Works in Investigational New Drugs, 2020, Vol 38, Issue 5

Results: 46

Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1365, doi. 10.1007/s10637-020-00937-y

By:

Breen, Laura;
Gaule, Patricia B.;
Canonici, Alexandra;
Walsh, Naomi;
Collins, Denis M.;
Cremona, Mattia;
Hennessy, Bryan T.;
Duffy, Michael J.;
Crown, John;
Donovan, Norma O';
Eustace, Alex J.

Publication type:

Article

Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1526, doi. 10.1007/s10637-020-00935-0

By:

Yu, Huixin;
Janssen, Julie M.;
de Weger, Vincent A.;
Nuijen, Bastiaan;
Stuurman, Rik E.;
Marchetti, Serena;
Schellens, Jan H. M.;
Beijnen, Jos H.;
Dorlo, Thomas P. C.;
Huitema, Alwin D. R.

Publication type:

Article

Dasatinib-induced chylothorax: report of a case and review of the literature.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1627, doi. 10.1007/s10637-020-00932-3

By:

Chen, Bojiang;
Wu, Zuohong;
Wang, Qin;
Li, Weimin;
Cheng, Deyun

Publication type:

Article

A randomized, phase 2 study of deoxyuridine triphosphatase inhibitor, TAS-114, in combination with S-1 versus S-1 alone in patients with advanced non-small-cell lung cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1588, doi. 10.1007/s10637-020-00930-5

By:

Yamamoto, Nobuyuki;
Hayashi, Hidetoshi;
Planchard, David;
Morán, Teresa;
Gregorc, Vanesa;
Dowell, Jonathan;
Sakai, Hiroshi;
Yoh, Kiyotaka;
Nishio, Makoto;
Cortot, Alexis B.;
Benhadji, Karim A.;
Soni, Nital;
Huang, Jinhong;
Makris, Lukas;
Cedres, Susana

Publication type:

Article

Phase 1 dose escalation trial of TAS-102 (trifluridine/tipiracil) and temozolomide in the treatment of advanced neuroendocrine tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1520, doi. 10.1007/s10637-020-00929-y

By:

Uboha, Nataliya V.;
Lubner, Sam J.;
LoConte, Noelle K.;
Mulkerin, Daniel L.;
Eickhoff, Jens C.;
Deming, Dustin A.

Publication type:

Article

Open-label, single-center, phase I trial to investigate the mass balance and absolute bioavailability of the highly selective oral MET inhibitor tepotinib in healthy volunteers.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1507, doi. 10.1007/s10637-020-00926-1

By:

Johne, Andreas;
Scheible, Holger;
Becker, Andreas;
van Lier, Jan Jaap;
Wolna, Peter;
Meyring, Michael

Publication type:

Article

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1495, doi. 10.1007/s10637-020-00924-3

By:

Okano, Naohiro;
Naruge, Daisuke;
Kawai, Kirio;
Kobayashi, Takaaki;
Nagashima, Fumio;
Endou, Hitoshi;
Furuse, Junji

Publication type:

Article

Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1350, doi. 10.1007/s10637-020-00923-4

By:

Łupicka-Słowik, Agnieszka;
Psurski, Mateusz;
Grzywa, Renata;
Cuprych, Monika;
Ciekot, Jarosław;
Goldeman, Waldemar;
Wojaczyńska, Elżbieta;
Wojaczyński, Jacek;
Oleksyszyn, Józef;
Sieńczyk, Marcin

Publication type:

Article

Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1618, doi. 10.1007/s10637-020-00922-5

By:

Maulhardt, Holly A.;
Marin, Alyson M.;
diZerega, Gere S.

