Works matching IS 01676997 AND DT 2014 AND VI 32 AND IP 2

Results: 26

A Phase I study of intermittently dosed vorinostat in combination with bortezomib in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 323, doi. 10.1007/s10637-013-0035-8

By:

Deming, Dustin;
Ninan, Jacob;
Bailey, Howard;
Kolesar, Jill;
Eickhoff, Jens;
Reid, Joel;
Ames, Matthew;
McGovern, Renee;
Alberti, Dona;
Marnocha, Rebecca;
Espinoza-Delgado, Igor;
Wright, John;
Wilding, George;
Schelman, William

Publication type:

Article

Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 330, doi. 10.1007/s10637-013-0042-9

By:

Strickler, John;
McCall, Shannon;
Nixon, Andrew;
Brady, John;
Pang, Herbert;
Rushing, Christel;
Cohn, Allen;
Starodub, Alexander;
Arrowood, Christy;
Haley, Sherri;
Meadows, Kellen;
Morse, Michael;
Uronis, Hope;
Blobe, Gerard;
Hsu, S.;
Zafar, S.;
Hurwitz, Herbert

Publication type:

Article

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)

Published in:

2014

By:

Richter, Suzanne;
Bedard, Philippe;
Chen, Eric;
Clarke, Blaise;
Tran, Ben;
Hotte, Sebastien;
Stathis, Anastasios;
Hirte, Hal;
Razak, Albiruni;
Reedijk, Michael;
Chen, Zhuo;
Cohen, Brenda;
Zhang, Wen-Jiang;
Wang, Lisa;
Ivy, S.;
Moore, Malcolm;
Oza, Amit;
Siu, Lillian;
McWhirter, Elaine

Publication type:

Journal Article

Reduced folate carrier (RFC) as a predictive marker for response to pemetrexed in advanced non-small cell lung cancer (NSCLC)

Published in:

2014

By:

Alvarez-Fernandez, Carlos;
Perez-Arnillas, Quionia;
Ruiz-Echeverria, Lucrecia;
Rodriguez-Rubi, David;
Sanchez-Lorenzo, Luisa;
Li-Torres, Walter;
Izquierdo-Manuel, Marta;
Berros, Jose;
Luque-Cabal, Maria;
Jimenez-Fonseca, Paula;
Villanueva-Palicio, Noemi;
Esteban-Gonzalez, Emilio

Publication type:

Journal Article

Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses.

Published in:

2014

By:

Uhl, Wolfgang;
Zühlsdorf, Michael;
Koernicke, Thomas;
Forssmann, Ulf;
Kovar, Andreas

Publication type:

Journal Article

Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB.

Published in:

2014

By:

Liu, Weiguo;
Zhou, Jinming;
Geng, Guoyan;
Lin, Rongtuan;
Wu, Jian

Publication type:

Journal Article

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 243, doi. 10.1007/s10637-013-9965-4

By:

Richter, Suzanne;
Bedard, Philippe;
Chen, Eric;
Clarke, Blaise;
Tran, Ben;
Hotte, Sebastien;
Stathis, Anastasios;
Hirte, Hal;
Razak, Albiruni;
Reedijk, Michael;
Chen, Zhuo;
Cohen, Brenda;
Zhang, Wen-Jiang;
Wang, Lisa;
Ivy, S.;
Moore, Malcolm;
Oza, Amit;
Siu, Lillian;
McWhirter, Elaine

Publication type:

Article

Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 340, doi. 10.1007/s10637-013-0048-3

By:

Jeong, Woondong;
Park, Sook;
Rapisarda, Annamaria;
Fer, Nicole;
Kinders, Robert;
Chen, Alice;
Melillo, Giovanni;
Turkbey, Baris;
Steinberg, Seth;
Choyke, Peter;
Doroshow, James;
Kummar, Shivaani

Publication type:

Article

A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 355, doi. 10.1007/s10637-013-0057-2

By:

