Found: 22
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The marine natural product Scalarin inhibits the receptor for advanced glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines.
- Published in:
- Investigational New Drugs, 2019, v. 37, n. 2, p. 262, doi. 10.1007/s10637-018-0635-4
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- Article
Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 252, doi. 10.1007/s10637-018-0626-5
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- Article
Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 210, doi. 10.1007/s10637-018-0623-8
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- Article
IMRT combined with S-1 concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a prospective phase II study.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 352, doi. 10.1007/s10637-018-00720-0
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- Article
Efficacy and safety of the combination of metformin, everolimus and exemestane in overweight and obese postmenopausal patients with metastatic, hormone receptor-positive, HER2-negative breast cancer: a phase II study.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 345, doi. 10.1007/s10637-018-0700-z
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- Article
Pazopanib with low fat meal (PALM) in advanced renal cell carcinoma.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 323, doi. 10.1007/s10637-018-0692-8
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- Article
A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 338, doi. 10.1007/s10637-018-0691-9
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- Article
Phase I/II study evaluating the safety and clinical efficacy of temsirolimus and bevacizumab in patients with chemotherapy refractory metastatic castration-resistant prostate cancer.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 331, doi. 10.1007/s10637-018-0687-5
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- Article
Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 378, doi. 10.1007/s10637-018-0666-x
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- Article
Identification of differentially expressed genes and signaling pathways using bioinformatics in interstitial lung disease due to tyrosine kinase inhibitors targeting the epidermal growth factor receptor.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 384, doi. 10.1007/s10637-018-0664-z
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- Article
Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 315, doi. 10.1007/s10637-018-0663-0
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- Article
A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 307, doi. 10.1007/s10637-018-0662-1
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- Article
Long-term adverse event: inflammatory orbitopathy induced by pembrolizumab in a patient with metastatic melanoma.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 375, doi. 10.1007/s10637-018-0659-9
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- Article
Phase I study of S-1 plus paclitaxel combination therapy as a first-line treatment in elderly patients with advanced non-small cell lung cancer.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 291, doi. 10.1007/s10637-018-0656-z
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- Article
A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 297, doi. 10.1007/s10637-018-0655-0
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- Article
Sarcoid-like reaction mimicking disease progression in an ALK-positive lung cancer patient receiving lorlatinib.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 360, doi. 10.1007/s10637-018-0652-3
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- Article
A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 282, doi. 10.1007/s10637-018-0648-z
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- Article
Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 364, doi. 10.1007/s10637-018-0647-0
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Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 271, doi. 10.1007/s10637-018-0627-4
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- Article
Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 223, doi. 10.1007/s10637-018-0620-y
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- Article
Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc<sup>Min/+</sup> mouse model of colon carcinogenesis.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 238, doi. 10.1007/s10637-018-0622-9
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- Article
Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.
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- Investigational New Drugs, 2019, v. 37, n. 2, p. 201, doi. 10.1007/s10637-018-0619-4
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- Article