Works matching IS 01676997 AND DT 2013 AND VI 31 AND IP 1

Results: 27

Multicenter phase II study of second-line bevacizumab plus doublet combination chemotherapy in patients with metastatic colorectal cancer progressed after upfront bevacizumab plus doublet combination chemotherapy.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 183, doi. 10.1007/s10637-012-9853-3

By:

Hong, Yong Sang;
Lee, Jeeyun;
Kim, Kyu-pyo;
Lee, Jae-Lyun;
Park, Young Suk;
Park, Joon Oh;
Park, Se Hoon;
Kim, Sun Young;
Baek, Ji Yeon;
Kim, Jee Hyun;
Lee, Keun-Wook;
Kim, Tae-You;
Kim, Tae Won

Publication type:

Article

Tumor therapy with a urokinase plasminogen activator-activated anthrax lethal toxin alone and in combination with paclitaxel.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 206, doi. 10.1007/s10637-012-9847-1

By:

Wein, Alexander N.;
Liu, Shihui;
Zhang, Yi;
McKenzie, Andrew T.;
Leppla, Stephen H.

Publication type:

Article

RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 200, doi. 10.1007/s10637-012-9845-3

By:

Garcia-Gomez, Antonio;
Ocio, Enrique M.;
Pandiella, Atanasio;
San Miguel, Jesús F.;
Garayoa, Mercedes

Publication type:

Article

The PDT activity of free and pegylated pheophorbide a against an amelanotic melanoma transplanted in C57/BL6 mice.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 192, doi. 10.1007/s10637-012-9844-4

By:

Rapozzi, Valentina;
Zorzet, Sonia;
Zacchigna, Marina;
Drioli, Sara;
Xodo, Luigi E.

Publication type:

Article

Pemetrexed in patients with refractory soft tissue sarcoma: A non-comparative multicenter phase II study of the German Sarcoma Group AIO-STS 005.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 167, doi. 10.1007/s10637-012-9840-8

By:

Hartmann, J. T.;
Bauer, S.;
Egerer, G.;
Horger, M. S.;
Kopp, H.-G.;
Grünwald, V.;
Mayer, F.

Publication type:

Article

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 66, doi. 10.1007/s10637-012-9835-5

By:

Granda, Teresa G.;
Cebrián, David;
Martínez, Sonia;
Anguita, Patricia Villanueva;
López, Estela Casas;
Link, Wolfgang;
Merino, Teresa;
Pastor, Joaquín;
Serelde, Beatriz G.;
Peregrina, Sandra;
Palacios, Irene;
Albarran, Maria Isabel;
Cebriá, Antonio;
Lorenzo, Milagros;
Alonso, Patricia;
Fominaya, Jesús;
López, Ana Rodríguez;
Bischoff, James R.

Publication type:

Article

Combination of bevacizumab and irradiation on uveal melanoma: an in vitro and in vivo preclinical study.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 59, doi. 10.1007/s10637-012-9834-6

By:

Sudaka, Anne;
Susini, Antoine;
Lo Nigro, Cristiana;
Fischel, Jean-Louis;
Toussan, Nicolas;
Formento, Patricia;
Tonissi, Federica;
Lattanzio, Laura;
Russi, Elvio;
Etienne-Grimaldi, Marie-Christine;
Merlano, Marco;
Milano, Gérard

Publication type:

Article

Topophore C: a liposomal nanoparticle formulation of topotecan for treatment of ovarian cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 46, doi. 10.1007/s10637-012-9832-8

By:

Patankar, Nilesh A.;
Waterhouse, Dawn;
Strutt, Dita;
Anantha, Malathi;
Bally, Marcel B.

Publication type:

Article

Additive effects of vorinostat and MLN8237 in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 39, doi. 10.1007/s10637-012-9831-9

By:

Muscal, Jodi A.;
Scorsone, Kathleen A.;
Zhang, Linna;
Ecsedy, Jeffrey A.;
Berg, Stacey L.

Publication type:

Article

Activity of the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in nasopharyngeal cancer cell lines.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 30, doi. 10.1007/s10637-012-9828-4

By:

Ma, Brigette B. Y.;
Lui, Vivian W. Y.;
Cheung, Crystal S.;
Lau, Cecilia P. Y.;
Ho, Kakiu;
Hui, Edwin P.;
Tsui, Stephen K. W.;
Ng, Margaret H.;
Cheng, S. H.;
Ng, Patrick K. S.;
Tsao, Sai Wai;
Chan, Anthony T. C.

Publication type:

Article

Investigation of bendamustine HCL in a Phase 2 study in women with resistant ovarian cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 160, doi. 10.1007/s10637-012-9827-5

By:

Baker, Amanda F.;
Roe, Denise J.;
Laughren, Cynthia;
Cohen, Janice L.;
Wright, Heather M.;
Clouser, Mary C.;
Cui, Haiyan;
Alberts, David S.;
Chambers, Setsuko K.

Publication type:

Article

Inhibitors of cathepsins B and L induce autophagy and cell death in neuroblastoma cells.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 20, doi. 10.1007/s10637-012-9826-6

By:

Cartledge, Donna M.;
Colella, Rita;
Glazewski, Lisa;
Lu, Guizhen;
Mason, Robert W.

Publication type:

Article

Phase II study of irinotecan plus capecitabine in anthracycline- and taxane- pretreated patients with metastatic breast cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 152, doi. 10.1007/s10637-012-9824-8

By:

Lee, Keun Seok;
Park, In Hae;
Nam, Byung-Ho;
Ro, Jungsil

Publication type:

Article

A preclinical and clinical study of mycophenolate mofetil in pancreatic cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 14, doi. 10.1007/s10637-012-9822-x

By:

Rodríguez-Pascual, J.;
Sha, P.;
García-García, E.;
Rajeshkumar, N. V.;
De Vicente, E.;
Quijano, Y.;
Cubillo, A.;
Angulo, B.;
Hernando, O.;
Hidalgo, M.