Kang, Yoon-Koo;
Muro, Kei;
Ryu, Min-Hee;
Yasui, Hirofumi;
Nishina, Tomohiro;
Ryoo, Baek-Yeol;
Kamiya, Yukimasa;
Akinaga, Shiro;
Boku, Narikazu

Publication type:

Article

Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 362, doi. 10.1007/s10637-013-0061-6

By:

Sharma, Neelesh;
Pennell, Nathan;
Nickolich, Myles;
Halmos, Balazs;
Ma, Patrick;
Mekhail, Tarek;
Fu, Pingfu;
Dowlati, Afshin

Publication type:

Article

Erratum to: Regorafenib in Japanese patients with solid tumors: phase I study of safety, efficacy, and pharmacokinetics.

Published in:

2014

By:

Sunakawa, Yu;
Furuse, Junji;
Okusaka, Takuji;
Ikeda, Masafumi;
Nagashima, Fumio;
Ueno, Hideki;
Mitsunaga, Shuichi;
Hashizume, Kensei;
Ito, Yuichiro;
Sasaki, Yasutsuna

Publication type:

Erratum

Phase I and pharmacodynamic study of vorinostat combined with capecitabine and cisplatin as first-line chemotherapy in advanced gastric cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 271, doi. 10.1007/s10637-013-9983-2

By:

Yoo, Changhoon;
Ryu, Min-Hee;
Na, Young-Soon;
Ryoo, Baek-Yeol;
Lee, Chae-Won;
Maeng, Jeheon;
Kim, Se-Yeon;
Koo, Dong;
Park, Inkeun;
Kang, Yoon-Koo

Publication type:

Article

Sorafenib plus dacarbazine in solid tumors: a phase I study with dynamic contrast-enhanced ultrasonography and genomic analysis of sequential tumor biopsy samples.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 312, doi. 10.1007/s10637-013-9993-0

By:

Lazar, Vladimir;
Lassau, Nathalie;
Meurice, Guillaume;
Loriot, Yohann;
Peña, Carol;
Massard, Christophe;
Robert, Caroline;
Robert, Thomas;
Berre, Marie-Aude;
Baere, Thierry;
Dessen, Philippe;
Soria, Jean-Charles;
Armand, Jean-Pierre

Publication type:

Article

Low skeletal muscle is associated with toxicity in patients included in phase I trials.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 382, doi. 10.1007/s10637-013-0053-6

By:

Cousin, Sophie;
Hollebecque, A.;
Koscielny, S.;
Mir, O.;
Varga, A.;
Baracos, V.;
Soria, J.;
Antoun, S.

Publication type:

Article

Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 227, doi. 10.1007/s10637-013-0040-y

By:

Liu, Weiguo;
Zhou, Jinming;
Geng, Guoyan;
Lin, Rongtuan;
Wu, Jian

Publication type:

Article

Icrucumab, a fully human monoclonal antibody against the vascular endothelial growth factor receptor-1, in the treatment of patients with advanced solid malignancies: a Phase 1 study.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 303, doi. 10.1007/s10637-013-9998-8

By:

LoRusso, Patricia;
Krishnamurthi, Smitha;
Youssoufian, Hagop;
Hall, Nancy;
Fox, Floyd;
Dontabhaktuni, Aruna;
Grebennik, Dmitri;
Remick, Scot

Publication type:

Article

Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 347, doi. 10.1007/s10637-013-0038-5

By:

Uhl, Wolfgang;
Zühlsdorf, Michael;
Koernicke, Thomas;
Forssmann, Ulf;
Kovar, Andreas

Publication type:

Article

Reduced folate carrier (RFC) as a predictive marker for response to pemetrexed in advanced non-small cell lung cancer (NSCLC).

