Works matching IS 01676997 AND DT 2012 AND VI 30 AND IP 6

Results: 46

Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas.

Published in:: 2012
Publication type:: Journal Article

A phase II trial of erlotinib in combination with gemcitabine and cisplatin in advanced pancreatic cancer.

Published in:: 2012
Publication type:: Journal Article

SOCS1 is significantly up-regulated in Nutlin-3-treated p53(wild-type) B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155.

Published in:

2012

By:

di Iasio, Maria Grazia;
Norcio, Alessia;
Melloni, Elisabetta;
Zauli, Giorgio

Publication type:

Journal Article

Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer.

Published in:

2012

By:

Laheru, Daniel;
Shah, Preeti;
Rajeshkumar, N V;
McAllister, Florencia;
Taylor, Gretchen;
Goldsweig, Howard;
Le, Dung T;
Donehower, Ross;
Jimeno, Antonio;
Linden, Sheila;
Zhao, Ming;
Song, Dongweon;
Rudek, Michelle A;
Hidalgo, Manuel

Publication type:

Journal Article

Ent-11[alpha]-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkB[alpha].

Published in:

2012

By:

Chen, George G;
Leung, Jackie;
Liang, Nian Ci;
Li, Li;
Wu, Kefeng;
Chan, Ursula P F;
Leung, Billy C S;
Li, Mingyue;
Du, Jing;
Deng, Yi Feng;
Gong, Xianling;
Lv, Yingnian;
Chak, Ernest C W;
Lai, Paul B S

Publication type:

Journal Article

Pretargeting of necrotic tumors with biotinylated hypericin using (123)I-labeled avidin: evaluation of a two-step strategy.

Published in:

2012

By:

Marysael, Thierry;
Bauwens, Matthias;
Ni, Yicheng;
Bormans, Guy;
Rozenski, Jef;
de Witte, Peter

Publication type:

Journal Article

Renal dysfunction in a renal transplant patient treated concurrently with cyclosporine and imatinib.

Published in:

2012

By:

Mulder, Karen;
Egorin, Merrill;
Sawyer, Michael

Publication type:

Report

Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2294, doi. 10.1007/s10637-011-9765-7

By:

Konner, Jason;
Grisham, Rachel;
Park, Jae;
O'Connor, Owen;
Cropp, Gillian;
Johnson, Robert;
Hannah, Alison;
Hensley, Martee;
Sabbatini, Paul;
Miranov, Svetlana;
Danishefsky, Samuel;
Hyman, David;
Spriggs, David;
Dupont, Jakob;
Aghajanian, Carol

Publication type:

Article

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2303, doi. 10.1007/s10637-011-9766-6

By:

Millward, Michael;
Price, Timothy;
Townsend, Amanda;
Sweeney, Christopher;
Spencer, Andrew;
Sukumaran, Shawgi;
Longenecker, Angie;
Lee, Lonnie;
Lay, Ana;
Sharma, Girish;
Gemmill, Robert;
Drabkin, Harry;
Lloyd, G.;
Neuteboom, Saskia;
McConkey, David;
Palladino, Michael;
Spear, Matthew

Publication type:

Article

Plasma protein binding of sorafenib, a multi kinase inhibitor: in vitro and in cancer patients.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2096, doi. 10.1007/s10637-011-9767-5

By:

Villarroel, Maria;
Pratz, Keith;
Xu, Linping;
Wright, John;
Smith, B.;
Rudek, Michelle

Publication type:

Article

Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2103, doi. 10.1007/s10637-011-9768-4

By:

Leung, Euphemia;
Rewcastle, Gordon;
Joseph, Wayne;
Rosengren, Rhonda;
Larsen, Lesley;
Baguley, Bruce

Publication type:

Article

(+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2087, doi. 10.1007/s10637-011-9762-x

By:

Freise, Christian;
Trowitzsch-Kienast, Wolfram;
Ruehl, Martin;
Erben, Ulrike;
Seehofer, Daniel;
Kim, Ki;
Zeitz, Martin;
Somasundaram, Rajan

Publication type:

Article

MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2113, doi. 10.1007/s10637-011-9770-x

By:

Wang, Li;
Mason, Kathy;
Ang, K.;
Buchholz, Thomas;
Valdecanas, David;
Mathur, Anjili;
Buser-Doepner, Carolyn;
Toniatti, Carlo;
Milas, Luka

Publication type:

