s10637-014-0078-5

By:

Schwandt, Anita;
Gruenigen, Vivian;
Wenham, Robert;
Frasure, Heidi;
Eaton, Susan;
Fusco, Nancy;
Fu, Pingfu;
Wright, John;
Dowlati, Afshin;
Waggoner, Steven

Publication type:

Article

The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 577, doi. 10.1007/s10637-014-0095-4

By:

He, Suqin;
Smith, Donald;
Sequeira, Manuel;
Sang, Jim;
Bates, Richard;
Proia, David

Publication type:

Article

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 598, doi. 10.1007/s10637-014-0076-7

By:

Chen, Esther;
Jacobson, Blake;
Patel, Manish;
Okon, Aniekan;
Li, Shui;
Xiong, Kerry;
Vaidya, Abhishek;
Bitterman, Peter;
Wagner, Carston;
Kratzke, Robert

Publication type:

Article

Phase I trial of everolimus, gemcitabine and cisplatin in patients with solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 710, doi. 10.1007/s10637-014-0096-3

By:

Costello, Brian;
Borad, Mitesh;
Qi, Yingwei;
Kim, George;
Northfelt, Donald;
Erlichman, Charles;
Alberts, Steven

Publication type:

Article

Kidney injuries related to ipilimumab.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 769, doi. 10.1007/s10637-014-0092-7

By:

Izzedine, Hassane;
Gueutin, Victor;
Gharbi, Chems;
Mateus, Christine;
Robert, Caroline;
Routier, Emilie;
Thomas, Marina;
Baumelou, Alain;
Rouvier, Philippe

Publication type:

Article

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 653, doi. 10.1007/s10637-014-0071-z

By:

Weekes, Colin;
Beeram, Muralidhar;
Tolcher, Anthony;
Papadopoulos, Kyriakos;
Gore, Lia;
Hegde, Priti;
Xin, Yan;
Yu, Ron;
Shih, L.;
Xiang, Hong;
Brachmann, Rainer;
Patnaik, Amita

Publication type:

Article

A phase I/II study of S-1 with sorafenib in patients with advanced hepatocellular carcinoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 723, doi. 10.1007/s10637-014-0077-6

By:

Ooka, Yoshihiko;
Chiba, Tetsuhiro;
Ogasawara, Sadahisa;
Arai, Kuniaki;
Suzuki, Eiichiro;
Tawada, Akinobu;
Yamashita, Tatsuya;
Kanai, Fumihiko;
Kaneko, Shuichi;
Yokosuka, Osamu

Publication type:

Article

A phase I/II trial of capecitabine combined with peginterferon α-2a in Patients with sorafenib-refractory advanced hepatocellular carcinoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 762, doi. 10.1007/s10637-014-0097-2

By:

Ogasawara, Sadahisa;
Chiba, Tetsuhiro;
Ooka, Yoshihiko;
Kanogawa, Naoya;
Motoyama, Tenyu;
Suzuki, Eiichiro;
Tawada, Akinobu;
Kanai, Fumihiko;
Yokosuka, and

Publication type:

Article

Dysphonia induced by anti-angiogenic compounds.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 774, doi. 10.1007/s10637-013-0049-2

By:

Saavedra, Erika;
Hollebecque, Antoine;
Soria, Jean-Charles;
Hartl, Dana

Publication type:

Article

Evaluation of two I-radiolabeled acridine derivatives for Auger-electron radionuclide therapy of melanoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 587, doi. 10.1007/s10637-014-0086-5

By:

Gardette, Maryline;
Viallard, Claire;
Paillas, Salomé;
Guerquin-Kern, Jean-Luc;
Papon, Janine;
Moins, Nicole;
Labarre, Pierre;
Desbois, Nicolas;
Wong-Wah-Chung, Pascal;
Palle, Sabine;
Wu, Ting-Di;
Pouget, Jean-Pierre;
Miot-Noirault, Elisabeth;
Chezal, Jean-Michel;
Degoul, Francoise

Publication type:

Article

A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naïve castration-resistant prostate cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 746, doi. 10.1007/s10637-014-0091-8

By:

Azad, Arun;
Beardsley, Emma;
Hotte, Sebastian;
Ellard, Susan;
Klotz, Lawrence;
Chin, Joseph;
Kollmannsberger, Christian;
Mukherjee, Som;
Chi, Kim

Publication type:

Article

Differences in maximum tolerated doses and approval doses of molecularly targeted oncology drug between Japan and Western countries.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 661, doi. 10.1007/s10637-014-0080-y

By:

Maeda, Hideki;
Kurokawa, Tatsuo

Publication type:

Article

A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 739, doi. 10.1007/s10637-014-0083-8

By:

De Jesus-Acosta, Ana;
Laheru, Daniel;
Maitra, Anirban;
Arcaroli, John;
Rudek, Michelle;
Dasari, Arvind;
Blatchford, Patrick;
Quackenbush, Kevin;
Messersmith, Wells

Publication type:

Article

Phase I and pharmacokinetic study of trabectedin, a DNA minor groove binder, administered as a 24-h continuous infusion in Japanese patients with soft tissue sarcoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 691, doi. 10.1007/s10637-014-0094-5

By:

Ueda, Takafumi;
Kakunaga, Shigeki;
Ando, Masashi;
Yonemori, Kan;
Sugiura, Hideshi;
Yamada, Kenji;
Kawai, Akira

Publication type:

Article

Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 682, doi. 10.1007/s10637-014-0088-3

By:

Bendell, Johanna;
Lenz, Heinz-Josef;
Ryan, Theresa;
El-Rayes, Bassel;
Marshall, John;
Modiano, Manuel;
Hart, Lowell;
Kingsley, Clint;
George, Thomas;
Nakashima, Daisuke;
Berlin, Jordan

Publication type:

Article

Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 4, p. 700, doi. 10.1007/s10637-014-0089-2

By:

Rangwala, Fatima;
Bendell, Johanna;
Kozloff, Mark;
Arrowood, Christy;
Dellinger, Andrew;
Meadows, Jennifer;
Tourt-Uhlig, Sandra;
Murphy, Jennifer;
Meadows, Kellen;
Starr, Aijing;
Broderick, Samuel;
Brady, John;
Cushman, Stephanie;
Morse, Michael;
Uronis, Hope;
Hsu, S.;
Zafar, S.;
Wallace, James;
Starodub, Alexander;
Strickler, John

Publication type:

Article