Works in Investigational New Drugs, 2020, Vol 38, Issue 1

Results: 23

Acknowledgement of Reviewers 2019.

Published in:: Investigational New Drugs, 2020, v. 38, n. 1, p. 219, doi. 10.1007/s10637-020-00893-7
Publication type:: Article

Association between metastatic sites and first-line pembrolizumab treatment outcome for advanced non–small cell lung cancer with high PD-L1 expression: a retrospective multicenter cohort study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 211, doi. 10.1007/s10637-019-00882-5

By:

Kawachi, Hayato;
Tamiya, Motohiro;
Tamiya, Akihiro;
Ishii, Seigo;
Hirano, Katsuya;
Matsumoto, Hirotaka;
Fukuda, Yasushi;
Yokoyama, Toshihide;
Kominami, Ryota;
Fujimoto, Daichi;
Hosoya, Kazutaka;
Suzuki, Hidekazu;
Hirashima, Tomonori;
Kanazu, Masaki;
Sawa, Nobuhiko;
Uchida, Junji;
Morita, Mitsunori;
Makio, Takeshi;
Hara, Satoshi;
Kumagai, Toru

Publication type:

Article

The effect of itraconazole on the pharmacokinetics of lorlatinib: results of a phase I, open-label, crossover study in healthy participants.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 131, doi. 10.1007/s10637-019-00872-7

By:

Patel, Maulik;
Chen, Joseph;
McGrory, Stephanie;
O'Gorman, Melissa;
Nepal, Sunil;
Ginman, Katherine;
Pithavala, Yazdi K.

Publication type:

Article

The influence of direct-acting antivirals in hepatitis C virus related hepatocellular carcinoma after curative treatment.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 202, doi. 10.1007/s10637-019-00870-9

By:

Kuo, Yuan-Hung;
Wang, Jing-Houng;
Chang, Kuo-Chin;
Hung, Chao-Hung;
Lu, Sheng-Nan;
Hu, Tsung-Hui;
Yen, Yi-Hao;
Kee, Kwong-Ming;
Chen, Chien-Hung

Publication type:

Article

Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 181, doi. 10.1007/s10637-019-00867-4

By:

Boussios, Stergios;
Karihtala, Peeter;
Moschetta, Michele;
Abson, Charlotte;
Karathanasi, Afroditi;
Zakynthinakis-Kyriakou, Nikolaos;
Ryan, Jake Edward;
Sheriff, Matin;
Rassy, Elie;
Pavlidis, Nicholas

Publication type:

Article

Germinal Immunogenetics predict treatment outcome for PD-1/PD-L1 checkpoint inhibitors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 160, doi. 10.1007/s10637-019-00845-w

By:

Refae, Sadal;
Gal, Jocelyn;
Ebran, Nathalie;
Otto, Josiane;
Borchiellini, Delphine;
Peyrade, Frederic;
Chamorey, Emmanuel;
Brest, Patrick;
Milano, Gérard;
Saada-Bouzid, Esma

Publication type:

Article

TS-1 add-on therapy in Japanese patients with triple-negative breast cancer after neoadjuvant or adjuvant chemotherapy: a feasibility study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 140, doi. 10.1007/s10637-019-00829-w

By:

Inoue, Kenichi;
Nagai, Shigenori E.;
Saito, Tsuyoshi;
Sakurai, Takashi;
Kimizuka, Kei;
Yamada, Hirofumi;
Kuroda, Toru;
Hata, Satoshi;
Yamazaki, Yasuo;
Kojima, Masato;
Futsuhara, Kazushige

Publication type:

Article

A randomized phase 2 trial of apatinib vs observation as maintenance treatment following first-line induction chemotherapy in extensive- stage small cell lung cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 148, doi. 10.1007/s10637-019-00828-x

By:

Luo, Hao;
Zhang, Liang;
Yang, Bo;
Feng, Yan;
Xiong, Yanli;
Zhang, Shiheng;
Li, Xuemei;
Qian, Chengyuan;
Dong, Wang;
Dai, Nan

Publication type:

Article

Negative impact of malignant effusion on osimertinib treatment for non-small cell lung cancer harboring EGFR mutation.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 194, doi. 10.1007/s10637-019-00808-1

By:

Kawamura, Takahisa;
Kenmotsu, Hirotsugu;
Kobayashi, Haruki;
Omori, Shota;
Nakashima, Kazuhisa;
Wakuda, Kazushige;
Ono, Akira;
Naito, Tateaki;
Murakami, Haruyasu;
Mori, Keita;
Endo, Masahiro;
Takahashi, Toshiaki

Publication type:

Article

Pharmacological effects of the simultaneous and sequential combinations of trifluridine/tipiracil (TAS-102) and 5-fluorouracil in fluoropyrimidine-sensitive colon cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 92, doi. 10.1007/s10637-019-00804-5

By:

Orlandi, Paola;
Gentile, Daniela;
Banchi, Marta;
Cucchiara, Federico;
Di Desidero, Teresa;
Cremolini, Chiara;
Moretto, Roberto;
Falcone, Alfredo;
Bocci, Guido