Article

First clinical pharmacokinetic dose-escalation study of sagopilone, a novel, fully synthetic epothilone, in Japanese patients with refractory solid tumors.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2327, doi. 10.1007/s10637-011-9773-7

By:

Araki, Kazuhiro;
Kitagawa, Koichi;
Mukai, Hirofumi;
Mukohara, Toru;
Kodama, Keiji;
Ando, Yuichi;
Narabayashi, Masaru;
Minami, Hironobu;
Mera, Kiyomi;
Sasaki, Yasutsuna

Publication type:

Article

Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2334, doi. 10.1007/s10637-011-9774-6

By:

Weiss, Glen;
Hidalgo, Manuel;
Borad, Mitesh;
Laheru, Daniel;
Tibes, Raoul;
Ramanathan, Ramesh;
Blaydorn, Lisa;
Jameson, Gayle;
Jimeno, Antonio;
Isaacs, Jeffrey;
Scaburri, Angela;
Pacciarini, Maria;
Fiorentini, Francesco;
Ciomei, Marina;
Hoff, Daniel

Publication type:

Article

A phase I study of temozolomide and everolimus (RAD001) in patients with newly diagnosed and progressive glioblastoma either receiving or not receiving enzyme-inducing anticonvulsants: an NCIC CTG study.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2344, doi. 10.1007/s10637-011-9775-5

By:

Mason, Warren;
MacNeil, Mary;
Kavan, Petr;
Easaw, Jacob;
Macdonald, David;
Thiessen, Brian;
Urva, Shweta;
Lwin, Zarnie;
McIntosh, Lynn;
Eisenhauer, Elizabeth

Publication type:

Article

Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2121, doi. 10.1007/s10637-011-9777-3

By:

Kolli-Bouhafs, Kaouther;
Boukhari, Abdelaziz;
Abusnina, Abdurazzag;
Velot, Emilie;
Gies, Jean-Pierre;
Lugnier, Claire;
Rondé, Philippe

Publication type:

Article

Pretargeting of necrotic tumors with biotinylated hypericin using I-labeled avidin: evaluation of a two-step strategy.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2132, doi. 10.1007/s10637-011-9778-2

By:

Marysael, Thierry;
Bauwens, Matthias;
Ni, Yicheng;
Bormans, Guy;
Rozenski, Jef;
Witte, Peter

Publication type:

Article

The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2148, doi. 10.1007/s10637-011-9782-6

By:

Nam, Hyun-Jin;
Kim, Hwang-Phill;
Yoon, Young-Kwang;
Song, Sang-Hyun;
Min, Ah-Rum;
Han, Sae-Won;
Im, Seock-Ah;
Kim, Tae-You;
Oh, Do-Youn;
Bang, Yung-Jue

Publication type:

Article

Bay846, a new irreversible small molecule inhibitor of EGFR and Her2, is highly effective against malignant brain tumor models.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2161, doi. 10.1007/s10637-011-9784-4

By:

Longo, Sharon;
Padalino, David;
McGillis, Sandra;
Petersen, Kirstin;
Schirok, Hartmut;
Politz, Oliver;
Canute, Gregory;
Post, Dawn

Publication type:

Article

Erratum to: Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.

Published in:

2012

By:

Konner, Jason;
Grisham, Rachel;
Park, Jae;
O'Connor, Owen;
Cropp, Gillian;
Johnson, Robert;
Hannah, Alison;
Hensley, Martee;
Sabbatini, Paul;
Mironov, Svetlana;
Danishefsky, Samuel;
Hyman, David;
Spriggs, David;
Dupont, Jakob;
Aghajanian, Carol

Publication type:

Correction Notice

Phase I dose-escalating study of ES-285 given as a three-hour intravenous infusion every three weeks in patients with advanced malignant solid tumors.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2318, doi. 10.1007/s10637-011-9772-8

By:

Massard, C.;
Salazar, R.;
Armand, J.;
Majem, M.;
Deutsch, E.;
García, M.;
Oaknin, A.;
Fernández-García, E.;
Soto, A.;
Soria, J.