Publication type:

Article

Dezocine promotes T lymphocyte activation and inhibits tumor metastasis after surgery in a mouse model.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1342, doi. 10.1007/s10637-020-00921-6

By:

Song, Qiang;
Liu, Geng;
Liu, Dongyi;
Feng, Chang

Publication type:

Article

Phase I study of metformin in combination with carboplatin/paclitaxel chemotherapy in patients with advanced epithelial ovarian cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1454, doi. 10.1007/s10637-020-00920-7

By:

Broekman, K. Esther;
Hof, Marieke A. J.;
Touw, Daan J.;
Gietema, Jourik A.;
Nijman, Hans W.;
Lefrandt, Joop D.;
Reyners, An K. L.;
Jalving, Mathilde

Publication type:

Article

Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1463, doi. 10.1007/s10637-020-00918-1

By:

Viglietta, Vissia;
Shi, Fuxin;
Hu, Qi-Ying;
Ren, Yong;
Keilty, John;
Wolff, Heather;
McCarthy, Ryan;
Kropp, Jason;
Weber, Pete;
Soglia, John

Publication type:

Article

Clinical and radiation dose-volume factors related to pneumonitis after treatment with radiation and durvalumab in locally advanced non-small cell lung cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1612, doi. 10.1007/s10637-020-00917-2

By:

Inoue, Hiroto;
Ono, Akira;
Kawabata, Takanori;
Mamesaya, Nobuaki;
Kawamura, Takahisa;
Kobayashi, Haruki;
Omori, Shota;
Wakuda, Kazushige;
Kenmotsu, Hirotsugu;
Naito, Tateaki;
Murakami, Haruyasu;
Yasui, Kazuaki;
Ogawa, Hirofumi;
Onoe, Tsuyoshi;
Endo, Masahiro;
Harada, Hideyuki;
Takahashi, Toshiaki

Publication type:

Article

Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1472, doi. 10.1007/s10637-020-00916-3

By:

Kroschinsky, Frank;
Middeke, Jan Moritz;
Janz, Martin;
Lenz, Georg;
Witzens-Harig, Mathias;
Bouabdallah, Reda;
La Rosée, Paul;
Viardot, Andreas;
Salles, Gilles;
Kim, Seok Jin;
Kim, Tae Min;
Ottmann, Oliver;
Chromik, Joerg;
Quinson, Anne-Marie;
von Wangenheim, Ute;
Burkard, Ute;
Berk, Andreas;
Schmitz, Norbert

Publication type:

Article

Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1448, doi. 10.1007/s10637-020-00915-4

By:

Rowinsky, Eric K.;
Paner, Agne;
Berdeja, Jesus G.;
Paba-Prada, Claudia;
Venugopal, Parameswaran;
Porkka, Kimmo;
Gullbo, Joachim;
Linder, Stig;
Loskog, Angelica;
Richardson, Paul G.;
Landgren, Ola

Publication type:

Article

Administration of the vasopressin analog desmopressin for the management of bleeding in rectal cancer patients: results of a phase I/II trial.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1580, doi. 10.1007/s10637-020-00914-5

By:

Iseas, Soledad;
Roca, Enrique L.;
O'Connor, Juan M.;
Eleta, Martin;
Sanchez-Luceros, Analia;
Di Leo, Daniela;
Tinelli, Marcelo;
Fara, Maria L.;
Spitzer, Eduardo;
Demarco, Ignacio A.;
Ripoll, Giselle V.;
Pifano, Marina;
Garona, Juan;
Alonso, Daniel F.

Publication type:

Article

Adjuvant pembrolizumab versus high-dose interferon α-2b for Chinese patients with resected stage III melanoma: a retrospective cohort study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1334, doi. 10.1007/s10637-020-00913-6

By:

Li, Tao;
Jia, Dong-Dong;
Teng, Li-Song

Publication type:

Article

Retrospective review of the activity and safety of apatinib and anlotinib in patients with advanced osteosarcoma and soft tissue sarcoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1559, doi. 10.1007/s10637-020-00912-7

By:

Tian, Zhichao;
Liu, Huimin;
Zhang, Fan;
Li, Liangyu;
Du, Xinhui;
Li, Chao;
Yang, Jinpo;
Wang, Jiaqiang

Publication type:

Article

Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1326, doi. 10.1007/s10637-020-00911-8

By:

Ciftci, Halil I.;
Can, Mustafa;
Ellakwa, Doha E.;
Suner, Salih C.;
Ibrahim, Mohamed A.;
Oral, Ayhan;
Sekeroglu, Nazim;
Özalp, Barış;
Otsuka, Masami;
Fujita, Mikako;
Alparslan, Mustafa;
Radwan, Mohamed O.