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 377, doi. 10.1007/s10637-013-9992-1

By:

Alvarez-Fernandez, Carlos;
Perez-Arnillas, Quionia;
Ruiz-Echeverria, Lucrecia;
Rodriguez-Rubi, David;
Sanchez-Lorenzo, Luisa;
Li-Torres, Walter;
Izquierdo-Manuel, Marta;
Berros, Jose;
Luque-Cabal, Maria;
Jimenez-Fonseca, Paula;
Villanueva-Palicio, Noemi;
Esteban-Gonzalez, Emilio

Publication type:

Article

Phase I clinical trial of lenalidomide in combination with sorafenib in patients with advanced cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 279, doi. 10.1007/s10637-013-9966-3

By:

Ganesan, Prasanth;
Piha-Paul, Sarina;
Naing, Aung;
Falchook, Gerald;
Wheler, Jennifer;
Fu, Siqing;
Hong, David;
Kurzrock, Razelle;
Janku, Filip;
Laday, Shell;
Bedikian, Agop;
Kies, Merrill;
Wolff, Robert;
Tsimberidou, Apostolia

Publication type:

Article

Phase I trial of sorafenib in combination with ifosfamide in patients with advanced sarcoma: a Spanish group for research on sarcomas (GEIS) study.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 287, doi. 10.1007/s10637-013-9989-9

By:

Martín-Liberal, J.;
López-Pousa, A.;
Broto, J.;
Cubedo, R.;
Gallego, O.;
Brendel, E.;
Tirado, O.;
Muro, X.

Publication type:

Article

HLA-restricted NY-ESO-1 peptide immunotherapy for metastatic castration resistant prostate cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 235, doi. 10.1007/s10637-013-9960-9

By:

Sonpavde, Guru;
Wang, Mingjun;
Peterson, Leif;
Wang, Helen;
Joe, Teresa;
Mims, Martha;
Kadmon, Dov;
Ittmann, Michael;
Wheeler, Thomas;
Gee, Adrian;
Wang, Rong-Fu;
Hayes, Teresa

Publication type:

Article

Phase I study of sunitinib plus S-1 and cisplatin in Japanese patients with advanced or metastatic gastric cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 261, doi. 10.1007/s10637-013-9948-5

By:

Boku, Narikazu;
Muro, Kei;
Machida, Nozomu;
Hashigaki, Satoshi;
Kimura, Nobuyuki;
Suzuki, Mie;
Lechuga, Mariajose;
Miyata, Yoshinori

Publication type:

Article

A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 295, doi. 10.1007/s10637-013-9999-7

By:

Schelman, William;
Mohammed, Tabraiz;
Traynor, Anne;
Kolesar, Jill;
Marnocha, Rebecca;
Eickhoff, Jens;
Keppen, Michael;
Alberti, Dona;
Wilding, George;
Takebe, Naoko;
Liu, Glenn

Publication type:

Article

A phase I trial of bortezomib in combination with epirubicin, carboplatin and capecitabine (ECarboX) in advanced oesophagogastric adenocarcinoma.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 250, doi. 10.1007/s10637-013-9970-7

By:

Turkington, R.;
Purcell, C.;
James, C.;
Millar, J.;
Napier, E.;
Law, D.;
Gallagher, R.;
Morris, M.;
Wilson, R.;
Eatock, M.

Publication type:

Article

A prospective multicenter phase II study of sunitinib in patients with advanced aggressive fibromatosis.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 369, doi. 10.1007/s10637-013-0059-0

By:

Jo, Jae-Cheol;
Hong, Yong;
Kim, Kyu-Pyo;
Lee, Jae-Lyun;
Lee, Jeeyun;
Park, Young;
Kim, Sun;
Ryu, Jin-Sook;
Lee, Jong-Seok;
Kim, Tae

Publication type:

Article

Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.

Published in:

Investigational New Drugs, 2014, v. 32, n. 2, p. 213, doi. 10.1007/s10637-013-0036-7

By:

King, Constance;
Diaz, Henry;
Barnard, Darlene;
Barda, David;
Clawson, David;
Blosser, Wayne;
Cox, Karen;
Guo, Sherry;
Marshall, Mark

Publication type:

Article