Publication type:

Article

Discovery of a pyrimidine compound endowed with antitumor activity.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 39, doi. 10.1007/s10637-019-00762-y

By:

Taglieri, Ludovica;
Saccoliti, Francesco;
Nicolai, Alice;
Peruzzi, Giovanna;
Madia, Valentina Noemi;
Tudino, Valeria;
Messore, Antonella;
Di Santo, Roberto;
Artico, Marco;
Taurone, Samanta;
Salvati, Maurizio;
Costi, Roberta;
Scarpa, Susanna

Publication type:

Article

Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 79, doi. 10.1007/s10637-019-00793-5

By:

Yang, Jincheng;
Chen, Kun;
Wang, Bin;
Wang, Liudi;
Qi, Shuya;
Wang, Weihua

Publication type:

Article

Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 70, doi. 10.1007/s10637-019-00784-6

By:

Rodrigues-Junior, Dorival Mendes;
de Almeida Pontes, Nicolie Melanie;
de Albuquerque, Gabriela Estrela;
Carlin, Viviane;
Perecim, Givago Prado;
Raminelli, Cristiano;
Vettore, André Luiz

Publication type:

Article

MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 60, doi. 10.1007/s10637-019-00766-8

By:

Liu, Yang;
Tan, Juan;
Ou, Shuangyan;
Chen, Jun;
Chen, Limin

Publication type:

Article

Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 50, doi. 10.1007/s10637-019-00764-w

By:

Zhou, Jiabin;
Li, Genhua;
Han, Guangkui;
Feng, Song;
Liu, Yuhan;
Chen, Jun;
Liu, Chen;
Zhao, Lei;
Jin, Feng

Publication type:

Article

Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 172, doi. 10.1007/s10637-019-00801-8

By:

Ogasawara, Sadahisa;
Ooka, Yoshihiko;
Itokawa, Norio;
Inoue, Masanori;
Okabe, Shinichiro;
Seki, Atsuyoshi;
Haga, Yuki;
Obu, Masamichi;
Atsukawa, Masanori;
Itobayashi, Ei;
Mizumoto, Hideaki;
Sugiura, Nobuyuki;
Azemoto, Ryosaku;
Kanayama, Kengo;
Kanzaki, Hiroaki;
Maruta, Susumu;
Maeda, Takahiro;
Kusakabe, Yuko;
Yokoyama, Masayuki;
Kobayashi, Kazufumi

Publication type:

Article

Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 20, doi. 10.1007/s10637-019-00761-z

By:

Zheng, Yufan;
Chen, Hairong;
Zhao, Yang;
Zhang, Xuping;
Liu, Jinjin;
Pan, Yu;
Bai, Jin;
Zhang, Hongwei

Publication type:

Article

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 10, doi. 10.1007/s10637-019-00756-w

By:

Nasreddine, Ghenwa;
El-Sibai, Mirvat;
Abi-Habib, Ralph J.

Publication type:

Article

Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 29, doi. 10.1007/s10637-019-00753-z

By:

Wu, Jing-De;
Cui, Ying-Jie;
Zhou, Yi-Gang;
Tang, Long-Qian;
Zhang, Cheng-Mei;
Liu, Zhao-Peng

Publication type:

Article

Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 1, doi. 10.1007/s10637-019-00752-0

By:

Abdelfatah, Sara;
Fleischer, Edmond;
Klinger, Anette;
Wong, Vincent Kam Wai;
Efferth, Thomas

Publication type:

Article

A phase I study to determine the maximum tolerated dose of trifluridine/tipiracil and oxaliplatin in patients with refractory metastatic colorectal cancer: LUPIN study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 111, doi. 10.1007/s10637-019-00749-9

By:

Suenaga, Mitsukuni;
Wakatsuki, Takeru;
Mashima, Tetsuo;
Ogura, Mariko;
Ichimura, Takashi;
Shinozaki, Eiji;
Nakayama, Izuma;
Osumi, Hiroki;
Ota, Yumiko;
Takahari, Daisuke;
Chin, Keisho;
Seimiya, Hiroyuki;
Yamaguchi, Kensei

Publication type:

Article

A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 99, doi. 10.1007/s10637-019-00745-z

By:

Lee, Jih-Hsiang;
Chen, Tom Wei-Wu;
Hsu, Chih-Hung;
Yen, Yu-Hsin;
Yang, James Chih-Hsin;
Cheng, Ann-Lii;
Sasaki, Shun-ichi;
Chiu, LiYin (Lillian);
Sugihara, Masahiro;
Ishizuka, Tomoko;
Oguma, Toshihiro;
Tajima, Naoyuki;
Lin, Chia-Chi

Publication type:

Article

A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody–drug conjugate, in patients with breast cancer and other advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 1, p. 120, doi. 10.1007/s10637-019-00754-y

By:

Rosen, Lee S.;
Wesolowski, Robert;
Baffa, Raffaele;
Liao, Kai-Hsin;
Hua, Steven Y.;
Gibson, Brenda L.;
Pirie-Shepherd, Steven;
Tolcher, Anthony W.

Publication type:

Article