Publication type:

Article

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1570, doi. 10.1007/s10637-020-00910-9

By:

Wick, Antje;
Desjardins, Annick;
Suarez, Cristina;
Forsyth, Peter;
Gueorguieva, Ivelina;
Burkholder, Tiana;
Cleverly, Ann Louise;
Estrem, Shawn T.;
Wang, Shuaicheng;
Lahn, Michael M.;
Guba, Susan C.;
Capper, David;
Rodon, Jordi

Publication type:

Article

Evaluating the antitumor activity of sphingosine-1-phosphate against human triple-negative breast cancer cells with basal-like morphology.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1316, doi. 10.1007/s10637-020-00909-2

By:

Abuhussein, Omar;
Yang, Jian

Publication type:

Article

A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1483, doi. 10.1007/s10637-020-00908-3

By:

Cleary, James M.;
Calvo, Emiliano;
Moreno, Victor;
Juric, Dejan;
Shapiro, Geoffrey I.;
Vanderwal, Carol Ann;
Hu, Beibei;
Gifford, Maryella;
Barch, David;
Roberts-Rapp, Lisa;
Ansell, Peter J.;
Xiong, Hao;
Ocampo, Christopher;
Tolcher, Anthony W.

Publication type:

Article

Phase 1 study of the MDM2 antagonist RO6839921 in patients with acute myeloid leukemia.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1430, doi. 10.1007/s10637-020-00907-4

By:

Uy, Geoffrey L.;
Assouline, Sarit;
Young, Anne-Marie;
Blotner, Steven;
Higgins, Brian;
Chen, Lin-Chi;
Yee, Karen

Publication type:

Article

Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1373, doi. 10.1007/s10637-020-00906-5

By:

Zhao, Man-Fei;
Liang, Gong-Da;
Zhou, Yu-Jie;
Chi, Zhi-Ping;
Zhuang, He;
Zhu, Song-Ling;
Wang, Yao;
Liu, Gui-Rong;
Zhao, Jing-Bo;
Liu, Shu-Lin

Publication type:

Article

Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1303, doi. 10.1007/s10637-020-00905-6

By:

OM, Hendawy;
El-Naggar, Mehrez E.;
El-Banna, Mona;
Fouda, Moustafa M. G.;
Othman, Sarah I.;
Allam, Ahmed A.;
Morsy, Osama M.

Publication type:

Article

Phase I dose-escalation study of the safety, tolerability, and pharmacokinetics of aflibercept in combination with S-1 in Japanese patients with advanced solid malignancies.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1390, doi. 10.1007/s10637-019-00888-z

By:

Doi, Toshihiko;
Boku, Narikazu;
Onozawa, Yusuke;
Takahashi, Keishiro;
Kawaguchi, Osamu;
Ohtsu, Atsushi

Publication type:

Article

A Canadian cancer trials group phase IB study of durvalumab (anti-PD-L1) plus tremelimumab (anti-CTLA-4) given concurrently or sequentially in patients with advanced, incurable solid malignancies.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1442, doi. 10.1007/s10637-020-00904-7

By:

Nehra, J.;
Bradbury, P. A.;
Ellis, P. M.;
Laskin, J.;
Kollmannsberger, C.;
Hao, D.;
Juergens, R. A.;
Goss, G.;
Wheatley-Price, P.;
Hotte, S. J.;
Gelmon, K.;
Tinker, A. V.;
Brown-Walker, P.;
Gauthier, I.;
Tu, D.;
Song, X.;
Khan, A.;
Seymour, Lesley;
Smoragiewicz, M.

Publication type:

Article

Sorafenib may enhance antitumour efficacy in hepatocellular carcinoma patients by modulating the proportions and functions of natural killer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1247, doi. 10.1007/s10637-019-00885-2

By:

Hu, Jie;
Wang, Enxin;
Liu, Lei;
Wang, Qiuhe;
Xia, Dongdong;
Bai, Wei;
Tie, Jun;
Li, Xiaomei;
Yuan, Jie;
Yang, Shuya;
Jiang, Dongbo;
Shi, Jingqi;
Sun, Yuanjie;
Wang, Jing;
Zhang, Chunmei;
Niu, Jing;
Li, Kai;
He, Chuangye;
Guo, Wengang;
Lv, Yong

Publication type:

Article

Effective upfront treatment with low-dose ibrutinib for a patient with B cell prolymphocytic leukemia.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1598, doi. 10.1007/s10637-020-00902-9