Publication type:

Article

A phase II study of tasisulam sodium (LY573636 sodium) as second-line or third-line treatment for patients with unresectable or metastatic soft tissue sarcoma.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 145, doi. 10.1007/s10637-012-9819-5

By:

Ryan, Christopher W.;
Matias, Chacon;
Agulnik, Mark;
Lopez-Pousa, Antonio;
Williams, Charles;
de Alwis, Dinesh P.;
Kaiser, Christopher;
Miller, Mary Alice;
Ermisch, Sabine;
Ilaria, Robert Jr;
Keohan, M. L.

Publication type:

Article

Circulating vascular endothelial growth factor receptor 2/pAkt-positive cells as a functional pharmacodynamic marker in metastatic colorectal cancers treated with antiangiogenic agent.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 1, doi. 10.1007/s10637-012-9817-7

By:

Shin, Sang Joon;
Hwang, Jee Won;
Ahn, Joong Bae;
Rha, Sun Young;
Roh, Jae Kyung;
Chung, Hyun Cheol

Publication type:

Article

Phase I dose-escalation study to examine the safety and tolerability of LY2603618, a checkpoint 1 kinase inhibitor, administered 1 day after pemetrexed 500 mg/m<sup>2</sup> every 21 days in patients with cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 136, doi. 10.1007/s10637-012-9815-9

By:

Weiss, Glen J.;
Donehower, Ross C.;
Iyengar, Tara;
Ramanathan, Ramesh K.;
Lewandowski, Karen;
Westin, Eric;
Hurt, Karla;
Hynes, Scott M.;
Anthony, Stephen P.;
McKane, Scott

Publication type:

Article

Phase I, pharmacokinetic and pharmacodynamic evaluation of CYT997, an orally-bioavailable cytotoxic and vascular-disrupting agent.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 126, doi. 10.1007/s10637-012-9813-y

By:

Burge, Matthew;
Francesconi, Alessandra B.;
Kotasek, Dusan;
Fida, Rosa;
Smith, Gregg;
Wilks, Andrew;
Vasey, Paul A.;
Lickliter, Jason D.

Publication type:

Article

A phase I study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 115, doi. 10.1007/s10637-012-9812-z

By:

Dasari, A.;
Gore, L.;
Messersmith, W. A.;
Diab, S.;
Jimeno, A.;
Weekes, C. D.;
Lewis, K. D.;
Drabkin, H. A.;
Flaig, T. W.;
Camidge, D. R.

Publication type:

Article

First report of the safety, tolerability, and pharmacokinetics of the Src kinase inhibitor saracatinib (AZD0530) in Japanese patients with advanced solid tumours.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 108, doi. 10.1007/s10637-012-9809-7

By:

Fujisaka, Yasuhito;
Onozawa, Yusuke;
Kurata, Takayasu;
Yasui, Hirofumi;
Goto, Isao;
Yamazaki, Kentaro;
Machida, Nozomu;
Watanabe, Junichiro;
Shimada, Hitoshi;
Shi, Xiaojin;
Boku, Narikazu

Publication type:

Article

Phase I trial of dasatinib and ixabepilone in patients with solid tumors.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 92, doi. 10.1007/s10637-012-9805-y

By:

Herbolsheimer, P.;
Kapoor, R.;
Smith, K. L.;
Perry, D.;
Verma, N.;
Veytsman, I.;
Jelinek, J.;
Swain, S. M.

Publication type:

Article

Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 175, doi. 10.1007/s10637-012-9842-6

By:

Manegold, Christian;
Vansteenkiste, Johan;
Cardenal, Felipe;
Schuette, Wolfgang;
Woll, Penella J.;
Ulsperger, Ernst;
Kerber, Anne;
Eckmayr, Josef;
von Pawel, Joachim

Publication type:

Article

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 99, doi. 10.1007/s10637-012-9807-9

By:

Thomas Yau;
Cheng, P. N.;
Pierre Chan;
William Chan;
Li Chen;
Jimmy Yuen;
Roberta Pang;
Fan, S. T.;
Poon, Ronnie T.

Publication type:

Article

Phase 1, open-label study of MEDI-547 in patients with relapsed or refractory solid tumors.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 77, doi. 10.1007/s10637-012-9801-2

By:

Annunziata, Christina M.;
Kohn, Elise C.;
LoRusso, Patricia;
Houston, Nicole D.;
Coleman, Robert L.;
Buzoianu, Manuela;
Robbie, Gabriel;
Lechleider, Robert

Publication type:

Article

A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 85, doi. 10.1007/s10637-012-9802-1

By:

Kordes, Sil;
Richel, Dick J.;
Klümpen, Heinz-Josef;
Weterman, Mariëtte J.;
Stevens, Arnoldus J. W. M.;
Wilmink, Johanna W.

Publication type:

Article

Investigational agents in development for the treatment of ovarian cancer.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 213, doi. 10.1007/s10637-012-9837-3

By:

Westin, Shannon;
Herzog, Thomas;
Coleman, Robert

Publication type:

Article

Development of artemisinin compounds for cancer treatment.

Published in:

Investigational New Drugs, 2013, v. 31, n. 1, p. 230, doi. 10.1007/s10637-012-9873-z

By:

Lai, Henry;
Singh, Narendra;
Sasaki, Tomikazu

Publication type:

Article