Works matching IS 01676997 AND DT 2011 AND VI 29 AND IP 4

Results: 25

A phase 1, multicenter, open-label study of the safety of two dose levels of a human monoclonal antibody to human [alpha] integrins, intetumumab, in combination with docetaxel and prednisone in patients with castrate-resistant metastatic prostate cancer.

Published in:

2011

By:

Chu, Franklin M.;
Picus, Joel;
Fracasso, Paula;
Dreicer, Robert;
Lang, Zhihui;
Foster, Brenda

Publication type:

Journal Article

Anoikis induction and metastasis suppression by a new integrin [alpha]v[beta]3 inhibitor in human melanoma cell line m21.

Published in:

2011

By:

Zhang, Yongci;
Yang, Ming;
Ji, Qing;
Fan, Dongmei;
Peng, Hui;
Yang, Chunzheng;
Xiong, Dongsheng;
Zhou, Yuan

Publication type:

Journal Article

Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 627, doi. 10.1007/s10637-010-9401-y

By:

Fu, Jia-ning;
Li, Jing;
Tan, Qiang;
Yin, Han-wei;
Xiong, Kun;
Wang, Tian-yu;
Ren, Xiao-yuan;
Zeng, Hui-hui

Publication type:

Article

Factual understanding of randomized clinical trials: a multicenter case-control study in cancer patients.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 700, doi. 10.1007/s10637-009-9315-8

By:

Leroy, Tanguy;
Christophe, Véronique;
Penel, Nicolas;
Antoine, Pascal;
Clisant, Stéphanie

Publication type:

Article

A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 523, doi. 10.1007/s10637-009-9379-5

By:

Shahabuddin, M.;
Nambiar, Mridula;
Moorthy, Balaji;
Naik, Prakruthi;
Choudhary, Bibha;
Advirao, Gopal;
Raghavan, Sathees

Publication type:

Article

Phase II study of combination chemotherapy with irinotecan and cetuximab for pretreated metastatic colorectal cancer harboring wild-type KRAS.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 688, doi. 10.1007/s10637-009-9382-x

By:

Shitara, Kohei;
Yokota, Tomoya;
Takahari, Daisuke;
Shibata, Takashi;
Ura, Takashi;
Utsunomiya, Setsuo;
Inaba, Yoshitaka;
Yamaura, Hidekazu;
Sato, Yozo;
Najima, Mina;
Kawai, Hiroki;
Tajika, Masahiro;
Sawaki, Akira;
Yatabe, Yasushi;
Muro, Kei

Publication type:

Article

Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 534, doi. 10.1007/s10637-009-9384-8

By:

Hirai, Hiroshi;
Takahashi-Suziki, Ikuko;
Shimomura, Toshiyasu;
Fukasawa, Kazuhiro;
Machida, Takumitsu;
Takaki, Toru;
Kobayashi, Makiko;
Eguchi, Tomohiro;
Oki, Hiroko;
Arai, Tsuyoshi;
Ichikawa, Koji;
Hasako, Shinichi;
Kodera, Tsutomu;
Kawanishi, Nobuhiko;
Nakatsuru, Yoko;
Kotani, Hidehito;
Iwasawa, Yoshikazu

Publication type:

Article

A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 694, doi. 10.1007/s10637-010-9386-6

By:

El-Rayes, Bassel;
Philip, Philip;
Sarkar, Fazlul;
Shields, Anthony;
Ferris, Ann;
Hess, Kenneth;
Kaseb, Ahmad;
Javle, Milind;
Varadhachary, Gauri;
Wolff, Robert;
Abbruzzese, James

Publication type:

Article

Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 544, doi. 10.1007/s10637-010-9387-5

By:

Wilmes, Anja;
Rawson, Pisana;
Peng, Lifeng;
McLauchlan, Danyl;
Northcote, Peter;
Jordan, T.;
Miller, John

Publication type:

Article

LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 574, doi. 10.1007/s10637-010-9391-9

By:

Gao, Jian-Jun;
Gao, Zu-Hua;
Zhao, Cui-Rong;
Yuan, Yi;
Cui, Shu-Xiang;
Zhang, Xiao-Fan;
Cheng, Yan-Na;
Xu, Wen-Fang;
Tang, Wei;
Qu, Xian-Jun

Publication type:

Article

Proposal for size justification of expanded cohort at phase-2-recommended dose.