Publication type:

Article

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2210, doi. 10.1007/s10637-011-9791-5

By:

Chen, George;
Leung, Jackie;
Liang, Nian;
Li, Li;
Wu, Kefeng;
Chan, Ursula;
Leung, Billy;
Li, Mingyue;
Du, Jing;
Deng, Yi;
Gong, Xianling;
Lv, Yingnian;
Chak, Ernest;
Lai, Paul

Publication type:

Article

Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2201, doi. 10.1007/s10637-011-9790-6

By:

Proia, David;
Sang, Jim;
He, Suqin;
Smith, Donald;
Sequeira, Manuel;
Zhang, Chaohua;
Liu, Yuan;
Ye, Shuxia;
Zhou, Dan;
Blackman, Ronald;
Foley, Kevin;
Koya, Keizo;
Wada, Yumiko

Publication type:

Article

Severe meningo-radiculo-nevritis associated with ipilimumab.

Published in:

2012

By:

Bompaire, Flavie;
Mateus, Christine;
Taillia, Hervé;
Greslan, Thierry;
Lahutte, Marion;
Sallansonnet-Froment, Magali;
Ouologuem, Madani;
Renard, Jean-Luc;
Gorochov, Guy;
Robert, Caroline;
Ricard, Damien

Publication type:

Report

SOCS1 is significantly up-regulated in Nutlin-3-treated p53 B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155.

Published in:

2012

By:

di Iasio, Maria;
Norcio, Alessia;
Melloni, Elisabetta;
Zauli, Giorgio

Publication type:

Report

Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2173, doi. 10.1007/s10637-011-9785-3

By:

Clémenson, Céline;
Chargari, Cyrus;
Désiré, Laurent;
Casagrande, Anne-Sophie;
Bourhis, Jean;
Deutsch, Eric

Publication type:

Article

Phase I and pharmacokinetic study of dacomitinib (PF-00299804), an oral irreversible, small molecule inhibitor of human epidermal growth factor receptor-1, -2, and -4 tyrosine kinases, in Japanese patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2352, doi. 10.1007/s10637-011-9789-z

By:

Takahashi, Toshiaki;
Boku, Narikazu;
Murakami, Haruyasu;
Naito, Tateaki;
Tsuya, Asuka;
Nakamura, Yukiko;
Ono, Akira;
Machida, Nozomu;
Yamazaki, Kentaro;
Watanabe, Junichiro;
Ruiz-Garcia, Ana;
Imai, Keiji;
Ohki, Emiko;
Yamamoto, Nobuyuki

Publication type:

Article

Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2187, doi. 10.1007/s10637-011-9788-0

By:

Mare, Jo-Anne;
Lawson, Jessica;
Chiwakata, Maynard;
Beukes, Denzil;
Edkins, Adrienne;
Blatch, Gregory

Publication type:

Article

Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2219, doi. 10.1007/s10637-012-9793-y

By:

Atreya, Chloe;
Ducker, Gregory;
Feldman, Morris;
Bergsland, Emily;
Warren, Robert;
Shokat, Kevan

Publication type:

Article

Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: a phase II study of Korean gastrointestinal stromal tumors study group.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2377, doi. 10.1007/s10637-012-9795-9

By:

Park, S.;
Ryu, M.;
Ryoo, B.;
Im, S.;
Kwon, H.;
Lee, S.;
Kang, B.;
Kang, Y.

Publication type:

Article

Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2141, doi. 10.1007/s10637-011-9781-7

By:

Sturzu, Alexander;
Sheikh, Sumbla;
Klose, Uwe;
Echner, Hartmut;
Kalbacher, Hubert;
Deeg, Martin;
Nägele, Thomas;
Horger, Marius;
Ernemann, Ulrike;
Heckl, Stefan

Publication type:

Article

Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2226, doi. 10.1007/s10637-012-9794-x

By:

Ruban, Angela;
Berkutzki, Tamara;
Cooper, Itzik;
Mohar, Boaz;
Teichberg, Vivian

Publication type:

Article

A phase II trial of Erlotinib in combination with gemcitabine and cisplatin in advanced pancreatic cancer.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2371, doi. 10.1007/s10637-012-9792-z

By:

Hwang, In;
Jang, Joung-Soon;
Oh, Sung;
Lee, Suee;
Kwon, Hyuk;
Lee, Gyeong;
Go, Seil;
Kang, Myoung;
Cha, Young;
Kang, Jung

Publication type:

Article

Erratum to: Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy.