By:

Oka, Satoko;
Ono, Kazuo;
Nohgawa, Masaharu

Publication type:

Article

Effectiveness and safety of eribulin in Japanese patients with HER2-negative, advanced breast cancer: a 2-year post-marketing observational study in a real-world setting.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1540, doi. 10.1007/s10637-019-00890-5

By:

Inoue, Kenichi;
Takahashi, Masato;
Mukai, Hirofumi;
Yamanaka, Takashi;
Egawa, Chiyomi;
Sakata, Yukinori;
Ikezawa, Hiroki;
Matsuoka, Toshiyuki;
Tsurutani, Junji

Publication type:

Article

A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1533, doi. 10.1007/s10637-019-00889-y

By:

Goyal, Lipika;
Chaudhary, Surendra Pal;
Kwak, Eunice L.;
Abrams, Thomas A.;
Carpenter, Amanda N.;
Wolpin, Brian M.;
Wadlow, Raymond C.;
Allen, Jill N.;
Heist, Rebecca;
McCleary, Nadine Jackson;
Chan, Jennifer A.;
Goessling, Wolfram;
Schrag, Deborah;
Ng, Kimmie;
Enzinger, Peter C.;
Ryan, David P.;
Clark, Jeffrey W.

Publication type:

Article

A multi-center phase II trial evaluating the efficacy of palbociclib in combination with carboplatin for the treatment of unresectable recurrent or metastatic head and neck squamous cell carcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1550, doi. 10.1007/s10637-020-00898-2

By:

Swiecicki, Paul L.;
Durm, Greg;
Bellile, Emily;
Bhangale, Apurva;
Brenner, J. Chad;
Worden, Francis P.

Publication type:

Article

Metabolomic profiling to evaluate the efficacy of proxalutamide, a novel androgen receptor antagonist, in prostate cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1292, doi. 10.1007/s10637-020-00901-w

By:

Qu, Feng;
Gu, Yue;
Wang, Qizhi;
He, Mingzhe;
Zhou, Fang;
Sun, Jianguo;
Wang, Guangji;
Peng, Ying

Publication type:

Article

A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1421, doi. 10.1007/s10637-020-00899-1

By:

Smith, David C.;
Kroiss, Matthias;
Kebebew, Electron;
Habra, Mouhammed Amir;
Chugh, Rashmi;
Schneider, Bryan J.;
Fassnacht, Martin;
Jafarinasabian, Pegah;
Ijzerman, M. Marian;
Lin, Vivian H.;
Mohideen, Pharis;
Naing, Aung

Publication type:

Article

KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1282, doi. 10.1007/s10637-020-00896-4

By:

Hwang, Jungjoong;
Song, Insuk;
Lee, Kwangho;
Kim, Hyoung Rae;
Hong, Eun-Hye;
Hwang, Jung Soon;
Ahn, Sung-Hoon;
Lee, Jongkook

Publication type:

Article

Pharmacokinetics of mitomycin-c lipidic prodrug entrapped in liposomes and clinical correlations in metastatic colorectal cancer patients.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1411, doi. 10.1007/s10637-020-00897-3

By:

Gabizon, Alberto A.;
Tahover, Esther;
Golan, Talia;
Geva, Ravit;
Perets, Ruth;
Amitay, Yasmine;
Shmeeda, Hilary;
Ohana, Patricia

Publication type:

Article

W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1218, doi. 10.1007/s10637-019-00886-1

By:

Liang, Dong;
Wang, Hong-Ying;
Fan, Shu;
Wang, Jin;
Shen, Ying;
Gao, Chen-Ying;
Wu, Man-Li;
Lu, She-Min;
Zhang, San-Qi;
Han, Wei

Publication type:

Article

A phase I study of an oral selective gamma secretase (GS) inhibitor RO4929097 in combination with neoadjuvant paclitaxel and carboplatin in triple negative breast cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1400, doi. 10.1007/s10637-020-00895-5

By:

Sardesai, Sagar;
Badawi, Mohamed;
Mrozek, Ewa;
Morgan, Evan;
Phelps, Mitch;
Stephens, Julie;
Wei, Lai;
Kassem, Mahmoud;
Ling, Yonghua;
Lustberg, Maryam;
Stover, Daniel;
Williams, Nicole;
Layman, Rachel;
Reinbolt, Raquel;
VanDeusen, Jeffrey;
Cherian, Mathew;
Grever, Michael;
Carson, William;
Ramaswamy, Bhuvaneswari;
Wesolowski, Robert