Published in:

2011

By:

Penel, Nicolas;
Fournier, Charles;
Bérille, Jocelyne

Publication type:

Report

AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 554, doi. 10.1007/s10637-010-9389-3

By:

Torres, Mylin;
Raju, Uma;
Molkentine, David;
Riesterer, Oliver;
Milas, Luka;
Ang, K.

Publication type:

Article

A phase 1, multicenter, open-label study of the safety of two dose levels of a human monoclonal antibody to human α integrins, intetumumab, in combination with docetaxel and prednisone in patients with castrate-resistant metastatic prostate cancer.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 674, doi. 10.1007/s10637-010-9388-4

By:

Chu, Franklin;
Picus, Joel;
Fracasso, Paula;
Dreicer, Robert;
Lang, Zhihui;
Foster, Brenda

Publication type:

Article

Escalating weekly doses of cetuximab and correlation with skin toxicity: A phase I study.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 680, doi. 10.1007/s10637-010-9396-4

By:

Ho, Cheryl;
Sangha, Randeep;
Beckett, Laurel;
Tanaka, Michael;
Lau, Derick;
Eisen, Daniel;
Burich, Rachel;
Luciw, Paul;
Khan, Imran;
Mack, Philip;
Gandara, David;
Davies, Angela

Publication type:

Article

The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF- and VEGF-receptor, are liver-size-dependent after partial hepatectomy in rats.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 593, doi. 10.1007/s10637-010-9394-6

By:

Deng, Meihong;
Huang, Hai;
Jin, Hao;
Dirsch, Olaf;
Dahmen, Uta

Publication type:

Article

Anticancer activity and mode of action of titanocene C.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 607, doi. 10.1007/s10637-010-9395-5

By:

Olszewski, Ulrike;
Claffey, James;
Hogan, Megan;
Tacke, Matthias;
Zeillinger, Robert;
Bednarski, Patrick;
Hamilton, Gerhard

Publication type:

Article

Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 562, doi. 10.1007/s10637-010-9390-x

By:

Hoyt, Mirth;
Palchaudhuri, Rahul;
Hergenrother, Paul

Publication type:

Article

A natural compound, methyl angolensate, induces mitochondrial pathway of apoptosis in Daudi cells.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 583, doi. 10.1007/s10637-010-9393-7

By:

Chiruvella, Kishore;
Raghavan, Sathees

Publication type:

Article

Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 615, doi. 10.1007/s10637-010-9398-2

By:

Chan, Ariane;
Andreae, Peter;
Northcote, Peter;
Miller, John

Publication type:

Article

Avascular necrosis of the femoral head: a rare class-effect of anti-VEGF agents.

Published in:

2011

By:

Mir, Olivier;
Coriat, Romain;
Gregory, Thomas;
Ropert, Stanislas;
Billemont, Bertrand;
Goldwasser, François

Publication type:

Report

B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 646, doi. 10.1007/s10637-010-9403-9

By:

Liang, Xin;
Wu, Aibin;
Xu, Yufang;
Xu, Ke;
Liu, Jianwen;
Qian, Xuhong

Publication type:

Article

Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 637, doi. 10.1007/s10637-010-9402-x

By:

Xu, Xiao-Fang;
Cai, Bo-Lei;
Guan, Su-Min;
Li, Yan;
Wu, Jun-Zheng;
Wang, Yong;
Liu, Bin

Publication type:

Article

Suppressive effects of liquid crystal compounds on the growth of the A549 human lung cancer cell line.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 659, doi. 10.1007/s10637-010-9411-9

By:

Takahashi, Yuuka;
Hazawa, Masaharu;
Takahashi, Kenji;
Nishizawa, Ayumi;
Yoshizawa, Atsushi;
Kashiwakura, Ikuo

Publication type:

Article

Anoikis induction and metastasis suppression by a new integrin αvβ3 inhibitor in human melanoma cell line M21.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 666, doi. 10.1007/s10637-010-9616-y

By:

Zhang, Yongci;
Yang, Ming;
Ji, Qing;
Fan, Dongmei;
Peng, Hui;
Yang, Chunzheng;
Xiong, Dongsheng;
Zhou, Yuan

Publication type:

Article

The notorious 'drug lag' for oncology drugs in Japan.

Published in:

Investigational New Drugs, 2011, v. 29, n. 4, p. 706, doi. 10.1007/s10637-011-9638-0

By:

Yonemori, Kan;
Hirakawa, Akihiro;
Ando, Masashi;
Hirata, Taizo;
Yunokawa, Mayu;
Shimizu, Chikako;
Katsumata, Noriyuki;
Tamura, Kenji;
Fujiwara, Yasuhiro

Publication type:

Article