Published in:

2012

By:

Clémenson, Céline;
Chargari, Cyrus;
Désiré, Laurent;
Casagrande, Anne-Sophie;
Bourhis, Jean;
Deutsch, Eric

Publication type:

Correction Notice

Aurora kinase inhibitors: Progress towards the clinic.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2411, doi. 10.1007/s10637-012-9798-6

By:

Kollareddy, Madhu;
Zheleva, Daniella;
Dzubak, Petr;
Brahmkshatriya, Pathik;
Lepsik, Martin;
Hajduch, Marian

Publication type:

Article

Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherin expression.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2236, doi. 10.1007/s10637-012-9803-0

By:

D'Costa, Zarina;
Leong, Cheng-Mee;
Shields, Justin;
Matthews, Charles;
Hibma, Merilyn

Publication type:

Article

Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2252, doi. 10.1007/s10637-012-9804-z

By:

Zanotto-Filho, Alfeu;
Braganhol, Elizandra;
Battastini, Ana;
Moreira, José

Publication type:

Article

Screening candidate anticancer drugs for brain tumor chemotherapy: Pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2263, doi. 10.1007/s10637-012-9806-x

By:

Lv, Hua;
Wang, Fan;
Reddy, M.;
Zhou, Qingyu;
Zhang, Xiaoping;
Reddy, E.;
Gallo, James

Publication type:

Article

Phase I trial of ixabepilone administered as three oral doses each separated by 6 hours every 3 weeks in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2364, doi. 10.1007/s10637-012-9800-3

By:

Kunz, Pamela;
He, Aiwu;
Colevas, A.;
Pishvaian, Michael;
Hwang, Jimmy;
Clemens, Pamela;
Messina, Marianne;
Kaleta, Remigiusz;
Abrahao, Fernanda;
Sikic, Branimir;
Marshall, John

Publication type:

Article

Phase II study of bevacizumab and erlotinib in the treatment of advanced hepatocellular carcinoma patients with sorafenib-refractory disease.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2384, doi. 10.1007/s10637-012-9808-8

By:

Yau, Thomas;
Wong, Hilda;
Chan, Pierre;
Yao, T.;
Pang, R.;
Cheung, T.;
Fan, S.;
Poon, Ronnie

Publication type:

Article

Clinical development of insulin-like growth factor receptor-1 (IGF-1R) inhibitors: At the crossroad?

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2433, doi. 10.1007/s10637-012-9811-0

By:

Gombos, Andrea;
Metzger-Filho, Otto;
Dal Lago, Lissandra;
Awada-Hussein, Ahmad

Publication type:

Article

Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2274, doi. 10.1007/s10637-012-9810-1

By:

Ziegler, Patrick;
Chahoud, Tuhama;
Wilhelm, Thomas;
Pällman, Nora;
Braig, Melanie;
Wiehle, Valeska;
Ziegler, Susanne;
Schröder, Marcus;
Meier, Chris;
Kolodzik, Adrian;
Rarey, Matthias;
Panse, Jens;
Hauber, Joachim;
Balabanov, Stefan;
Brümmendorf, Tim

Publication type:

Article

Anti-leukemic effect of 2-pyrone derivatives via MAPK and PI3 kinase pathways.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2284, doi. 10.1007/s10637-012-9814-x

By:

Yoon, Jin;
Won, Young;
Kim, Seo;
Oh, Suk;
Kim, Eun;
Kim, Byoung;
Cho, Cheon;
Choi, Jung;
Park, Byeong;
Lee, Min;
Lee, Young

Publication type:

Article

Integrated preclinical and clinical development of S- trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2391, doi. 10.1007/s10637-012-9818-6

By:

Laheru, Daniel;
Shah, Preeti;
Rajeshkumar, N.;
McAllister, Florencia;
Taylor, Gretchen;
Goldsweig, Howard;
Le, Dung;
Donehower, Ross;
Jimeno, Antonio;
Linden, Sheila;
Zhao, Ming;
Song, Dongweon;
Rudek, Michelle;
Hidalgo, Manuel

Publication type:

Article

Predictive factors for response to treatment in patients with advanced renal cell carcinoma.

Published in:

Investigational New Drugs, 2012, v. 30, n. 6, p. 2443, doi. 10.1007/s10637-012-9836-4

By:

Muriel López, Carolina;
Esteban, Emilio;
Astudillo, Aurora;
Pardo, Pablo;
Berros, Jose;
Izquierdo, Marta;
Crespo, Guillermo;
Fonseca, Paula;
Sanmamed, Miguel;
Martínez-Camblor, Pablo

Publication type:

Article