Publication type:

Article

Patient selection for a developmental therapeutics program using whole genome and Transcriptome analysis.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1601, doi. 10.1007/s10637-020-00892-8

By:

Lavoie, Jean-Michel;
Mitchell, Teresa;
Lee, Sung-Eun;
Deol, Balvir;
Chia, Stephen K.;
Gelmon, Karen A.;
Kollmannsberger, Christian K.;
Tinker, Anna V.;
Jones, Steven J. M.;
Marra, Marco;
Laskin, Janessa;
Renouf, Daniel J.

Publication type:

Article

Efficacy of different dosing schedules of capecitabine for metastatic breast cancer: a single-institution experience.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1605, doi. 10.1007/s10637-020-00891-9

By:

Suresh, Anupama;
Ganju, Akannsha;
Morgan, Evan;
Palettas, Marilly;
Stephens, Julie A.;
Liu, Joseph;
Berger, Michael;
Vargo, Craig;
Noonan, Anne;
Reinbolt, Raquel;
Cherian, Mathew;
VanDeusen, Jeffrey;
Sardesai, Sagar;
Wesolowski, Robert;
Stover, Daniel G.;
Lustberg, Maryam;
Ramaswamy, Bhuvaneswari;
Williams, Nicole

Publication type:

Article

Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1227, doi. 10.1007/s10637-019-00884-3

By:

Zhao, Chengbin;
Gao, Yuyuan;
Guo, Ruiming;
Li, Hongwei;
Yang, Bo

Publication type:

Article

[HuArgI (co)-PEG5000]-induced arginine deprivation leads to autophagy dependent cell death in pancreatic cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1236, doi. 10.1007/s10637-019-00883-4

By:

Khalil, Nathalie;
Abi-Habib, Ralph J.

Publication type:

Article

NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1383, doi. 10.1007/s10637-019-00880-7

By:

Molina, Ana M.;
van der Mijn, Johannes C.;
Christos, Paul;
Wright, John;
Thomas, Charlene;
Dutcher, Janice P.;
Nanus, David M.;
Tagawa, Scott T.;
Gudas, Lorraine J.

Publication type:

Article

Design, synthesis and cytotoxicity of the antitumor agent 1-azabicycles for chemoresistant glioblastoma cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1257, doi. 10.1007/s10637-019-00877-2

By:

Oliveira, Mona;
de Santana, Lourenço Luis Botelho;
Serafim, José Claudio;
Santos, Airam Oliveira;
Quintino, Michelle Pereira;
Correia, José Tiago Menezes;
Damasceno, Fabiano;
Sabino, José Ricardo;
Pires, Thiago Rubens Cardim;
Coelho, Paulo Lucas Cerqueira;
de Faria Lopes, Giselle Pinto;
Ulrich, Henning;
Costa, Silvia Lima;
Cunha, Silvio

Publication type:

Article

Combination of a novel microtubule inhibitor MBRI-001 and gemcitabine synergistically induces cell apoptosis by increasing DNA damage in pancreatic cancer cell lines.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1207, doi. 10.1007/s10637-019-00874-5

By:

Liu, Yuqian;
Zang, Ruochen;
Li, Feifei;
Shi, Chuanqin;
Zhao, Jianchun;
Zhong, Lili;
Wang, Xin;
Yang, Jinbo;
Li, Wenbao

Publication type:

Article

Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models.

Published in:

Investigational New Drugs, 2020, v. 38, n. 5, p. 1272, doi. 10.1007/s10637-019-00868-3

By:

Wang, Li;
Hu, Chen;
Wang, Aoli;
Chen, Cheng;
Wu, Jiaxin;
Jiang, Zongru;
Zou, Fengming;
Yu, Kailin;
Wu, Hong;
Liu, Juan;
Wang, Wenliang;
Wang, Zuowei;
Wang, Beilei;
Qi, Ziping;
Liu, Qingwang;
Wang, Wenchao;
Li, Lili;
Ge, Jian;
Liu, Jing;
Liu, Qingsong

Publication type:

Article